Clinical Pediatrics最新文献_第5页

Eradication of Methicillin-Resistant Staphylococcus aureus in Cystic Fibrosis. 囊性纤维化中耐甲氧西林金黄色葡萄球菌的根除。

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 DOI: 10.1177/00099228251375413

Aynur Guliyeva, Cansu Yilmaz Yegit, Muruvvet Yanaz, Mine Kalyoncu, Merve Selçuk Balci, Seyda Karabulut, Gamze Tastan, Burcu Uzunoglu, Hüseyin Arslan, Hakan Yazan, Gülay Bas Bilgin, Ayse Ayzıt Kılınc Sakallı, Almala Pinar Ergenekon, Saniye Girit, Erkan Cakır, Yasemin Gokdemir, Ela Erdem Eralp, Fazilet Karakoc, Bulent Karadag

{"title":"Eradication of Methicillin-Resistant Staphylococcus aureus in Cystic Fibrosis.","authors":"Aynur Guliyeva, Cansu Yilmaz Yegit, Muruvvet Yanaz, Mine Kalyoncu, Merve Selçuk Balci, Seyda Karabulut, Gamze Tastan, Burcu Uzunoglu, Hüseyin Arslan, Hakan Yazan, Gülay Bas Bilgin, Ayse Ayzıt Kılınc Sakallı, Almala Pinar Ergenekon, Saniye Girit, Erkan Cakır, Yasemin Gokdemir, Ela Erdem Eralp, Fazilet Karakoc, Bulent Karadag","doi":"10.1177/00099228251375413","DOIUrl":"https://doi.org/10.1177/00099228251375413","url":null,"abstract":"Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) in cystic fibrosis (CF) impairs lung function and contributes to the progression of the disease. Optimal eradication regimens for new-onset MRSA infections in people with CF (pwCF) remain undefined.Materials and methods: This prospective, multicenter study evaluated a standardized, step-up MRSA eradication regimen in pwCF with new-onset MRSA infections between 2020 and 2022.Results: Ninety-one pwCF (52.7% male, median age: 9 years) were included. Our treatment regimen included oral rifampicin and co-trimoxazole or oral rifampicin and fusidic acid. Intravenous teicoplanin treatment was initiated in patients whose clinical condition was unstable. The eradication success rates after 1 year were 82.4%, 92.9%, and 55.6%, respectively. No significant changes in median FEV1% predicted or BMI z-scores were observed between MRSA-eradicated and non-eradicated groups at baseline or 12 months.Conclusion: A standardized step-up MRSA eradication protocol is effective for new-onset MRSA infections in pwCF. Randomized controlled trials are needed to confirm these findings.","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251375413"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Care Clinician Perspectives on Medication Prescribing for Child Mental Health Concerns. 初级保健临床医生对儿童心理健康问题药物处方的看法。

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2025-03-25 DOI: 10.1177/00099228251328142

Cody A Hostutler, Noelle Wolf, Katrice Stallworth, Rachel Herbst, Kathryn W Hoffses, Julie Pajek, David Curtis, Jennifer A Mautone, Andrew R Riley, Jeffrey D Shahidullah

{"title":"Primary Care Clinician Perspectives on Medication Prescribing for Child Mental Health Concerns.","authors":"Cody A Hostutler, Noelle Wolf, Katrice Stallworth, Rachel Herbst, Kathryn W Hoffses, Julie Pajek, David Curtis, Jennifer A Mautone, Andrew R Riley, Jeffrey D Shahidullah","doi":"10.1177/00099228251328142","DOIUrl":"10.1177/00099228251328142","url":null,"abstract":"This study describes the frequency and comfort of pediatric primary care clinicians (PCCs) as it relates to initiating, continuing, and stopping medications for attention-deficit/hyperactivity disorder (ADHD), anxiety/depression, and sleep problems across age groups (≤5 years, 6-12, and 13+). Primary care clinicians (N = 148) within an integrated primary care national research consortium participated in an anonymous online survey including questions examining practice settings, provider characteristics, prescribing frequency, and prescribing comfort. Results indicate that comfort and prescribing practices vary by patient age, practice setting, provider experience, and presenting diagnoses. Primary care clinicians generally felt more comfortable prescribing for school-age children and older and prescribing for ADHD-related concerns. Primary care clinicians appeared similarly comfortable starting, maintaining, and stopping medications. Rural PCCs reported greater comfort initiating and managing medication. Results highlight the need for ongoing training and support for PCCs in managing common childhood mental health conditions. Implications for establishing collaborative infrastructure support and team-based care are discussed.","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1264-1273"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and Safety of High-Dose Oral Phenobarbital in Children With Recurrent and Treatment-Refractory Seizures. 大剂量口服苯巴比妥治疗复发性和难治性癫痫患儿的有效性和安全性。

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2025-03-24 DOI: 10.1177/00099228251328136

Muhittin Bodur, Rabia Tutuncu Toker

{"title":"Effectiveness and Safety of High-Dose Oral Phenobarbital in Children With Recurrent and Treatment-Refractory Seizures.","authors":"Muhittin Bodur, Rabia Tutuncu Toker","doi":"10.1177/00099228251328136","DOIUrl":"10.1177/00099228251328136","url":null,"abstract":"In this study, we applied high-dose oral phenobarbital (PB) to children with recurrent and treatment-refractory seizures or recurrent status epilepticus and evaluated the effectiveness and safety of this treatment. We retrospectively reviewed patients' medical records who received oral high-dose PB treatment between January 2019 and July 2024. In this study, recurrent and treatment-refractory seizures was defined as the persistence of daily epileptic seizures or recurrent attacks of status epilepticus despite treatment with oral antiepileptic drugs or continuous intravenous midazolam therapy. High-dose oral PB therapy was performed on 11 patients (7 females and 4 males). The median age at the onset of epilepsy was 2 months (range: 0.06-132 months). The underlying disorders or comorbidity were genetic disorders (1q14 del, compound heterozygous for the PNKP gene, Wolf-Hirschhorn syndrome, ring chromosome 14 syndrome) in 4 patients, cerebral palsy in 2 patients, metabolic disorders (Zellweger syndrome, pyridoxine-dependent epilepsy) in 2 patients, traumatic brain injury and hypoxia, hemimegalencephaly, and ataxia and intellectual disability in 1 patient. The median age at initiation of high-dose PB therapy was 11 months (range: 2-203 months). The maximal dose of PB ranged from 6 to 14.7 mg/kg/d (median: 10 mg/kg/day). The maximal serum PB levels ranged from 33 to 56 µg/mL (median: 44 µg/mL). We evaluated the effectiveness of this treatment as follows: \"effective\" represented more than 50% seizure reduction, \"ineffective\" represented less than 50% seizure reduction, and \"exacerbation\" represented an increase in seizure frequency. In 7 of the 11 patients (63.6%), oral high-dose PB therapy was effective and was transiently effective in the other 4 patients. Adverse effects were noted in 6 patients (54.5%) during high-dose oral PB therapy: drowsiness in 5 patients and mild elevations in transaminases in 2 patients.","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1259-1263"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between US Pediatric Resident Burnout and the Learning Environment. 美国儿科住院医师职业倦怠与学习环境的关系

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2025-08-25 DOI: 10.1177/00099228251326652

E Rodriguez Lien, E Zwemer, A Schwartz, P M Wilson, J C Babal, J R Serwint, K Sieplinga, K Donnelly, M Nichols, M Batra

{"title":"Relationship Between US Pediatric Resident Burnout and the Learning Environment.","authors":"E Rodriguez Lien, E Zwemer, A Schwartz, P M Wilson, J C Babal, J R Serwint, K Sieplinga, K Donnelly, M Nichols, M Batra","doi":"10.1177/00099228251326652","DOIUrl":"https://doi.org/10.1177/00099228251326652","url":null,"abstract":"There is a paucity of literature evaluating the association between the pediatric residency learning environment (LE) and resident well-being. A cross-sectional study investigated the association between pediatric residents' LE satisfaction and their burnout, and whether LE subcomponents influenced LE satisfaction. A total of 2043 (69%) residents representing 46 pediatric programs responded, indicating that 40% of participants met the burnout classification. Residents not meeting burnout classification reported greater mean LE satisfaction (4.4 vs 3.6, P < .001), LE collaboration (4.4 vs 4.1, P < .001), resident mentorship (3.7 vs 3.1, P < .001), and resident education (4.1 vs 3.5, P < .001) than their colleagues with burnout. Residents reporting greater LE collaboration (B = 0.62, 95% confidence interval (CI) = 0.57-0.67, P < .001), greater resident mentorship (B = 0.51, 95% CI = 0.48-0.55, P < .001), and greater resident education (B = 0.72, 95% CI = 0.68-0.75, P < .001) had higher LE satisfaction, controlling for individual/program characteristics and clustering. This study demonstrates associations between LE satisfaction and burnout from a national group of pediatric residents.","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":"64 9","pages":"1227-1233"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thunderclap Headache and Seizure in a Teenage Boy. 少年的霹雳头痛和癫痫。

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2025-05-28 DOI: 10.1177/00099228251342962

Erin Warnick, Christine Zhang, Akilah Evans, Melissa Schafer

引用次数: 0

Is Insulin Resistance Present in Children With Subclinical Hypothyroidism? 亚临床甲状腺功能减退症患儿是否存在胰岛素抵抗？

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2025-04-12 DOI: 10.1177/00099228251333302

Amine Aktar Karakaya, Edip Unal, Aslı Beştaş, Ozan Kapçay

引用次数: 0

Corrigendum to "Virtual Schooling and Pediatric Mental Health During the COVID-19 Pandemic". COVID-19大流行期间的虚拟学校教育与儿童心理健康》的更正。

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2024-01-18 DOI: 10.1177/00099228241229511

引用次数: 0

Vessel Wall MRI for Pediatric Basal Ganglia Stroke After Mild Head Injury. 轻度颅脑损伤后儿童基底神经节卒中的血管壁MRI。

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 DOI: 10.1177/00099228251380443

Fei-Fei Yao

引用次数: 0

Severe Constipation in Adolescence: Don't Miss Depression. 青春期严重便秘：不要错过抑郁症。

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2025-05-25 DOI: 10.1177/00099228251340440

Asha Janardhan, Prasanna Kumar, Shalini G Hegde

引用次数: 0

Prevalence of Torque Teno Virus in Portuguese Children Younger Than 3 Years Old: A Single-Center Study. 葡萄牙3岁以下儿童中Torque Teno病毒的流行：一项单中心研究

IF 0.7 4区医学

Clinical Pediatrics Pub Date : 2025-10-01 Epub Date: 2025-05-09 DOI: 10.1177/00099228251339047

Maria-Jesus Chasqueira, Pedro Paixão, Carla Barreiros, Madalena Tuna, Mónica Marçal, Paulo Paixão

引用次数: 0