Clinical Neuroradiology最新文献_第3页

Measurement of Healthy Adult Brain Temperature Using ¹H Magnetic Resonance Spectroscopy Thermometry. 利用 1H 磁共振波谱温度计测量健康成年人的脑温

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-10-30 DOI: 10.1007/s00062-024-01467-3

Yahong Tan, Wenjia Liu, Yanhua Li, Nan Zhang, Mingxiao Wang, Shuo Sun, Lin Ma

{"title":"Measurement of Healthy Adult Brain Temperature Using 1H Magnetic Resonance Spectroscopy Thermometry.","authors":"Yahong Tan, Wenjia Liu, Yanhua Li, Nan Zhang, Mingxiao Wang, Shuo Sun, Lin Ma","doi":"10.1007/s00062-024-01467-3","DOIUrl":"https://doi.org/10.1007/s00062-024-01467-3","url":null,"abstract":"Purpose: The purpose of this study is to measure the brain temperature (Tbr) by using 1H magnetic resonance spectroscopy (1H MRS) thermometry and investigate its age and gender differences in healthy adults. The brain temperature was further compared with the body temperature (Tbo) to investigate the possible existence of brain-body temperature gradient (∆T).Methods: A total of 80 subjects were included in this study. 1H MRS data were collected on a 3.0T MR scanner using Point Resolved Selective Spectroscopy (PRESS) sequence. Voxels were positioned in the right frontal (RF) lobe and left frontal (LF) lobe, respectively. The temperature of each voxel was calculated by chemical shift difference (∆δ) between H2O and NAA which was obtained by LCModel software. The average temperature of bilateral frontal lobe voxels was defined as Tbr for each subject. The average forehead temperature was acquired before MR scanning, defined as Tbo, in this study. The difference between Tbr and Tbo, denoted as the brain-body temperature gradient (∆T), was calculated. Age and gender characteristics of Tbr, ∆T and Tbo were analyzed.Results: Tbr (38.51 ± 0.59℃) was higher than Tbo (36.47 ± 0.26℃) (P < 0.05). Negative correlations were observed between Tbr and age (r = -0.49, P < 0.05) and between ∆T and age (r = -0.44, P < 0.05), whereas no correlation existed between Tbo and age (r = -0.03, P = 0.79).Conclusion: Our observation demonstrated that the brain temperature, derived from 1H MRS thermometry, is significantly higher than the body temperature, indicating the existence of a brain-body temperature gradient, and the brain temperature gradually decreases with age.","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inferior Vena Cava Thrombosis in the Setting of Lumbar Spondylodiscitis. 腰椎间盘炎导致的下腔静脉血栓形成

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-10-23 DOI: 10.1007/s00062-024-01466-4

Valeria Ortega, Alexander Levitt

引用次数: 0

Evaluation of an Image-based Classification Model to Identify Glioma Subtypes Using Arterial Spin Labeling Perfusion MRI On the Publicly Available UCSF Glioma Dataset. 在公开的加州大学旧金山分校胶质瘤数据集上评估使用动脉自旋标记灌注磁共振成像识别胶质瘤亚型的图像分类模型。

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-10-17 DOI: 10.1007/s00062-024-01465-5

K Amador, H Kniep, J Fiehler, N D Forkert, T Lindner

{"title":"Evaluation of an Image-based Classification Model to Identify Glioma Subtypes Using Arterial Spin Labeling Perfusion MRI On the Publicly Available UCSF Glioma Dataset.","authors":"K Amador, H Kniep, J Fiehler, N D Forkert, T Lindner","doi":"10.1007/s00062-024-01465-5","DOIUrl":"https://doi.org/10.1007/s00062-024-01465-5","url":null,"abstract":"Purpose: Glioma is a complex cancer comprising various subtypes and mutations, which may have different metabolic characteristics that can potentially be investigated and identified using perfusion imaging. Therefore, the aim of this work was to use radiomics and machine learning analysis of arterial spin labeling MRI data to automatically differentiate glioma subtypes and mutations.Methods: A total of 495 Arterial Spin Labeling (ASL) perfusion imaging datasets from the UCSF Glioma database were used in this study. These datasets were segmented to delineate the tumor volume and classified according to tumor grade, pathological diagnosis, and IDH status. Perfusion image data was obtained from a 3T MRI scanner using pseudo-continuous ASL. High level texture features were extracted for each ASL dataset using PyRadiomics after tumor volume segmentation and then analyzed using a machine learning framework consisting of ReliefF feature ranking and logistic model tree classification algorithms.Results: The results of the evaluation revealed balanced accuracies for the three endpoints ranging from 55.76% (SD = 4.28, 95% CI: 53.90-57.65) for the tumor grade using 25.4 ± 37.21 features, 62.53% (SD = 2.86, 95% CI: 61.27-63.78) for the mutation status with 23.3 ± 29.17 picked features, and 80.97% (SD = 1.83, 95% CI: 80.17-81.78) for the pathological diagnosis which used 47.3 ± 32.72 selected features.Conclusions: Radiomics and machine learning analysis of ASL perfusion data in glioma patients hold potential for aiding in the diagnosis and treatment of glioma, mainly for discerning glioblastoma from astrocytoma, while performance for tumor grading and mutation status appears limited.","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Influencing the Association of 24-hour National Institutes of Health Stroke Scale & 90-day Modified Rankin Score. 影响 24 小时美国国立卫生研究院卒中量表与 90 天改良 Rankin 评分关联的因素。

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-10-15 DOI: 10.1007/s00062-024-01459-3

Alexander Stebner, Salome L Bosshart, Andrew Demchuk, Alexandre Poppe, Raul Nogueira, Ryan McTaggart, Brian Buck, Aravind Ganesh, Michael Hill, Mayank Goyal, Johanna Ospel

{"title":"Factors Influencing the Association of 24-hour National Institutes of Health Stroke Scale & 90-day Modified Rankin Score.","authors":"Alexander Stebner, Salome L Bosshart, Andrew Demchuk, Alexandre Poppe, Raul Nogueira, Ryan McTaggart, Brian Buck, Aravind Ganesh, Michael Hill, Mayank Goyal, Johanna Ospel","doi":"10.1007/s00062-024-01459-3","DOIUrl":"https://doi.org/10.1007/s00062-024-01459-3","url":null,"abstract":"Purpose: The modified Rankin Scale (mRS) at 90 days is the primary outcome in most acute stroke studies, but the long follow-up period has disadvantages. The National Institutes of Health Stroke Scale (NIHSS) at 24 h shows a strong, but imperfect, association with 90-day mRS. This study examines the association between 24-hour NIHSS and 90-day mRS and reasons for discrepancies.Methods: Data are from the ESCAPE-NA1 thrombectomy patients. To address the non-normality distribution of the NIHSS and include deceased patients, a 7-point ordinal score was generated by grouping 24-hour NIHSS. The association of ordinal 24-hour NIHSS and 90-day mRS was assessed with adjusted ordinal logistic regression. Differences in baseline and treatment/post-treatment variables were compared between patients with discordant and concordant outcomes.Results: One-thousand-seventy-six patients with available 24-hour NIHSS and 90-day mRS were included (median 24-hour NIHSS 6[IQR: 2-14], median 90-day mRS 2[IQR: 1-4]). Ordinal 24-hour NIHSS was associated with 90-day mRS (adjusted cOR 2.53 [95%CI 2.33-2.74]). Forty-eight (4.5%) patients had discordant outcomes. Of those, 19(1.8%) had 24-hour NIHSS < 6 and 90-day mRS5-6; all of which had ≥ 1 severe adverse event, most commonly pneumonia (6[31.6%]) or recurrent stroke (4[21.1%]). Twenty-nine patients (2.7%) had 24-hour NIHSS > 14 and 90-day mRS 0-2. In these patients, baseline NIHSS and ASPECTS was lower, and collateral status was worse.Conclusion: An ordinal NIHSS score that includes death at 24 h shows a strong association with 90-day mRS, suggesting that it could be used as an alternative outcome. Patients with discrepant outcomes differed from the remaining patients regarding their baseline NIHSS, ASPECTS, collateral status, and post-stroke complications.","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombectomy Outcomes for Anterior Circulation Stroke in the 6-24 h Time Window Solely Based On NCCT and CTA: A Single Center Study. 仅根据 NCCT 和 CTA 在 6-24 小时时间窗内对前循环卒中进行血栓清除术的结果：单中心研究。

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-10-01 DOI: 10.1007/s00062-024-01462-8

Dmytro Shchehlov, Stanislav Konotopchk, Valentyna Pankiv, Farida Rzayeva, Sergii Kolomiichenko, Mykola Vyval, Fabian Flottmann, Jens Fiehler, Anna A Kyselyova

{"title":"Thrombectomy Outcomes for Anterior Circulation Stroke in the 6-24 h Time Window Solely Based On NCCT and CTA: A Single Center Study.","authors":"Dmytro Shchehlov, Stanislav Konotopchk, Valentyna Pankiv, Farida Rzayeva, Sergii Kolomiichenko, Mykola Vyval, Fabian Flottmann, Jens Fiehler, Anna A Kyselyova","doi":"10.1007/s00062-024-01462-8","DOIUrl":"https://doi.org/10.1007/s00062-024-01462-8","url":null,"abstract":"Purpose: Since perfusion imaging may be unavailable in smaller hospitals, alternative imaging selection methods for acute ischemic stroke can improve outcomes and optimize resources. This study assessed the safety and effectiveness of using imaging criteria other than DEFUSE 3 and DAWN for thrombectomy beyond 6 h from symptom onset in patients stroke in the anterior circulation.Methods: This is a retrospective, single-center analysis of consecutive patients with large vessel occlusion in the anterior circulation undergoing thrombectomy. Patients were categorized into two groups based on the collateral status (moderate collaterals and good collaterals).Results: Among 198 patients, 106 (54%) met the inclusion criteria and were analyzed. Good collateral status was observed in 78 (74%) patients. Patients with good collaterals showed significantly lower mRS scores at discharge and at 90 days compared to their counterparts with moderate collateral status (4 (3-4) vs. 4 (4-5); p = 0.001 and 2 (0-4) vs. 6 (3-6); p < 0.001, respectively). More patients with good collateral status achieved favorable outcomes at 90 days compared to those with moderate status (48 (61.5%) vs. 5 (17.9%); p < 0.001). Good collaterals were an independent predictor of good clinical outcomes at 90 days (OR = 1.31, 95% CI: 1.13-1.53, p < 0.001).Conclusion: Selecting patients for endovascular treatment of acute ischemic stroke using non-contrast CT and CT angiography shows 90-day outcomes similar to the DAWN and DEFUSE-3 trials. Using collateral status on CT angiography can predict favorable outcomes after mechanical thrombectomy in resource-limited settings where perfusion imaging is unavailable.","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Artificial Intelligence Algorithm Integrated into the Clinical Workflow Can Ensure High Quality Acute Intracranial Hemorrhage CT Diagnostic. 融入临床工作流程的人工智能算法可确保高质量的急性颅内出血 CT 诊断。

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-09-26 DOI: 10.1007/s00062-024-01461-9

K Villringer, R Sokiranski, R Opfer, L Spies, M Hamann, A Bormann, M Brehmer, I Galinovic, J B Fiebach

{"title":"An Artificial Intelligence Algorithm Integrated into the Clinical Workflow Can Ensure High Quality Acute Intracranial Hemorrhage CT Diagnostic.","authors":"K Villringer, R Sokiranski, R Opfer, L Spies, M Hamann, A Bormann, M Brehmer, I Galinovic, J B Fiebach","doi":"10.1007/s00062-024-01461-9","DOIUrl":"https://doi.org/10.1007/s00062-024-01461-9","url":null,"abstract":"Purpose: Intracranial hemorrhage (ICH) is a life-threatening condition requiring rapid diagnostic and therapeutic action. This study evaluates whether Artificial intelligence (AI) can provide high-quality ICH diagnostics and turnaround times suitable for routine radiological practice.Methods: A convolutional neural network (CNN) was trained and validated to detect ICHs on DICOM images of cranial CT (CCT) scans, utilizing about 674,000 individually labeled slices. The CNN was then incorporated into a commercial AI engine and seamlessly integrated into three pilot centers in Germany. A real-world test-dataset was extracted and manually annotated by two experienced experts. The performance of the AI algorithm against the two raters was assessed and compared to the inter-rater agreement. The overall time ranging from data acquisition to the delivery of the AI results was analyzed.Results: Out of 6284 CCT examinations acquired in three different centers, 947 (15%) had ICH. Breakdowns of hemorrhage types included 8% intraparenchymal, 3% intraventricular, 6% subarachnoidal, 7% subdural, < 1% epidural hematomas. Comparing the AI's performance on a subset of 255 patients with two expert raters, it achieved a sensitivity of 0.90, a specificity of 0.96, an accuracy of 0.96. The corresponding inter-rater agreement was 0.84, 0.98, and 0.96. The overall median processing times for the three centers were 9, 11, and 12 min, respectively.Conclusion: We showed that an AI algorithm for the automatic detection of ICHs can be seamlessly integrated into clinical workflows with minimal turnaround time. The accuracy was on par with radiology experts, making the system suitable for routine clinical use.","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focally Enlarged Perivascular Spaces in Pediatric and Adolescent Patients with Polymicrogyria—an MRI Study 小儿和青少年多发性微小病变患者血管周围间隙局部增大--磁共振成像研究

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-09-13 DOI: 10.1007/s00062-024-01457-5

Maximilian Rauch, Karsten Lachner, Lea Frickel, Monika Lauer, Simon Jonas Adenauer, Elisabeth Neuhaus, Elke Hattingen, Luciana Porto

{"title":"Focally Enlarged Perivascular Spaces in Pediatric and Adolescent Patients with Polymicrogyria—an MRI Study","authors":"Maximilian Rauch, Karsten Lachner, Lea Frickel, Monika Lauer, Simon Jonas Adenauer, Elisabeth Neuhaus, Elke Hattingen, Luciana Porto","doi":"10.1007/s00062-024-01457-5","DOIUrl":"https://doi.org/10.1007/s00062-024-01457-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3>Polymicrogyria (PMG) is a cortical malformation frequently associated with epilepsy. Our aim was to investigate the frequency and conspicuity of enlarged perivascular spaces (EPVS) underneath dysplastic cortex as a potentially underrecognized feature of PMG in pediatric and adolescent patients undergoing clinical magnetic resonance imaging (MRI).<h3 data-test=\"abstract-sub-heading\">Methods</h3>We analyzed data from 28 pediatric and adolescent patients with PMG and a matched control group, ranging in age from 2 days to 21 years, who underwent MRI at 1.5T or 3T. T2-weighted MR images were examined for the presence of EPVS underneath the dysplastic cortex. The quantity of EPVS was graded from 0 to 4 (0: none, 1: < 10, 2: 11–20, 3: 21–40, 4: > 40 EPVS). We then compared the presence and quantity of EPVS to the matched controls in terms of total EPVS scores, and EPVS scores underneath the dysplastsic cortex depending on the age groups, the localization of PMG, and the MRI field strength.<h3 data-test=\"abstract-sub-heading\">Results</h3>In 23/28 (82%) PMG patients, EPVS spatially related to the dysplastic cortex were identified. EPVS scores were significantly higher in PMG patients compared to controls, independent from age or PMG location. No significant differences were observed in EPVS scores in patients examined at 1.5T compared to those examined at 3T.<h3 data-test=\"abstract-sub-heading\">Conclusion</h3>EPVS underneath the dysplastic cortex were identified in 82% of patients. EPVS may serve as an important clue for PMG and a marker for cortical malformation.","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing more than the Tip of the Iceberg: Approaches to Subthreshold Effects in Functional Magnetic Resonance Imaging of the Brain. 看到的不仅仅是冰山一角：大脑功能磁共振成像中的阈下效应研究方法。

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-09-01 Epub Date: 2024-06-06 DOI: 10.1007/s00062-024-01422-2

Benedikt Sundermann, Bettina Pfleiderer, Anke McLeod, Christian Mathys

引用次数: 0

Retrograde Parent Artery Occlusion for Ruptured Intracranial Vertebral Artery Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery: The "Breakwater" Technique. 逆行母动脉闭塞术治疗涉及小脑后下动脉的颅内椎动脉破裂夹层动脉瘤：防波堤 "技术。

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-09-01 Epub Date: 2024-02-02 DOI: 10.1007/s00062-024-01388-1

Satoshi Kitamura, Yoshiki Hanaoka, Jun-Ichi Koyama, Daisuke Yamazaki, Takuya Nakamura, Tetsuyoshi Horiuchi

引用次数: 0

Hemodynamic Impairments of Evaluating Symptomatic Intracranial Atherosclerotic Stenosis using Quantitative Flow Ratio on Digital Subtraction Angiography : A Comparison with Computed Tomography Perfusion, MRI and Fractional Flow Reserve. 利用数字减影血管造影术的定量血流比评估有症状的颅内动脉粥样硬化性狭窄的血流动力学损伤：与计算机断层扫描灌注、核磁共振成像和分数血流储备的比较。

IF 2.8 3区医学

Clinical Neuroradiology Pub Date : 2024-09-01 Epub Date: 2024-03-15 DOI: 10.1007/s00062-024-01395-2

Yingchun Wu, Feng Gao, Honglin Feng

{"title":"Hemodynamic Impairments of Evaluating Symptomatic Intracranial Atherosclerotic Stenosis using Quantitative Flow Ratio on Digital Subtraction Angiography : A Comparison with Computed Tomography Perfusion, MRI and Fractional Flow Reserve.","authors":"Yingchun Wu, Feng Gao, Honglin Feng","doi":"10.1007/s00062-024-01395-2","DOIUrl":"10.1007/s00062-024-01395-2","url":null,"abstract":"Purpose: Cerebral hemodynamics are important for the management of intracranial atherosclerotic stenosis (ICAS). The quantitative flow ratio (QFR) is a novel angiography-derived index for assessing the functional relevance of ICAS without pressure wires and adenosine. Good diagnostic yield with the hyperemic fractional flow reserve (FFR) have been reported, while data on the comparison of QFR to FFR are scarce.Methods: In this prospective study 56 patients with anterior circulation symptomatic ICAS who received endovascular treatment were included. The new method of computing QFR from a single angiographic view, i.e., the Murray law-based QFR (μQFR), was applied to the examined vessels. An artificial intelligence algorithm was developed to realize the automatic delineation of vascular contour. Pressure gradients were measured before and after treatment within the lesion vessel using a pressure guidewire and the FFR was calculated.Results: There was a good correlation between μQFR and FFR. Preoperative FFR predicted DWI watershed infarction (FFR optimal cut-off level: 0.755). Preoperative μQFR predicted DWI watershed infarction (μQFR optimal cut-off level: 0.51). Preoperative FFR predicted CTP hypoperfusion (FFR best predictive value: 0.62). Preoperative μQFR predicted CTP hypoperfusion (μQFR best predictive value: 0.375).Conclusion: The μQFR based on DSA images can be used as an indicator to assess the functional status of the lesion in patients with ICAS.","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"613-624"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0