Clinical Neuroradiology最新文献

{"title":"DWI Reversibility in Acute Ischemic Stroke Due to Basilar Artery Occlusion Following Successful Recanalization.","authors":"Niclas Launhardt, Jessica Jesser, Dimah Hasan, Rebecca May, Omid Nikoubashman, Martin Wiesmann, Thanh N Nguyen, Markus A Möhlenbruch, Julius Kernbach, Charlotte S Weyland","doi":"10.1007/s00062-025-01512-9","DOIUrl":"10.1007/s00062-025-01512-9","url":null,"abstract":"<p><strong>Purpose: </strong>Diffusion Weighted Imaging (DWI) represents the infarct core in acute ischemic stroke. DWI reversibility is a phenomenon reported for the anterior circulation affecting small brain areas of the white matter. This study aims to define DWI reversibility in the posterior circulation after successful recanalization of basilar artery occlusion (BAO) and its influence on patient outcome.</p><p><strong>Methods: </strong>This was a retrospective analysis of two tertiary stroke-centers analyzing stroke patients between January 2015 and December 2022. Inclusion criteria were available MRI before and after acute stroke treatment and successful BAO recanalization. Brain areas were defined as brainstem, cerebellum and supratentorial brain areas supplied by the posterior circulation. These areas were compared in univariate analysis. Secondarily, patient outcome was compared between patients with DWI reversibility and patients without in univariate analysis with good outcome as primary endpoint (mRS 90d 0 to 2).</p><p><strong>Results: </strong>In total, 5/28 of included patients (21.74%) showed DWI reversibility, which was exclusively found in the brainstem. The overall extent of brainstem infarction correlated better with patient outcome compared to cerebellar or supratentorial infarction (Spearman's ρ = 0.757; p < 0.001). Good outcome was more frequent in patients with DWI reversibility compared to those without (mRS 0-2, DWI+ n = 4, 80% vs. DWI- n = 6, 26%, p = 0.023).</p><p><strong>Conclusion: </strong>DWI restriction reversibility was observed in the brainstem of acute stroke patients with BAO. In this study, patient outcome correlates stronger with the extent of brainstem infarction compared to cerebellar or supratentorial infarction.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"551-558"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact Factor for Clinical Neuroradiology: Development 2024 and Perspectives.","authors":"Martin Bendszus","doi":"10.1007/s00062-025-01551-2","DOIUrl":"https://doi.org/10.1007/s00062-025-01551-2","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"35 3","pages":"431-432"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of CT and MRI Radiomics for an Early Assessment of Diffuse Axonal Injury in Patients with Traumatic Brain Injury Compared to Conventional Radiological Diagnosis.","authors":"Anna-Katharina Meißner, Robin Gutsche, Lenhard Pennig, Christian Nelles, Enrico Budzejko, Christina Hamisch, Martin Kocher, Marc Schlamann, Roland Goldbrunner, Stefan Grau, Philipp Lohmann","doi":"10.1007/s00062-025-01507-6","DOIUrl":"10.1007/s00062-025-01507-6","url":null,"abstract":"<p><strong>Background: </strong>De- and acceleration traumata can cause diffuse axonal injury (DAI) in patients with traumatic brain injury (TBI). The diagnosis of DAI on CT is challenging due to the lack of structural abnormalities. Radiomics, a method from the field of artificial intelligence (AI) offers the opportunity to extract additional information from imaging data. The purpose of this work was the evaluation of the feasibility of radiomics for an improved diagnosis of DAI in comparison to conventional radiological image assessment.</p><p><strong>Methods: </strong>CT and MR imaging was performed in 42 patients suspicious of DAI due to the clinical state, and two control groups (n = 44;42). DAI was diagnosed by experienced neuroradiologists. Radiomics features were extracted using a standardized MRI-based atlas of the predilection areas for DAI. Different MRI and CT based models were trained and validated by five-fold cross validation. Diagnostic performance was compared to the reading of two experienced radiologists and further validated in an external test dataset.</p><p><strong>Results: </strong>The MRI and CT models showed significant differences in radiomics features between patients with DAI and controls. The developed MRI based random forest classifier yielded an accuracy of 80-90%. The best performing CT model yielded an accuracy of 88% in the training data and 70% in the external test data. The results were comparable to conventional image analysis which achieved an accuracy of 70-81% for CT-based diagnosis.</p><p><strong>Conclusion: </strong>MRI- and CT-based radiomics analysis is feasible for the assessment of DAI. The radiomics classifier achieved equivalent performance rates as visual radiological image diagnosis. Especially a radiomics based CT classifier can be of clinical value as a screening and AI-based decision support tool for patients with TBI.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"521-532"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Multicenter Study of Arterial Thromboembolic Events in Hospitalized COVID-19 Patients: Incidence and Imaging Characteristics.","authors":"David Schinz, Marcel Ploch, Andreas Saleh, Philipp Paprottka, Karl-Ludwig Laugwitz, Tareq Ibrahim, Maria Berndt-Mück, Isabelle Riederer, Michael Uder, Christian Maegerlein, Jan Kirschke, Claus Zimmer, Tobias Boeckh-Behrens","doi":"10.1007/s00062-025-01503-w","DOIUrl":"10.1007/s00062-025-01503-w","url":null,"abstract":"<p><strong>Objectives: </strong>Throughout the pandemic, it has become evident that COVID-19 should be recognized as a systemic disease that can affect the coagulation system, potentially resulting in arterial thrombotic events (ATE) with partially bulky free-floating clots. This study aimed to investigate the incidence and imaging characteristics of ATE in hospitalized patients with COVID-19 using clinical and imaging data.</p><p><strong>Methods: </strong>From January 2020 to May 2021, databases of five German tertiary care centers were retrospectively screened for COVID-19 patients with coincidental ATE. ATE were analyzed for localization, time of occurrence, imaging characteristics, and associations with clinical data and laboratory parameters.</p><p><strong>Results: </strong>Out of 3267 patients, 110 ATE (102 patients, mean age, 72.01 ± 15.64 years; 63 men) were observed in the presence of COVID-19 (3.1%). ATE included ischemic stroke (40%), myocardial infarction (46.4%, %), peripheral infarction (3.6%), thrombi in precerebral arteries (3.6%), mesenteric ischemia (2.7%), thrombi in the aorta (1.8%), splenic infarction (0.9%), and kidney infarction (0.9%). The median time interval between the onset of typical respiratory COVID-19 symptoms and ATE was four days (range, -5-58, negative values indicate ATE prior to symptom onset). A significant percentage of patients exhibited ATEs with an atypical free-floating appearance (10.0%) and multiple occlusions (21.2%).</p><p><strong>Conclusion: </strong>COVID-19 is a systemic disease associated with ATE in all vascular regions, with a predilection for the heart and brain. The incidence of ATE might be higher than in comparable viral infections and ATE possibly exhibit distinct imaging features rarely seen, such as bulky free-floating clot masses and multiple occlusions. ATE occur most frequently during the first week around the COVID-19 diagnosis.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"511-519"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sense of Smell in Individuals with Fibromyalgia: a Tractography Study.","authors":"İlyas Uçar, Fatih Çiçek, Fatma Gül Ülkü Demir, Turgut Seber, Mehmet Hilmi Akdeniz, Ahmet Payas, Kerem Kökoğlu","doi":"10.1007/s00062-025-01515-6","DOIUrl":"10.1007/s00062-025-01515-6","url":null,"abstract":"<p><strong>Purpose: </strong>The etiopathogenesis of fibromyalgia (FM), which affects millions of people worldwide, is still debated. Recent research provides significant evidence that there are changes in the functions of the central and peripheral nervous systems and the sense of smell. This study analyzed the clinical assessment results of the sense of smell in individuals with FM and examined the olfactory-related structures in the nervous system.</p><p><strong>Methods: </strong>Thirty patients with FM and 31 age- and sex-matched asymptomatic controls participated in this cross-sectional study. Participants' sense of smell was assessed with the Connecticut Chemosensory Clinical Research Center (CCCRC) including the Butanol threshold test (BET) and Smell Identification Tests. The total number of fibers, mean fiber length, the ratio of the number of fibers in this pathway to the number of fibers in the whole brain of the same individual, fractional anisotropy (FA), mean diffusion (MD), axial diffusion (AD) and radial diffusion (RD) values were calculated by tractography. Additionally, entorhinal cortex volume calculation was performed in MriStudio and MriCloud software using Diffusion tensor imaging (DTI) data in DICOM format.</p><p><strong>Results: </strong>The BET and CCCRC test scores were lower in the FM group (p < 0.05). Similarly, the mean FA values of the olfactory tract were lower on both the right and left sides in the FM group (p < 0.05). However, the entorhinal cortex volumes were similar, and there was no correlation between the right and left FA values of the olfactory tract and the BET scores or CCCRC scores in both groups (p > 0.05).</p><p><strong>Conclusion: </strong>Our study, which included participants' self-assessments and data obtained from central nervous system (CNS) images, supports the idea that individuals with FM have a decreased olfactory function. Decreased FA values in individuals with FM may be an indicator of impaired myelin structure and axonal adaptation in individuals with FM.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"573-579"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative Radiation Exposure Post Aneurysmal Subarachnoid Haemorrhage.","authors":"Shreepad H Asundi, Mark P Plummer, Krishnaswamy Sundararajan, Gerry O'Callaghan, Palash Kar, Alistair Jukes, Chris M Boyd, Weitong Chen, Chang Dong, Timothy Webber","doi":"10.1007/s00062-025-01513-8","DOIUrl":"10.1007/s00062-025-01513-8","url":null,"abstract":"<p><strong>Background: </strong>Patients with aneurysmal subarachnoid haemorrhage (aSAH) often receive multiple radiation based diagnostic studies. Cumulative radiation exposure has been associated with long term health consequences from both dose dependent deterministic harm and increased risk of developing adverse events in a non-dose dependant manner i.e. stochastic harm.</p><p><strong>Objective: </strong>The objective was to calculate cumulative radiation exposure in the acute phase after aSAH.</p><p><strong>Design, setting, participants, main outcome measures: </strong>Single centre retrospective, observational study of consecutive adult patients admitted to the ICU for management of aSAH over five years. Organ and effective radiation doses were determined using institution specific conversion coefficients based on scanner radiation output metrics for all computed tomography imaging and fluoroscopy examinations. Calculated patient doses for the duration of the hospital admission were determined using National Cancer Institute radiation dosimetry tools.</p><p><strong>Results: </strong>A total of 276 patients met the inclusion criteria; 180 females (65%), mean (SD) age 56 (13) years. There were 222 (80%) patients who survived to hospital discharge. The median [IQR] effective cumulative radiation dose was 17.7 [9.7-30.5] mSv. Twenty-one patients (8%) received an effective dose > 50 mSV consistent with potentially harmful ionising radiation exposure. In 162 patients (59%), the equivalent radiation dose to the lens of the eye exceeded the 500 mSv threshold for radiation induced damage.</p><p><strong>Conclusion: </strong>Survivors of aSAH are exposed to high levels of medical radiation. The eyes are particularly at risk with most patients exposed to levels known to induce lens damage. This highlights the importance of strategies to reduce incidental and cumulative medical radiation exposure in this population.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"559-564"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged Venous Transit Independently Predicts Worse Functional Outcomes at Discharge in Successfully Reperfused Patients with Large Vessel Occlusion Stroke.","authors":"Janet Mei, Hamza A Salim, Dhairya A Lakhani, Aneri Balar, Adam A Dmytriw, Meisam Hoseinyazdi, Licia Luna, Francis Deng, Vaibhav Vagal, Nathan Z Hyson, Adrien Guenego, Gregory W Albers, Hanzhang Lu, Victor C Urrutia, Kambiz Nael, Elisabeth B Marsh, Argye E Hillis, Raf Llinas, Max Wintermark, Jeremy J Heit, Tobias D Faizy, Vivek Yedavalli","doi":"10.1007/s00062-025-01509-4","DOIUrl":"10.1007/s00062-025-01509-4","url":null,"abstract":"<p><strong>Background and purpose: </strong>Venous outflow (VO) impairment predicts unfavorable outcomes in patients with acute ischemic stroke caused by large vessel occlusion (AIS-LVO). Prolonged venous transit (PVT), a visual qualitative VO marker on CT perfusion (CTP) time to maximum (Tmax) maps, has been associated with 90-day mortality despite successful reperfusion. This study investigates the association between PVT and modified Rankin Scale (mRS) score at discharge among AIS-LVO patients who have undergone successful reperfusion.</p><p><strong>Methods: </strong>We performed a retrospective analysis of prospectively collected data from consecutive adult AIS-LVO patients with successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b/2c/3). PVT+ was defined as Tmax ≥ 10 s in at least one of the following locations: superior sagittal sinus and/or torcula. The primary outcome was dichotomous mRS scores at discharge (favorable: mRS 0-2; unfavorable: mRS 3-6). Regression analyses were performed to assess the effect of PVT on discharge mRS.</p><p><strong>Results: </strong>In 119 patients of median (IQR) age 71 (63-81) years, a significantly higher proportion of PVT+ patients exhibited unfavorable mRS scores compared to PVT- patients (88.8% vs. 62.7%, p = 0.004). After adjusting for age, sex, hyperlipidemia, diabetes, history of stroke or transient ischemic attack (TIA), tobacco use, administration of intravenous thrombolysis (IVT), admission National Institutes of Health Stroke Scale (NIHSS), Alberta Stroke Program Early CT (ASPECTS) score, and ischemic core volume, the PVT+ remains significantly associated with unfavorable mRS (OR = 0.231, 95%CI 0.054-0.980, p = 0.047).</p><p><strong>Conclusions: </strong>PVT+ was significantly associated with unfavorable mRS at discharge despite successful reperfusion in AIS-LVO patients, underscoring the importance of VO impairment in short-term functional outcomes. PVT serves as a valuable adjunct imaging biomarker derived from CTP for assessing VO profiles in AIS-LVO.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"565-572"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary Adenomas in Children: : Specific Imaging Features According to Hormonal Secretion.","authors":"Fares Kassem, Raphael Levy, Arnault Tauziède-Espariat, Charles-Joris Roux, Thomas Samoyeau, Alexis Ollitrault, Graziella Pinto, Dinane Samara-Boustani, Dulanjalee Kariyawasam, Michel Polak, Kevin Beccaria, Thomas Blauwblomme, Pascale Varlet, Nathalie Boddaert, Volodia Dangouloff-Ros","doi":"10.1007/s00062-025-01499-3","DOIUrl":"10.1007/s00062-025-01499-3","url":null,"abstract":"<p><strong>Purpose: </strong>Pituitary adenomas are much rarer in children than in adults. We aimed to analyze their imaging characteristics in this age group and to compare them according to the hormonal secretion. We conducted an observational monocentric retrospective study on clinical and imaging data.</p><p><strong>Methods: </strong>We analyzed imaging features before surgery or drug treatment of pituitary adenomas in children confirmed by histopathology or hormonal secretion. We assessed tumoral signal intensity, volume and aggressiveness, and compared it according to the hormonal secretion.</p><p><strong>Results: </strong>We included 31 children (13 lactotroph (42%), 8 corticotroph (26%), 5 somatotroph (16%), 5 plurihormonal adenomas (16%) including 1 non-secreting macroadenoma) with a median age of 13 years (range 2-16 years-old), without age or sex difference between secretion types. Lactotroph and somatotroph adenomas were larger than corticotroph adenomas (p = 0.007) and were more aggressive (p = 0.01). They also had higher signal intensity on T2-weighted images (p = 0.04). T1 signal intensity was similar between the groups on pre and post-contrast images (lower enhancement than the normal pituitary). No non-secreting micro-adenoma became clinically significant enough to lead to a pathological confirmation or specific treatment. Genetic research was conducted on 20 children, finding MEN1 mutations in 80% of the patients.</p><p><strong>Conclusions: </strong>Pituitary adenomas in children are rare but should be considered when facing similar imaging features than in adults. Imaging characteristics may allow to suspect the hormonal secretion.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"451-457"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes After Thrombectomy for Primary and Secondary Medium Vessel MCA Occlusions: a Nationwide Registry Study.","authors":"Björn M Hansen, Emma Hall, Birgitta Ramgren, Teresa Ullberg, Johan Wassélius","doi":"10.1007/s00062-025-01511-w","DOIUrl":"10.1007/s00062-025-01511-w","url":null,"abstract":"<p><strong>Background: </strong>Medium vessel occlusions (MeVO) can be either isolated events (primary), or secondary to thrombus migration from a large vessel occlusion to a medium-sized vessel. Outcomes following endovascular thrombectomy (EVT) in the middle cerebral artery (MCA) may differ between primary and secondary MeVOs. This study aimed to assess the association between primary/secondary MeVOs and clinical outcomes following EVT in a nationwide patient cohort.</p><p><strong>Method: </strong>Patients undergoing EVT were included in two Swedish quality registries. Secondary MeVO was defined as distal migration of a solitary thrombus between baseline CT-angiography and EVT, or basal ganglia infarction on postoperative CT in a patient that presented with a single MeVO on baseline CT-angiography. The primary outcome was good 90-day functional outcome (modified Rankin Scale 0-2). Postoperative change in the National Institutes of Health Stroke Scale-score (NIHSS), was a secondary outcome. Successfully revascularized patients (mTICI 2b-3) were compared with non-revascularized patients in exploratory analyzes.</p><p><strong>Results: </strong>Of the 5662 EVTs performed in Sweden (2018-2022), 1118 (20%) targeted solitary MCA territory MeVOs, with 819 (73%) being primary and 299 (27%) secondary. Functional outcomes did not differ between the primary and secondary MeVO groups (OR 0.86, CI 95% 0.65-1.14). Likewise, there was no significant difference in postoperative NIHSS scores (0.26, CI 95% -0.71 to 1.24), between groups (p = 0.597). Successful revascularization was associated with increased chance of good functional outcome for both primary (OR 3.77, CI95% 2.28-6.24, p < 0.001) and secondary MeVOs (OR 2.49, CI95% 1.21-5.14, p = 0.013).</p><p><strong>Conclusions: </strong>Patients with a single primary or secondary MCA MeVOs have similar EVT outcomes and both groups seem to benefit from recanalization in exploratory analyses. This indicates that that EVT should not be withheld based on primary/secondary MeVO status.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"541-549"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioarchitecture of Twig-like Middle Cerebral Artery: the Looping Lenticulostriate Artery Anastomoses as an Angiographic Landmark for Hemorrhagic Presentation.","authors":"Bikei Ryu, Alessandro Sgreccia, Silvia Pizzuto, Federico Di Maria, Yasunari Niimi, Georges Rodesch, Arturo Consoli","doi":"10.1007/s00062-025-01506-7","DOIUrl":"10.1007/s00062-025-01506-7","url":null,"abstract":"<p><strong>Purpose: </strong>The twig-like middle cerebral artery (TL-MCA) is a vascular anomaly reconstituting the MCA-M1 segment through a plexiform arterial network. Most patients with TL-MCA have a high risk of hemorrhage, but the associated vascular anatomical risk factors are poorly understood. To investigate the angioarchitecture of TL-MCA in detail to distinguish the radiological differences between hemorrhagic and non-hemorrhagic onset.</p><p><strong>Methods: </strong>3214 cerebral digital subtraction angiography procedures were performed, and patients with TL-MCA were included and their clinical and anatomical characteristics were retrospectively reviewed.</p><p><strong>Results: </strong>12 patients (median age 47 years, and 9 women) with TL-MCA were included (incidence rate, 0.37%). Among them, four had hemorrhagic stroke, five had ischemic stroke, and three had no symptoms. Perforator anastomoses were identified in five patients (41.6%). Among the four patients with intraparenchymal hemorrhage (IPH), three had looping lenticulostriate artery (LSA) anastomoses and one had non-looping LSA anastomosis. One looping LSA anastomosis was discovered fortuitously in a patient explored for headaches. The recurrent artery of Heubner, which is responsible for the plexiform arterial network, was identified in 10 patients (83.3%). Angiographic evolutions (de novo TL-MCA) were observed in three patients, and one patient experienced a clinical evolution of a TL-MCA with non-looping LSA anastomosis, progressing from no symptoms to IPH.</p><p><strong>Conclusions: </strong>In this small series, looping LSA anastomoses were mainly observed in TL-MCA with IPH. This anatomical disposition could represent a potential risk factor. The TL-MCA always affects the subpallial segment of the MCA-M1, and may be a subpallium-related pathology.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"433-442"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}