亚临床甲状腺功能减退症患儿是否存在胰岛素抵抗？

IF 1 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2025-04-12 DOI:10.1177/00099228251333302

Amine Aktar Karakaya, Edip Unal, Aslı Beştaş, Ozan Kapçay

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引用次数: 0

摘要

文献报道亚临床甲状腺功能减退症（SH）对儿童胰岛素抵抗和糖代谢的影响的研究数量有限。本研究比较了50名SH患者和50名健康受试者的胰岛素、葡萄糖和体内稳态模型评估（HOMA-IR）值。然而，两组之间没有发现显著差异。此外，在SH患者中，TSH和fT4水平与血糖、胰岛素和HOMA-IR值之间没有明显的相关性。我们的研究表明，SH不会导致胰岛素抵抗。SH患者的体重增加可能高于正常水平。需要对SH的长期代谢和心血管影响进行更全面的研究。

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Is Insulin Resistance Present in Children With Subclinical Hypothyroidism?

There are limited number of studies in the literature reporting the effect of subclinical hypothyroidism (SH) on insulin resistance and glucose metabolism in children. This study compared insulin, glucose and Homeostasis Model Assessment (HOMA-IR) values in 50 patients with SH and 50 healthy subjects. However, no significant difference was found between the groups. In addition, no significant correlation was observed between the TSH and fT4 levels and blood glucose, insulin and HOMA-IR values in patients with SH. Our study showed that SH does not lead to insulin resistance. Weight gain may be higher than normal in patients with SH. More comprehensive studies are needed for the long-term metabolic and cardiovascular effects of SH.

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.