Clinical Obesity最新文献

{"title":"What is known about the use of weight loss medication in women with overweight/obesity on fertility and reproductive health outcomes? A scoping review","authors":"Kate Maslin,&nbsp;Rabab Alkutbe,&nbsp;Jeremy Gilbert,&nbsp;Jonathan Pinkney,&nbsp;Jill Shawe","doi":"10.1111/cob.12690","DOIUrl":"10.1111/cob.12690","url":null,"abstract":"<p>Pregnancy during or soon after treatment with weight loss medication, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), is contraindicated due to potential teratogenicity. The aim of this scoping review is to investigate what is known about the use of weight loss medication in women of childbearing age in relation to reproductive health outcomes, focusing on the three medications licenced in the United Kingdom at the time of the search. A systematic search of studies that assessed reproductive health outcomes in women taking either orlistat, liraglutide or semaglutide was undertaken in July 2023 and updated in January 2024 across MEDLINE, Embase, CINAHL, Scopus, ClinicalTrials.gov, PROSPERO, Epistemonikos and OpenGrey. Studies focused on polycystic ovarian syndrome, diabetes or animals were excluded. Titles and abstracts were screened, and data from included articles were extracted. After removal of duplicates, 341 titles remained, of which 318 were excluded. Of the final 18 articles included, there were five interventional trials, one retrospective case-control study, six narrative reviews, two systematic reviews, three systematic review protocols and one registry protocol yet to start recruitment. All five interventional trials involved orlistat given preconceptionally, showing no improvement in live birth rate, despite improvement in reproductive hormone levels. There were no studies with primary data about GLP-1 RAs. There were no qualitative studies. There is an absence of primary data about the role of GLP-1 RAs on the reproductive health of women of childbearing age without polycystic ovarian syndrome. Future research should explore short- and long-term effects on reproductive health, pregnancy outcomes and experiences.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol transfer to high-density lipoprotein in obesity and the effects of weight loss after bariatric surgery","authors":"Wilson Pascoalino Camargo de Oliveira,&nbsp;Fatima Rodrigues Freitas,&nbsp;Maurício Tavares Costa,&nbsp;Aline de Oliveira Silva,&nbsp;Roberto de Cleva,&nbsp;Roberto Kalil Filho,&nbsp;Marco Aurélio Santo,&nbsp;Raul Cavalcante Maranhão","doi":"10.1111/cob.12688","DOIUrl":"10.1111/cob.12688","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Obesity increases serum triglycerides and decreases high-density lipoprotein cholesterol (HDL-C). The objective is to explore some functions of HDL, cholesterol transfers and antioxidant, in subjects with grade I (G1-OB) and III (G3-OB) obesity and effects of bariatric surgery on G3-OB. Fifteen G3-OB patients (43 ± 6 years, BMI 49 ± 3 kg/m²) were studied before and 1 year after bariatric surgery; 15 G1-OB (32 ± 2 years, 32 ± 2 kg/m²) and 15 normal weight (NW) (38 ± 6 years, 22 ± 1 kg/m²) were also studied. HDL diameter, cholesterol transfer to HDL and antioxidant capacity of HDL were determined. G3-OB had higher triglycerides and lower HDL-C; G1-OB had higher triglycerides than NW but HDL-C was equal. Compared to NW, HDL size was smaller in G3-OB but equal in G1-OB. One year after bariatric surgery, BMI and triglycerides of G3-OB decreased (<i>p</i> &lt; .0001 and <i>p</i> = .0012, respectively) and HDL-C increased (<i>p</i> &lt; .0001), equalling of NW group. Antioxidant capacity and cholesterol transfers were not different in groups and were unchanged 1 year after bariatric surgery in G3-OB. HDL antioxidant capacity and transfer of cholesterol to HDL were not defective in obesity despite HDL-C reduction and smaller HDL size. In addition, pronounced weight loss by bariatric surgery did not change those protective functions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare professionals perceptions of obesity management: An IMI2 SOPHIA qualitative study","authors":"Nele Steenackers,&nbsp;Seppe Willio,&nbsp;Anne Bruneel,&nbsp;Ellen Deleus,&nbsp;Matthias Lannoo,&nbsp;Christophe Matthys,&nbsp;Ann Mertens,&nbsp;Eline Van Craeyveld,&nbsp;Roman Vangoitsenhoven,&nbsp;Bart Van der Schueren","doi":"10.1111/cob.12686","DOIUrl":"10.1111/cob.12686","url":null,"abstract":"<p>Understanding healthcare professionals' perceptions and approaches to obesity management is limited, as are the barriers impeding effective care. A questionnaire was developed to explore the perception, and barriers to obesity management. To ensure content validity, an expert and stakeholder panel evaluated the relevance and comprehension of each item. Consequently, a cross-sectional survey was administered to endocrinologists (Endo), general practitioners (GP), and pharmacists (Pharm). A 46-item questionnaire was developed, validated, and completed by 502 healthcare professionals (Endo: <i>n</i> = 127; GP: <i>n</i> = 138; Pharm: <i>n</i> = 237). The majority agreed that obesity is a chronic disease (Endo = 96%; GP = 92.7%; Pharm = 87%). The conversation about obesity management is mostly initiated by the healthcare professional (Endo = 95.3%; GP = 73.9%; Pharm = 5.9%) instead of the patient (Endo = 55.1%; GP = 21.7%; Pharm = 11.8%). All professionals stated unanimously that there is a need to optimise obesity care in Belgium with identified barriers: motivational (Endo = 90.8%; GP = 90.8%; Pharm = 89.2%), financial (Endo = 96.9%; GP = 88.5%; Pharm = 76.3%), and a lack of structure (Endo = 81.5%; GP = 78.6%; Pharm = 81.5%). A total of 42.4% of the healthcare providers indicated that they did not follow any additional training. These findings highlight that healthcare professionals recognise obesity as a chronic disease, but that barriers need to be addressed to enhance effective care and support for people living with obesity.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12686","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of metabolic and bariatric surgery on weight loss and insulin requirements in type 1 and insulin-treated type 2 diabetes","authors":"Kamal Abi Mosleh,&nbsp;Yara Salameh,&nbsp;Wissam Ghusn,&nbsp;Noura Jawhar,&nbsp;Manpreet S. Mundi,&nbsp;Maria L. Collazo-Clavell,&nbsp;Michael L. Kendrick,&nbsp;Omar M. Ghanem","doi":"10.1111/cob.12689","DOIUrl":"10.1111/cob.12689","url":null,"abstract":"<div>\u0000 \u0000 <p>Metabolic and Bariatric Surgery (MBS) is effective in improving metabolic outcomes and reducing weight in patients with obesity and diabetes, with less explored benefits in type 1 diabetes (T1D). This study aimed to evaluate the impact of MBS on weight loss and insulin requirements in T1D patients compared to insulin-treated type 2 diabetes (T2D) patients over a 5-year period. This retrospective analysis included patients who underwent primary sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) with a confirmed preoperative diagnosis of either T1D or insulin-treated T2D. Primary endpoints focusing on weight loss and secondary outcomes assessing changes in insulin dosage and glycemic control. After 5 years, weight loss was similar across groups, with total weight loss at 14.2% for T1D and 17.6% for insulin-treated T2D in SG, and 22.6% for T1D vs. 26.8% for insulin-treated T2D in RYGB. Additionally, there was a significant reduction in median daily insulin doses from 140.5 units at baseline to 77.5 units at 1 year postoperatively, sustained at 90 units at 5 years. The differential impact of MBS procedure was also highlighted, where RYGB patients showed a more pronounced and enduring decrease in insulin requirements compared to SG.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical weight loss in older persons with obesity","authors":"Alessandro Gavras,&nbsp;John A. Batsis","doi":"10.1111/cob.12684","DOIUrl":"10.1111/cob.12684","url":null,"abstract":"<div>\u0000 \u0000 <p>The prevalence of individuals with obesity or overweight has steadily increased over the past decades both worldwide, and in the United States. This trend is also evident in the older adult population, which has experienced a continuous rise in the number of individuals with overweight or obesity. This is relevant due to the impact of obesity in older adults' quality of life, physical function, morbidity, and healthcare costs. This review aims to provide practical guidance and currently available approaches for healthcare professionals in managing this population. Both non-pharmacological methods such as intensive behavioural therapy, nutritional interventions, and physical activity, as well as anti-obesity medications, are discussed, with a focus on their potential positive and negative effects in older adults. Additionally, bariatric therapy is evaluated, including current procedures available and the associated results and risks in the older population.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preservation of healthy lean body mass and function during weight loss","authors":"T. J. Wilkinson,&nbsp;D. Papamargaritis,&nbsp;J. A. King,&nbsp;J. A. Sargeant,&nbsp;C. Sutcliffe,&nbsp;L. A. Baker,&nbsp;S. Taheri,&nbsp;T. Yates,&nbsp;M. J. Davies","doi":"10.1111/cob.12683","DOIUrl":"10.1111/cob.12683","url":null,"abstract":"","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like-peptide 1 receptor agonism and attempted suicide: A Mendelian randomisation study to assess a potential causal association","authors":"Anthony Nguyen,&nbsp;Emily Smith,&nbsp;Habiba Hashemy,&nbsp;Sri Mahavir Agarwal,&nbsp;Margaret K. Hahn,&nbsp;Andrew D. Paterson,&nbsp;Satya Dash","doi":"10.1111/cob.12676","DOIUrl":"10.1111/cob.12676","url":null,"abstract":"<p>Glucagon-like-peptide 1 receptor agonists (GLP-1RA) have transformed type 2 diabetes (T2D) and obesity management. Multiple regulatory agencies are investigating reported associations between GLP1-RA and increased suicide attempts (SA), but observational data may be prone to confounding. Randomised control trials (RCT) of GLP-1RA were largely undertaken in people at lower risk of SA. Real-world data suggest semaglutide use associates with reduced suicidal ideation and depression but was under-powered to statistically assess risk of SA. Mendelian randomisation (MR) leverages genetic instrument(s) to infer potential causal association between an exposure and an outcome. We undertook MR using missense variants in the gene encoding <i>GLP1R</i> that improve glycemia, lower T2D risk and/or lower BMI, to investigate potential causal association between GLP-1RA and SA. In people of European ancestry, MR did not find evidence genetically proxied GLP1RA increased SA in a general population cohort: (rs10305492, exposure: HbA1c, odds ratio [OR] and 95% confidence interval [CI]: 1.38, 0.41–4.62, <i>p</i> = .60), (rs10305492, exposure: FG, OR 1.27, 0.52–3.13, <i>p</i> = .60) and (rs1042044, exposure BMI, OR 0.30, 0.06–1.48) with concordant results in a multi-ancestry SA case–control cohort. In conclusion, we did not find MR evidence that increased GLP-1RA impacts SA. This awaits confirmation with RCT and real-world data.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal important difference in weight loss following bariatric surgery: Enhancing BODY-Q interpretability","authors":"Farima Dalaei,&nbsp;Phillip J. Dijkhorst,&nbsp;Sören Möller,&nbsp;Claire E. E. de Vries,&nbsp;Lotte Poulsen,&nbsp;Sophocles H. Voineskos,&nbsp;Manraj N. Kaur,&nbsp;Jørn Bo Thomsen,&nbsp;Ruben N. van Veen,&nbsp;Claus B. Juhl,&nbsp;Alin Andries,&nbsp;René K. Støving,&nbsp;Stefan J. Cano,&nbsp;Anne F. Klassen,&nbsp;Andrea L. Pusic,&nbsp;Jens A. Sørensen","doi":"10.1111/cob.12675","DOIUrl":"10.1111/cob.12675","url":null,"abstract":"<p>BODY-Q is a patient-reported outcome measure for comprehensive assessment of outcomes specific to patients undergoing bariatric surgery. The clinical utility of BODY-Q is hampered by the lack of guidance on score interpretation. This study aimed to determine minimal important difference (MID) for assessment of BODY-Q. Prospective BODY-Q data from Denmark and the Netherlands pre- and post-bariatric surgery were collected. Two distribution-based methods were used to estimate MID by 0.2 standard deviations of baseline scores and the mean standardized response change of scores from baseline to 3-years postoperatively. In total, 5476 assessments from 2253 participants were included of which 1628 (72.3%) underwent Roux-en-Y gastric bypass, 586 (26.0%) sleeve gastrectomy, 33 (1.5%) gastric banding, and 6 (0.03%) other surgeries. The mean age was 45.1 ± 10.9 with a mean BMI of 46.6 ± 9.6. Baseline MID ranged from 1 to 4 in health-related quality of life (HRQL) and from 2 to 8 in appearance scales. The mean change of scores ranged from 4 to 5 in HRQL and from 4 to 7 in the appearance scales. The estimated MID for the change in BODY-Q HRQL and appearance scales ranged from 3 to 8 and is recommended for use to interpret BODY-Q scores and assess treatment effects in bariatric surgery.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations on self-management interventions for adults living with obesity: COMPAR-EU project","authors":"Melixa Medina-Aedo,&nbsp;Jessica Beltran,&nbsp;Claudia Valli,&nbsp;Carlos Canelo-Aybar,&nbsp;Yang Song,&nbsp;Marta Ballester,&nbsp;Jacqueline Bowman-Busato,&nbsp;Christos Christogiannis,&nbsp;Maria G. Grammatikopoulou,&nbsp;Oliver Groene,&nbsp;Monique Heijmans,&nbsp;Martine Hoogendorn,&nbsp;Sarah Louise Killeen,&nbsp;Katerina-Maria Kontouli,&nbsp;Dimitris Mavridis,&nbsp;Inka Miñambres,&nbsp;Beate Sigrid Mueller,&nbsp;Ena Niño de Guzman,&nbsp;Janneke Noordman,&nbsp;Carola Orrego,&nbsp;Lilisbeth Perestelo-Perez,&nbsp;Zuleika Saz-Parkinson,&nbsp;Georgios Seitidis,&nbsp;Rosa Suñol,&nbsp;Sofia Tsokani,&nbsp;Pablo Alonso-Coello","doi":"10.1111/cob.12667","DOIUrl":"10.1111/cob.12667","url":null,"abstract":"<div>\u0000 \u0000 <p>Self-management interventions (SMIs) may improve disease management in adults living with obesity. We formulated evidence-based recommendations for SMIs within the context of the COMPAR-EU project. The multidisciplinary panel selected critical outcomes based on the COMPAR-EU core outcome set and established decision thresholds for each outcome. Recommendations were informed by systematic reviews of effects, cost-effectiveness, and a contextual assessment. To assess the certainty of the evidence and formulate the recommendations, we used the GRADE approach guidance. Overall, SMIs were deemed to have a small impact, but the absence of harmful effects and potential cumulative benefits indicated a favourable balance of effects, despite low certainty. SMIs showed variations in structure, intensity, and resource utilisation, but overall are likely to be cost-effective. Adapting SMIs to local contexts would enhance equity, acceptability, and feasibility, considering patients' values, and availability of resources and teamwork. Consequently, the panel made conditional recommendations favouring SMIs over usual care. The rigorous and explicit recommendations demonstrated the effectiveness of SMIs for adults living with obesity. However, the gaps in the literature influenced the panel to make only conditional recommendations in favour of SMIs. Further research is needed to strengthen the evidence base and improve recommendations' certainty and applicability.</p>\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in weight-loss outcomes among race-gender subgroups by behavioural intervention delivery mode: An analysis of the POWER trial","authors":"Kristal L. Brown,&nbsp;Nae-Yuh Wang,&nbsp;Wendy L. Bennett,&nbsp;Kimberly A. Gudzune,&nbsp;Gail Daumit,&nbsp;Arlene Dalcin,&nbsp;Gerald J. Jerome,&nbsp;Janelle W. Coughlin,&nbsp;Lawrence J. Appel,&nbsp;Jeanne M. Clark","doi":"10.1111/cob.12670","DOIUrl":"10.1111/cob.12670","url":null,"abstract":"<p>Prior in-person behavioural intervention studies have documented differential weight loss between men and women and by race, with Black women receiving the least benefit. Remotely delivered interventions are now commonplace, but few studies have compared outcomes by race-gender groups and delivery modality. We conducted a secondary analysis of POWER, a randomized trial (NCT00783315) designed to determine the effectiveness of 2 active, lifestyle-based, weight loss interventions (remote vs. in-person) compared to a control group. Participants with obesity and at least one cardiovascular disease risk factor (<i>N</i> = 415) were recruited in the Baltimore, MD area. Data from 233 white and 170 Black individuals were used for this analysis. Following an intention-to-treat approach, we compared the mean percent weight loss at 24 months by race-gender subgroups using repeated-measures, mixed-effects models. Everyone lost weight in the active interventions however, weight loss differed by race and gender. white and Black men had similar results for both interventions (white: in-person (−7.6%) remote (−7.4%); Black: in-person (−4.7%) remote (−4.4%)). In contrast, white women lost more weight with the in-person intervention (in-person (−7.2%) compared to the remote (−4.4%)), whereas Black women lost less weight in the in-person group compared to the remote intervention at 24 months (−2.0% vs. −3.0%, respectively; <i>p</i> for interaction &lt;.001). We found differences between the effectiveness of the 2 weight loss interventions—in-person or remote—in white and Black women at 24 months. Future studies should consider intervention modality when designing weight loss interventions for women.</p>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}