Clinical Neuroradiology最新文献

{"title":"CT Angiography, MR Angiography, and Their Combined Use for Detection of Unruptured Intracranial Aneurysms: Comparison with Digital Subtraction Angiography and 3-dimensional Rotational Angiography.","authors":"Jee Hyun Lim, Dae Young Yoon, Eun Soo Kim, Hong Jun Jeon, Jong Young Lee, Young Lan Seo, Eun Joo Yun","doi":"10.1007/s00062-024-01491-3","DOIUrl":"10.1007/s00062-024-01491-3","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the diagnostic accuracy of CT angiography (CTA), MR angiography (MRA), and their combined use for detecting unruptured intracranial aneurysms (UIAs).</p><p><strong>Methods: </strong>Between September 2019 and August 2023, 235 patients suspected of having UIA underwent CTA, MRA, and digital subtraction angiography (DSA)/3-dimensional rotational angiography (3DRA). Two neuroradiologists retrospectively reviewed these images for UIA presence. The value of combining modalities was assessed using confidence rating scores for each. The sensitivity, specificity, and accuracy of these modalities were calculated on a per-aneurysm basis and compared using DSA/3DRA as the reference standard. Subgroup analyses were performed based on aneurysm size (≤ 3 or > 3 mm).</p><p><strong>Results: </strong>DSA/3DRA detected 252 UIAs in 182 patients, no aneurysms detected in 53 (mean age: 61.9 years ±11.6, 83 men). The overall sensitivity/specificity/accuracy of the combined analysis of CTA and MRA were 91.3%/88.7%/90.7%, respectively, which were significantly higher than those of CTA alone (86.9%/71.8%/83.6%) (P = 0.006/0.003/<0.001) and MRA alone (86.9%/80.3%/85.5%) (P =0.003/0.041/<0.001). No significant differences were found in sensitivity, specificity, or accuracy between the use of CTA and MRA (P = 1/0.26/0.45). CTA and MRA sensitivity and accuracy for aneurysms ≤3 mm were significantly lower than for those aneurysms larger. (P < 0.001, each).</p><p><strong>Conclusion: </strong>Combining CTA and MRA analysis improves sensitivity, specificity, and accuracy for UIA detection compared to using each modality alone.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"355-362"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Based Automated Quantification of Arterial Stenosis in Head and Neck CT Angiography: A Comparison with Manual Measurements from Digital Subtraction Angiography and CT Angiography.","authors":"Xinyue Huan, Yang Yang, Shengwen Niu, Yongwei Yang, Bitong Tian, Dajing Guo, Kunhua Li","doi":"10.1007/s00062-024-01464-6","DOIUrl":"10.1007/s00062-024-01464-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the performance of an artificial intelligence (AI) algorithm for automated quantification of arterial stenosis in head and neck CT angiography (CTA).</p><p><strong>Methods: </strong>Patients who received head and neck CTA and DSA between January 2019 and December 2021 in two centers were included. The quantitative performance of CerebralDoc per-lesion was evaluated through intraclass correlation coefficients (ICCs) and Bland-Altman analysis, comparing automated stenosis measurements and manual measurements across 0-100%, < 50%, ≥ 50% and ≥ 70% thresholds. Sensitivity analysis included linear and logistic regression, and subgroups analysis was performed to identify influencing factors.</p><p><strong>Results: </strong>287 patients with 1765 lesions were analyzed. ICCs between CerebralDoc and DSA for ≥ 50% and ≥ 70% stenosis were excellent (0.955, 0.922, respectively), for 0-100% stenosis was good (0.735), and for < 50% stenosis was poor (0.056). For ≥ 50% and ≥ 70% stenosis of CerebralDoc and CTA manual measurements versus DSA, ICCs were close (0.955 vs 0.994; 0.922 vs 0.986), and differences were small (0.258% vs -0.362%; 0.369% vs -0.199%). The sensitivity analysis revealed that specific locations (V1, V2, V3, V4) and slender vessels have large or remarkable differences ranging from 15.551% to 44.238%.</p><p><strong>Conclusion: </strong>CerebralDoc exhibited excellent performance in automatically quantifying arterial stenosis of ≥ 50% and ≥ 70% in head and neck CTA. However, further research was needed to improve its performance for < 50% stenosis and to address differences in specific locations and slender vessels.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"255-268"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Reader Confidence and Differentiation of Calcification from Cerebral Microbleed Diagnosis Using QSM Relative to SWI.","authors":"Chris Kang, Pritesh Mehta, Yi S Chang, Rafeeque A Bhadelia, Rafael Rojas, Max Wintermark, Jalal B Andre, Ethan Yang, Magdy Selim, Ajith J Thomas, Aristotelis Filippidis, Yan Wen, Pascal Spincemaille, Nils D Forkert, Yi Wang, Salil Soman","doi":"10.1007/s00062-024-01478-0","DOIUrl":"10.1007/s00062-024-01478-0","url":null,"abstract":"<p><strong>Purpose: </strong>Accurate detection of cerebral microbleeds (CMBs) is important for detection of multiple conditions. However, CMBs can be challenging to identify on MR images, especially for distinguishing CMBs from the mimic of calcification. We performed a comparative reader study to assess the diagnostic performance of two primary MR sequences for differentiating CMBs from calcification.</p><p><strong>Methods: </strong>Under IRB approved exempt retrospective protocol, 49 adult patients with identifiable intracranial hemorrhage who underwent multi-echo 3D Gradient Recall Echo (GRE) using 3T MRI were non-sequentially recruited under a retrospective IRB approved protocol. Multi-echo complex total field inversion quantitative susceptibility mapping (QSM) and susceptibility weighted imaging/phase (SWI/P) images were generated for all patients. 53 lesion ROIs were identified and classified on provided images by an expert panel of three neuroradiologists as either: CMB, Blood, Calcification, or Other. Three additional neuroradiologists subsequently reviewed the same SWI/P and QSM images in independent sessions and designated lesions as either blood and/or calcification using a 5-point Likert scale. Statistical analyses, on lesion classification and reader diagnostic accuracy, reader confidence-level, reader agreement-level, and the predictability of mean susceptibility values between SWI/P and QSM were conducted with logistic regression and calculation of Fleiss' κ, Kendall's w, Krippendorff's α.</p><p><strong>Results: </strong>Across all qualitative assessment and quantitative metrics measured (simple accuracy, confidence as degree of ground truth alignment, and inter-rater agreement) QSM outperformed SWI/P. Additionally, logistic regression of average QSM voxel susceptibility achieved near-perfect separation in differentiating between CMB and calcification in the limited number of CMB/Calcification ROIs, indicating a high predictability.</p><p><strong>Conclusion: </strong>Our study demonstrates that QSM offers improved detectability and classification of CMBs compared to the conventionally utilized SWI/P sequence. In addition, QSM simplifies the interpretation workflow by reducing the number of requisite images compared with the conventional counterpart, with improved diagnostic confidence.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"303-313"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need of Fine-Tuned Radiology Aware Open-Source Large Language Models for Neuroradiology.","authors":"Partha Pratim Ray","doi":"10.1007/s00062-024-01454-8","DOIUrl":"10.1007/s00062-024-01454-8","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"405-407"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role and Safety of Tirofiban in Peri-Interventional Antiplatelet Management for Aneurysm Treatment.","authors":"Rana Garayzade, Ansgar Berlis, Tim Tobias Arndt, Christina Wolfert, Björn Sommer, Gernot Müller, Christoph J Maurer","doi":"10.1007/s00062-024-01480-6","DOIUrl":"10.1007/s00062-024-01480-6","url":null,"abstract":"<p><strong>Background: </strong>Tirofiban is administered for the treatment of aneurysms in cases of thromboembolic complications, as well as in cases of acute stenting or flow-diverter implantation required within the scope of aneurysm treatment. We aimed to investigate the efficacy and safety of tirofiban in this group of patients.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of all patients undergoing aneurysm treatment and receiving peri-interventional tirofiban administration at our institution between 2009 and 2019.</p><p><strong>Results: </strong>A total of 105 patients were included, with 61% women and 39% men (mean age = 53 years, IQR: 44-60 years). Sixty-seven patients underwent emergency aneurysm treatment, and thirty-eight were treated electively. Hemorrhagic events occurred in 22% (15/67) of the patients treated acutely, with 7.46% (5/67) exhibiting symptoms. Patients undergoing elective aneurysm treatment experienced no hemorrhagic events (p = 0.002). Among the 35 patients who required an external ventricular drain (EVD), 22.86% (8/35) developed EVD-related hemorrhages; however, none were symptomatic (p = 0.007). Of the five patients who required a craniotomy, two experienced significant bleeding, and one experienced non-significant craniotomy-related bleeding (p = 0.20).</p><p><strong>Conclusion: </strong>Tirofiban may be safe for use during peri-interventional complications or emergency stenting in aneurysm treatment. However, caution is necessary when craniotomy is required. In elective aneurysm treatments, administering Tirofiban in response to periprocedural complications appears to be safe.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"247-254"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors and Implications of Myocardial Injury in Intracerebral Hemorrhage.","authors":"Felix Hess, Julian McGinnis, Enayatullah Baki, Tun Wiltgen, Arne Müller, Christian Maegerlein, Jan Kirschke, Claus Zimmer, Bernhard Hemmer, Silke Wunderlich, Mark Mühlau","doi":"10.1007/s00062-025-01498-4","DOIUrl":"10.1007/s00062-025-01498-4","url":null,"abstract":"<p><strong>Purpose: </strong>Myocardial injury, indicated by an elevation of high-sensitive cardiac Troponin (hs-cTnT), is a frequent stroke-related complication. Most studies investigated patients with ischemic stroke, but only little is known about its occurrence in patients with intracerebral hemorrhage (ICH). This study aimed to assess the frequency, predictors, and implications of myocardial injury in ICH patients.</p><p><strong>Methods: </strong>Our retrospective analysis included 322 ICH patients. We defined myocardial injury as an elevation of hs-cTnT above the 99th percentile (i.e. 14 ng/L). Acute myocardial injury was defined as either a changing pattern of > 50% within 24 h or an excessive elevation of initial hs-cTnT (> 52 ng/L). 3D brain scans were assessed for ICH visually and quantitatively by a deep learning algorithm. Multiple regression models and Voxel-based Lesion-Symptom Mapping (VLSM) were applied.</p><p><strong>Results: </strong>63.0% (203/322) of patients presented with myocardial injury, which was associated with more severe strokes and worse outcomes during the in-hospital phase (P < 0.01). Acute myocardial injury occurred in 24.5% (79/322) of patients. The only imaging finding associated with acute myocardial injury was midline shift (69.8% vs. 44.6% for normal or stable hs-cTnT, P < 0.01), which also independently predicted it (odds ratio 3.29, confidence interval 1.38-7.87, P < 0.01). In contrast, VLSM did not identify any specific brain region significantly associated with acute myocardial injury. Acute myocardial injury did not correlate with preexisting cardiac diseases; however, the frequency of adverse cardiac events was higher in the acute myocardial injury group (11.4% vs. 4.1% in patients with normal and/or stable patterns of hs-cTnT, P < 0.05).</p><p><strong>Conclusion: </strong>Myocardial injury occurs frequently in ICH and is linked to poor outcomes. Acute myocardial injury primarily correlates to space-occupying effects of ICH but is less dependent on premorbid cardiac status. Nonetheless, it is associated with a higher rate of adverse cardiac events.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"395-404"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freiburg Neuropathology Case Conference: Gait Ataxia, Segmental Hypoesthesia, and Combined Incontinence in a 57-Years-Old Patient.","authors":"L Miarka, U Taschner, R Rölz, M Prinz, H Urbach, D Erny, C A Taschner","doi":"10.1007/s00062-025-01528-1","DOIUrl":"10.1007/s00062-025-01528-1","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"417-425"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Societies' Communications.","authors":"","doi":"10.1007/s00062-025-01522-7","DOIUrl":"10.1007/s00062-025-01522-7","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"427-430"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating Cognitive Function with Antihypertensive Medications: a Comprehensive Systematic Review On FMRI Studies.","authors":"Sama Rahnemayan, Elham Mehdizadehfar, Arezoo Fathalizadeh","doi":"10.1007/s00062-024-01494-0","DOIUrl":"10.1007/s00062-024-01494-0","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is a prevalent cardiovascular condition associated with cognitive impairments, including memory deficits and attention lapses. Understanding the neural mechanisms underlying HTN-related cognitive dysfunction is crucial for optimizing treatment strategies.</p><p><strong>Method: </strong>A systematic review was conducted to explore the impact of antihypertensive medications on cognition, focusing on memory, attention, and emotion processing using functional magnetic resonance imaging (fMRI). Searches were performed in PubMed and Scopus up to March 10, 2024, with no language restrictions.</p><p><strong>Results: </strong>A total of 108 articles were identified, of which 12 systematic reviews and meta-analyses met the inclusion criteria. Included studies investigated various antihypertensive drugs, including losartan, propranolol, spironolactone, and telmisartan, and their effects on cognitive processes. Losartan improved negative memory encoding and facilitated fear extinction via hippocampal and prefrontal modulation. Propranolol disrupted fear reconsolidation and reduced emotional memory retrieval, affecting the amygdala and hippocampus. Spironolactone prevented stress-induced memory shifts in the amygdala. Findings indicated distinct impacts of these medications on memory encoding, fear extinction, and stress-induced memory modulation, as evidenced by alterations in neural activity patterns observed on fMRI.</p><p><strong>Conclusion: </strong>Antihypertensive medications, such as losartan and propranolol, demonstrate potential in modulating memory, fear-related memory reconsolidation, and stress-induced memory modulation, highlighting their therapeutic implications for conditions like posttraumatic stress disorder (PTSD) and anxiety disorders. This review underscores the importance of fMRI studies in elucidating the neural correlates of HTN-related cognitive impairments and optimizing treatment approaches.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"231-237"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetry of Selected Brain Regions-Can We Compare MRI Examinations of Different Manufacturers and Field Strengths?","authors":"Svea Seehafer, Lars-Patrick Schmill, Sönke Peters, Olav Jansen, Schekeb Aludin","doi":"10.1007/s00062-024-01489-x","DOIUrl":"10.1007/s00062-024-01489-x","url":null,"abstract":"<p><strong>Purpose: </strong>Magnetic Resonance Imaging based brain segmentation and volumetry has become an important tool in clinical routine and research. However the impact of the used hardware is only barely investigated. This study aims to assess the influence of scanner manufacturer, field strength and head-coil on volumetry results.</p><p><strong>Methods: </strong>10 healthy subjects (27.4 ± 1.71 years) were prospectively examined in a Philips Achieva 1.5T, Philips Ingenia CX 3T, Siemens MAGNETOM Aera 1.5T and Siemens MAGNETOM Vida 3T, the latter equipped with three different head coils, within one day. Brain volumetry of the whole brain, total white and grey matter, the cortical grey matter of the supratentorial lobes as well as regions important for the differentiation of neurodegenerative diseases of the dementia and movement disorder spectrum and the ventricular system was performed using the CE-certified software mdbrain by mediaire (Berlin, Germany). Both raw volumetry results and percentile allocation provided by the software were analysed.</p><p><strong>Results: </strong>This study reveals significantly different volumetry results for all examined brain regions beside the ventricular system between the different MRI devices but comparable results between the different head coils. When examining the percentile allocation provided by used software, the Intraclass-Correlation-Coefficient (ICC) values were even lower than the raw volume ICC values ranging from poor to excellent correlation.</p><p><strong>Conclusion: </strong>The present study reveals highly relevant results that need to be considered both in clinical routine when analysing follow-up examinations from different scanner types and clinical research, especially when planning longitudinal and/or multicentre studies.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"363-378"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}