Clinical NeuroradiologyPub Date : 2024-12-01Epub Date: 2024-11-14DOI: 10.1007/s00062-024-01472-6
Martin Bendszus
{"title":"Endovascular Treatment of Large Core Infarcts: no Limits?","authors":"Martin Bendszus","doi":"10.1007/s00062-024-01472-6","DOIUrl":"10.1007/s00062-024-01472-6","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"34 4","pages":"747-748"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-12-01Epub Date: 2024-07-25DOI: 10.1007/s00062-024-01439-7
Fredrik Ståhl, Håkan Almqvist, Åsa Aspelin, Jens Kolloch, Odett Ghalamkari, Vamsi Gontu, Dirk Schäfer, Peter van de Haar, Klaus-Jürgen Engel, Fred van Nijnatten, Åke Holmberg, Michael V Mazya, Michael Söderman, Anna Falk Delgado
{"title":"Stroke Evaluation in the Interventional Suite Using Dual-Layer Detector Cone-Beam CT: a First-in-human Prospective Cohort Study (the Next Generation X-ray Imaging System Trial).","authors":"Fredrik Ståhl, Håkan Almqvist, Åsa Aspelin, Jens Kolloch, Odett Ghalamkari, Vamsi Gontu, Dirk Schäfer, Peter van de Haar, Klaus-Jürgen Engel, Fred van Nijnatten, Åke Holmberg, Michael V Mazya, Michael Söderman, Anna Falk Delgado","doi":"10.1007/s00062-024-01439-7","DOIUrl":"10.1007/s00062-024-01439-7","url":null,"abstract":"<p><strong>Purpose: </strong>Cone-beam CT in the interventional suite could be an alternative to CT to shorten door-to-thrombectomy time. However, image quality in cone-beam CT is limited by artifacts and poor differentiation between gray and white matter. This study compared non-contrast brain dual-layer cone-beam CT in the interventional suite to reference standard CT in stroke patients.</p><p><strong>Methods: </strong>A prospective single-center study enrolled consecutive participants with ischemic or hemorrhagic stroke. The hemorrhage detection accuracy, per-region ASPECTS accuracy and subjective image quality (Likert scales for gray-white matter differentiation, structure perception and artifacts) were assessed by three neuroradiologists blinded to clinical data on dual-layer cone-beam CT 75 keV monoenergetic images compared to CT. Objective image quality was assessed by region-of-interest metrics. Non-inferiority for hemorrhage detection and ASPECTS accuracy was determined by the exact binomial test with a one-sided lower performance boundary prospectively set to 80% (98.75% CI).</p><p><strong>Results: </strong>27 participants were included (74 years ± 9; 19 female) in the hyperacute or acute stroke phase. One reader missed a small bleeding, but all hemorrhages were detected in the majority analysis (100% accuracy, CI lower boundary 86%, p = 0.002). ASPECTS majority analysis showed 90% accuracy (CI lower boundary 85%, p < 0.001). Sensitivity was 66% (individual readers 67%, 69%, and 76%), specificity was 97% (97%, 96%, 89%). Subjective and objective image quality were inferior to CT.</p><p><strong>Conclusion: </strong>In a small single-center cohort, dual-layer cone-beam CT showed non-inferior hemorrhage detection and ASPECTS accuracy to CT. Despite inferior image quality, the technique may be useful for stroke evaluation in the interventional suite.</p><p><strong>Trial registration number: </strong>NCT04571099 (clinicaltrials.gov). Prospectively registered 2020-09-04.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"929-937"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-12-01Epub Date: 2024-06-19DOI: 10.1007/s00062-024-01409-z
Guoming Li, Xuecheng Cen, Zelan Ma, Fajun Chen
{"title":"Roles of Nontraditional Lipid Parameters for Predicting Restenosis in Patients with Intracranial Atherosclerotic Stenosis After Endovascular Treatment.","authors":"Guoming Li, Xuecheng Cen, Zelan Ma, Fajun Chen","doi":"10.1007/s00062-024-01409-z","DOIUrl":"10.1007/s00062-024-01409-z","url":null,"abstract":"<p><strong>Purpose: </strong>Nontraditional lipid parameters are associated with intracranial atherosclerotic stenosis (ICAS) progression. This study aimed to investigate the association of nontraditional lipid parameters with the risk of restenosis in patients with ICAS after endovascular treatment (EVT).</p><p><strong>Methods: </strong>This study retrospectively enrolled consecutive patients with symptomatic ICAS after successful EVT followed by at least 3 months of angiography. Participants were divided into restenosis or non-restenosis groups based on the angiographic follow-up results. The nontraditional lipid parameters were calculated from conventional lipid parameters. The COX regression models and restricted cubic splines (RCS) were used to explore the association between nontraditional lipid parameters and restenosis.</p><p><strong>Results: </strong>This study recruited 222 cases with 224 lesions eligible for our study, of which 56 (25%) had restenosis. Compared with the non-restenosis group, patients in the restenosis group had higher levels of the atherogenic index of plasma (AIP) (0.211, interquartile range, IQR, 0.065-0.404 vs. 0.083, IQR, -0.052-0.265, P = 0.001), remnant cholesterol (RC) (0.55, IQR, 0.33-0.77 vs. 0.30, IQR, 0.18-0.49, P < 0.001) and Castelli's index‑I (CRI-I) (4.13, IQR, 3.39-5.34 vs. 3.74, IQR, 2.94-4.81, P = 0.030). In the multivariable COX regression analysis, a 0.1 unit increase of AIP was an independent risk factor for restenosis (hazard ratio, HR = 1.20, 95% confidence interval, CI 1.05-1.35, P = 0.005) whereas such an association was not observed for RC (HR = 1.01, 95% CI 0.90-1.15, P = 0.835). The restricted cubic spline (RCS) plot revealed a linear relationship between AIP and restenosis (P for nonlinear = 0.835) but a nonlinear relationship for RC (P for nonlinear = 0.012). Patients were stratified according to tertiles (T) of AIP and RC and the risk of restenosis increased in T3 compared to T1 (HR = 3.21, 95% CI 1.35-7.62, P = 0.008 and HR = 2.99, 95% CI 1.11-8.03, P = 0.030, respectively). Furthermore, this association remained stable within each LDL‑C level subgroup.</p><p><strong>Conclusion: </strong>The AIP and RC were positively and independently associated with restenosis in patients with ICAS after EVT.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"827-840"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-12-01Epub Date: 2024-07-01DOI: 10.1007/s00062-024-01431-1
Bin Han, Xu Tong, Raynald, Baixue Jia, Anxin Wang, Dapeng Mo, Feng Gao, Ning Ma, Zhongrong Miao
{"title":"Thrombectomy Plus Intra-Arterial Thrombolysis Versus Thrombectomy for Acute Large Vessel Occlusions: a Matched-Control Study.","authors":"Bin Han, Xu Tong, Raynald, Baixue Jia, Anxin Wang, Dapeng Mo, Feng Gao, Ning Ma, Zhongrong Miao","doi":"10.1007/s00062-024-01431-1","DOIUrl":"10.1007/s00062-024-01431-1","url":null,"abstract":"<p><strong>Aim: </strong>We conducted a matched-control analysis to compare the outcomes of large vessel occlusion (LVO) patients treated with mechanical thrombectomy (MT) plus Intra-arterial thrombolysis (IAT) versus those treated with MT alone.</p><p><strong>Methods: </strong>The subjects of this study were chosen from ANGEL-ACT registry. All patients who received MT were identified and categorized into two groups: \"MT + IAT\" and \"MT,\" based on whether or not they received additional intra-arterial medication IAT during the MT procedure. After being subjected to 1:1 propensity score matching, the outcome measures, including modified Rankin Scale (mRS) score at 90 days, successful recanalization at the final angiogram, symptomatic intracranial hemorrhage (sICH) within 36 h, and death within 90 days, were compared.</p><p><strong>Results: </strong>The study encompassed a total of 1607 patients, with 641 individuals assigned to the MT + IAT group and 966 to the MT group. After applying propensity score matching, a total of 524 pairs were identified for comparison. The results indicated that there were no significant differences between the two groups with regard to the modified Rankin Scale (mRS) score (median: 3 vs. 3 points; P = 0.83), successful recanalization (89.9 vs. 88.9%; P = 0.62), sICH (8.3 vs. 8.7%; P = 0.79), and death (15.5 vs. 16.4%; P = 0.70).</p><p><strong>Conclusions: </strong>IAT during MT does not confer an elevated risk of sICH or mortality. Furthermore, the combination of MT and IAT may produce comparable functional outcomes in comparison to MT alone, when treating acute LVO patients.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"871-879"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical NeuroradiologyPub Date : 2024-12-01Epub Date: 2024-10-23DOI: 10.1007/s00062-024-01468-2
M Schwabenland, L Becker, C J Gizaw, M Prinz, H Urbach, D Erny, C A Taschner
{"title":"Freiburg Neuropathology Case Conference : Posterior fossa tumour 15 years after microsurgical resection of a cerebellar pilocytic astrocytoma.","authors":"M Schwabenland, L Becker, C J Gizaw, M Prinz, H Urbach, D Erny, C A Taschner","doi":"10.1007/s00062-024-01468-2","DOIUrl":"10.1007/s00062-024-01468-2","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"983-989"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rana Garayzade, Ansgar Berlis, Tim Tobias Arndt, Christina Wolfert, Björn Sommer, Gernot Müller, Christoph J Maurer
{"title":"Role and Safety of Tirofiban in Peri-Interventional Antiplatelet Management for Aneurysm Treatment.","authors":"Rana Garayzade, Ansgar Berlis, Tim Tobias Arndt, Christina Wolfert, Björn Sommer, Gernot Müller, Christoph J Maurer","doi":"10.1007/s00062-024-01480-6","DOIUrl":"https://doi.org/10.1007/s00062-024-01480-6","url":null,"abstract":"<p><strong>Background: </strong>Tirofiban is administered for the treatment of aneurysms in cases of thromboembolic complications, as well as in cases of acute stenting or flow-diverter implantation required within the scope of aneurysm treatment. We aimed to investigate the efficacy and safety of tirofiban in this group of patients.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of all patients undergoing aneurysm treatment and receiving peri-interventional tirofiban administration at our institution between 2009 and 2019.</p><p><strong>Results: </strong>A total of 105 patients were included, with 61% women and 39% men (mean age = 53 years, IQR: 44-60 years). Sixty-seven patients underwent emergency aneurysm treatment, and thirty-eight were treated electively. Hemorrhagic events occurred in 22% (15/67) of the patients treated acutely, with 7.46% (5/67) exhibiting symptoms. Patients undergoing elective aneurysm treatment experienced no hemorrhagic events (p = 0.002). Among the 35 patients who required an external ventricular drain (EVD), 22.86% (8/35) developed EVD-related hemorrhages; however, none were symptomatic (p = 0.007). Of the five patients who required a craniotomy, two experienced significant bleeding, and one experienced non-significant craniotomy-related bleeding (p = 0.20).</p><p><strong>Conclusion: </strong>Tirofiban may be safe for use during peri-interventional complications or emergency stenting in aneurysm treatment. However, caution is necessary when craniotomy is required. In elective aneurysm treatments, administering Tirofiban in response to periprocedural complications appears to be safe.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derrek Schartz, Alan J Finkelstein, Emily Schartz, Saanya Lingineni, Matthew Sipple, Zoe Williams, Matthew T Bender, Henry Wang
{"title":"Optic Nerve Sheath Dilation Is a Possible Marker of CSF Dyshomeostasis in Idiopathic Intracranial Hypertension.","authors":"Derrek Schartz, Alan J Finkelstein, Emily Schartz, Saanya Lingineni, Matthew Sipple, Zoe Williams, Matthew T Bender, Henry Wang","doi":"10.1007/s00062-024-01476-2","DOIUrl":"https://doi.org/10.1007/s00062-024-01476-2","url":null,"abstract":"<p><strong>Purpose: </strong>Idiopathic intracranial hypertension (IIH) is a complex neurological disease characterized by symptoms of raised intracranial pressure of unclear etiology. Although optic nerve sheath dilation is a common MR neuroimaging feature of IIH, how and why it occurs remains poorly understood. The purpose of the presented analysis was to investigate if optic nerve sheath dilation might be associated with neuroimaging correlates of cerebrospinal and interstitial fluid homeostasis.</p><p><strong>Methods: </strong>IIH patients were retrospectively identified from 2016-2023 from our tertiary healthcare system. Brain MRIs were computationally segmented using FreeSurfer. Additionally, diffusion tensor imaging along the perivascular space (DTI-ALPS) was employed to assess cerebral glymphatic flow. The mean perioptic subarachnoid space (PSAS) to optic nerve sheath diameter (ONSD) ratio from both eyes was correlated with neuroimaging markers of CSF and interstitial fluid homeostasis (choroid plexus, ventricle, and gray and white matter volume) and glymphatic flow. All volumes of interest were normalized to total intracranial volume. Multiple linear regression was used to evaluate for associations between continuous variables accounting for covariates of patient age, sex, and body mass index.</p><p><strong>Results: </strong>In total, 55 IIH patients (89% female; mean age: 30.3 years [SD: 7.6]) were included. Increasing PSAS/ONSD was found to be significantly associated with increasing normalized total choroid plexus volume (p = 0.001, R = 0.48) and total ventricle volume (P = 0.014, R = 0.39). Additionally, increasing PSAS/ONSD was associated with declining/worsening cerebral glymphatic clearance based on DTI-APLS (p = 0.043, R = 0.34). Additionally, there was a significant association between increasing PSAS/ONSD and increasing normalized total gray matter volume (p = 0.025, R = 0.36) and declining normalized total white matter volume (p = 0.012, R = 0.40).</p><p><strong>Conclusion: </strong>These findings suggest that MR optic nerve sheath dilation in IIH might be associated with CSF dyshomeostasis with possible choroid plexus hyperplasia and impaired cerebral glymphatic flow based on DTI-ALPS. These findings encourage future research into the ocular glymphatic system in IIH patients.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Boriesosdick, Iram Shahzadi, Long Xie, Bogdan Georgescu, Eli Gibson, Lynn Johann Frohwein, Saher Saeed, Nina P Haag, Sebastian Horstmeier, Christoph Moenninghoff, Julius Henning Niehoff, Alexey Surov, Jan Borggrefe, Jan Robert Kroeger
{"title":"Deep Learning Based Detection of Large Vessel Occlusions in Acute Ischemic Stroke Using High-Resolution Photon Counting Computed Tomography and Conventional Multidetector Computed Tomography.","authors":"Jan Boriesosdick, Iram Shahzadi, Long Xie, Bogdan Georgescu, Eli Gibson, Lynn Johann Frohwein, Saher Saeed, Nina P Haag, Sebastian Horstmeier, Christoph Moenninghoff, Julius Henning Niehoff, Alexey Surov, Jan Borggrefe, Jan Robert Kroeger","doi":"10.1007/s00062-024-01471-7","DOIUrl":"https://doi.org/10.1007/s00062-024-01471-7","url":null,"abstract":"<p><strong>Purpose: </strong>Deep learning (DL) methods for detecting large vessel occlusion (LVO) in acute ischemic stroke (AIS) show promise, but the effect of computed tomography angiography (CTA) image quality on DL performance is unclear. Our study investigates the impact of improved image quality from Photon Counting Computed Tomography (PCCT) on LVO detection in AIS using a DL-based software prototype developed by a commercial vendor, which incorporates a novel deep learning architecture.</p><p><strong>Materials and methods: </strong>443 cases that underwent stroke diagnostics with CTA were included. Positive cases featured vascular occlusions in the Internal Carotid Artery (ICA), M1, and M2 segments of the Middle Cerebral Artery (MCA). Negative cases showed no vessel occlusion on CTA. The performance of the DL-based LVO detection software prototype was assessed using Syngo.via version VB80.</p><p><strong>Results: </strong>Our study included 267 non-occlusion cases and 176 cases. Among them, 150 cases were scanned via PCCT (no occlusion = 100, ICA and M1 = 41, M2 = 9), while 293 cases were scanned using conventional CT (no occlusion = 167, ICA and M1 = 89, M2 = 37). Independent of scanner type, the algorithm showed sensitivity and specificity of 70.5 and 98.9% for the detection of all occlusions. DL algorithm showed improved performance after excluding M2 occlusions (sensitivity 86.2%). After stratification by scanner type, the algorithm showed significantly a trend towards better performance (p = 0.013) on PCCT CTA images for the detection of all occlusions (sensitivity 84.0%, specificity 99%) compared to CTA images from conventional CT scanner (sensitivity 65.1%, specificity 98.8%). The detection of M2 occlusions was also better on PCCT CTA images (sensitivity 55.6%) compared to conventional scanner CTA images (sensitivity 18.9%), but the sample size for M2 occlusions was limited, and further research is needed to confirm these findings.</p><p><strong>Conclusion: </strong>Our study suggests that PCCT CTA images may offer improved detection of large vessel occlusion, particularly for M2 occlusions. However further research is needed to confirm these findings. One of the limitations of our study is the inability to exclude the presence of a perfusion deficit, despite ruling out vascular occlusion, due to the lack of CT perfusion (CTP) imaging data. Future research may investigate CNNs by leveraging both CTA and CTP images from PCCT for improved performance.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martin Lewis, Juveria Siddiqui, Sara Sciacca, Vishwajeet Singh, Jeremy Lynch, Thomas Booth, Naga Kandasamy, Parthiban Balasundaram
{"title":"The ASCEND Technique-A Modified Direct Aspiration First Pass Technique for a Faster and Cost-effective Mechanical Thrombectomy.","authors":"Martin Lewis, Juveria Siddiqui, Sara Sciacca, Vishwajeet Singh, Jeremy Lynch, Thomas Booth, Naga Kandasamy, Parthiban Balasundaram","doi":"10.1007/s00062-024-01469-1","DOIUrl":"10.1007/s00062-024-01469-1","url":null,"abstract":"<p><strong>Purpose: </strong>Direct aspiration first pass technique (ADAPT) has been the standard for aspiration thrombectomy (AT) in anterior circulation large vessel occlusion (AC-LVO) with modifications of the technique based on devices used and difficulties encountered. We introduce the ASCEND technique (Aspiration with Steam-shaped Catheter, Excluding additioNal Devices), and hypothesize that it improves catheter navigation, leading to time and cost savings in MT.</p><p><strong>Methods: </strong>This is a single institute, retrospective, pre-post intervention study, including consecutive patients with AC-LVO who underwent AT as first-pass technique. Patients were divided into two groups based on the first-pass technique attempted (ASCEND vs conventional ADAPT). Baseline characteristics, primary outcomes (first pass time, total procedure time, total additional devices and device cost) and secondary outcomes (recanalization, complications) were compared between groups. Multiple linear regression models were built for primary outcomes to look for the effect of steam-shaping when covariates are present to reflect real-world setting. Multi-national survey performed to introduce the technique and feedback obtained.</p><p><strong>Results: </strong>ASCEND (n = 39) and cADAPT (n = 40) groups were similar in baseline clinical characteristics. Anterior genu and ophthalmic segment were crossed in 94.9%, clot reached in 84.6%, and entire MT procedure completed in 59.0% of patients of the ASCEND group without use of additional materials. Groups were similar in performance and safety indicators. ASCEND technique was superior to conventional ADAPT with less first-pass time (8.9 vs 14.7 min), total procedure time (20.2 vs 35.4 min), additional devices used (0 vs 3) and cost involved (2083 vs 5830 £) per procedure (all P < 0.05). Multiple linear regression models maintained improved primary outcomes with steam-shaping (all P < 0.05). Neurointerventionalists who tried ASCEND (n = 11) affirmed that it was safe and likely to save time and cost involved.</p><p><strong>Conclusion: </strong>ASCEND technique, involving a simple step of steam-shaping the aspiration catheter during MT can provide huge benefits in time and cost savings, without compromise of performance or safety.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}