Menekse Ozcelik , Fatih Kurt ∗ , Süheyla Karadağ Erkoç , Hakan Yilmaz , Derya Gokmen , Cihangir Akyol , Mehmet Ali Koç , Sevda Ünver , Neslihan Alkis
{"title":"The effect of three different analgesia techniques on pain scores in patients undergoing colorectal surgery with an Enhanced Recovery After Surgery (ERAS) protocol","authors":"Menekse Ozcelik , Fatih Kurt ∗ , Süheyla Karadağ Erkoç , Hakan Yilmaz , Derya Gokmen , Cihangir Akyol , Mehmet Ali Koç , Sevda Ünver , Neslihan Alkis","doi":"10.1016/j.clnesp.2024.10.025","DOIUrl":"10.1016/j.clnesp.2024.10.025","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 498-499"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cedar J. Fowler ∗ , Beatrice Sun , Tiffany Yue , Byrne Lee
{"title":"Impact of Enhanced Recovery After Surgery (ERAS) Protocol Adoption for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) on Analgesia Practices and Patient-Reported Pain","authors":"Cedar J. Fowler ∗ , Beatrice Sun , Tiffany Yue , Byrne Lee","doi":"10.1016/j.clnesp.2024.10.028","DOIUrl":"10.1016/j.clnesp.2024.10.028","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Page 500"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel Alvarez-Mejia , Cesar Augusto Restrepo , Felipe Marulanda-Mejia , Clara Helena González-Correa
{"title":"Association between hypovitaminosis D and sarcopenic obesity in patients with chronic kidney disease stages 3 and 4","authors":"Miguel Alvarez-Mejia , Cesar Augusto Restrepo , Felipe Marulanda-Mejia , Clara Helena González-Correa","doi":"10.1016/j.clnesp.2024.11.020","DOIUrl":"10.1016/j.clnesp.2024.11.020","url":null,"abstract":"<div><div>The relationship between sarcopenic obesity and hypovitaminosis D in individuals with chronic kidney disease is complex and has significant impacts on muscle and bone health. An observational, cross-sectional, and analytical study was conducted to analyze possible associations between serum vitamin D levels and sarcopenic obesity in patients with chronic kidney disease stages 3 and 4 in a cohort of patients under nephrology care. The presence of sarcopenic obesity was assessed using bioimpedance criteria, and vitamin D levels were measured and recorded for each patient. Statistically significant associations were found between sarcopenic obesity and suboptimal vitamin D levels (p < 0.005) as well as between severe sarcopenia and hypovitaminosis D (p < 0.05) in patients with chronic kidney disease stages 3 and 4. Patients with optimal levels of vitamin D showed better muscle quality and a lower prevalence of sarcopenia and severe sarcopenia. The findings suggest that vitamin D levels play a crucial role in muscle quality in patients with CKD stages 3 and 4. Maintaining optimal levels of vitamin D may help reduce the prevalence of sarcopenic obesity and improve quality of life in these patients.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 205-208"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jianxiao Liu , Xusheng Liu , Chaoyang Wang , Yongjiang Yu ∗
{"title":"Diagnostic accuracy of C-reactive protein for the early diagnosis of infectious complications after gastrectomy for gastric cancer: A meta-analysis and systematic review","authors":"Jianxiao Liu , Xusheng Liu , Chaoyang Wang , Yongjiang Yu ∗","doi":"10.1016/j.clnesp.2024.10.033","DOIUrl":"10.1016/j.clnesp.2024.10.033","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Page 502"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yijie Chen , Jun Chen , Ji Wu , Xianguo Qu , Zhifen Zhang
{"title":"Metabolome-wide Mendelian randomization assessing the causal relationship between blood metabolites and primary ovarian insufficiency","authors":"Yijie Chen , Jun Chen , Ji Wu , Xianguo Qu , Zhifen Zhang","doi":"10.1016/j.clnesp.2024.11.013","DOIUrl":"10.1016/j.clnesp.2024.11.013","url":null,"abstract":"<div><h3>Background & aims</h3><div>Primary ovarian insufficiency (POI) is a significant clinical syndrome that leads to female infertility, and its incidence continues to increase. We used metabolome-specific Mendelian randomization (MR) to identify causally associated metabolites and explore the relationship between candidate metabolites and upstream genetic variations.</div></div><div><h3>Methods</h3><div>The primary MR analysis utilized the inverse variance weighted (IVW) method as the primary approach to assess the causal relationship between exposure and POI. Multiple sensitivity analyses included MR-Egger, weighted median, and weighted mode methods.</div></div><div><h3>Results</h3><div>After using genetic variants as probes, we identified 27 metabolites of 278 that are associated with the risk of POI, including dodecanedioate (OR 0.052, 95 % CI 0.010–0.265; P < 0.001), adrenate (OR 0.113, 95 % CI 0.016–0.822; P = 0.031), indolepropionate (OR 0.174, 95 % CI 0.051–0.593; P = 0.005), homocitrulline (OR 0.194, 95 % CI 0.051–0.741; P = 0.016), and 3-methylhistidine (OR 0.404, 95 % CI 0.193–0.848; P = 0.017). Our study indicated the presence of heterogeneity; therefore, we employed the IVW random-effects model as the primary approach. KEGG pathway enrichment analysis identified six significant metabolic pathways, primarily including biosynthesis of unsaturated fatty acids, phenylalanine, tyrosine and tryptophan biosynthesis, aminoacyl-tRNA biosynthesis, linoleic acid metabolism, valine, leucine and isoleucine biosynthesis, ubiquinone and other terpenoid-quinone biosynthesis.</div></div><div><h3>Conclusions</h3><div>By integrating genomics and metabolomics, this study provides novel insights into the causal relationship linking circulating metabolites and the onset of POI.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 331-338"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Letícia Van-Lume Lima, Ana Elisa Toscano, Joaci Pereira dos Santos Júnior, Eulália Rebeca da Silva-Araújo, José Geneilson Silva, Raul Manhães-de-Castro
{"title":"Letter to the editor: Comment on “Maternal non-compliance with recommended folic acid supplement use alters global DNA methylation in cord blood of newborns: A cohort study”","authors":"Letícia Van-Lume Lima, Ana Elisa Toscano, Joaci Pereira dos Santos Júnior, Eulália Rebeca da Silva-Araújo, José Geneilson Silva, Raul Manhães-de-Castro","doi":"10.1016/j.clnesp.2024.10.169","DOIUrl":"10.1016/j.clnesp.2024.10.169","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 236-237"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sílvia Castro , A. Tomé , C. Granja , A. Macedo , A. Binnie
{"title":"High vs low protein intake in chronic critical illness: A systematic review and meta-analysis","authors":"Sílvia Castro , A. Tomé , C. Granja , A. Macedo , A. Binnie","doi":"10.1016/j.clnesp.2024.12.003","DOIUrl":"10.1016/j.clnesp.2024.12.003","url":null,"abstract":"<div><h3>Background & aims</h3><div>Patients with persistent organ dysfunction after the first week of intensive care unit (ICU) admission are considered to have chronic critical illness (CCI). Acquired muscle weakness is a common feature of CCI that is accompanied by loss of muscle mass and electromyographic features of myopathy. Optimizing protein intake may help prevent acquired muscle weakness and/or promote muscle recovery, however, the optimal level of protein intake in CCI is uncertain and there is a lack of consensus in published nutritional guidelines. This systematic review focuses on the impact of high versus low protein intake as part of a nutritional strategy for patients with CCI.</div></div><div><h3>Methods</h3><div>The terms “protein intake” and “critically ill” were systematically searched in PUBMED, CENTRAL (Cochrane Central Register of Controlled Trials), and WEB OF SCIENCE on 06/01/2023. We included studies that (1) enrolled critically ill adults (aged 18 years or over) who were in the ICU for more than 7 days and that compared (2) protein intake above and below 1.3 gr/kg administered by any route (enteral and/or parenteral), (3) had an intervention period that occurred primarily after the first 7 days of critical illness and (4) reported clinical outcomes including length of ICU and hospital stay, duration of invasive mechanical ventilation (IMV), mortality, ICU acquired infections, muscle mass and physical function. Studies pertaining to elective surgery, those with intervention periods shorter than 7 days or occurring primarily within the first 7 days of critical illness, those measuring only laboratory parameters as outcomes, and safety and feasibility studies were excluded.</div></div><div><h3>Results</h3><div>Four studies were included (N = 1730) in the meta-analysis and systematic review. Higher (>1.3 g/kg/d) versus lower protein intake was associated with a decrease in early mortality (defined as ICU or 28-day mortality) hazard ratio (HR) 0.42 (95 % confidence interval (CI): 0.26–0.70, P < 0.001), but had no impact on late mortality (defined as the latest mortality timepoint in each study): HR 0.93 (95 % CI 0.76–1.15, P = 0.51). There was no significant difference between intervention and control groups with respect to duration of IMV, duration of ICU or hospital stay, muscle mass, or the incidence of ICU-acquired infections. One study reported improvements in physical function at 3 and 6 months in the intervention group.</div></div><div><h3>Conclusion</h3><div>After the first week of critical illness, increasing protein intake to >1.3 g/kg/d may improve early mortality but not late mortality or other clinical outcomes. The small number of relevant studies and the heterogeneity of outcomes assessed, weaken these conclusions. Further studies are warranted to discern whether higher protein intake is beneficial in chronic critical illness.</div><div>PROSPERO registration number: CRD42023403554; PROSPERO regis","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 249-255"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Morales-Suarez-Varela , Oscar Andrés Rocha-Velasco
{"title":"Impact of ultra-processed food consumption during pregnancy on maternal and child health outcomes: A comprehensive narrative review of the past five years","authors":"Maria Morales-Suarez-Varela , Oscar Andrés Rocha-Velasco","doi":"10.1016/j.clnesp.2024.12.006","DOIUrl":"10.1016/j.clnesp.2024.12.006","url":null,"abstract":"<div><h3>Background & aims</h3><div>Ultra-processed foods (UPF) are increasingly prevalent in modern diets and are associated with negative health outcomes such as chronic diseases due to their high processing and low nutrient density. Despite the potential impact of UPF intake during pregnancy on maternal and child health, studies in this area are limited. Therefore, this narrative comprehensive review aimed to identify associations between UPF consumption, categorized by the NOVA system, during pregnancy and maternal and child health outcomes over the past five years (2019–2024).</div></div><div><h3>Methods</h3><div>Following PRISMA-ScR criteria (2018), MedLine/PubMed, Scopus, and Embase databases were searched for articles on maternal and child health outcomes associated with UPF consumption categorized by the NOVA system during pregnancy, out of 767 studies identified, 22 were eligible.</div></div><div><h3>Results</h3><div>Overall, high UPF consumption during pregnancy was positively associated with various adverse maternal-child outcomes, including gestational diabetes mellitus, gestational weight gain, poor glycemic control, negative nutrition biomarkers, inflammatory markers, and hypertensive disorders during pregnancy. It also negatively impacted child growth and development, and was associated with adiposity gain, potential adverse mental disorders, indicators of poor nutrition, and poor overall diet quality.</div></div><div><h3>Conclusions</h3><div>Despite the limited data, high consumption of UPF during pregnancy adversely affected the health outcomes of both mothers and children, impacting nutrition indicators and diet quality. Further studies on this topic are needed. Promoting healthy eating habits among pregnant women is crucial for achieving optimal health outcomes.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Pages 288-304"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Corcoy ∗ , Carlos Rodríguez-Hernández , Yulibeth Geraldine Curbelo-Peña , Cristina Rodriguez , Ester Vila , Luis Aguilera , Ester Marco
{"title":"Impact of a Prehabilitation Program on Six-Month Survival in Frail Patients Following Surgery","authors":"Marta Corcoy ∗ , Carlos Rodríguez-Hernández , Yulibeth Geraldine Curbelo-Peña , Cristina Rodriguez , Ester Vila , Luis Aguilera , Ester Marco","doi":"10.1016/j.clnesp.2024.10.039","DOIUrl":"10.1016/j.clnesp.2024.10.039","url":null,"abstract":"","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"65 ","pages":"Page 505"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143132168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}