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Resistance to Epoetin-Stimulating Agents in Children Receiving Renal Replacement Therapy. 接受肾脏替代治疗的儿童对催卵素刺激药物的耐药性。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-12-17 DOI: 10.1177/00099228241299893
Mehtap Kaya, Neslihan Cicek, Sercin Guven, Harika Alpay, Ibrahim Gokce
{"title":"Resistance to Epoetin-Stimulating Agents in Children Receiving Renal Replacement Therapy.","authors":"Mehtap Kaya, Neslihan Cicek, Sercin Guven, Harika Alpay, Ibrahim Gokce","doi":"10.1177/00099228241299893","DOIUrl":"10.1177/00099228241299893","url":null,"abstract":"<p><p>The incidence of anemia increases with the stage of chronic kidney disease (CKD). Erythropoietin (EPO) deficiency is a common cause of anemia in CKD. Erythropoietin-stimulating agents (ESAs) are the mainstay of the treatment. Treatment can be challenging due to erythropoietin resistance (ER), which can be assessed using the erythropoietin resistance index (ERI). Our aim was to investigate the factors contributing to high ERI levels in children receiving renal replacement therapy (RRT). Thirty-three children receiving RRT for at least 3 months were included. The mean ERI value was 15.7 IU/kg/w/g/dL. A significant association was observed between serum phosphorus levels and ERI (<i>P</i> = .016, <i>r</i> = 0.41). The mean parathormone (PTH) level was also higher in the high ERI group (599 ± 351 vs 392 ± 320 pg/mL, <i>P</i> = .088). An association, approaching statistical significance, was found between ERI and hypertension (<i>P</i> = .06, <i>r</i> = 0.32). Our study indicated a potential relationship between hyperphosphatemia, possibly secondary hyperparathyroidism, and ERI in children undergoing RRT.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"816-823"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Associated With Repeat Pediatric Influenza Vaccination Among Inconsistent Vaccinators. 不坚持接种者重复接种小儿流感疫苗的相关因素。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-10-18 DOI: 10.1177/00099228241286970
Claire Abraham, Melissa B Gilkey, Kathleen E Walsh, Madison R Hickingbotham, Alison A Galbraith
{"title":"Factors Associated With Repeat Pediatric Influenza Vaccination Among Inconsistent Vaccinators.","authors":"Claire Abraham, Melissa B Gilkey, Kathleen E Walsh, Madison R Hickingbotham, Alison A Galbraith","doi":"10.1177/00099228241286970","DOIUrl":"10.1177/00099228241286970","url":null,"abstract":"<p><p>Promoting consistent vaccination practices may help improve suboptimal influenza vaccination rates. This study evaluated the prevalence and correlates of repeat influenza (flu) vaccination among children who had previously received the vaccine inconsistently. An online survey study was conducted in 2022 among parents of commercially insured children ages 3 to 19 years who were previously inconsistently vaccinated. Of 317 respondents, 85% reported that their child received a flu vaccine in the 2021 to 2022 flu season. Among these parents, 61% reported concern that their child would get sick from flu as the most important reason for vaccinating. Repeat vaccination was less likely among parents who reported that school/daycare requirements were a reason for vaccinating in the prior season (odd ratio [OR] = 0.17, 95% confidence interval [CI] = 0.05-0.55). Our findings suggest that school policies may improve vaccination rates among inconsistent vaccinators.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"681-694"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycopyrrolate Premedication and Procedure-Related Events in Pediatric Upper Endoscopy. 小儿上内窥镜检查中的甘草酸苷预处理和手术相关事件。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-10-10 DOI: 10.1177/00099228241288145
Dmitry Tumin, Daniel A Ladin, Matthew Ledoux
{"title":"Glycopyrrolate Premedication and Procedure-Related Events in Pediatric Upper Endoscopy.","authors":"Dmitry Tumin, Daniel A Ladin, Matthew Ledoux","doi":"10.1177/00099228241288145","DOIUrl":"10.1177/00099228241288145","url":null,"abstract":"<p><p>Glycopyrrolate premedication is used for pediatric upper endoscopy procedures, with limited clinical evidence for efficacy. We investigated whether glycopyrrolate use is associated with lower incidence of procedure-related events and serious adverse events (SAEs) using the Pediatric Sedation Research Consortium registry. Pediatric upper endoscopy procedures performed between April 27, 2020 and February 3, 2022 were included (<i>N</i> = 1046). The primary outcome was the incidence of any procedure-related events during induction, maintenance, or recovery, and the secondary outcome was incidence of SAEs. The event rate was 15%, including 30 SAEs (3%). On multivariable analysis, glycopyrrolate was not associated with the overall event rate (odds ratio [OR]: 1.08; 95% confidence interval [CI]: 0.72, 1.61), but was associated with lower odds of SAEs (OR: 0.34; 95% CI: 0.13, 0.91). Although glycopyrrolate was associated with lower odds of SAEs after accounting for patient and procedure characteristics, validation through prospective trials is needed to support its routine use in clinical practice.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"703-711"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 1.3-Year-Old Toddler Who Refused to Walk. 拒绝走路的 1.3 岁幼儿。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-10-13 DOI: 10.1177/00099228241288982
Efrat Ben Nun Yaari, Amit Ziv, Eugene Kotz, Yosef Uziel, Ruby Haviv
{"title":"A 1.3-Year-Old Toddler Who Refused to Walk.","authors":"Efrat Ben Nun Yaari, Amit Ziv, Eugene Kotz, Yosef Uziel, Ruby Haviv","doi":"10.1177/00099228241288982","DOIUrl":"10.1177/00099228241288982","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"736-738"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal Seizures and White Matter Injury in a Newborn. 新生儿癫痫发作和白质损伤。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-09-29 DOI: 10.1177/00099228241285539
Carlotta Rubino, Tatiana Boetti, Tiziana Borro, Aba Tocchet, Giovanni Morana, Maria Francesca Campagnoli
{"title":"Neonatal Seizures and White Matter Injury in a Newborn.","authors":"Carlotta Rubino, Tatiana Boetti, Tiziana Borro, Aba Tocchet, Giovanni Morana, Maria Francesca Campagnoli","doi":"10.1177/00099228241285539","DOIUrl":"10.1177/00099228241285539","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"742-746"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pacifiers and Teething Devices: A Risk for Craniofacial Injury in Children Under 2 Years Old. 奶嘴和出牙器：两岁以下儿童颅面损伤的风险。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-10-13 DOI: 10.1177/00099228241288738
Alyssa D Reese, Alaina Kenny, Victoria Miller, Meghan Long, Hannah M Smith, Sara Neimanis, Clinton Morrison
{"title":"Pacifiers and Teething Devices: A Risk for Craniofacial Injury in Children Under 2 Years Old.","authors":"Alyssa D Reese, Alaina Kenny, Victoria Miller, Meghan Long, Hannah M Smith, Sara Neimanis, Clinton Morrison","doi":"10.1177/00099228241288738","DOIUrl":"10.1177/00099228241288738","url":null,"abstract":"<p><p>Pacifiers and teething devices are commonly introduced during infancy to soothe and comfort. This study aimed to investigate the incidence of emergency room visits for pediatric craniofacial injuries associated with pacifiers and teething devices. All craniofacial injuries due to \"Pacifiers or Teething Rings\" in children less than 2 years old were retrieved from the National Electronic Injury Surveillance System (NEISS). Age, sex, race, context of injury, cause of injury, and patient disposition were collected. Query revealed an estimated nationwide incidence of 5424 injuries from the years 2012 to 2021, with a mean age of 12.1 months at the time of injury. Most injuries occurred at home (70.2%), often resulting from falls while using the pacifier/teething device (71.0%). An estimated 97.6% of patients were released after emergency room treatment. Education regarding abstaining from pacifier and teething device use during activity may reduce the incidence of these injuries.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"675-680"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Directed Content Analysis of Discussions Between Mothers and Pediatricians Around Feeding and Growth Topics During Infant Well-Child Visits. 对母亲和儿科医生在婴儿健康访视期间围绕喂养和成长话题进行讨论的定向内容分析。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-10-10 DOI: 10.1177/00099228241287629
Meghan C Savidge, Melanie K Bean, Laura J Caccavale, Romesh Wijesooriya, Elizabeth L Adams
{"title":"A Directed Content Analysis of Discussions Between Mothers and Pediatricians Around Feeding and Growth Topics During Infant Well-Child Visits.","authors":"Meghan C Savidge, Melanie K Bean, Laura J Caccavale, Romesh Wijesooriya, Elizabeth L Adams","doi":"10.1177/00099228241287629","DOIUrl":"10.1177/00099228241287629","url":null,"abstract":"<p><p>This study identified specific feeding and growth topics discussed during 2-, 4-, and 6-month well-child visits. Conversations between mothers (N = 20) and pediatricians (N = 5) during visits were audio-recorded. Conversation segments were classified as pediatrician-initiated guidance, mother-initiated questions/concerns, or updates using directed content analysis. Pediatricians and mothers completed surveys on perceptions of guidance delivered. Feeding clusters included introducing solids/drinks, breast milk/formula amount and timing, feeding in specific situations; and breast milk/formula preparation. Growth clusters included appropriate growth and growth tracking. There was considerable variability in specific topics discussed between and within families across visits. Mothers desired additional guidance around introducing solids (42.1%) and allergen foods (31.6%). Pediatricians (80%) felt the amount of guidance to deliver in a standard visit was too much, and additional guidance outside of visits would benefit caregivers. Future research should investigate strategies to further support families by offering additional guidance during or outside of well-child visits.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"665-674"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embracing Difference in Intersex Variations. 拥抱双性变异中的差异。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-11-25 DOI: 10.1177/00099228241299909
Camilia Kamoun, Katharine B Dalke
{"title":"Embracing Difference in Intersex Variations.","authors":"Camilia Kamoun, Katharine B Dalke","doi":"10.1177/00099228241299909","DOIUrl":"10.1177/00099228241299909","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"753-760"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Acupuncture for Tourette Syndrome in Children: A Meta-Analysis and Systematic Review. 针灸治疗儿童抽动症的有效性和安全性：荟萃分析与系统综述》。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-09-30 DOI: 10.1177/00099228241283279
Siran Lai, Hongjun Wan, Fuyuan Deng, Yue Li, Yue An, Junsheng Peng, Xiang-Na Yang
{"title":"Efficacy and Safety of Acupuncture for Tourette Syndrome in Children: A Meta-Analysis and Systematic Review.","authors":"Siran Lai, Hongjun Wan, Fuyuan Deng, Yue Li, Yue An, Junsheng Peng, Xiang-Na Yang","doi":"10.1177/00099228241283279","DOIUrl":"10.1177/00099228241283279","url":null,"abstract":"<p><p>Despite the widespread use of acupuncture, its effectiveness and safety in treating Tourette syndrome (TS) remain controversial. Our research seeks to further evaluate the safety and effectiveness of acupuncture as a replacement therapy approach for children with TS. We conducted a comprehensive search for studies published from their inception to October 2023. The statistical analysis and subgroup analysis were conducted by software. Conduct a meta-analysis on the extracted data using the appropriate effect models. The meta-analysis was conducted on 26 studies consisting 1862 pediatric patients, which were selected from 976 identified articles. Acupuncture group demonstrated a significantly lower risk with a risk ratio (RR) of 0.29 (95% confidence interval [CI] = 0.19, 0.44, <i>P</i> < .0001), with only 5% of participants experiencing adverse reactions. Acupuncture treatment resulted in an 18% improvement in total effectiveness rates (RR = 1.18, 95% CI = [1.12, 1.25], <i>P</i> < .00001). The pooled data demonstrated that acupuncture therapy had a significant advantage in reducing the total score with the weighted mean difference (WMD) -4.92 (95% CI = [-6.38, -3.45], <i>P</i> < .00001) of the Yale Global Tic Severity Scale (YGTSS), the motor tic scores (WMD = -2.24, 95% CI = [-3.14, -1.35], <i>P</i> < .00001), the vocal tic scores (WMD: -2.34, 95% CI = [-3.31, -1.37], <i>P</i> < .00001), and the Traditional Chinese Medicine Syndrome Scores (TCMSS) (WMD: -2.47, 95% CI = [-2.87, -2.07], <i>P</i> < .0001). This meta-analysis reveals that acupuncture is more effective than most existing treatments in mitigating the symptoms of motor and vocal tics in children with TS, while also reducing the incidence of adverse reactions.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"719-735"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three Therapy Regimens and Their Cost-effectiveness for Girls With Central Precocious Puberty: A Real-World Clinical Study. 针对中枢性性早熟女孩的三种治疗方案及其成本效益：一项真实世界的临床研究。
IF 1 4区 医学
Clinical Pediatrics Pub Date : 2025-06-01 Epub Date: 2024-10-19 DOI: 10.1177/00099228241288977
Hua-Hong Wu, Ya-Qin Zhang, Hui Li
{"title":"Three Therapy Regimens and Their Cost-effectiveness for Girls With Central Precocious Puberty: A Real-World Clinical Study.","authors":"Hua-Hong Wu, Ya-Qin Zhang, Hui Li","doi":"10.1177/00099228241288977","DOIUrl":"10.1177/00099228241288977","url":null,"abstract":"<p><p>The objective of this study was to evaluate the effectiveness and cost-effectiveness of different therapy regimens for girls with central precocious puberty (CPP). This study retrospectively analyzed CPP girls from 2013 to 2021 and grouped them into GnRHa, Mixed, and GnRHa+GH based on therapy regimen. While comparing the differences among these groups, initial age and bone age of GnRHa group girls were significantly lower than Mixed and GnRHa+GH groups, but their growth level was significantly higher (<i>P</i> < .05). In the Mixed group, starting with GnRHa alone, the predicted adult height improvement (ΔPAH) decreased to -1.0 cm in the second year, prompting addition of growth hormone (GH) therapy in the third year, resulting in a ΔPAH increase to 3.0 cm. At therapy completion, final predicted adult heights (PAHs) were similar among the groups at 155.6 to 156.7 cm, with ΔPAH between 5.8 and 6.5 cm and no significant intergroup differences (<i>P</i> > .05). Younger CPP girls with greater height can begin therapy with GnRHa alone. Consideration of combining GH therapy depends on growth velocity and PAH during treatment.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"712-718"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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