膳食酸负荷增加心电图中轻微ST段和T波异常的几率：一项基于人群的大型研究结果。

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-06-10 DOI:10.1016/j.clnesp.2025.06.004

Najmeh Seifi , Sara Saffar Soflaei , Ali Ebrahimi Dabagh , Glareh Koochackpoor , Hedieh Alimi , Asal Yadollahi , Habibollah Esmaily , Gordon A. Ferns , Mohsen Moohebati , Majid Ghayour-Mobarhan

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引用次数: 0

摘要

背景：心电图（ECGs）在预测普通人群心血管疾病（cvd）方面是有用的。在ECG异常中，孤立的小ST段和T波（ST-T）改变被认为与cvd和cvd相关的死亡率有关。饮食是心血管疾病的一个可改变的危险因素，被认为与心电图异常有关。目的：我们旨在调查社区成人中孤立的轻微ST-T异常与膳食酸负荷之间的关系。方法：在本横断面研究中，包括6413名年龄在35-65岁之间的参与者。膳食酸度水平的评估使用净内源性产酸（NEAP）和潜在肾酸负荷（PRAL）评分，这些评分来自经过验证的食物频率问卷（FFQ）。明尼苏达州编码系统用于处理心电图上轻微的ST-T段异常。以比值比（OR）对四种不同的模型进行多元逻辑回归。结果：研究表明，在各种模型中，较高的饮食酸度与孤立的轻微ST-T异常风险增加有关。在完全校正模型中，PRAL分位数最高的个体与分位数最低的个体相比，单独的轻微ST-T异常的几率高出79% (OR （95%CI): 1.79 (1.13-2.82), p=0.01）。NEAP的最高分位数与最低分位数相比，也与孤立性轻微ST-T异常的几率增加有关(在全校正模型中OR （95%CI): 1.79 (1.13-2.83), p=0.01）。结论：单独的轻微ST-T变化与膳食酸负荷评分显著相关，NEAP和PRAL评分越高，单独的轻微ST-T异常的几率越高。

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Dietary acid load increases odds of minor ST segment and T wave abnormalities in electrocardiogram: Results of a large population-based study

Background

Electrocardiograms (ECGs) are useful in predicting cardiovascular diseases (CVDs) in the general population. Among ECG abnormalities, isolated minor ST segment and T Wave (ST-T) changes are introduced to be associated with CVDs and CVD-associated mortality in apparently-healthy individuals. Diet, a modifiable risk factor of CVDs, is proposed to be associated with ECG abnormalities.

Objectives

we aimed to investigate the association between isolated minor ST-T abnormalities and dietary acid load in a community-based adult population.

Methods

In this cross-sectional study, 6413 participants aged 35–65 were included. Dietary acidity levels were assessed using the Net Endogenous Acid Production (NEAP) and Potential Renal Acid Load (PRAL) scores, derived from a validated food frequency questionnaire (FFQ). The Minnesota coding system was used to address minor ST-T segment abnormalities on ECGs. Multiple logistic regression was conducted in four distinct models reported as odds ratios (OR).

Results

The study revealed that higher dietary acidity was associated with an increased risk of isolated minor ST-T abnormalities across various models. Individuals in the highest tertile of PRAL compared to the lowest, had 79 % higher odds of isolated minor ST-T abnormalities in the fully-adjusted model (OR (95%CI): 1.79 (1.13–2.82), p = 0.01). The highest tertile of NEAP compared to the lowest was also associated with an increased odds of isolated minor ST-T abnormalities (In the full-adjusted model OR (95%CI): 1.79 (1.13–2.83), p = 0.01).

Conclusion

Isolated minor ST-T changes were significantly associated with dietary acid load score, in a way that higher NEAP and PRAL scores were related to increased odds of minor isolated ST-T abnormalities.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.