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Advances in Cell Therapy for Chronic Graft-versus-Host Disease: Prophylactic and Therapeutic Perspectives. 慢性移植物抗宿主病的细胞治疗进展：预防和治疗的观点。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-05-05 DOI: 10.1007/s10238-026-02120-8
Zahra Taghinejad, Nahid Moradi, Athar Talebi, Leila Jafari, Hadis Soleimanzadeh, Amir Ali Hamidieh
{"title":"Advances in Cell Therapy for Chronic Graft-versus-Host Disease: Prophylactic and Therapeutic Perspectives.","authors":"Zahra Taghinejad, Nahid Moradi, Athar Talebi, Leila Jafari, Hadis Soleimanzadeh, Amir Ali Hamidieh","doi":"10.1007/s10238-026-02120-8","DOIUrl":"https://doi.org/10.1007/s10238-026-02120-8","url":null,"abstract":"<p><p>Chronic graft-versus-host disease (cGvHD) can affect about 70% of people who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT). This condition is characterized by a complex immune dysregulation that leads to persistent inflammation and fibrosis. These complications can lead to long-term health issues that significantly affect the quality of life after HSCT. Conventional therapies such as corticosteroids and broad immunosuppressants are partially effective and have significant toxicity. They also fail to reverse established fibrotic damage. Advances in targeted pharmacological agents, including Bruton's tyrosine kinase inhibitors and JAK inhibitors, show improved outcomes for steroid-refractory cGvHD. However, their high costs and variable responses highlight the unmet need for more effective approaches. Cell-based therapies have emerged as promising strategies to modulate pathogenic immune responses and prevent or even treat cGvHD. Mesenchymal stromal cells (MSCs), regulatory T cells (Tregs), natural killer (NK) cells, and chimeric antigen receptor (CAR) T cells are being investigated for their immunoregulatory potential in preclinical and clinical trials, and they are considered a safer, more effective, and targeted approach to managing cGvHD. MSC-derived cytokines and exosomes can suppress Th17 cells and promote the generation of IL-10-expressing Tregs. This dual action helps reduce inflammation and tissue fibrosis associated with the cGvHD. Tregs and NK cells also help rebalance immune responses and suppress alloreactivity through different mechanisms. This review highlights underlying mechanisms, clinical efficacy, and challenges in translating these therapies into routine clinical practice. Additionally, it suggests that future trials should incorporate patient stratification based on cGvHD phases and phase-relevant biomarkers for managing disease progression more precisely.</p>","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic changes in gut microbiota and discovery of prognostic biomarkers in locally advanced pancreatic cancer during chemoradiotherapy. 局部晚期胰腺癌放化疗期间肠道微生物群的动态变化和预后生物标志物的发现。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-05-04 DOI: 10.1007/s10238-026-02158-8
Haohua Wang, Fuhao Wang, Qi Guo, Benkui Zou, Peihang Li, Xiaoqing Xu, Junyi He, Shumei Jiang, Jinbo Yue
{"title":"Dynamic changes in gut microbiota and discovery of prognostic biomarkers in locally advanced pancreatic cancer during chemoradiotherapy.","authors":"Haohua Wang, Fuhao Wang, Qi Guo, Benkui Zou, Peihang Li, Xiaoqing Xu, Junyi He, Shumei Jiang, Jinbo Yue","doi":"10.1007/s10238-026-02158-8","DOIUrl":"10.1007/s10238-026-02158-8","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":"26 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signal Transduction and Transcription Activator 1 in Pan-Cancer: Prognostic and Immunological Value. 泛癌中的信号转导和转录激活因子1：预后和免疫学价值。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-29 DOI: 10.1007/s10238-026-02152-0
Ying Wang, Yongguang Zhang, Fengmei Wang, Longguan Tang, Xun Xiao, Hu Zhao, Qingsong Sheng
{"title":"Signal Transduction and Transcription Activator 1 in Pan-Cancer: Prognostic and Immunological Value.","authors":"Ying Wang, Yongguang Zhang, Fengmei Wang, Longguan Tang, Xun Xiao, Hu Zhao, Qingsong Sheng","doi":"10.1007/s10238-026-02152-0","DOIUrl":"https://doi.org/10.1007/s10238-026-02152-0","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovations in biomarker stratification for precision oncology. 精准肿瘤学生物标志物分层的创新。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-28 DOI: 10.1007/s10238-026-02150-2
Ronak Naeemaee, Keith Harris, Neil Cross, Jon Griffin, Lewis A Quayle
{"title":"Innovations in biomarker stratification for precision oncology.","authors":"Ronak Naeemaee, Keith Harris, Neil Cross, Jon Griffin, Lewis A Quayle","doi":"10.1007/s10238-026-02150-2","DOIUrl":"https://doi.org/10.1007/s10238-026-02150-2","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comorbidities in lipedema: toward a systemic perspective - a narrative review. 脂肪水肿的合并症：从系统的角度看-叙述回顾。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-28 DOI: 10.1007/s10238-026-02157-9
Elettra Fiengo, Andrea Sbarbati
{"title":"Comorbidities in lipedema: toward a systemic perspective - a narrative review.","authors":"Elettra Fiengo, Andrea Sbarbati","doi":"10.1007/s10238-026-02157-9","DOIUrl":"https://doi.org/10.1007/s10238-026-02157-9","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing false positives in breast cancer screening with computer-aided detection. 用计算机辅助检测减少乳腺癌筛查中的假阳性。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-27 DOI: 10.1007/s10238-026-02147-x
Taihu Wan, Xue Sang, Zhengyang Wu, Lei Li, Nan Liu, Hemoren Yi
{"title":"Reducing false positives in breast cancer screening with computer-aided detection.","authors":"Taihu Wan, Xue Sang, Zhengyang Wu, Lei Li, Nan Liu, Hemoren Yi","doi":"10.1007/s10238-026-02147-x","DOIUrl":"https://doi.org/10.1007/s10238-026-02147-x","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A genomic and transcriptomic integration study of CCL19-driven macrophage-immune crosstalk in chronic hepatitis B. 慢性乙型肝炎中ccl19驱动的巨噬细胞免疫串扰的基因组和转录组整合研究
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-25 DOI: 10.1007/s10238-026-02128-0
Tao Pan, Li Yang, Jiming Liu
{"title":"A genomic and transcriptomic integration study of CCL19-driven macrophage-immune crosstalk in chronic hepatitis B.","authors":"Tao Pan, Li Yang, Jiming Liu","doi":"10.1007/s10238-026-02128-0","DOIUrl":"https://doi.org/10.1007/s10238-026-02128-0","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The SUMO specific peptidase SENP3 promotes papillary thyroid cancer progression by deSUMOylation of SETDB1 and regulating GLI2 transcription. SUMO特异性肽酶SENP3通过去umoylation SETDB1和调节GLI2转录来促进甲状腺乳头状癌的进展。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-23 DOI: 10.1007/s10238-026-02151-1
Zhe Wang, Ze Yang, Yong Chen, Xiaojing Zhao, Dengfeng Gao, Nancy Wang, Albert Williams
{"title":"The SUMO specific peptidase SENP3 promotes papillary thyroid cancer progression by deSUMOylation of SETDB1 and regulating GLI2 transcription.","authors":"Zhe Wang, Ze Yang, Yong Chen, Xiaojing Zhao, Dengfeng Gao, Nancy Wang, Albert Williams","doi":"10.1007/s10238-026-02151-1","DOIUrl":"https://doi.org/10.1007/s10238-026-02151-1","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simvastatin in liver diseases: therapeutic value and research advances. 辛伐他汀在肝病中的治疗价值及研究进展。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-19 DOI: 10.1007/s10238-026-02149-9
Haodong Zhang, Lei Xu, Yong Cui, Wei Gou, Jinjin Li
{"title":"Simvastatin in liver diseases: therapeutic value and research advances.","authors":"Haodong Zhang, Lei Xu, Yong Cui, Wei Gou, Jinjin Li","doi":"10.1007/s10238-026-02149-9","DOIUrl":"https://doi.org/10.1007/s10238-026-02149-9","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leukemia during pregnancy and survivorship: gestational age-stratified multidisciplinary management framework. 妊娠期白血病和生存率：胎龄分层多学科管理框架。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-19 DOI: 10.1007/s10238-026-02154-y
Ning Zhang, Yin Jiang, Xilian Li, Wenlan Fu, Zhiyuan Gao, Haiwei He, Xiaoqing Zhang, Biao Gao
{"title":"Leukemia during pregnancy and survivorship: gestational age-stratified multidisciplinary management framework.","authors":"Ning Zhang, Yin Jiang, Xilian Li, Wenlan Fu, Zhiyuan Gao, Haiwei He, Xiaoqing Zhang, Biao Gao","doi":"10.1007/s10238-026-02154-y","DOIUrl":"https://doi.org/10.1007/s10238-026-02154-y","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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