G Amati, G Sandri, A Bertani, D Vaccari, A Pecchi, B Bongiovanni, M Orlandi, G Ciancio, M Pecchini, O Secchi, A Colecchia, P Torricelli, D Giuggioli
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They discontinued tumor necrosis factor α inhibitors (TNFαi) at least 3 months before the MRE execution. Most patients had an ileal CD location (65.0%) and a stricturing behavior of disease (50.0%). Thirty-five percent of patients underwent ileocecal resection. One out of ten patients were treated with at least one TNFαi. Active SI, capsulitis, erosions, sclerosis, and ankylosis were present in 10.5%, 0.5%, 2.0%, 2.5%, and 1.5%, respectively. No significant correlations have been evidenced between the presence of SI and demographic and clinical variables. The presence of an asymmetric hyperenhancement of the bowel wall was instead directly associated with the presence of SI (OR 8.61, 95% CI 1.47-50.4, p = 0.017). In this study, subclinical SI is a frequent finding in CD patients being present in one out of ten MRE examination. 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引用次数: 0
摘要
磁共振肠造影(MRE)被推荐用于评估克罗恩病(CD)的小肠改变。骶髂关节(sij)成像在骶髂炎(SI)的早期诊断中具有核心作用。MRE可以评估sij的急性和结构性表现。我们的目的是评估MRE在一组CD患者中检测到的SI的患病率,以及SI与人口统计学和临床特征以及肠道MRE结果的关系。选取了2011年至2023年间200例CD患者(M:F: 1:1,中位年龄49.5(22.5)岁,中位CD持续时间4.75(16.2)年)进行MRE检测。他们在MRE执行前至少3个月停止使用肿瘤坏死因子α抑制剂(TNFαi)。大多数患者有回肠CD位置(65.0%)和疾病狭窄行为(50.0%)。35%的患者接受回盲切除术。十分之一的患者接受了至少一种tnf - αi治疗。活动性SI、囊炎、糜烂、硬化症和强直分别为10.5%、0.5%、2.0%、2.5%和1.5%。SI的存在与人口统计学和临床变量之间没有明显的相关性。相反,肠壁不对称高强化的存在与SI的存在直接相关(OR 8.61, 95% CI 1.47-50.4, p = 0.017)。在这项研究中,亚临床SI是乳糜泻患者的常见发现,在十分之一的MRE检查中出现。这种现象与不对称壁强化显著相关,这是一种特殊的CD肠道病变。
Prevalence of sacroiliitis on magnetic resonance enterography in Crohn's disease and its association with intestinal findings: a monocentric observational cross-sectional study.
Magnetic resonance enterography (MRE) is recommended for the assessment of small intestine alterations in Crohn's disease (CD). Sacroiliac joints (SIJs) imaging has a central role in the early diagnosis of sacroiliitis (SI). MRE can evaluate both acute and structural findings of SIJs. We aimed to assess the prevalence of SI detected by MRE in a cohort of CD patients, and the associations of SI with demographic and clinical features and with intestinal MRE findings. Two hundred patients affected by CD (M:F 1:1, median age 49.5 (22.5) years, median CD duration 4.75 (16.2) years) tested with MRE between 2011 and 2023 were selected. They discontinued tumor necrosis factor α inhibitors (TNFαi) at least 3 months before the MRE execution. Most patients had an ileal CD location (65.0%) and a stricturing behavior of disease (50.0%). Thirty-five percent of patients underwent ileocecal resection. One out of ten patients were treated with at least one TNFαi. Active SI, capsulitis, erosions, sclerosis, and ankylosis were present in 10.5%, 0.5%, 2.0%, 2.5%, and 1.5%, respectively. No significant correlations have been evidenced between the presence of SI and demographic and clinical variables. The presence of an asymmetric hyperenhancement of the bowel wall was instead directly associated with the presence of SI (OR 8.61, 95% CI 1.47-50.4, p = 0.017). In this study, subclinical SI is a frequent finding in CD patients being present in one out of ten MRE examination. This phenomenon was significantly associated with asymmetric mural enhancement, a specific CD intestinal lesion at MRE.
期刊介绍:
Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.