Clinical Neuroradiology最新文献

{"title":"3D T1-Weighted Black-Blood MRI in the Diagnosis and Follow-Up of Facial Neuritis: a Single-Center Prospective Study.","authors":"Ahmet Kursat Karaman, Bora Korkmazer, Ahmet Öz, Nursena Erener, Musa Musayev, Cesur Samancı, Melih Tütüncü, Alperen Vural, Yetkin Zeki Yılmaz, Osman Kızılkılıç, Serdar Arslan","doi":"10.1007/s00062-025-01540-5","DOIUrl":"https://doi.org/10.1007/s00062-025-01540-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the diagnostic performance of 3D T1-weighted black-blood (T1W BB) MRI compared to 3D T1-weighted turbo field echo (T1-TFE) in diagnosing facial neuritis (FN) and to investigate its role in disease monitoring.</p><p><strong>Materials and methods: </strong>22 patients with acute idiopathic FN were included in this prospective study. All patients underwent MRI within the first week of clinical presentation including 3D T1W BB and 3D T1-TFE sequences. Two neuroradiologists independently analyzed six facial nerve segments, evaluating contrast enhancement using a three-point grading scale (0-2). Diagnostic accuracy, sensitivity, specificity, and area under the curve (AUC) were compared between the two sequences. Follow-up MRI was performed in 8 patients to monitor temporal changes in nerve enhancement, and these findings were analyzed in relation to House-Brackmann (HB) scores.</p><p><strong>Results: </strong>The sensitivity, specificity, and accuracy for FN detection were 97.7%, 93.2%, and 95.5% for 3D T1W BB, compared to 86.4%, 97.7%, and 92% for 3D T1-TFE, respectively. Sensitivity was significantly higher with 3D T1W BB (p < 0.05), while AUCs were higher but not significant for both readers. Mean enhancement grades in all affected nerve segments were significantly higher on 3D T1W BB (p < 0.05). Follow-up imaging showed enhancement reduction in 87.5% of patients, correlating with HB score improvements. Enhancement grades significantly correlated with HB scores on T1W BB but not on T1-TFE.</p><p><strong>Conclusion: </strong>3D T1W BB has comparable diagnostic performance with 3D T1-TFE for diagnosing FN and can be used as an effective tool in confirming the diagnosis and in follow-up.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Dose Reduction and Image Quality Improvement of UHR CT of the Neck by Novel Deep-learning Image Reconstruction.","authors":"Dominique Alya Messerle, Nils F Grauhan, Laura Leukert, Ann-Kathrin Dapper, Roman H Paul, Andrea Kronfeld, Bilal Al-Nawas, Maximilian Krüger, Marc A Brockmann, Ahmed E Othman, Sebastian Altmann","doi":"10.1007/s00062-025-01532-5","DOIUrl":"https://doi.org/10.1007/s00062-025-01532-5","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated a dedicated dose-reduced UHR-CT for head and neck imaging, combined with a novel deep learning reconstruction algorithm to assess its impact on image quality and radiation exposure.</p><p><strong>Methods: </strong>Retrospective analysis of ninety-eight consecutive patients examined using a new body weight-adapted protocol. Images were reconstructed using adaptive iterative dose reduction and advanced intelligent Clear-IQ engine with an already established (DL-1) and a newly implemented reconstruction algorithm (DL-2). Additional thirty patients were scanned without body-weight-adapted dose reduction (DL-1-SD). Three readers evaluated subjective image quality regarding image quality and assessment of several anatomic regions. For objective image quality, signal-to-noise ratio and contrast-to-noise ratio were calculated for temporalis and masseteric muscle and the floor of the mouth. Radiation dose was evaluated by comparing the computed tomography dose index (CTDIvol) values.</p><p><strong>Results: </strong>Deep learning-based reconstruction algorithms significantly improved subjective image quality (diagnostic acceptability: DL‑1 vs AIDR OR of 25.16 [6.30;38.85], p < 0.001 and DL‑2 vs AIDR 720.15 [410.14;> 999.99], p < 0.001). Although higher doses (DL-1-SD) resulted in significantly enhanced image quality, DL‑2 demonstrated significant superiority over all other techniques across all defined parameters (p < 0.001). Similar results were demonstrated for objective image quality, e.g. image noise (DL‑1 vs AIDR OR of 19.0 [11.56;31.24], p < 0.001 and DL‑2 vs AIDR > 999.9 [825.81;> 999.99], p < 0.001). Using weight-adapted kV reduction, very low radiation doses could be achieved (CTDIvol: 7.4 ± 4.2 mGy).</p><p><strong>Conclusion: </strong>AI-based reconstruction algorithms in ultra-high resolution head and neck imaging provide excellent image quality while achieving very low radiation exposure.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Isotropic FLAIR-T2* Fusion Imaging for Central Vein Sign Detection in Multiple Sclerosis: a Comparative Study at 1.5 T and 3 T.","authors":"Yunus Emre Senturk, Ahmet Peker, Hande Ozen Atalay, Ayse Altintas, Ali Yusuf Oner","doi":"10.1007/s00062-025-01531-6","DOIUrl":"https://doi.org/10.1007/s00062-025-01531-6","url":null,"abstract":"<p><strong>Purpose: </strong>The central vein sign (CVS) is a promising imaging biomarker for multiple sclerosis (MS) diagnosis. While isotropic T2* at 3 T and 7 T has demonstrated high diagnostic performance, its utility at 1.5 T remains unclear. This study evaluates the performance of unenhanced FLAIR-T2* fusion at 1.5 T compared to 3 T in MS participants.</p><p><strong>Methods: </strong>This prospective observational study included 20 MS patients and 20 control subjects. Each participant underwent unenhanced isotropic Epi-T2* and isotropic FLAIR (0.8 mm voxel size) at both 1.5 T and 3 T. Subsequently, the derived isotropic T2* and FLAIR were combined to create the final FLAIR-T2* fusion in both magnetic field strengths. Two independent raters assessed the CVS status of white matter (WM) lesions using NAIMS criteria. WM lesions were classified as CVS+ or CVS-, and two methods-select-n* and CVS+ proportion-were applied. Sensitivity and specificity were computed, and CVS performance was compared across WM lesion locations.</p><p><strong>Results: </strong>Among eligible WM lesions (MS: 258; controls: 255), the mean CVS+ lesion proportion per participant was 66.9 ± 15.4% for 1.5 T FLAIR-T2* and 77.0 ± 13.6% for 3 T FLAIR-T2* (p < 0.01). At a 40% threshold, 1.5 T FLAIR-T2* achieved 90% sensitivity and 95% specificity, while 3 T FLAIR-T2* achieved 100% sensitivity and 95% specificity. The Select-6* method resulted in only one MS patient being misclassified at both field strengths. 3 T FLAIR-T2* detected more CVS+ lesions in deep WM (87.5% vs. 57.1%, p = 0.05).</p><p><strong>Conclusion: </strong>1.5 T FLAIR-T2* fusion demonstrates high performance in CVS assessment, although slightly outperformed by 3 T FLAIR-T2*. The select-6* method may enhance 1.5 T performance, supporting its feasibility for CVS evaluation.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Large Language Models for Suggesting Nerve Involvement in Upper Limbs MRI Reports with Muscle Denervation Signs.","authors":"Teodoro Martín-Noguerol, Pilar López-Úbeda, Antonio Luna, Manuel Gómez-Río, Juan M Górriz","doi":"10.1007/s00062-025-01533-4","DOIUrl":"https://doi.org/10.1007/s00062-025-01533-4","url":null,"abstract":"<p><strong>Objectives: </strong>Determining the involvement of specific peripheral nerves (PNs) in the upper limb associated with signs of muscle denervation can be challenging. This study aims to develop, compare, and validate various large language models (LLMs) to automatically identify and establish potential relationships between denervated muscles and their corresponding PNs.</p><p><strong>Materials and methods: </strong>We collected 300 retrospective MRI reports in Spanish from upper limb examinations conducted between 2018 and 2024 that showed signs of muscle denervation. An expert radiologist manually annotated these reports based on the affected peripheral nerves (median, ulnar, radial, axillary, and suprascapular). BERT, DistilBERT, mBART, RoBERTa, and Medical-ELECTRA models were fine-tuned and evaluated on the reports. Additionally, an automatic voting system was implemented to consolidate predictions through majority voting.</p><p><strong>Results: </strong>The voting system achieved the highest F1 scores for the median, ulnar, and radial nerves, with scores of 0.88, 1.00, and 0.90, respectively. Medical-ELECTRA also performed well, achieving F1 scores above 0.82 for the axillary and suprascapular nerves. In contrast, mBART demonstrated lower performance, particularly with an F1 score of 0.38 for the median nerve.</p><p><strong>Conclusions: </strong>Our voting system generally outperforms the individually tested LLMs in determining the specific PN likely associated with muscle denervation patterns detected in upper limb MRI reports. This system can thereby assist radiologists by suggesting the implicated PN when generating their radiology reports.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Antegrade Flow in the Internal Carotid Artery During Carotid Artery Stenting with a 7F Optimo Balloon Guide Catheter Following Common Carotid Artery Occlusion.","authors":"Kei Harada, Kei Arakawa, Masahito Kajihara","doi":"10.1007/s00062-025-01525-4","DOIUrl":"https://doi.org/10.1007/s00062-025-01525-4","url":null,"abstract":"<p><strong>Background: </strong>Carotid artery stenting (CAS) using the 7F Optimo balloon guide catheter (BGC) allows for smooth navigation and facilitates proximal flow control. However, this method may allow antegrade flow in the internal carotid artery (ICA). This study aims to identify predictors of antegrade flow during CAS with the common carotid artery (CCA) occlusion.</p><p><strong>Methods: </strong>We retrospectively analyzed 102 lesions treated with CAS using the 7F Optimo BGC and distal filter protection. The ICA flow pattern was assessed via contrast injection during CCA occlusion.</p><p><strong>Results: </strong>Antegrade flow in the ICA was observed in 22 lesions (22%). Compared with lesions where ICA flow control (stagnation or reverse flow) was achieved, the external carotid artery (ECA) diameter was significantly larger (4.4 ± 0.7 mm vs. 3.6 ± 1.2 mm, p < 0.001), and the minimum lesion diameter was significantly larger (3.2 ± 1.2 mm vs. 2.1 ± 1.0 mm, p < 0.001). Multivariate analysis identified a minimum lesion diameter ≥ 2.1 mm (OR 4.8, 95% CI 1.44-16.1; p = 0.01) and an ECA diameter ≥ 4.2 mm (OR 3.2, 95% CI 1.08-9.09; p = 0.04) as independent predictors of antegrade flow. High-intensity spots in postoperative diffusion-weighted magnetic resonance imaging and the incidence of ischemic events were not significantly different between both groups.</p><p><strong>Conclusions: </strong>Lesions with a minimum lesion diameter ≥ 2.1 mm or an ECA diameter ≥ 4.2 mm may exhibit antegrade ICA flow with BGC regardless of CCA occlusion, suggesting that an additional distal filter may help reduce embolic risk.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradermal Advanced Glycation End-products Relate to Reduced Sciatic Nerve Structural Integrity in Type 2 Diabetes.","authors":"Christoph M Mooshage, Dimitrios Tsilingiris, Lukas Schimpfle, Thomas Fleming, Stephan Herzig, Julia Szendroedi, Sabine Heiland, Martin Bendszus, Stefan Kopf, Felix Kurz, Johann Jende, Zoltan Kender","doi":"10.1007/s00062-024-01493-1","DOIUrl":"10.1007/s00062-024-01493-1","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular risk management is beneficial, but stringent glycemic control does not prevent the progression of distal sensorimotor polyneuropathy (DSPN). Persistent hyperglycemia-induced alterations and cardiovascular factors may contribute to diabetes-associated nerve damage. This study aimed to evaluate the correlation between skin auto-fluorescence (sAF), an indicator of dermal advanced glycation end-product (AGE) accumulations, cardiovascular risk, and changes in peripheral nerve integrity.</p><p><strong>Methods: </strong>Sixty-two individuals with type 2 diabetes (T2D) (20 women and 42 men), including 29 diagnosed with DSPN (7 women and 22 men), and 10 healthy controls (HC) underwent diffusion tensor MR imaging of the sciatic nerve to assess fractional anisotropy (FA), an indicator of nerve structural integrity. sAF measurements were combined with clinical, serological, and electrophysiological evaluations. Arterial stiffness was assessed via pulse wave velocity (PWV).</p><p><strong>Results: </strong>sAF (HC 2.1 ± 0.25 AU, nDSPN 2.3 ± 0.47, DSPN 2.6 ± 0.43; p = 0.005) was higher in individuals with DSPN compared to HC (p = 0.010) and individuals without DSPN (p = 0.035). Within the group of T2D FA correlated negatively with sAF (r = -0.49, p < 0.001), PWV (r = -0.40, p = 0.009) and high-sensitivity troponin T (hsTNT), a marker of microvascular damage (r = -0.39, p < 0.001). In DSPN, sAF correlated positively with hsTNT (r = 0.58, p = 0.005) and with PWV (r = 0.52, p = 0.007), the sciatic nerve's FA correlated negatively with PWV (r = -0.47, p = 0.010).</p><p><strong>Conclusions: </strong>This study is the first to show close correlations between reduced peripheral nerve integrity and both intradermal AGE deposition and arterial stiffness in individuals with T2D. These findings highlight a mechanistic link between glycation-related vascular injury and neuronal damage emphasizing the importance of cardiovascular risk management in preventing DSPN.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"385-394"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structured Training in Modules E and F-A Success Story in Interventional Neuroradiology in Germany.","authors":"Stefan Rohde, Ansgar Berlis, Werner Weber, Peter Schramm","doi":"10.1007/s00062-025-01523-6","DOIUrl":"https://doi.org/10.1007/s00062-025-01523-6","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"35 2","pages":"227-230"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Nerve Sheath Dilation Is a Possible Marker of CSF Dyshomeostasis in Idiopathic Intracranial Hypertension.","authors":"Derrek Schartz, Alan J Finkelstein, Emily Schartz, Saanya Lingineni, Matthew Sipple, Zoe Williams, Matthew T Bender, Henry Wang","doi":"10.1007/s00062-024-01476-2","DOIUrl":"10.1007/s00062-024-01476-2","url":null,"abstract":"<p><strong>Purpose: </strong>Idiopathic intracranial hypertension (IIH) is a complex neurological disease characterized by symptoms of raised intracranial pressure of unclear etiology. Although optic nerve sheath dilation is a common MR neuroimaging feature of IIH, how and why it occurs remains poorly understood. The purpose of the presented analysis was to investigate if optic nerve sheath dilation might be associated with neuroimaging correlates of cerebrospinal and interstitial fluid homeostasis.</p><p><strong>Methods: </strong>IIH patients were retrospectively identified from 2016-2023 from our tertiary healthcare system. Brain MRIs were computationally segmented using FreeSurfer. Additionally, diffusion tensor imaging along the perivascular space (DTI-ALPS) was employed to assess cerebral glymphatic flow. The mean perioptic subarachnoid space (PSAS) to optic nerve sheath diameter (ONSD) ratio from both eyes was correlated with neuroimaging markers of CSF and interstitial fluid homeostasis (choroid plexus, ventricle, and gray and white matter volume) and glymphatic flow. All volumes of interest were normalized to total intracranial volume. Multiple linear regression was used to evaluate for associations between continuous variables accounting for covariates of patient age, sex, and body mass index.</p><p><strong>Results: </strong>In total, 55 IIH patients (89% female; mean age: 30.3 years [SD: 7.6]) were included. Increasing PSAS/ONSD was found to be significantly associated with increasing normalized total choroid plexus volume (p = 0.001, R = 0.48) and total ventricle volume (P = 0.014, R = 0.39). Additionally, increasing PSAS/ONSD was associated with declining/worsening cerebral glymphatic clearance based on DTI-APLS (p = 0.043, R = 0.34). Additionally, there was a significant association between increasing PSAS/ONSD and increasing normalized total gray matter volume (p = 0.025, R = 0.36) and declining normalized total white matter volume (p = 0.012, R = 0.40).</p><p><strong>Conclusion: </strong>These findings suggest that MR optic nerve sheath dilation in IIH might be associated with CSF dyshomeostasis with possible choroid plexus hyperplasia and impaired cerebral glymphatic flow based on DTI-ALPS. These findings encourage future research into the ocular glymphatic system in IIH patients.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"239-245"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT Angiography, MR Angiography, and Their Combined Use for Detection of Unruptured Intracranial Aneurysms: Comparison with Digital Subtraction Angiography and 3-dimensional Rotational Angiography.","authors":"Jee Hyun Lim, Dae Young Yoon, Eun Soo Kim, Hong Jun Jeon, Jong Young Lee, Young Lan Seo, Eun Joo Yun","doi":"10.1007/s00062-024-01491-3","DOIUrl":"10.1007/s00062-024-01491-3","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the diagnostic accuracy of CT angiography (CTA), MR angiography (MRA), and their combined use for detecting unruptured intracranial aneurysms (UIAs).</p><p><strong>Methods: </strong>Between September 2019 and August 2023, 235 patients suspected of having UIA underwent CTA, MRA, and digital subtraction angiography (DSA)/3-dimensional rotational angiography (3DRA). Two neuroradiologists retrospectively reviewed these images for UIA presence. The value of combining modalities was assessed using confidence rating scores for each. The sensitivity, specificity, and accuracy of these modalities were calculated on a per-aneurysm basis and compared using DSA/3DRA as the reference standard. Subgroup analyses were performed based on aneurysm size (≤ 3 or > 3 mm).</p><p><strong>Results: </strong>DSA/3DRA detected 252 UIAs in 182 patients, no aneurysms detected in 53 (mean age: 61.9 years ±11.6, 83 men). The overall sensitivity/specificity/accuracy of the combined analysis of CTA and MRA were 91.3%/88.7%/90.7%, respectively, which were significantly higher than those of CTA alone (86.9%/71.8%/83.6%) (P = 0.006/0.003/<0.001) and MRA alone (86.9%/80.3%/85.5%) (P =0.003/0.041/<0.001). No significant differences were found in sensitivity, specificity, or accuracy between the use of CTA and MRA (P = 1/0.26/0.45). CTA and MRA sensitivity and accuracy for aneurysms ≤3 mm were significantly lower than for those aneurysms larger. (P < 0.001, each).</p><p><strong>Conclusion: </strong>Combining CTA and MRA analysis improves sensitivity, specificity, and accuracy for UIA detection compared to using each modality alone.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"355-362"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Based Automated Quantification of Arterial Stenosis in Head and Neck CT Angiography: A Comparison with Manual Measurements from Digital Subtraction Angiography and CT Angiography.","authors":"Xinyue Huan, Yang Yang, Shengwen Niu, Yongwei Yang, Bitong Tian, Dajing Guo, Kunhua Li","doi":"10.1007/s00062-024-01464-6","DOIUrl":"10.1007/s00062-024-01464-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the performance of an artificial intelligence (AI) algorithm for automated quantification of arterial stenosis in head and neck CT angiography (CTA).</p><p><strong>Methods: </strong>Patients who received head and neck CTA and DSA between January 2019 and December 2021 in two centers were included. The quantitative performance of CerebralDoc per-lesion was evaluated through intraclass correlation coefficients (ICCs) and Bland-Altman analysis, comparing automated stenosis measurements and manual measurements across 0-100%, < 50%, ≥ 50% and ≥ 70% thresholds. Sensitivity analysis included linear and logistic regression, and subgroups analysis was performed to identify influencing factors.</p><p><strong>Results: </strong>287 patients with 1765 lesions were analyzed. ICCs between CerebralDoc and DSA for ≥ 50% and ≥ 70% stenosis were excellent (0.955, 0.922, respectively), for 0-100% stenosis was good (0.735), and for < 50% stenosis was poor (0.056). For ≥ 50% and ≥ 70% stenosis of CerebralDoc and CTA manual measurements versus DSA, ICCs were close (0.955 vs 0.994; 0.922 vs 0.986), and differences were small (0.258% vs -0.362%; 0.369% vs -0.199%). The sensitivity analysis revealed that specific locations (V1, V2, V3, V4) and slender vessels have large or remarkable differences ranging from 15.551% to 44.238%.</p><p><strong>Conclusion: </strong>CerebralDoc exhibited excellent performance in automatically quantifying arterial stenosis of ≥ 50% and ≥ 70% in head and neck CTA. However, further research was needed to improve its performance for < 50% stenosis and to address differences in specific locations and slender vessels.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"255-268"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}