{"title":"Taste Issues of Amino Acid-Based and Rice-Based Formulas in Cow's Milk Allergy.","authors":"Sait Karaman","doi":"10.1177/00099228251380449","DOIUrl":"https://doi.org/10.1177/00099228251380449","url":null,"abstract":"<p><p>In managing infants with cow's milk protein allergy (CMPA), amino acid-based or rice-based formulas are commonly prescribed when dairy products are eliminated. However, poor taste frequently leads to formula refusal. This retrospective cross-sectional study aimed to assess the palatability and acceptability of such formulas in infants with CMPA. The primary outcome measure was the proportion of infants accepting the prescribed formula within the first 7 days of initiation. A total of 102 patients from the Pediatric Allergy and Immunology Clinic of Manisa City Hospital were included. Infants diagnosed with immunoglobulin E (IgE)-mediated or non-IgE-mediated CMPA (excluding other allergic diseases) were given a milk-free diet supported by formulas like Neocate Numil, Aptamil Pregomin-Numil, Alfamino-Nestlé, or rice-based Evolvia RP-Montero. Overall, 43.1% (44/102) had IgE-mediated and 56.9% (58/102) had non-IgE-mediated allergies. Among first-time formula users, 47.1% (48/102) (95% confidence interval [CI]: 37.1-57.2) accepted the formula, increasing to 50% (51/102) (95% CI: 39.9-60.1) after switching. No significant differences in formula acceptance were observed based on gender, age, allergy type, or breastfeeding status. Taste remains a major barrier, as roughly half of infants reject these formulas regardless of demographic or clinical factors.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251380449"},"PeriodicalIF":0.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibrahim Sandokji, Mohammad Shalaby, Hasan Aljefri, Layla Basheer, Khalid Alwadie, Jameela Kari
{"title":"Nationwide Insights Into Genetic Testing Awareness, Availability, Utilization Challenges in Children With Chronic Kidney Diseases.","authors":"Ibrahim Sandokji, Mohammad Shalaby, Hasan Aljefri, Layla Basheer, Khalid Alwadie, Jameela Kari","doi":"10.1177/00099228251372712","DOIUrl":"https://doi.org/10.1177/00099228251372712","url":null,"abstract":"<p><strong>Background: </strong>Genetic testing identifies underlying causative mutations in many children with kidney diseases. However, several factors prevent the widespread implementation of this useful tool in clinical practice. We aim to evaluate the perception and current state of genetic testing utilization among pediatric nephrologists.</p><p><strong>Methods: </strong>This study involved a nationwide survey including questions about the availability of genetic testing, perceptions, modalities, indications, and barriers to routine utilization in clinical practice.</p><p><strong>Results: </strong>Forty pediatric nephrologists completed the survey. Over 60% of respondents reported that genetic testing services were available at their institutions and over 70% reported that whole exome sequencing was the most frequent genetic testing modality. Barriers to genetic testing were mostly financial or due to a lack of awareness among providers. Glomerulopathies, tubulopathies, and ciliopathies were the most common reasons for sending genetic samples.</p><p><strong>Conclusion: </strong>Despite the availability at most centers, pediatric nephrologists face difficulties in interpreting genetic test results.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"99228251372712"},"PeriodicalIF":0.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-10-01Epub Date: 2025-04-18DOI: 10.1177/00099228251333221
Itai Gross, Idit Rabello, Eldad Erez, Amit Hess, Lea Ohana Sarna Cahan, Naama Pines, Uri Pollak, Saar Hashavya
{"title":"Etiologies, Clinical Courses and Outcomes of Pediatric Cardiothoracic Surgery: A Retrospective Analysis of Postsurgery Presentations at the PED.","authors":"Itai Gross, Idit Rabello, Eldad Erez, Amit Hess, Lea Ohana Sarna Cahan, Naama Pines, Uri Pollak, Saar Hashavya","doi":"10.1177/00099228251333221","DOIUrl":"10.1177/00099228251333221","url":null,"abstract":"<p><p>Congenital heart defects, the most common of all birth defects, often necessitate complex postoperative care due to the risk of severe complications. This retrospective cohort study evaluated the clinical presentations, outcomes, and complications in the records of 730 children who underwent 877 cardiothoracic surgeries at Hadassah Medical Center, Jerusalem, from 2011 to 2018. During the first postoperative year, 295 of these patients (40.4%) presented to the Pediatric Emergency Department. Single ventricle defects were associated with higher presentation rates than biventricular repairs (69.3% vs 53.7%, <i>P</i> < .001). Serious bacterial infections were found in 5% of the cases. The overall admission rate was 34%, with a Pediatric Intensive Care Unit admission rate of 1.45%. Complications such as chylothorax and pleural effusion were primarily found in Glenn and Fontan procedures, respectively. The study underscores the complex needs and major health care challenges faced by postsurgical pediatric patients, and emphasizes the importance of informed and prompt management.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1281-1288"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-10-01Epub Date: 2025-04-12DOI: 10.1177/00099228251330121
Francisco José García Díaz, María Moreno Ortega, Marcos Medina Bethencourt, María Esther Quintana Gallego, Laura Carrasco Hernández, Carmen Delgado Pecellín, Isabel Delgado Pecellín
{"title":"Real-Life in Cystic Fibrosis Pediatric Patients Treated With Kaftrio: A Descriptive Observational Study.","authors":"Francisco José García Díaz, María Moreno Ortega, Marcos Medina Bethencourt, María Esther Quintana Gallego, Laura Carrasco Hernández, Carmen Delgado Pecellín, Isabel Delgado Pecellín","doi":"10.1177/00099228251330121","DOIUrl":"10.1177/00099228251330121","url":null,"abstract":"<p><p>In 2020, Kaftrio, a combination of Elexacaftor, Tezacaftor, and Ivacaftor, gained approval for treating cystic fibrosis (CF) in patients from the age of 12 years. This study aims to analyze 1 year of treatment with Kaftrio in pediatric patients, comparing their clinical characteristics with pre-treatment data. This is an observational, descriptive, and longitudinal study in patients with CF older than 12 years with at least 1 F508del mutation treated with Kaftrio for 1 year. Forced expiratory volume in 1 second (FEV1) z-score increased by +1.1 (95% confidence interval [CI] = 0.55 to 1.64), forced vital capacity (FVC) by +0.56 (95% CI = 0.10 to 1.04), and maximal mid-expiratory flow (MMEF) 25/75 improved by +1.53 (95% CI = 0.59 to 2.47). In addition, a reduction of 25.50 points (95% CI = -37.95 to -13.06) in sweat chloride levels was observed. Body mass index (BMI)-for-age z-score (WHO 2006/2007) increased +0.39 (95% CI = 0.02 to 0.77). A transient increase in cough and secretions was noted in 61.53% after starting treatment. Kaftrio improves lung function and BMI and also reduces respiratory exacerbations and sweat chloride levels.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1289-1295"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-10-01Epub Date: 2025-05-25DOI: 10.1177/00099228251343949
Kirsten Simonton, Vikash Patel, Emily A Eismann, Sarat Thikkurissy, Sarah J Beal, Mary V Greiner
{"title":"Oral Health of Children in Foster Care.","authors":"Kirsten Simonton, Vikash Patel, Emily A Eismann, Sarat Thikkurissy, Sarah J Beal, Mary V Greiner","doi":"10.1177/00099228251343949","DOIUrl":"10.1177/00099228251343949","url":null,"abstract":"<p><p>The objective of this study was to evaluate the prevalence of dental disease among children in protective custody (eg, foster care) and associations with foster placement characteristics. We analyzed data from 778 patients ≥12 months of age who received oral health examinations by a pediatrician at a foster care clinic in a large urban setting, including 37 who were additionally examined by a dental resident. Examination findings were classified as routine, in need of urgent referral, or in need of emergent referral. Overall, 53% of children in protective custody had at least 1 abnormal dental finding, most commonly restorations (24%) and caries (22%). Twenty-four percent of patients required an urgent dental referral, of which 92% were due to dental caries. Variables associated with receiving an urgent dental referral included younger age, shorter time in protective custody, and being in a placement other than a group home.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1234-1243"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-10-01Epub Date: 2025-05-04DOI: 10.1177/00099228251335851
Ramey Moore, Rachel S Purvis, Don E Willis, Ji Li, Sara Sorrell, Simon Craddock Lee, Erin P Finley, Kevin Sexton, Shashank Kraleti, C'Asia James, Pearl A McElfish
{"title":"A Qualitative Study of Social Processes, HPV Vaccine Attitudes, and Vaccination Behavior Among Hesitant Adopter Parents.","authors":"Ramey Moore, Rachel S Purvis, Don E Willis, Ji Li, Sara Sorrell, Simon Craddock Lee, Erin P Finley, Kevin Sexton, Shashank Kraleti, C'Asia James, Pearl A McElfish","doi":"10.1177/00099228251335851","DOIUrl":"10.1177/00099228251335851","url":null,"abstract":"<p><p>Despite the availability of a highly effective human papillomavirus (HPV) vaccine, uptake remains below Healthy People 2030 targets, particularly in rural areas where HPV-related cancers are more prevalent. This study aimed to explore how social processes influence parents' HPV vaccination decisions, focusing on vaccine-hesitant parents who vaccinated their child(ren) against HPV despite their hesitancy, eg, \"hesitant adopters.\" We conducted a qualitative exploratory analysis of in-depth interviews with hesitant adopter parents (n = 8) to explore how social interactions with trusted interlocutors influenced their decision-making. Hesitant adopter parents identified relevant professional expertise, direct experience with the HPV vaccine, and social proximity to interlocutors as influential factors. We argue that rather than a single moment or decision, vaccination decision-making is a dynamic, ongoing process affected by social processes. This study adds nuance to our understanding of how prior vaccination behavior functions in future vaccine acceptance.</p>","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1388-1399"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-10-01Epub Date: 2025-04-21DOI: 10.1177/00099228251337932
{"title":"Expression of concern: Neonatal Eating Assessment Tool-Bottle-Feeding: Norm-Reference Values for Infants Less Than 7 Months Old.","authors":"","doi":"10.1177/00099228251337932","DOIUrl":"10.1177/00099228251337932","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1492"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-10-01Epub Date: 2025-05-17DOI: 10.1177/00099228251339983
Yamenah Ambreen, Maxwell Gruber, Jennifer J Tscholl, Ann Kebede, Shilpa Hari, Eric A Sribnick
{"title":"Vitamin K Deficiency Bleeding Intracranially Resulting in Shunt-Dependent Hydrocephalus.","authors":"Yamenah Ambreen, Maxwell Gruber, Jennifer J Tscholl, Ann Kebede, Shilpa Hari, Eric A Sribnick","doi":"10.1177/00099228251339983","DOIUrl":"10.1177/00099228251339983","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1475-1478"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical PediatricsPub Date : 2025-10-01Epub Date: 2024-11-25DOI: 10.1177/00099228241301908
{"title":"Corrigendum to \"Point-of-Care Ultrasound for the General Pediatric Resident: A Needs Assessment\".","authors":"","doi":"10.1177/00099228241301908","DOIUrl":"10.1177/00099228241301908","url":null,"abstract":"","PeriodicalId":10363,"journal":{"name":"Clinical Pediatrics","volume":" ","pages":"1345"},"PeriodicalIF":0.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}