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Leukemia during pregnancy and survivorship: gestational age-stratified multidisciplinary management framework. 妊娠期白血病和生存率：胎龄分层多学科管理框架。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-19 DOI: 10.1007/s10238-026-02154-y
Ning Zhang, Yin Jiang, Xilian Li, Wenlan Fu, Zhiyuan Gao, Haiwei He, Xiaoqing Zhang, Biao Gao
{"title":"Leukemia during pregnancy and survivorship: gestational age-stratified multidisciplinary management framework.","authors":"Ning Zhang, Yin Jiang, Xilian Li, Wenlan Fu, Zhiyuan Gao, Haiwei He, Xiaoqing Zhang, Biao Gao","doi":"10.1007/s10238-026-02154-y","DOIUrl":"https://doi.org/10.1007/s10238-026-02154-y","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of key programmed cell death genes-necroptosis-related genes in systemic lupus erythematosus. 系统性红斑狼疮关键细胞程序性死亡基因-坏死相关基因的鉴定。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-19 DOI: 10.1007/s10238-026-02144-0
Lu Wang, Yuanyuan Li, Xinyi Liu, Shichang Song, Yichen Han, Lingfei Mo, Hanchao Li, Xiaohao Wang, Ying Pan, Jian Sun, Jing Wang
{"title":"Identification of key programmed cell death genes-necroptosis-related genes in systemic lupus erythematosus.","authors":"Lu Wang, Yuanyuan Li, Xinyi Liu, Shichang Song, Yichen Han, Lingfei Mo, Hanchao Li, Xiaohao Wang, Ying Pan, Jian Sun, Jing Wang","doi":"10.1007/s10238-026-02144-0","DOIUrl":"https://doi.org/10.1007/s10238-026-02144-0","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatogenous diabetes in the era of precision medicine: diagnosis, management, and future directions. 精准医疗时代的肝源性糖尿病：诊断、管理与未来方向。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-19 DOI: 10.1007/s10238-026-02112-8
Gasser El-Azab, Mohamed Akl Rady, Medhat Assem, Hanaa Nagdy
{"title":"Hepatogenous diabetes in the era of precision medicine: diagnosis, management, and future directions.","authors":"Gasser El-Azab, Mohamed Akl Rady, Medhat Assem, Hanaa Nagdy","doi":"10.1007/s10238-026-02112-8","DOIUrl":"10.1007/s10238-026-02112-8","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the applicability, combined strategies, and challenges of ablation in hematology based on its characteristics and immunomodulatory mechanisms. 基于消融术的特点和免疫调节机制，探讨消融术在血液学中的适用性、联合策略和挑战。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-13 DOI: 10.1007/s10238-026-02129-z
Muyun Wu, Jiaqi Fu, Runjie Sun, Manya Yu, Mengting Xia, Ye Yang, Xing Cui
{"title":"Exploring the applicability, combined strategies, and challenges of ablation in hematology based on its characteristics and immunomodulatory mechanisms.","authors":"Muyun Wu, Jiaqi Fu, Runjie Sun, Manya Yu, Mengting Xia, Ye Yang, Xing Cui","doi":"10.1007/s10238-026-02129-z","DOIUrl":"https://doi.org/10.1007/s10238-026-02129-z","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bidirectional interplay between gut and liver in inflammatory bowel disease and hepatobiliary conditions. 肠道和肝脏在炎症性肠病和肝胆疾病中的双向相互作用。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-07 DOI: 10.1007/s10238-026-02102-w
Ali Abdulla, Ayan M Sheikhnoor, Kevin Ferrao, Lucy I Stiles, Kosha J Mehta
{"title":"Bidirectional interplay between gut and liver in inflammatory bowel disease and hepatobiliary conditions.","authors":"Ali Abdulla, Ayan M Sheikhnoor, Kevin Ferrao, Lucy I Stiles, Kosha J Mehta","doi":"10.1007/s10238-026-02102-w","DOIUrl":"10.1007/s10238-026-02102-w","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A gene interaction network-based molecular taxonomy of dilated cardiomyopathy highlighting immune and inflammatory heterogeneity. 基于基因相互作用网络的扩张型心肌病分子分类学，强调免疫和炎症异质性。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-07 DOI: 10.1007/s10238-026-02130-6
Youyang Zheng, Fangfang Wan, Shulun Ma, Haijie Chen, Leqi Wang, Yuanrui Deng, Ge Zhang, Lei Song, Mo Zhang
{"title":"A gene interaction network-based molecular taxonomy of dilated cardiomyopathy highlighting immune and inflammatory heterogeneity.","authors":"Youyang Zheng, Fangfang Wan, Shulun Ma, Haijie Chen, Leqi Wang, Yuanrui Deng, Ge Zhang, Lei Song, Mo Zhang","doi":"10.1007/s10238-026-02130-6","DOIUrl":"https://doi.org/10.1007/s10238-026-02130-6","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The neutrophil-percentage-to-albumin ratio (NPAR) shows a nonlinear correlation with all-cause mortality in patients with anemia. 中性粒细胞百分比-白蛋白比（NPAR）与贫血患者的全因死亡率呈非线性相关。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-06 DOI: 10.1007/s10238-026-02119-1
Anqi Peng, Jizhe Li, Jun Huang, Yuqiong Yang, Yizhi Jiang, Dongping Huang
{"title":"The neutrophil-percentage-to-albumin ratio (NPAR) shows a nonlinear correlation with all-cause mortality in patients with anemia.","authors":"Anqi Peng, Jizhe Li, Jun Huang, Yuqiong Yang, Yizhi Jiang, Dongping Huang","doi":"10.1007/s10238-026-02119-1","DOIUrl":"https://doi.org/10.1007/s10238-026-02119-1","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A DLBCL Prognostic model superior to the IPI score: Mechanistic study and clinical validation based on RFC2- and RFC4-mediated DNA damage repair. 一个优于IPI评分的DLBCL预后模型：基于RFC2和rfc4介导的DNA损伤修复的机制研究和临床验证
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-04 DOI: 10.1007/s10238-026-02135-1
Shuainan Wang, Yang Liu, Haoyu Zang, Laibing Guo, Wenjing Du, Jingyan Song, Fei Wang, Luo Lu, Qing Li, Yongqiang Shi, Tongbing Chen, Weiying Gu
{"title":"A DLBCL Prognostic model superior to the IPI score: Mechanistic study and clinical validation based on RFC2- and RFC4-mediated DNA damage repair.","authors":"Shuainan Wang, Yang Liu, Haoyu Zang, Laibing Guo, Wenjing Du, Jingyan Song, Fei Wang, Luo Lu, Qing Li, Yongqiang Shi, Tongbing Chen, Weiying Gu","doi":"10.1007/s10238-026-02135-1","DOIUrl":"https://doi.org/10.1007/s10238-026-02135-1","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benchmarking LLM decision support in inflammatory aneurysms: DeepSeek-R1, DeepSeek-V3 and ChatGPT-4o. 对标LLM在炎性动脉瘤中的决策支持：DeepSeek-R1， DeepSeek-V3和chatgpt - 40。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-03 DOI: 10.1007/s10238-026-02045-2
Jianqiang Hao, Changwei Zhang
{"title":"Benchmarking LLM decision support in inflammatory aneurysms: DeepSeek-R1, DeepSeek-V3 and ChatGPT-4o.","authors":"Jianqiang Hao, Changwei Zhang","doi":"10.1007/s10238-026-02045-2","DOIUrl":"https://doi.org/10.1007/s10238-026-02045-2","url":null,"abstract":"<p><p>Decision support for inflammatory aneurysms demands guideline-concordant specificity. We compared three large-language-model systems-DeepSeek-R1, ChatGPT-4o and DeepSeek-V3-on accuracy and time efficiency for core diagnostic, interventional and surveillance decisions. In a prospective, rater-blinded evaluation, each model completed a 50-item instrument aligned to contemporary aortic guidance in five independent clean-context sessions (15 answer sets). Five consultant vascular specialists scored all outputs using a prespecified 0/1/2 rubric. The primary outcome was total accuracy (0-100); secondary outcomes were completion time and domain subscores. Inter-rater reliability was summarised with Fleiss' κ and ICC(2,k). Mean total scores were 89.8 ± 1.8 (DeepSeek-R1), 88.4 ± 1.8 (ChatGPT-4o) and 77.8 ± 1.5 (DeepSeek-V3). One-way ANOVA showed a significant model effect (F(2,12) = 75.34, p = 1.61 × 10⁻⁷); Tukey contrasts indicated near-parity between R1 and 4o (Δ 1.44, p = 0.397) with both exceeding V3 (R1-V3 Δ 12.00, p = 2.80 × 10⁻⁷; 4o-V3 Δ 10.56, p = 1.13 × 10⁻⁶). Completion time separated strongly (R1 58.5 ± 0.95 s; 4o 33.4 ± 0.46 s; V3 19.8 ± 0.89 s; F(2,12) = 3053, p = 5.69 × 10⁻¹⁷), and accuracy rose with time (Pearson r = 0.802, 95% CI 0.49-0.93, p = 3.24 × 10⁻⁴; Theil-Sen 0.285 points·s⁻¹). Differences concentrated in guideline-derived items (R1 36.44 ± 1.49; 4o 36.32 ± 1.45; V3 29.16 ± 0.86). Inter-rater agreement was substantial at item level (κ = 0.662) and excellent for totals (ICC[2,k] = 0.973); intra-model variability was ≈ 2%. In rule-dense, safety-critical decisions for inflammatory aneurysms, slower, reasoning-oriented decoding yields the highest accuracy, while a low-latency multimodal system achieves near-parity at markedly shorter times; a throughput-optimised model trades speed for omission-prone answers. Model selection should align with task criticality, with human verification retained.</p>","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiome remodeling across hepatocellular carcinoma progression and transarterial chemoembolization is associated with therapeutic response and prognosis. 肝细胞癌进展和经动脉化疗栓塞的肠道微生物群重塑与治疗反应和预后相关。
IF 3.5 4区 医学
Clinical and Experimental Medicine Pub Date : 2026-04-03 DOI: 10.1007/s10238-026-02137-z
Bing Liu, Shu-Hui Wan, Yi-Tian Zhang, Jun-Hao Lin, Xun-Chang Ke, Wei-Hua Lin, Mei-Xiao Zhan
{"title":"Gut microbiome remodeling across hepatocellular carcinoma progression and transarterial chemoembolization is associated with therapeutic response and prognosis.","authors":"Bing Liu, Shu-Hui Wan, Yi-Tian Zhang, Jun-Hao Lin, Xun-Chang Ke, Wei-Hua Lin, Mei-Xiao Zhan","doi":"10.1007/s10238-026-02137-z","DOIUrl":"https://doi.org/10.1007/s10238-026-02137-z","url":null,"abstract":"","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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