{"title":"Probiotics as Functional Dietary Interventions for Gut Health, Immune Modulation, and Overall Well-Being: A Systematic Review.","authors":"Smriti Mishra, Shikha Saxena","doi":"10.1177/00099228261480530","DOIUrl":"https://doi.org/10.1177/00099228261480530","url":null,"abstract":"<p><strong>Background: </strong>The pediatric gut microbiome influences immune maturation, neurodevelopment, and disease susceptibility. Probiotic supplementation has been investigated across multiple childhood conditions, yet strain-specific efficacy remains inconsistent.</p><p><strong>Objective: </strong>The objective of this review is to systematically evaluate strain-specific probiotic interventions in children and assess clinical efficacy, safety, and mechanistic pathways.</p><p><strong>Methodology: </strong>A systematic review was conducted following PRISMA 2020 guidelines. PubMed, Scopus, and Web of Science were searched for studies (2006-2024).</p><p><strong>Results: </strong>Strong evidence supports Lactobacillus rhamnosus GG and Saccharomyces boulardii for acute diarrhea. Mixed strains show moderate benefit in atopic dermatitis. Adjunct probiotic therapy improves Helicobacter pylori eradication rates. Evidence in asthma and autism spectrum disorder remains preliminary.</p><p><strong>Conclusion: </strong>Significant heterogeneity in strains, dosing, and study design limits generalizability. Probiotic efficacy in pediatrics is strain and condition-specific. Standardized RCTs and precision microbiome approaches are required.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261480530"},"PeriodicalIF":0.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lotte R Rappoldt, Carola de Wit, Marthe M van der Pol, Simone Slaghekke, Caroline Houben, Kees J Kan, André B Rietman, Damiaan Denys, Elisabeth M W J Utens, Nienke C C Vulink
{"title":"Clinical Characteristics of Children and Adolescents With Misophonia.","authors":"Lotte R Rappoldt, Carola de Wit, Marthe M van der Pol, Simone Slaghekke, Caroline Houben, Kees J Kan, André B Rietman, Damiaan Denys, Elisabeth M W J Utens, Nienke C C Vulink","doi":"10.1177/00099228261467192","DOIUrl":"https://doi.org/10.1177/00099228261467192","url":null,"abstract":"<p><p>Misophonia has a serious impact on children and families. Few studies have, however, assessed the specific phenomenology of misophonia in youth. We investigated clinical characteristics in a treatment-seeking sample of youth with misophonia (n = 95, 8-18 years), using validated instruments to assess misophonia phenomenology, psychiatric comorbidity, emotional/behavioral problems, attention problems, sensory processing, and quality of life. The most prevalent triggers were eating sounds and the most common responses irritation/anger and anticipation anxiety. Psychiatric comorbidity was present in 27.4% of cases (eg, anxiety disorders 10.5%; attention-deficit hyperactivity disorder 8.4%). Internalizing psychopathology was more prevalent than externalizing. Adolescents reported differences in auditory, tactile, visual, and taste/smell sensory processing compared with a norm group, as well as heightened sensory awareness and avoidance. Misophonia severity was inversely related to quality of life in children/parents. Future research should investigate the underlying mechanisms of misophonia in youth. Pre-registered: The Netherlands Trial Register (CCMO): NL-OMON20775, https://onderzoekmetmensen.nl/nl/trial/20775.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261467192"},"PeriodicalIF":0.8,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erin McLaughlin, Alexandra B Yonts, Anand Gourishankar
{"title":"Child Opportunity Index: Paradoxical Risk of Pediatric Long COVID Cases.","authors":"Erin McLaughlin, Alexandra B Yonts, Anand Gourishankar","doi":"10.1177/00099228261487907","DOIUrl":"https://doi.org/10.1177/00099228261487907","url":null,"abstract":"<p><p>Pediatric long COVID is a chronic, multisystem condition with potential physical, cognitive, and psychosocial effects. Although children in under-resourced communities experienced a disproportionate COVID-19 burden, access to post-COVID specialty care may be uneven. We conducted a retrospective cross-sectional study of 194 pediatric long COVID patients from Washington, DC, Maryland, and Virginia, who presented to a multidisciplinary tertiary care clinic between May 2021 and January 2024. Patients had a mean age of 12.8 years; 57% were female and 63% were non-Hispanic white. Most patients lived in very high-opportunity areas, while few lived in low-opportunity areas. Spatial hotspots were identified in urban and suburban census tracts, including parts of Maryland, Virginia, and Washington, DC; cold spots were identified in rural and exurban areas. These findings suggest that clinic-based pediatric long COVID presentation may reflect access to specialty evaluation as well as underlying disease burden. Broader screening and community-based approaches may help identify unmet need in under-resourced communities.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261487907"},"PeriodicalIF":0.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andre Brissett, Abigail F Nixon, Tanner W Mercer, Haamid Chamdawala, James A Meltzer
{"title":"Oropharyngeal Gonorrhea and Chlamydia Testing in the Pediatric Emergency Department.","authors":"Andre Brissett, Abigail F Nixon, Tanner W Mercer, Haamid Chamdawala, James A Meltzer","doi":"10.1177/00099228261484453","DOIUrl":"https://doi.org/10.1177/00099228261484453","url":null,"abstract":"<p><p>Gonorrhea and chlamydia (GCCT) are among the most commonly reported sexually transmitted infections (STIs), particularly in adolescents. Screening guidelines recommend only urogenital testing for most patients. With changing trends in sexual practice, we sought to determine whether the addition of oropharyngeal GCCT testing would improve STI detection in our Pediatric Emergency Department (PED). In December 2021, our PED began incorporating routine oropharyngeal testing for all patients undergoing urogenital GCCT testing. This retrospective study of patients ages 13 to 21 years examined patients who underwent both urogenital and oropharyngeal testing from February 2022 to January 2025. McNemar's chi-square test was used to determine percentage differences of combined oropharyngeal and urogenital GCCT testing versus urogenital testing alone. In total, 218 adolescents underwent both urogenital and oropharyngeal testing. The median age was 19 years (interquartile range = 18, 20), and 152 (70%) were female. Ten patients had an oropharyngeal test positive for GCCT but a negative urogenital test. With both urogenital and oropharyngeal testing, there was a significant increase in the overall GCCT positivity rate compared with urogenital testing alone (58 [27%] vs 48 [22%], <i>P</i> = 0.002). By expanding STI testing to include universal oropharyngeal testing, we identified several adolescents with GCCT who might have been missed by standard urogenital screening.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261484453"},"PeriodicalIF":0.8,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamie Crandell, Jinhee Park, Suzanne Thoyre, Hayley Estrem
{"title":"Letter in Response to \"Interpretive Considerations for Continuous Percentile Scores in Pediatric Feeding Assessment\".","authors":"Jamie Crandell, Jinhee Park, Suzanne Thoyre, Hayley Estrem","doi":"10.1177/00099228261484808","DOIUrl":"https://doi.org/10.1177/00099228261484808","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261484808"},"PeriodicalIF":0.8,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Triaging Benign Paroxysmal Movements in Infants and Young Children.","authors":"Matthew Chase Lustig","doi":"10.1177/00099228261481708","DOIUrl":"https://doi.org/10.1177/00099228261481708","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261481708"},"PeriodicalIF":0.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Telehealth in Pediatrics: A Quick Review.","authors":"Tanya Tandon","doi":"10.1177/00099228261479615","DOIUrl":"https://doi.org/10.1177/00099228261479615","url":null,"abstract":"<p><p>Telehealth has become a cornerstone of modern pediatric care, offering continuity, access and efficiency across a wide range of clinical settings. Initially a supplementary model, its rapid expansion during the COVID-19 pandemic accelerated innovation in virtual care delivery. Post-pandemic, pediatric telehealth remains a vital tool for improving access to behavioral health, chronic disease management and preventive care, particularly in underserved communities. However, variability in policy, equity gaps and reimbursement barriers continue to challenge sustainability. This review summarizes policy, lessons learned, best practices and strategic directions for telehealth integration in pediatric practice, integrating artificial intelligence and advocating for systemic policy reform to sustain long-term use and address social determinants of health.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261479615"},"PeriodicalIF":0.8,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heather B Howell, Jonathan Lebowitz, Jeffrey Wilhite, Chanelle Coble-Sadaphal, Meaghan McGrath, Rachel Ramsey, Lisa Altshuler, Sondra Zabar, Purnahamsi V Desai
{"title":"The Doctor Will Zoom You Now: An Experiential Telemedicine Assessment for Pediatric Residents.","authors":"Heather B Howell, Jonathan Lebowitz, Jeffrey Wilhite, Chanelle Coble-Sadaphal, Meaghan McGrath, Rachel Ramsey, Lisa Altshuler, Sondra Zabar, Purnahamsi V Desai","doi":"10.1177/00099228261465379","DOIUrl":"https://doi.org/10.1177/00099228261465379","url":null,"abstract":"<p><p>There has been increased use of telemedicine in clinical practice, but telemedicine curricula are not standard in pediatric residency training. We developed a 2-case, Virtual Objective Structured Clinical Exam (VOSCE) for pediatric residents with telemedicine learning objectives. Resident competency was assessed using a behaviorally anchored checklist, and residents completed a pre/post self-assessment. Less than half of the residents met mastery for the following behaviors: confirmation of patient identifiers, optimization of technical aspects and partnering with the patient to perform a physical exam. Resident self-assessment improved after participating in the VOSCE but remained low in key domains such as virtual physical exam and mental health issue identification and guidance. Most pediatric residents have not mastered all the skills needed for a successful telemedicine encounter. Incorporating a curriculum focused on telemedicine best practices into residency training is highly merited.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228261465379"},"PeriodicalIF":0.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}