Clinical Neuroradiology最新文献

{"title":"Added Value of Cerebral Small Vascular Disease Burden Based On MRI for Prediction Poor Outcome of Intracerebral Hemorrhage.","authors":"Sihui Wang, Yingjie Zhang, Xiaochen Wang, Hongwei Li, Xuening Zhao, Lingxu Chen, Mengyuan Yuan, Yi Ju, Shengjun Sun","doi":"10.1007/s00062-025-01517-4","DOIUrl":"10.1007/s00062-025-01517-4","url":null,"abstract":"<p><strong>Background: </strong>The significance between cerebral small vessel disease (CSVD) markers on MRI and clinical outcome in intracerebral hemorrhage (ICH) patients is unclear. This study aimed to explore the connection between CSVD markers and short-term outcome in ICH patients.</p><p><strong>Methods: </strong>We retrospectively included 318 ICH patients. Patients were categorized into unfavorable and favorable prognosis groups based on their 90-day modified Rankin Scale (mRS) score (mRS > 3 indicates unfavorable). We conducted an MRI-based assessment of CSVD markers and investigated the predictive power of individual markers and the overall burden on prognosis.</p><p><strong>Results: </strong>White matter hyperintensities (WMH) with a modified Fazekas score ≥ 2 (95% CI 2.367-17.421, p < 0.001), the presence of cortical superficial siderosis (CSS) (95 % CI 2.582-28.212, p < 0.001 in Model 1; 95 % CI 2.701-27.385, p < 0.001 in Model 2), and total CSVD burden (95 % CI 1.249-2.352, p < 0.05) are independent risk factors for unfavorable outcome of ICH.</p><p><strong>Conclusions: </strong>MRI-based markers of CSVD are valuable in assessing the risk of poor outcome in ICH. WMH with a modified Fazekas score ≥ 2, the presence of CSS, and higher CSVD burden are independently associated with adverse functional outcome.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"581-587"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of pEGASUS-HPC and CREDO Heal stent systems deployed via NeuroSpeed percutaneous angioplasty balloon catheter for treatment of acute symptomatic intracranial stenosis and occlusion.","authors":"Abdallah Aburub, Mohammad Almohammad, Ali Khanafer, Zakarya Ali, Mariana Gurschi, Yashar Aghazadeh, Mete Dadak, Tawfik Moher Alsady, Lars Timmermann, Ole Simon, Anja Gerstner, Bayan Alhaj Moustafa, Oussama Dob, Christopher Nimsky, Benjamin Saß, Hans Henkes, André Kemmling","doi":"10.1007/s00062-025-01544-1","DOIUrl":"https://doi.org/10.1007/s00062-025-01544-1","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy and safety of the pEGASUS-HPC and CREDO heal coated stent systems used with the NeuroSpeed percutaneous angioplasty (PTA) balloon catheter, for treating acute symptomatic intracranial artery stenosis (ICAS) with or without acute vessel occlusion (VO).</p><p><strong>Methods: </strong>This retrospective, multicenter study included patients with ICAS between June-2021 and June-2024 treated with the NeuroSpeed PTA balloon catheter and either stent system. Clinical endpoints included National Institutes of Health Stroke Scale (NIHSS) scores and modified ranking scores (mRS), safety and efficacy endpoints included in-stent thrombosis and in-stent stenosis.</p><p><strong>Results: </strong>Sixty-nine patients were included (pEGASUS-HPC, n = 34; CREDO heal, n = 35). Both groups showed significant improvement in arterial diameter post-intervention (pEGASUS-HPC: 0.47 mm (SD 0.27 mm) to 1.69 mm (SD 0.55 mm); CREDO heal: 0.57 mm (SD 0.41 mm) to 1.89 mm (SD 0.62 mm)). Revascularization success, defined as residual stenosis < 50%, was achieved in 32/34 (93.9%) patients in the pEGASUS-HPC group and 33/35 (94.3%) in the CREDO heal group. In-stent re-stenosis occurred in 5/34 (14.7%) of patients in the pEGASUS-HPC group and 2/35 (5.7%) in the CREDO heal group and retreatment with PTA was performed in 3/34 (8.8%) and 2/35 (5.7%), respectively. Peri- or postprocedural in-stent thrombosis occurred in 3/34 (8.8%) of patients in the pEGASUS-HPC group and 2/35 (5.7%) in the CREDO heal group. At 3-6 months, the proportion of patients achieving an mRS score of 0-2 was 25/34 (73.5%) in the pEGASUS-HPC group and 28/35 (80.0%) in the CREDO heal group (p = 0.578).</p><p><strong>Conclusion: </strong>Both stent systems proved effective and safe, showing significant post-intervention arterial dilation, high revascularization rates, and similar functional outcomes (mRS 0-2 at 3-6 months), though they differed in in-stent restenosis rates.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thin-Slice Brain CT Image Quality and Lesion Detection Evaluation in Deep Learning Reconstruction Algorithm.","authors":"Jiali Sun, Hui Yao, Tailin Han, Yan Wang, Le Yang, Xizhe Hao, Su Wu","doi":"10.1007/s00062-025-01542-3","DOIUrl":"https://doi.org/10.1007/s00062-025-01542-3","url":null,"abstract":"<p><strong>Background: </strong>Clinical evaluation of Artificial Intelligence (AI)-based Precise Image (PI) algorithm in brain imaging remains limited. PI is a deep-learning reconstruction (DLR) technique that reduces image noise while maintaining a familiar Filtered Back Projection (FBP)-like appearance at low doses. This study aims to compare PI, Iterative Reconstruction (IR), and FBP-in improving image quality and enhancing lesion detection in 1.0 mm thin-slice brain computed tomography (CT) images.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on brain non-contrast CT scans from August to September 2024 at our institution. Each scan was reconstructed using four methods: routine 5.0 mm FBP (Group A), thin-slice 1.0 mm FBP (Group B), thin-slice 1.0 mm IR (Group C), and thin-slice 1.0 mm PI (Group D). Subjective image quality was assessed by two radiologists using a 4- or 5‑point Likert scale. Objective metrics included contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and image noise across designated regions of interest (ROIs).</p><p><strong>Results: </strong>60 patients (65.47 years ± 18.40; 29 males and 31 females) were included. Among these, 39 patients had lesions, primarily low-density lacunar infarcts. Thin-slice PI images demonstrated the lowest image noise and artifacts, alongside the highest CNR and SNR values (p < 0.001) compared to Groups A, B, and C. Subjective assessments revealed that both PI and IR provided significantly improved image quality over routine FBP (p < 0.05). Specifically, Group D (PI) achieved superior lesion conspicuity and diagnostic confidence, with a 100% detection rate for lacunar lesions, outperforming Groups B and A.</p><p><strong>Conclusions: </strong>PI reconstruction significantly enhances image quality and lesion detectability in thin-slice brain CT scans compared to IR and FBP, suggesting its potential as a new clinical standard.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo Assessment of the Proximal Branches of the Anterior Cerebral Artery Using Rotational Angiography.","authors":"Maximilian Rauch, Joachim Berkefeld, Janine Mokbel, Thomas Deller, Elke Hattingen, Stefan Weidauer","doi":"10.1007/s00062-025-01539-y","DOIUrl":"https://doi.org/10.1007/s00062-025-01539-y","url":null,"abstract":"<p><strong>Background: </strong>The anatomy of the proximal anterior cerebral artery (ACA) and its branches, including the recurrent artery of Heubner (RAH) and medial lenticulostriate arteries (MLSAs), is known for frequent variations. Impairment of these branches can result in severe consequences, including neurological deficits or cognitive impairment. This study aimed to analyze these branches and their variations in vivo, using data from 3D rotational angiographies (3D-RA).</p><p><strong>Material and methods: </strong>We reviewed 3D-RAs of 209 hemispheres from 191 patients with pathologies remote from the region of interest. The presence, origin and course of the RAH were investigated. Delineation, origin and number of perforator vessels originating from the A1 segment (MLSAs) were assessed.</p><p><strong>Results: </strong>The RAH was observed in 151 hemispheres (72%), including a single RAH in 144 (69%) and a doubled RAH in 7 (3%) hemispheres. In 37% of cases, the RAH originated from the A1 segment, in 56% from the A1/A2 transition, and in 7% from the A2 segment. In the presence of RAH, additional MLSAs originating from the A1 segment were present in 25% of hemispheres. A weak negative correlation was identified between the presence of one or two RAH and the frequency of additional MLSAs.</p><p><strong>Conclusion: </strong>The study revealed significant differences in the presence and anatomical course of RAH and MLSAs compared to previous research. The findings highlight the importance of 3D-RA in visualizing the complex anatomy of the ACA, particularly to avoid complications during surgical or endovascular procedures.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D T1-Weighted Black-Blood MRI in the Diagnosis and Follow-Up of Facial Neuritis: a Single-Center Prospective Study.","authors":"Ahmet Kursat Karaman, Bora Korkmazer, Ahmet Öz, Nursena Erener, Musa Musayev, Cesur Samancı, Melih Tütüncü, Alperen Vural, Yetkin Zeki Yılmaz, Osman Kızılkılıç, Serdar Arslan","doi":"10.1007/s00062-025-01540-5","DOIUrl":"https://doi.org/10.1007/s00062-025-01540-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the diagnostic performance of 3D T1-weighted black-blood (T1W BB) MRI compared to 3D T1-weighted turbo field echo (T1-TFE) in diagnosing facial neuritis (FN) and to investigate its role in disease monitoring.</p><p><strong>Materials and methods: </strong>22 patients with acute idiopathic FN were included in this prospective study. All patients underwent MRI within the first week of clinical presentation including 3D T1W BB and 3D T1-TFE sequences. Two neuroradiologists independently analyzed six facial nerve segments, evaluating contrast enhancement using a three-point grading scale (0-2). Diagnostic accuracy, sensitivity, specificity, and area under the curve (AUC) were compared between the two sequences. Follow-up MRI was performed in 8 patients to monitor temporal changes in nerve enhancement, and these findings were analyzed in relation to House-Brackmann (HB) scores.</p><p><strong>Results: </strong>The sensitivity, specificity, and accuracy for FN detection were 97.7%, 93.2%, and 95.5% for 3D T1W BB, compared to 86.4%, 97.7%, and 92% for 3D T1-TFE, respectively. Sensitivity was significantly higher with 3D T1W BB (p < 0.05), while AUCs were higher but not significant for both readers. Mean enhancement grades in all affected nerve segments were significantly higher on 3D T1W BB (p < 0.05). Follow-up imaging showed enhancement reduction in 87.5% of patients, correlating with HB score improvements. Enhancement grades significantly correlated with HB scores on T1W BB but not on T1-TFE.</p><p><strong>Conclusion: </strong>3D T1W BB has comparable diagnostic performance with 3D T1-TFE for diagnosing FN and can be used as an effective tool in confirming the diagnosis and in follow-up.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Dose Reduction and Image Quality Improvement of UHR CT of the Neck by Novel Deep-learning Image Reconstruction.","authors":"Dominique Alya Messerle, Nils F Grauhan, Laura Leukert, Ann-Kathrin Dapper, Roman H Paul, Andrea Kronfeld, Bilal Al-Nawas, Maximilian Krüger, Marc A Brockmann, Ahmed E Othman, Sebastian Altmann","doi":"10.1007/s00062-025-01532-5","DOIUrl":"https://doi.org/10.1007/s00062-025-01532-5","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated a dedicated dose-reduced UHR-CT for head and neck imaging, combined with a novel deep learning reconstruction algorithm to assess its impact on image quality and radiation exposure.</p><p><strong>Methods: </strong>Retrospective analysis of ninety-eight consecutive patients examined using a new body weight-adapted protocol. Images were reconstructed using adaptive iterative dose reduction and advanced intelligent Clear-IQ engine with an already established (DL-1) and a newly implemented reconstruction algorithm (DL-2). Additional thirty patients were scanned without body-weight-adapted dose reduction (DL-1-SD). Three readers evaluated subjective image quality regarding image quality and assessment of several anatomic regions. For objective image quality, signal-to-noise ratio and contrast-to-noise ratio were calculated for temporalis and masseteric muscle and the floor of the mouth. Radiation dose was evaluated by comparing the computed tomography dose index (CTDIvol) values.</p><p><strong>Results: </strong>Deep learning-based reconstruction algorithms significantly improved subjective image quality (diagnostic acceptability: DL‑1 vs AIDR OR of 25.16 [6.30;38.85], p < 0.001 and DL‑2 vs AIDR 720.15 [410.14;> 999.99], p < 0.001). Although higher doses (DL-1-SD) resulted in significantly enhanced image quality, DL‑2 demonstrated significant superiority over all other techniques across all defined parameters (p < 0.001). Similar results were demonstrated for objective image quality, e.g. image noise (DL‑1 vs AIDR OR of 19.0 [11.56;31.24], p < 0.001 and DL‑2 vs AIDR > 999.9 [825.81;> 999.99], p < 0.001). Using weight-adapted kV reduction, very low radiation doses could be achieved (CTDIvol: 7.4 ± 4.2 mGy).</p><p><strong>Conclusion: </strong>AI-based reconstruction algorithms in ultra-high resolution head and neck imaging provide excellent image quality while achieving very low radiation exposure.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Isotropic FLAIR-T2* Fusion Imaging for Central Vein Sign Detection in Multiple Sclerosis: a Comparative Study at 1.5 T and 3 T.","authors":"Yunus Emre Senturk, Ahmet Peker, Hande Ozen Atalay, Ayse Altintas, Ali Yusuf Oner","doi":"10.1007/s00062-025-01531-6","DOIUrl":"https://doi.org/10.1007/s00062-025-01531-6","url":null,"abstract":"<p><strong>Purpose: </strong>The central vein sign (CVS) is a promising imaging biomarker for multiple sclerosis (MS) diagnosis. While isotropic T2* at 3 T and 7 T has demonstrated high diagnostic performance, its utility at 1.5 T remains unclear. This study evaluates the performance of unenhanced FLAIR-T2* fusion at 1.5 T compared to 3 T in MS participants.</p><p><strong>Methods: </strong>This prospective observational study included 20 MS patients and 20 control subjects. Each participant underwent unenhanced isotropic Epi-T2* and isotropic FLAIR (0.8 mm voxel size) at both 1.5 T and 3 T. Subsequently, the derived isotropic T2* and FLAIR were combined to create the final FLAIR-T2* fusion in both magnetic field strengths. Two independent raters assessed the CVS status of white matter (WM) lesions using NAIMS criteria. WM lesions were classified as CVS+ or CVS-, and two methods-select-n* and CVS+ proportion-were applied. Sensitivity and specificity were computed, and CVS performance was compared across WM lesion locations.</p><p><strong>Results: </strong>Among eligible WM lesions (MS: 258; controls: 255), the mean CVS+ lesion proportion per participant was 66.9 ± 15.4% for 1.5 T FLAIR-T2* and 77.0 ± 13.6% for 3 T FLAIR-T2* (p < 0.01). At a 40% threshold, 1.5 T FLAIR-T2* achieved 90% sensitivity and 95% specificity, while 3 T FLAIR-T2* achieved 100% sensitivity and 95% specificity. The Select-6* method resulted in only one MS patient being misclassified at both field strengths. 3 T FLAIR-T2* detected more CVS+ lesions in deep WM (87.5% vs. 57.1%, p = 0.05).</p><p><strong>Conclusion: </strong>1.5 T FLAIR-T2* fusion demonstrates high performance in CVS assessment, although slightly outperformed by 3 T FLAIR-T2*. The select-6* method may enhance 1.5 T performance, supporting its feasibility for CVS evaluation.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Large Language Models for Suggesting Nerve Involvement in Upper Limbs MRI Reports with Muscle Denervation Signs.","authors":"Teodoro Martín-Noguerol, Pilar López-Úbeda, Antonio Luna, Manuel Gómez-Río, Juan M Górriz","doi":"10.1007/s00062-025-01533-4","DOIUrl":"https://doi.org/10.1007/s00062-025-01533-4","url":null,"abstract":"<p><strong>Objectives: </strong>Determining the involvement of specific peripheral nerves (PNs) in the upper limb associated with signs of muscle denervation can be challenging. This study aims to develop, compare, and validate various large language models (LLMs) to automatically identify and establish potential relationships between denervated muscles and their corresponding PNs.</p><p><strong>Materials and methods: </strong>We collected 300 retrospective MRI reports in Spanish from upper limb examinations conducted between 2018 and 2024 that showed signs of muscle denervation. An expert radiologist manually annotated these reports based on the affected peripheral nerves (median, ulnar, radial, axillary, and suprascapular). BERT, DistilBERT, mBART, RoBERTa, and Medical-ELECTRA models were fine-tuned and evaluated on the reports. Additionally, an automatic voting system was implemented to consolidate predictions through majority voting.</p><p><strong>Results: </strong>The voting system achieved the highest F1 scores for the median, ulnar, and radial nerves, with scores of 0.88, 1.00, and 0.90, respectively. Medical-ELECTRA also performed well, achieving F1 scores above 0.82 for the axillary and suprascapular nerves. In contrast, mBART demonstrated lower performance, particularly with an F1 score of 0.38 for the median nerve.</p><p><strong>Conclusions: </strong>Our voting system generally outperforms the individually tested LLMs in determining the specific PN likely associated with muscle denervation patterns detected in upper limb MRI reports. This system can thereby assist radiologists by suggesting the implicated PN when generating their radiology reports.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Antegrade Flow in the Internal Carotid Artery During Carotid Artery Stenting with a 7F Optimo Balloon Guide Catheter Following Common Carotid Artery Occlusion.","authors":"Kei Harada, Kei Arakawa, Masahito Kajihara","doi":"10.1007/s00062-025-01525-4","DOIUrl":"https://doi.org/10.1007/s00062-025-01525-4","url":null,"abstract":"<p><strong>Background: </strong>Carotid artery stenting (CAS) using the 7F Optimo balloon guide catheter (BGC) allows for smooth navigation and facilitates proximal flow control. However, this method may allow antegrade flow in the internal carotid artery (ICA). This study aims to identify predictors of antegrade flow during CAS with the common carotid artery (CCA) occlusion.</p><p><strong>Methods: </strong>We retrospectively analyzed 102 lesions treated with CAS using the 7F Optimo BGC and distal filter protection. The ICA flow pattern was assessed via contrast injection during CCA occlusion.</p><p><strong>Results: </strong>Antegrade flow in the ICA was observed in 22 lesions (22%). Compared with lesions where ICA flow control (stagnation or reverse flow) was achieved, the external carotid artery (ECA) diameter was significantly larger (4.4 ± 0.7 mm vs. 3.6 ± 1.2 mm, p < 0.001), and the minimum lesion diameter was significantly larger (3.2 ± 1.2 mm vs. 2.1 ± 1.0 mm, p < 0.001). Multivariate analysis identified a minimum lesion diameter ≥ 2.1 mm (OR 4.8, 95% CI 1.44-16.1; p = 0.01) and an ECA diameter ≥ 4.2 mm (OR 3.2, 95% CI 1.08-9.09; p = 0.04) as independent predictors of antegrade flow. High-intensity spots in postoperative diffusion-weighted magnetic resonance imaging and the incidence of ischemic events were not significantly different between both groups.</p><p><strong>Conclusions: </strong>Lesions with a minimum lesion diameter ≥ 2.1 mm or an ECA diameter ≥ 4.2 mm may exhibit antegrade ICA flow with BGC regardless of CCA occlusion, suggesting that an additional distal filter may help reduce embolic risk.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradermal Advanced Glycation End-products Relate to Reduced Sciatic Nerve Structural Integrity in Type 2 Diabetes.","authors":"Christoph M Mooshage, Dimitrios Tsilingiris, Lukas Schimpfle, Thomas Fleming, Stephan Herzig, Julia Szendroedi, Sabine Heiland, Martin Bendszus, Stefan Kopf, Felix Kurz, Johann Jende, Zoltan Kender","doi":"10.1007/s00062-024-01493-1","DOIUrl":"10.1007/s00062-024-01493-1","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular risk management is beneficial, but stringent glycemic control does not prevent the progression of distal sensorimotor polyneuropathy (DSPN). Persistent hyperglycemia-induced alterations and cardiovascular factors may contribute to diabetes-associated nerve damage. This study aimed to evaluate the correlation between skin auto-fluorescence (sAF), an indicator of dermal advanced glycation end-product (AGE) accumulations, cardiovascular risk, and changes in peripheral nerve integrity.</p><p><strong>Methods: </strong>Sixty-two individuals with type 2 diabetes (T2D) (20 women and 42 men), including 29 diagnosed with DSPN (7 women and 22 men), and 10 healthy controls (HC) underwent diffusion tensor MR imaging of the sciatic nerve to assess fractional anisotropy (FA), an indicator of nerve structural integrity. sAF measurements were combined with clinical, serological, and electrophysiological evaluations. Arterial stiffness was assessed via pulse wave velocity (PWV).</p><p><strong>Results: </strong>sAF (HC 2.1 ± 0.25 AU, nDSPN 2.3 ± 0.47, DSPN 2.6 ± 0.43; p = 0.005) was higher in individuals with DSPN compared to HC (p = 0.010) and individuals without DSPN (p = 0.035). Within the group of T2D FA correlated negatively with sAF (r = -0.49, p < 0.001), PWV (r = -0.40, p = 0.009) and high-sensitivity troponin T (hsTNT), a marker of microvascular damage (r = -0.39, p < 0.001). In DSPN, sAF correlated positively with hsTNT (r = 0.58, p = 0.005) and with PWV (r = 0.52, p = 0.007), the sciatic nerve's FA correlated negatively with PWV (r = -0.47, p = 0.010).</p><p><strong>Conclusions: </strong>This study is the first to show close correlations between reduced peripheral nerve integrity and both intradermal AGE deposition and arterial stiffness in individuals with T2D. These findings highlight a mechanistic link between glycation-related vascular injury and neuronal damage emphasizing the importance of cardiovascular risk management in preventing DSPN.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"385-394"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}