Clinical Obesity最新文献_第4页

Impact of Tirzepatide Therapy on Thyroid Disease: Understanding Risks and Emerging Insights. 替西肽治疗对甲状腺疾病的影响：了解风险和新见解。

IF 2.4

Clinical Obesity Pub Date : 2026-06-01 DOI: 10.1111/cob.70084

Emiliano G Manueli Laos, Bianca Serafica, Andres Fontaine-Nicola, Lily Zhang, Khaled Abdelhady, Reed Berger, Francisco Schlottmann, Amber Pirzada, Mario A Masrur

{"title":"Impact of Tirzepatide Therapy on Thyroid Disease: Understanding Risks and Emerging Insights.","authors":"Emiliano G Manueli Laos, Bianca Serafica, Andres Fontaine-Nicola, Lily Zhang, Khaled Abdelhady, Reed Berger, Francisco Schlottmann, Amber Pirzada, Mario A Masrur","doi":"10.1111/cob.70084","DOIUrl":"10.1111/cob.70084","url":null,"abstract":"The dual GLP-1/GIP agonist tirzepatide is a highly effective anti-obesity therapy. While promising, it is associated with potential adverse effects, including thyroid disease reported in animal models. Due to limited human data, this study seeks to identify and characterise risk factors for thyroid disease development in patients undergoing 1 year of tirzepatide treatment. This study retrospectively analysed medical records of patients completing a 12-month course of tirzepatide (2.5-15 mg weekly) between September 2023 and September 2024. The primary endpoint is the development or worsening of any thyroid disease including DIT, Hashimoto thyroiditis, Graves' disease, benign neoplasms, goitre, and thyroid cancer. In 527 patients on tirzepatide, 28 (5.3%) developed or had progression of thyroid disease. The most frequent diagnoses were Nodular/Goitre Disease and Drug-Induced Thyroiditis. Multivariate analysis showed that a history of End-Stage Renal Disease (OR = 2.94) and baseline thyroid disease (OR = 3.78) were significant risk factors. Baseline thyroid disease and end-stage renal disease are significantly associated with an increased risk of new or recurrent thyroid disorders during tirzepatide treatment. These conditions should be classified as high risk, warranting periodic thyroid testing and further large-scale prospective validation.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 3","pages":"e70084"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Municipality-Based Lifestyle Intervention of Childhood Overweight and Obesity: 4-Years Follow-Up on BMI Trajectories. 以城市为基础的儿童超重和肥胖生活方式干预：4年BMI轨迹随访。

IF 2.4

Clinical Obesity Pub Date : 2026-06-01 DOI: 10.1111/cob.70082

Mette Fogh, Jane Nautrup Østergaard, Helene Kirkegaard, Eeva-Liisa Røssell, Helle Terkildsen Maindal, Gunnar Toft, Henrik Støvring, Jens Meldgaard Bruun

{"title":"Municipality-Based Lifestyle Intervention of Childhood Overweight and Obesity: 4-Years Follow-Up on BMI Trajectories.","authors":"Mette Fogh, Jane Nautrup Østergaard, Helene Kirkegaard, Eeva-Liisa Røssell, Helle Terkildsen Maindal, Gunnar Toft, Henrik Støvring, Jens Meldgaard Bruun","doi":"10.1111/cob.70082","DOIUrl":"10.1111/cob.70082","url":null,"abstract":"To examine 4-year changes in Body Mass Index z-score (BMIz) among children and adolescents with overweight or obesity who participated in municipality-based interventions, and to assess whether effects varied by age, sex or baseline weight category. This matched cohort study included children aged 5-15 years. The intervention group received a municipality-based early treatment intervention. Controls (up to five) were matched on age, sex, baseline weight category and calendar year, and received school-based surveillance consisting of mandatory school health examinations with repeated anthropometric assessments. BMIz trajectories were analysed using mixed effects models with linear splines, adjusting for socioeconomic factors derived from national registries. Among 1274 children and adolescents (216 intervention, 1058 control), 56.9%-58.0% in both groups were living with overweight at baseline. No significant differences in BMIz trajectories were observed over the 4-year period. Both groups showed an initial decrease in BMIz during the first 6 months (intervention: -0.18; control: -0.28), followed by an increase from 6 to 12 months (intervention: 0.12; control: 0.21) and a plateau from 12 to 48 months (intervention: -0.01; control: -0.03). Municipality-based interventions did not result in greater long-term BMIz reductions than matched controls. Both groups had modest short-term improvements, which may reflect beneficial effects of both the structured interventions and the active school-based surveillance received by controls. The similar BMIz trajectories suggest system-level equivalence within the Danish school health system. These findings underscore the need for understanding the mechanisms behind these early changes and how to support long-term maintenance.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 3","pages":"e70082"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle Intervention During Pregnancy Is Associated With Favourable Changes of Vitronectin in Women With Obesity: Results From the Randomised LiP Trial. 怀孕期间的生活方式干预与肥胖妇女玻璃体粘连蛋白的有利变化有关：来自随机LiP试验的结果

IF 2.4

Clinical Obesity Pub Date : 2026-06-01 DOI: 10.1111/cob.70085

Birgitte Moeller Luef, Katrine Sølling Borlund Mortensen, Lasse Møllegaard Obel, Louise Laage Stentebjerg, Per Glud Ovesen, Patrick M Catalano, Jan Stener Jørgensen, Dorte Møller Jensen, Christina Anne Vinter, Martin Overgaard

{"title":"Lifestyle Intervention During Pregnancy Is Associated With Favourable Changes of Vitronectin in Women With Obesity: Results From the Randomised LiP Trial.","authors":"Birgitte Moeller Luef, Katrine Sølling Borlund Mortensen, Lasse Møllegaard Obel, Louise Laage Stentebjerg, Per Glud Ovesen, Patrick M Catalano, Jan Stener Jørgensen, Dorte Møller Jensen, Christina Anne Vinter, Martin Overgaard","doi":"10.1111/cob.70085","DOIUrl":"10.1111/cob.70085","url":null,"abstract":"Obesity in pregnancy is a well-established risk factor for adverse maternal and neonatal outcomes, including gestational diabetes mellitus (GDM). This study aimed to examine the effects of lifestyle intervention during pregnancy on the cardio-metabolic protein profile and its association with maternal and neonatal health. The Lifestyle in Pregnancy (LiP) study was a randomised controlled trial conducted between 2007 and 2010 in Denmark. It included 360 pregnant women with obesity (BMI 30-45 kg/m2), aged 18-40 years, who were allocated to either a lifestyle intervention (dietary counselling, physical activity program, free fitness club membership) or standard care. Fasting serum samples from 303 women were collected at 12-15 and 28-30 weeks' gestation and analysed using a 26-plex cardio-metabolic proteomics assay. When comparing the cardio-metabolic protein profiles between the intervention and control groups before and after the intervention in pregnancy, we found that in late pregnancy the levels of two proteins, vitronectin and vitamin D-binding protein, were significantly lower in the intervention group. In the total cohort, elevated vitronectin was associated with a higher risk of GDM (adjusted odds ratio = 1.45 (95% CI: 1.06-1.98), p = 0.02) and neonatal intensive care unit (NICU) admissions (adjusted odds ratio = 1.68 (95% CI: 1.03-2.73), p = 0.037). Vitronectin may represent a modifiable biomarker linked to metabolic dysfunction in pregnant women with obesity, suggesting a potential underlying pathway by which lifestyle interventions could improve pregnancy outcomes.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 3","pages":"e70085"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial. 有氧运动加低热量饮食对原发性高血压和超重/肥胖成人血清瘦素浓度的影响：来自Exercise - hta试验的结果

IF 2.4

Clinical Obesity Pub Date : 2026-06-01 DOI: 10.1111/cob.70080

Virginia A Aparicio, Pablo Corres, Ilargi Gorostegi-Anduaga, Javier Margareto, Sara Maldonado-Martín

{"title":"Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.","authors":"Virginia A Aparicio, Pablo Corres, Ilargi Gorostegi-Anduaga, Javier Margareto, Sara Maldonado-Martín","doi":"10.1111/cob.70080","DOIUrl":"10.1111/cob.70080","url":null,"abstract":"Hyperleptinaemia is an emerging mechanism involved in the pathogenesis of obesity-related primary hypertension (HTN). This substudy from a large clinical trial aimed to determine differences in [leptin] in physically inactive adults (n = 69, 46.4% women) with HTN and living with overweight or obesity following a 16-week supervised aerobic exercise training (EX group, 2 days/week) intervention with an attention control (AC, only physical advice) group, both combined with a hypocaloric diet; to analyse whether the changes observed after the intervention were maintained after 6 months (6M); and to explore differences and potential mechanisms affected by sex. Cardiorespiratory fitness and body composition evaluation, and biochemical measurements were conducted. After the intervention [leptin] decreased in both groups (EX, 36%, p = 0.003; AC, 23%, p = 0.06), returning to baseline concentrations after 6M of follow-up in both groups. Changes over time were similar in both sexes, with no significant time × group interaction (p > 0.05). For all participants, body mass index was the only factor independently associated with [leptin] (β = 0.339, B = 2.11, SE = 0.53), explaining 12% of the variability (p < 0.001). Among women, waist-to-hip ratio (12%, β = 0.365, B = 135.8, SE = 59.4) and fat-free mass (11%, β = -0.443, B = -2.33, SE = -2.27) additionally and independently explained leptin variability (p < 0.05). A hypocaloric diet combined with supervised exercise appears to be an effective strategy for regulating [leptin] and improving metabolic health in individuals with HTN and overweight or obesity. The influence of fat distribution on leptin dynamics in women calls for research to consider sexual dimorphism.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 3","pages":"e70080"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation in Tier 3 Specialist Weight Management Services Within the National Health Service (NHS): Insights From Four NHS Sites in England and Wales. 国家卫生服务（NHS）内三级专家体重管理服务的变化：来自英格兰和威尔士四个NHS站点的见解。

IF 2.4

Clinical Obesity Pub Date : 2026-06-01 DOI: 10.1111/cob.70086

Mengxi Zhang, Pranay Singh Deo, Frances Griffiths, Keith R Abrams, Peter Auguste, Thomas M Barber, Tracy Gazeley, Richard M Green, Amy Grove, Jonathan M Hazlehurst, Siew Wan Hee, Claire Jones, Akhila Mallipedhi, Sarah O'Toole, Arjun Panesar, Nick R Parsons, Iain Souttar, Charlotte Summers, Manreet Thind, Marie Thorpe, Anjali Zalin, Petra Hanson

{"title":"Variation in Tier 3 Specialist Weight Management Services Within the National Health Service (NHS): Insights From Four NHS Sites in England and Wales.","authors":"Mengxi Zhang, Pranay Singh Deo, Frances Griffiths, Keith R Abrams, Peter Auguste, Thomas M Barber, Tracy Gazeley, Richard M Green, Amy Grove, Jonathan M Hazlehurst, Siew Wan Hee, Claire Jones, Akhila Mallipedhi, Sarah O'Toole, Arjun Panesar, Nick R Parsons, Iain Souttar, Charlotte Summers, Manreet Thind, Marie Thorpe, Anjali Zalin, Petra Hanson","doi":"10.1111/cob.70086","DOIUrl":"10.1111/cob.70086","url":null,"abstract":"There are significant regional disparities in NHS Tier 3 specialist weight management services (SWMS) across the UK. In the context of an ongoing policy shift from hospital to community-based care, a detailed examination of the components of Tier 3 services is needed to clarify the distribution of responsibilities across the weight management pathway. We conducted a comparative service mapping of SWMS across four NHS sites in England and Wales, with on-site observation, staff interviews and document review. While the core structure and service delivery at the four sites broadly aligned with the National Institute for Health and Care Excellence (NICE) guidance, substantial variations were identified in service accessibility and content, alongside widespread resource constraints and communication challenges. These findings suggest that the strategic shift of SWMS care from hospitals to community settings is proceeding without an infrastructure to meet anticipated demand. Clearer definitions of service requirements within SWMS, sustainable funding mechanisms and data-driven commissioning may help reduce regional variation and inequalities in service provision.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 3","pages":"e70086"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Cardiovascular Risk Using Machine Learning Based on Maximal Oxygen Consumption, Physical Fitness, and Anthropometry. 基于最大耗氧量、身体健康和人体测量的机器学习预测心血管风险。

IF 2.4

Clinical Obesity Pub Date : 2026-06-01 DOI: 10.1111/cob.70081

Rodrigo Yáñez-Sepúlveda, Rodrigo Olivares, Eduardo Guzmán-Muñoz, Yeny Concha-Cisternas, Josivaldo de Souza-Lima, Exal Garcia-Carrillo, Jacqueline Páez-Herrera, Daniel Rojas-Valverde, Guillermo Cortés-Roco, Vicente Clemente-Suárez, José Francisco López-Gil

{"title":"Prediction of Cardiovascular Risk Using Machine Learning Based on Maximal Oxygen Consumption, Physical Fitness, and Anthropometry.","authors":"Rodrigo Yáñez-Sepúlveda, Rodrigo Olivares, Eduardo Guzmán-Muñoz, Yeny Concha-Cisternas, Josivaldo de Souza-Lima, Exal Garcia-Carrillo, Jacqueline Páez-Herrera, Daniel Rojas-Valverde, Guillermo Cortés-Roco, Vicente Clemente-Suárez, José Francisco López-Gil","doi":"10.1111/cob.70081","DOIUrl":"10.1111/cob.70081","url":null,"abstract":"Cardiovascular risk factors in adolescence, often persist into adulthood, with low cardiorespiratory fitness representing one of the strongest predictors of future cardiovascular disease. We aimed to classify cardiovascular risk associated with low cardiorespiratory fitness in adolescents using machine learning models based on anthropometric and muscular fitness variables. A cross-sectional dataset of 7,852 adolescents aged 13-16 years was analysed. Predictors included body mass index, waist circumference, waist-to-height ratio, standing long jump, push-ups, and sit-ups, while the binary outcome was cardiovascular risk derived from maximal oxygen consumption (VO2 max) cut-points. Data were standardised, class imbalance was addressed using Synthetic Minority Over-sampling TEchnique (SMOTE), and eight supervised classifiers were trained with stratified five-fold cross-validation and grid search. Ensemble tree-based methods outperformed kernel-based models. Gradient Boosting achieved the best balance between predictive performance (area under the curve-receiver operating curve [AUC-ROC] 0.716, F1-score 0.857, recall 0.760, accuracy 0.755), followed by Random Forest. SHapley Additive exPlanations (SHAP) analyses indicated that muscular fitness measures, particularly push-ups, sit-ups and standing long jump, contributed most to risk classification, whereas anthropometric indicators showed lower importance. These findings suggest that machine learning models built from school-based muscular fitness tests and basic anthropometry can discriminate adolescents at cardiovascular risk due to low cardiorespiratory fitness, offering a feasible, low-cost strategy to support early identification and targeted physical activity interventions.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"16 3","pages":"e70081"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.1

Clinical Obesity Pub Date : 2026-05-27

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IF 2.1

Clinical Obesity Pub Date : 2026-05-27

引用次数: 0

IF 2.1

Clinical Obesity Pub Date : 2026-05-21

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IF 2.1

Clinical Obesity Pub Date : 2026-05-19

引用次数: 0