肺结核和糖尿病的双重负担:流行病学相关性。

IF 3.5 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Salma Bibi, Hayat Khan, Muhammad Salman, Jadoon Khan, Tawaf Ali Shah, Molalign Assefa, Hesham M Hassan
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引用次数: 0

摘要

本研究在一组200例结核病阳性患者中研究了糖尿病和结核病之间的关系,这些患者按性别、年龄、治疗方案和合并症(包括糖尿病、急性胃肠炎和高血压)与无其他并发症的结核病患者进行了分层。临床参数-随机血糖(RBS)、c反应蛋白(CRP)和红细胞沉降率(ESR)-在基线和抗结核治疗4个月后进行评估。结果显示,治疗后平均RBS或CRP水平无显著变化,但平均ESR显著降低。年龄和性别对RBS、CRP或ESR的治疗结果影响最小,尽管女性的ESR值高于男性。治疗方案,无论是单独Myrin P Forte还是联合链霉素,都没有显著改变临床参数。然而,伴有合并症(如糖尿病、高血压或肠胃炎)的结核病患者CRP水平有所改善。在结核病患者中发现了显著的糖尿病患病率(21.42%),其中女性和50岁以上患者的患病率更高。这些发现突出了糖尿病和结核病之间的显著关联。然而,抗结核治疗对临床参数的影响很小,这表明ESR和CRP可能不是结核病的可靠预后指标。该研究强调需要进一步进行大规模病例对照研究和分子研究,以便更好地了解糖尿病与结核病之间的关系,特别是考虑到结核病患者中糖尿病的高患病率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The dual burden of tuberculosis and diabetes mellitus: an epidemiological correlation.

The dual burden of tuberculosis and diabetes mellitus: an epidemiological correlation.

The dual burden of tuberculosis and diabetes mellitus: an epidemiological correlation.

The dual burden of tuberculosis and diabetes mellitus: an epidemiological correlation.

This study examined the association between diabetes mellitus and tuberculosis (TB) in a cohort of 200TB-positive patients, stratified by gender, age, treatment regimen, and comorbidities, including diabetes, acute gastroenteritis, and hypertension, compared to TB patients without additional complications. Clinical parameters-Random Blood Sugar (RBS), C-reactive protein (CRP), and Erythrocyte Sedimentation Rate (ESR)-were assessed at baseline and after four months of anti-TB therapy. The results showed no significant changes in mean RBS or CRP levels post-treatment, but a notable reduction in mean ESR was observed. Age and gender had minimal impact on therapeutic outcomes for RBS, CRP, or ESR, though females exhibited higher ESR values than males. Treatment regimens, whether Myrin P Forte alone or combined with streptomycin, did not significantly alter clinical parameters. However, CRP levels improved in TB patients with comorbidities, such as diabetes, hypertension, or gastroenteritis. A significant prevalence of diabetes (21.42%) was found among TB patients, with higher rates in females and those over 50 years. These findings highlight a notable association between diabetes and TB. However, the minimal effect of anti-TB therapy on clinical parameters suggests that ESR and CRP may not be reliable prognostic markers for TB. The study underscores the need for further large-scale case-control studies and molecular research to better understand the relationship between diabetes and TB, particularly given the high prevalence of diabetes among TB patients.

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来源期刊
Clinical and Experimental Medicine
Clinical and Experimental Medicine 医学-医学:研究与实验
CiteScore
4.80
自引率
2.20%
发文量
159
审稿时长
2.5 months
期刊介绍: Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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