Clinical Obesity最新文献_第8页

Exploring Australian Dietitians' knowledge, experience and perspectives of time-restricted eating in private practice: A qualitative study 探索澳大利亚营养师在私人执业中对限时进食的认识、经验和观点：定性研究。

IF 2.2

Clinical Obesity Pub Date : 2024-04-25 DOI: 10.1111/cob.12671

Caitlin Pye, Evelyn B. Parr, Steve A. Flint, Brooke L. Devlin

{"title":"Exploring Australian Dietitians' knowledge, experience and perspectives of time-restricted eating in private practice: A qualitative study","authors":"Caitlin Pye, Evelyn B. Parr, Steve A. Flint, Brooke L. Devlin","doi":"10.1111/cob.12671","DOIUrl":"10.1111/cob.12671","url":null,"abstract":"Time-restricted eating is a novel nutrition intervention with evidence of beneficial effects on weight loss, blood glucose management, and other metabolic health outcomes. Adherence to time-restricted eating is higher than some traditional nutrition interventions to support individuals living with overweight/obesity and type 2 diabetes mellitus. However, there may be an evidence-practice gap of time-restricted eating in Australian dietetic practice. The present study aimed to explore dietitians' knowledge, experiences, and perspectives of time-restricted eating and timing of eating advice in practice. Semi-structured interviews with 10 private practice dietitians across Australia were conducted. Audio recordings were transcribed and analysed thematically. Six themes were identified: (i) distinction of time-restricted eating to other fasting protocols; (ii) knowledge of health benefits of time-restricted eating; (iii) patient-led advice frequently given: timing of breakfast and dinner; (iv) dietitian-led advice frequently given: eating cut-off time to avoid late night snacking; (v) barriers and facilitators to offering time-restricted eating or timing of eating advice; (vi) timing of eating advice within professional guidelines and resources. These findings suggest the need for development of professional resources and educational development tools for dietitians on time-restricted eating.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140653173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal approach utilising a weight management programme prior to bariatric surgery in patients with BMI ≥50 kg/m2: A propensity score matching retrospective cohort study 对体重指数≥50 kg/m2的患者进行减肥手术前利用体重管理计划的多模式方法：倾向得分匹配回顾性队列研究。

IF 2.2

Clinical Obesity Pub Date : 2024-04-25 DOI: 10.1111/cob.12669

Cetin Sari, Connie Santana, Richard L. Seip, Dale Bond, Aziz Benbrahim, Edward Hannoush, Tara McLaughlin, Ya-Huei Li, Ilene Staff, Yin Wu, Pavlos Papasavas, Darren Tishler, Devika Umashanker

{"title":"Multimodal approach utilising a weight management programme prior to bariatric surgery in patients with BMI ≥50 kg/m2: A propensity score matching retrospective cohort study","authors":"Cetin Sari, Connie Santana, Richard L. Seip, Dale Bond, Aziz Benbrahim, Edward Hannoush, Tara McLaughlin, Ya-Huei Li, Ilene Staff, Yin Wu, Pavlos Papasavas, Darren Tishler, Devika Umashanker","doi":"10.1111/cob.12669","DOIUrl":"10.1111/cob.12669","url":null,"abstract":"<div>\u0000 \u0000 We evaluated preoperative weight loss and days from initial consult to surgery in patients with BMI ≥50 kg/m2 who were and were not enrolled in medical weight management (MWM) prior to laparoscopic sleeve gastrectomy. We retrospectively identified patients with BMI ≥50 kg/m2 who had primary sleeve gastrectomy between 2014 and 2019 at two bariatric surgery centres in our healthcare system. Patients presenting after 2017 that received preoperative MWM (n = 28) were compared to a historical cohort of non-MWM patients (n = 118) presenting prior to programme initiation in 2017 on preoperative percent total body weight loss (%TBWL) and days from initial consult to surgery. A total of 151 patients (MWM, 33; non-MWM, 118) met inclusion criteria. BMI was significantly greater in MWM versus non-MWM (p = .018). After propensity score matching, median BMI at initial consult in non-MWM versus MWM no longer differed (p = .922) neither were differences observed on the basis of weight, age, sex, race or ethnicity. After PSM, MWM had significantly lower BMI at surgery (p = .018), lost significantly more weight from consult to surgery (p < .001) and achieved significantly greater median %TBWL from consult to surgery (p < .001). We noted no difference between groups on 6-month weight loss (p = .533). Days from initial consult to surgery did not differ between groups (p < .863). A preoperative MWM programme integrated into multimodal treatment for obesity in patients with a BMI ≥50 kg/m2 resulted in clinically significant weight loss without prolonging time to surgery.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140653191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing the new wave of weight loss medication in general practice: A qualitative study 在全科医生中管理减肥药物的新浪潮：定性研究。

IF 3.3

Clinical Obesity Pub Date : 2024-04-25 DOI: 10.1111/cob.12666

Pernille Andreassen, Sissel Due Jensen, Jens M. Bruun, Annelli Sandbæk

{"title":"Managing the new wave of weight loss medication in general practice: A qualitative study","authors":"Pernille Andreassen, Sissel Due Jensen, Jens M. Bruun, Annelli Sandbæk","doi":"10.1111/cob.12666","DOIUrl":"10.1111/cob.12666","url":null,"abstract":"In early 2023, a new type of weight loss medication, Wegovy (semaglutide), was made available in Denmark. Both subsequent media coverage and public demand were huge. Wegovy is only available by prescription, primarily via general practitioners. However, there is very little knowledge about how healthcare professionals (HCPs) in general practice might deal with the great demand for and attention surrounding a new weight loss drug. The aim of this qualitative study was, therefore, to explore how Wegovy is managed and negotiated in general practice, particularly in terms of prescribing and follow-up. We conducted a focused ethnography study based on direct observation of consultations and both formal and informal interviews with seven doctors and four nurses from three general practices in Denmark. Using discourse analysis, we identified four central discourses revolving around trust in medicine, individual responsibility for health, the cost of weight loss medication, and the importance of shared decision-making. This study shows that the availability of a new, sought-after weight loss medication presents both opportunities and challenges for HCPs in general practice. The management of Wegovy involves numerous factors, including medical, economic, organizational, interpersonal and moral concerns.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A service evaluation of more than 1 million self-funding adults attending a community weight management programme 对参加社区体重管理计划的 100 多万自费成人进行服务评估。

IF 2.2

Clinical Obesity Pub Date : 2024-04-24 DOI: 10.1111/cob.12665

Josef Toon, Sarah-Elizabeth Bennett, Jacquie Lavin, Carolyn Pallister, Amanda Avery

{"title":"A service evaluation of more than 1 million self-funding adults attending a community weight management programme","authors":"Josef Toon, Sarah-Elizabeth Bennett, Jacquie Lavin, Carolyn Pallister, Amanda Avery","doi":"10.1111/cob.12665","DOIUrl":"10.1111/cob.12665","url":null,"abstract":"Scaled interventions are required to address levels of overweight and obesity and reduce health inequalities. Little data is available on the effectiveness of community weight management programmes for participants self-selecting to attend across different socio-economic backgrounds. This analysis investigates 3, 6, and 12-month outcomes of adults joining a real-life community weight management programme. Weight, attendance and Indices of Multiple Deprivation (IMD) data from all fee-paying adults joining Slimming World in 2016 were collated. Data were analysed using descriptive and inferential statistics to determine predictors of weight loss. Mean BMI of 1 094 676 adults (7.6% male) was 33.0 ± 6.4 kg/m2. Mean % weight change at 3, 6, and 12 months was −5.0% ± 3.6%, −5.9% ± 5.2%, and −6.0% ± 5.8%. Those attending 75% sessions achieved greater weight loss with mean weight losses at 3, 6, and 12-months of 7.7% ± 3.3%, 11.3% ± 5.2%, and 14.1% ± 7.5%, respectively. Effect sizes from comparison of weight change between deprivation deciles were negligible, with similar outcomes in the most and least deprived deciles at 12-months (−5.7% ± 5.9% vs. −6.2% ± 5.9%). This service evaluation of more than 1 million adults attending a community weight management programme found they were able to achieve and/or maintain an average 6% weight loss at 12 months, with high attenders achieving >14% loss. Men and those with higher levels of deprivation were accessing the support and achieving significant weight losses. Slimming World as a real-life, scalable weight management programme is well placed to help adults manage their weight and address health inequalities.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bariatric surgeons' views on pre-operative factors associated with improved health-related quality of life following surgery 减肥外科医生对与术后改善健康相关生活质量有关的术前因素的看法。

IF 2.2

Clinical Obesity Pub Date : 2024-04-20 DOI: 10.1111/cob.12668

M. Majstorovic, A. Chur-Hansen, J. M. Andrews, A. L. J. Burke

{"title":"Bariatric surgeons' views on pre-operative factors associated with improved health-related quality of life following surgery","authors":"M. Majstorovic, A. Chur-Hansen, J. M. Andrews, A. L. J. Burke","doi":"10.1111/cob.12668","DOIUrl":"10.1111/cob.12668","url":null,"abstract":"Bariatric surgery is an effective treatment for severe obesity, affording significant improvements in weight loss and health-related quality of life. However, bariatric surgeons' views on whether certain pre-operative factors predict improvements in post-operative health-related quality of life, and if so, which ones, are largely unknown. This cross-sectional survey study examined the views of 58 bariatric surgeons from Australia and New Zealand. A total of 18 factors were selected for exploration based on their mention in the literature. Participants rated the extent to which they thought these pre-operative factors would improve post-operative health-related quality of life. Responses showed that bariatric surgeons held diverse perspectives and revealed a lack of consensus regarding “predictive” factors. Generally, respondents agreed that better than average health literacy, higher socioeconomic status, good physical and psychological health, and positive social support were predictors of improved health-related quality of life following surgery. However, poor eating behaviours, smoking, and the use of alcohol or other substances were deemed negative predictors. Interestingly, aside from higher socioeconomic status, good psychological health, and positive social support, none of the aforementioned views aligned with existing literature. This study offers an initial insight into bariatric surgeons' views on the influence of different pre-operative factors on post-operative health-related quality of life. The array of views identified suggests that there may be an opportunity for medical education, but the findings warrant caution due to the sample size. Replication with a larger survey may be useful, especially as predicted health-related quality of life outcomes could guide decisions regarding surgical (non)progression.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12668","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140680721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender diversity among adolescents with obesity in a weight management programme 体重管理计划中肥胖青少年的性别多样性。

IF 2.2

Clinical Obesity Pub Date : 2024-04-15 DOI: 10.1111/cob.12664

Zachary J. E. Zytner, Joshua R. Stanley, Preeti Grewal, Elizabeth Dettmer, Alene Toulany, Mark R. Palmert, Julia C. Sorbara

{"title":"Gender diversity among adolescents with obesity in a weight management programme","authors":"Zachary J. E. Zytner, Joshua R. Stanley, Preeti Grewal, Elizabeth Dettmer, Alene Toulany, Mark R. Palmert, Julia C. Sorbara","doi":"10.1111/cob.12664","DOIUrl":"10.1111/cob.12664","url":null,"abstract":"Gender dysphoria (GD) and obesity share commonalities, including associations with mental health comorbidities, disordered eating, body dissatisfaction and may intensify with physical and developmental changes during adolescence. While associations of obesity and gender diversity have been identified, rates of gender diversity among adolescents with obesity remain unclear. The aim was to examine gender diversity among adolescents with obesity in a weight management programme. A single-centre cross-sectional questionnaire study was conducted. Eligible adolescents received the Gender Identity/GD Questionnaire for Adolescents and Adults (GIDYQ-AA), a validated instrument measuring gender diversity and GD. Gender identities, sexual orientations, questionnaire scores, and frequency of GD (GIDYQ-AA score <3) were determined. The relationship of GIDYQ-AA scores and BMI Z-score (BMIz) was assessed. Of 72 consenting youth, 29 assigned females (AF) and 17 assigned males (AM) completed GIDYQ-AA and demographic questions. Seventeen (59%) AF reported non-heterosexual orientations, and 6 (21%) reported non-cisgender identities. One (6%) AM reported non-cisgender identity. Two (4%) AF individuals had GD based on GIDYQ-AA scores. GIDYQ-AA scores did not correlate with BMIz. In conclusion, adolescents with obesity, particularly AF with non-heterosexual orientation, reported high rates of non-cisgender identity and GD. Routine screening for gender-related concerns in weight management settings may be warranted.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceptions of an acceptance-based weight management treatment among adults living in rural areas 生活在农村地区的成年人对以接受为基础的体重管理治疗的看法。

IF 2.2

Clinical Obesity Pub Date : 2024-04-12 DOI: 10.1111/cob.12662

Viviana Bauman, Taylor N. Swanson, Abraham J. Eastman, Kathryn M. Ross, Michael G. Perri

{"title":"Perceptions of an acceptance-based weight management treatment among adults living in rural areas","authors":"Viviana Bauman, Taylor N. Swanson, Abraham J. Eastman, Kathryn M. Ross, Michael G. Perri","doi":"10.1111/cob.12662","DOIUrl":"10.1111/cob.12662","url":null,"abstract":"<div>\u0000 \u0000 Obesity and obesity-related comorbidities disproportionately affect rural communities. Research has emerged in support of a novel acceptance-based behavioural weight management treatment (ABT) that integrates the principles and procedures of acceptance-commitment therapy (ACT) with traditional components of standard behavioural treatment (SBT). The current study assessed the perceptions of community stakeholders in rural areas to session materials of a commercially available ABT program. Surveys and focus groups were used to solicit feedback from three former interventionists with experience delivering SBTs in rural counties and from 17 former participants in these programs. Qualitative responses encompassed four overarching themes: (1) recommendations to support participant engagement, (2) comments about preferences for specific ABT and SBT strategies, (3) concerns about specific aspects of treatment delivery, and (4) requests for aesthetic changes to session materials to enhance clarity and engagement. Overall, participants viewed ABT materials and concepts favourably but believed it would be important to begin the intervention with rapport building and training in traditional SBT strategies prior to delving into ACT strategies. Future studies should investigate the efficacy of ABT for weight loss in adults with obesity living in rural communities and continue to solicit feedback from rural community stakeholders.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IMPROVE 2022 International Meeting on Pathway-Related Obesity: Vision of Excellence IMPROVE 2022 年路径相关肥胖症国际会议：卓越愿景。

IF 3.3

Clinical Obesity Pub Date : 2024-04-11 DOI: 10.1111/cob.12659

Peter Kühnen, Jesús Argente, Karine Clément, Hélène Dollfus, Béatrice Dubern, Sadaf Farooqi, Corjan de Groot, Annette Grüters, Jens-Christian Holm, Mark Hopkins, Lotte Kleinendorst, Antje Körner, David Meeker, Mikael Rydén, Julia von Schnurbein, Matthias Tschöp, Giles S. H. Yeo, Stefanie Zorn, Martin Wabitsch

{"title":"IMPROVE 2022 International Meeting on Pathway-Related Obesity: Vision of Excellence","authors":"Peter Kühnen, Jesús Argente, Karine Clément, Hélène Dollfus, Béatrice Dubern, Sadaf Farooqi, Corjan de Groot, Annette Grüters, Jens-Christian Holm, Mark Hopkins, Lotte Kleinendorst, Antje Körner, David Meeker, Mikael Rydén, Julia von Schnurbein, Matthias Tschöp, Giles S. H. Yeo, Stefanie Zorn, Martin Wabitsch","doi":"10.1111/cob.12659","DOIUrl":"10.1111/cob.12659","url":null,"abstract":"Nearly 90 clinicians and researchers from around the world attended the first IMPROVE 2022 International Meeting on Pathway-Related Obesity. Delegates attended in person or online from across Europe, Argentina and Israel to hear the latest scientific and clinical developments in hyperphagia and severe, early-onset obesity, and set out a vision of excellence for the future for improving the diagnosis, treatment, and care of patients with melanocortin-4 receptor (MC4R) pathway-related obesity. The meeting co-chair Peter Kühnen, Charité Universitätsmedizin Berlin, Germany, indicated that change was needed with the rapidly increasing prevalence of obesity and the associated complications to improve the understanding of the underlying mechanisms and acknowledge that monogenic forms of obesity can play an important role, providing insights that can be applied to a wider group of patients with obesity. World-leading experts presented the latest research and led discussions on the underlying science of obesity, diagnosis (including clinical and genetic approaches such as the role of defective MC4R signalling), and emerging clinical data and research with targeted pharmacological approaches. The aim of the meeting was to agree on the questions that needed to be addressed in future research and to ensure that optimised diagnostic work-up was used with new genetic testing tools becoming available. This should aid the planning of new evidence-based treatment strategies for the future, as explained by co-chair Martin Wabitsch, Ulm University Medical Center, Germany.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12659","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed Tomography and Dual-Energy X-Ray Asorptiometry body composition parameter harmonisation to universalise adipose tissue measurements in a population-based cross-sectional study 计算机断层扫描和双能量 X 射线析像测量法身体成分参数协调，以普及基于人口的横断面研究中的脂肪组织测量。

IF 2.2

Clinical Obesity Pub Date : 2024-04-11 DOI: 10.1111/cob.12660

Elliot T. Varney, Seth Lirette, Peter T. Katzmarzyk, Frank Greenway, Candace M. Howard

{"title":"Computed Tomography and Dual-Energy X-Ray Asorptiometry body composition parameter harmonisation to universalise adipose tissue measurements in a population-based cross-sectional study","authors":"Elliot T. Varney, Seth Lirette, Peter T. Katzmarzyk, Frank Greenway, Candace M. Howard","doi":"10.1111/cob.12660","DOIUrl":"10.1111/cob.12660","url":null,"abstract":"<div>\u0000 \u0000 To harmonise computed tomography (CT) and dual-energy x-ray absorptiometry (DXA) body composition measurements allowing easy conversion in longitudinal assessments and across cohorts to assess cardiometabolic risk and disease. Retrospective cross-sectional observational study from 1996 to 2008 included participants in the Pennington Center Longitudinal Study (PCLS) (N = 1967; 571 African American/1396 White). Anthropometrics, whole-body DXA and abdominal CT images were obtained. Multi-layer segmentation techniques (Analyze; Rochester, MN) quantified visceral adipose tissue (VAT). Clinical biomarkers were obtained from routine blood samples. Linear models were used to predict CT-VAT from DXA-VAT and examine the effects of traditional biomarkers on cross-sectional-VAT. Predicted CT-VAT was highly associated with measured CT-VAT using ordinary least square linear regression analysis and random forest models (R2 = 0.84; 0.94, respectively, p < .0001). Model stratification effects showed low variability between races and sexes. Overall, associations between measured CT-VAT and DXA-predicted CT-VAT were good (R2 > 0.7) or excellent (R2 > 0.8) and improved for all stratification groups except African American men using random forest models. The clinical effects on measured CT-VAT and DXA-VAT showed no significant clinical difference in the measured adipose tissue areas (mean difference = 0.22 cm2). Random forest modelling seamlessly predicts CT-VAT from measured DXA-VAT to a degree of accuracy that falls within the bounds of universally accepted standard error.\u0000 </div>","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140713068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GNB1 and obesity: Evidence for a correlation between haploinsufficiency and syndromic obesity GNB1 与肥胖症：单倍体缺乏症与综合肥胖症之间存在相关性的证据。

IF 2.2

Clinical Obesity Pub Date : 2024-04-10 DOI: 10.1111/cob.12661

Lotte Kleinendorst, Ozair Abawi, Niels Vos, Eline S. van der Valk, Saskia M. Maas, Angela T. Morgan, Michael S. Hildebrand, Jorge D. Da Silva, Ralph J. Florijn, Peter Lauffer, Jenny A. Visser, Elisabeth F. C. van Rossum, Erica L. T. van den Akker, Mieke M. van Haelst

{"title":"GNB1 and obesity: Evidence for a correlation between haploinsufficiency and syndromic obesity","authors":"Lotte Kleinendorst, Ozair Abawi, Niels Vos, Eline S. van der Valk, Saskia M. Maas, Angela T. Morgan, Michael S. Hildebrand, Jorge D. Da Silva, Ralph J. Florijn, Peter Lauffer, Jenny A. Visser, Elisabeth F. C. van Rossum, Erica L. T. van den Akker, Mieke M. van Haelst","doi":"10.1111/cob.12661","DOIUrl":"10.1111/cob.12661","url":null,"abstract":"Most patients with GNB1 encephalopathy have developmental delay and/or intellectual disability, brain anomalies and seizures. Recently, two cases with GNB1 encephalopathy caused by haploinsufficiency have been reported that also show a Prader–Willi-like phenotype of childhood hypotonia and severe obesity. Here we present three new cases from our expert centre for genetic obesity in which GNB1 truncating and splice variants, probably leading to haploinsufficiency, were identified. They all have obesity, hyperphagia and intellectual deficit. The clinical cases and their weight courses are presented, together with a review of all 68 published cases with GNB1 encephalopathy. Information on weight was not mentioned in most of these articles, so we contacted authors for additional clinical information on weight status and hyperphagia. Of the 42 patients whose weight status we could determine, obesity was present in 8 patients (19%). Obesity is significantly over-represented in the group with truncating and splicing variants. In this group, we see an obesity prevalence of 75%. Since GNB1 has been linked to several key genes in the hypothalamic leptin-melanocortin pathway, which regulates satiety and energy expenditure, our data support the potential association between GNB1 haploinsufficiency and genetic obesity. We also suggest GNB1 is a candidate gene for the known obesity phenotype of the 1p36 microdeletion syndrome given this chromosomal region includes the GNB1 gene. Knowledge of an additional obesity phenotype is important for prognosis, early interventions against obesity and awareness when prescribing weight-inducing medication.","PeriodicalId":10399,"journal":{"name":"Clinical Obesity","volume":"14 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cob.12661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140716874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0