Clinical and Translational Allergy最新文献

{"title":"Dilemmas of nomenclature: Web search analysis reveals European preferences in atopic skin diseases","authors":"Hannah Wecker, Stefanie Ziehfreund, Sebastian Sitaru, Emma K. Johansson, Jesper Elberling, Anaïs Doll, Electra Nicolaidou, Emanuele Scala, Michael J. Boffa, Lea Schmidt, Mariusz Sikora, Tiago Torres, Pavel V. Chernyshov, Alexander Zink","doi":"10.1002/clt2.12355","DOIUrl":"https://doi.org/10.1002/clt2.12355","url":null,"abstract":"<p>Atopic dermatitis (AD) or atopic eczema (AE) is a complex chronic inflammatory skin disease with a high prevalence and disease burden.<span><sup>1</sup></span> The nomenclature for this condition has long been the subject of controversial debate within the medical community and even among global experts.<span><sup>2, 3</sup></span> However, the terminology used not only affects experts, daily clinical practice, and research but especially patients and the general public in terms of their understanding and access to disease-related information.<span><sup>2-5</sup></span> Given the potential of crowdsourced internet data,<span><sup>6</sup></span> this study aimed to investigate the use of ‘atopic dermatitis’, ‘atopic eczema’, and their lay terms in internet searches and the content of these searches across 21 European countries in their respective main language.</p><p>A total of 71,620,240 AD-related searches, 33,913,480 AE-related searches, and 136,405,350 searches to the respective lay terms were identified across European countries between 02/2019 and 01/2023 using Google Ads Keyword Planner. The top 20 keywords for each country and search term were translated into English and inductively classified into 9 categories: <i>age group</i>, <i>causes</i>, <i>comorbidities</i>, <i>general</i> information, <i>localisation</i>, <i>other disease</i>, <i>others</i>, <i>symptoms</i>, and <i>treatment</i>. Subcategories were formed for recurring keywords, for example, different body localisations. For cross-country comparison, the monthly number of web searches per 100,000 inhabitants was calculated. For detailed methodology, see the Appendix.</p><p>Most European countries (<i>n</i> = 11) had the highest median number of web searches per 100,000 inhabitants for AD-related lay terms, followed by AD (<i>n</i> = 8) and AE (<i>n</i> = 2, Figure 1). Analysis revealed common search themes across European countries, including <i>general</i> disease information, <i>age groups</i>, <i>localisations</i>, and <i>treatment</i>, with slight variations between countries (Figure 2A). The lay term's keywords were often about other diseases. Depending on the search terms, internet queries in some categories focused on different subcategories (Figure 2B). For example, when using the lay term, more countries searched for <i>(natural) remedies</i> and anogenital localisations, and only AD-related searches included searches for <i>animals</i>. However, there were also similarities between the search terms, with <i>face</i>, <i>hands</i>, and <i>scalp</i> being the most frequently searched localisations. <i>Age-</i>related internet searches concerned primarily babies and children, whereas in Austria and Germany, adults were the only search subjects. Search content for lay terms appeared less differentiated than for the other search terms.</p><p>Consistent with previous research, both a review study and a global crowdsourced approach found that the term AD was used more freque","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to HLA-A*24:02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms (DRESS) in HLA-B*58:01 carriers in Korean population; A multicenter cross-sectional case-control study","authors":"","doi":"10.1002/clt2.12351","DOIUrl":"https://doi.org/10.1002/clt2.12351","url":null,"abstract":"<p>M. Y. Kim, J. Yun, D. Y. Kang, T. H. Kim, M. K. Oh, S. Lee, et al. HLA-A* 24: 02 increase the risk of allopurinol-induced drug reaction with eosinophilia and systemic symptoms in HLA-B* 58: 01 carriers in a Korean population; a multicenter cross-sectional case-control study. Clin Transl Allergy. 2022 Sep 15;12(9):e12193.</p><p>This article [1] was published with a technical error in Figure 2, a size of bars in the allopurinol-tolerant controls. The authors have re-examined the data and confirmed that this correction would not have resulted in any alteration to the results or conclusion of the paper. The figure 2 should be shown as below.</p><p></p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study","authors":"Hui Wang,&nbsp;Jianyu Pang,&nbsp;Yuguan Zhou,&nbsp;Qi Qi,&nbsp;Yuheng Tang,&nbsp;Samina Gul,&nbsp;Miaomiao Sheng,&nbsp;Juhua Dan,&nbsp;Wenru Tang","doi":"10.1002/clt2.12350","DOIUrl":"https://doi.org/10.1002/clt2.12350","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Allergic diseases typically refer to a heterogeneous group of conditions primarily caused by the activation of mast cells or eosinophils, including atopic dermatitis (AD), allergic rhinitis (AR), and asthma. Asthma, AR, and AD collectively affect approximately one-fifth of the global population, imposing a significant economic burden on society. Despite the availability of drugs to treat allergic diseases, they have been shown to be insufficient in controlling relapses and halting disease progression. Therefore, new drug targets are needed to prevent the onset of allergic diseases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We employed a Mendelian randomization approach to identify potential drug targets for the treatment of allergic diseases. Leveraging 1798 genetic instruments for 1537 plasma proteins from the latest reported Genome-Wide Association Studies (GWAS), we analyzed the GWAS summary statistics of Ferreira MA et al. (nCase = 180,129, nControl = 180,709) using the Mendelian randomization method. Furthermore, we validated our findings in the GWAS data from the FinnGen and UK Biobank cohorts. Subsequently, we conducted sensitivity tests through reverse causal analysis, Bayesian colocalization analysis, and phenotype scanning. Additionally, we performed protein-protein interaction analysis to determine the interaction between causal proteins. Finally, based on the potential protein targets, we conducted molecular docking to identify potential drugs for the treatment of allergic diseases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;At Bonferroni significance (&lt;i&gt;p&lt;/i&gt; &lt; 3.25 × 10&lt;sup&gt;−5&lt;/sup&gt;), the Mendelian randomization analysis revealed 11 significantly associated protein-allergic disease pairs. Among these, the increased levels of TNFAIP3, ERBB3, TLR1, and IL1RL2 proteins were associated with a reduced risk of allergic diseases, with corresponding odds ratios of 0.82 (0.76–0.88), 0.74 (0.66–0.82), 0.49 (0.45–0.55), and 0.81 (0.75–0.87), respectively. Conversely, increased levels of IL6R, IL1R1, ITPKA, IL1RL1, KYNU, LAYN, and LRP11 proteins were linked to an elevated risk of allergic diseases, with corresponding odds ratios of 1.04 (1.03–1.05), 1.25 (1.18–1.34), 1.48 (1.25–1.75), 1.14 (1.11–1.18), 1.09 (1.05–1.12), 1.96 (1.56–2.47), and 1.05 (1.03–1.07), respectively. Bayesian colocalization analysis suggested that LAYN (coloc.abf-PPH4 = 0.819) and TNFAIP3 (coloc.abf-PPH4 = 0.930) share the same variant associated with allergic diseases.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our s","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140348563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world drug use in asthma, chronic obstructive pulmonary disease, rhinitis, cough, and cold in Finland from 1990 to 2021: Association with reduced disease burden","authors":"Tiina Mattila,&nbsp;Vesa Jormanainen,&nbsp;Marina Erhola,&nbsp;Tuula Vasankari,&nbsp;Sanna Toppila-Salmi,&nbsp;Fredrik Herse,&nbsp;Riikka-Leena Leskelä,&nbsp;Tari Haahtela","doi":"10.1002/clt2.12340","DOIUrl":"10.1002/clt2.12340","url":null,"abstract":"&lt;p&gt;Asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis are major long-term airway diseases.&lt;span&gt;&lt;sup&gt;1-5&lt;/sup&gt;&lt;/span&gt; Asthma appears in all age groups and COPD causes major morbidity and mortality particularly in smokers.&lt;span&gt;&lt;sup&gt;1, 2, 5&lt;/sup&gt;&lt;/span&gt; Allergic rhinitis and other allergic conditions are often associated with asthma.&lt;span&gt;&lt;sup&gt;3, 4, 6&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;In Finland, three nationwide respiratory programmes have been implemented since 1994: the Asthma Programme (1994–2004), the COPD Programme (1998–2007), and the Allergy Programme (2008–2018).&lt;span&gt;&lt;sup&gt;4, 6&lt;/sup&gt;&lt;/span&gt; After the 1990s, the burden of asthma, COPD, and allergic conditions has decreased and the prevalence has stabilised.&lt;span&gt;&lt;sup&gt;4, 6&lt;/sup&gt;&lt;/span&gt; Smoking has also decreased.&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;International guidelines are available for asthma (since 1995), COPD (since 1997), and chronic rhinitis (since 2005).&lt;span&gt;&lt;sup&gt;1-3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Inhaled short- and long-acting β2 adrenoceptor agonists (LABA), muscarinic receptor antagonists (LAMA), and corticosteroids (ICS) have been used for first-line treatment in asthma and COPD since the 1990s.&lt;span&gt;&lt;sup&gt;1, 2, 4, 8&lt;/sup&gt;&lt;/span&gt; Intranasal corticosteroids have been used in rhinitis for decades.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;In the present study, we present consumption (sales) data of medication for asthma, COPD, rhinitis, cough, and cold from 1990 to 2021, and analyse the overall costs of asthma and severe COPD from 1996 to 2018.&lt;/p&gt;&lt;p&gt;Since 1988, the &lt;i&gt;Social Insurance Institution of Finland&lt;/i&gt; (SII) and the &lt;i&gt;Finnish Medicines Agency&lt;/i&gt; (Fimea) have jointly published the &lt;i&gt;Finnish Statistics on Medicine&lt;/i&gt; (FSM), which includes all medications purchased in Finland.&lt;span&gt;&lt;sup&gt;8&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;For sales statistics, medications are listed according to the &lt;i&gt;Anatomical Therapeutic Chemical&lt;/i&gt; groups (R, Respiratory system).&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt; We report medication consumption for asthma and COPD (R03; inhaled (R03A-B), systemic (R03DC), and molecular targeted medications (R03DX05, R03DX08–10)), nasal preparations (R01), systemic antihistamines (R06), and medications for cough and cold (R05; such as expectorants (R05C) and cough suppressants (R05D)).&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Medication consumption was followed using the unit &lt;i&gt;Defined Daily Doses&lt;/i&gt; (DDD/1000 population/day) in the Finnish nationwide registries (FSM, SII). The results are presented as annual time series.&lt;/p&gt;&lt;p&gt;Cost analysis was made for asthma and severe COPD comparably to our previous work (data 1996–2018).&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; This included only those individuals entitled to special reimbursed medication (same criterions 1996–2018).&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;The population of Finland was accessed from &lt;i&gt;Statistics Finland,&lt;/i&gt; and it increased from 5.0 million in 1990 to 5.5 million in 2021 (+10%).&lt;/p&gt;&lt;p&gt;Respiratory medications consumption increased from 98 in 1996 to 200 DDD/1000/","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional, sex, and age inequities in asthma hospital admissions in Spain and Portugal","authors":"Rafael José Vieira,&nbsp;Ana Margarida Pereira,&nbsp;Luís Taborda-Barata,&nbsp;Frederico S. Regateiro,&nbsp;Manuel Marques-Cruz,&nbsp;Carlos Robalo Cordeiro,&nbsp;Cláudia Chaves Loureiro,&nbsp;Ignacio J. Dávila,&nbsp;Jean Bousquet,&nbsp;João A. Fonseca,&nbsp;Bernardo Sousa-Pinto","doi":"10.1002/clt2.12349","DOIUrl":"10.1002/clt2.12349","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Asthma presents a significant health challenge, imposing a considerable burden on healthcare services. Discrepancies in asthma-related hospitalisations may reflect underlying health disparities. We aimed to analyse inequities in asthma hospital admissions in mainland Portugal and Spain, from a regional perspective and considering sex and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective study using data from the Spanish and Portuguese national hospitalisations databases. We calculated crude national and regional yearly hospitalisation rates according per Nomenclature of Territorial Units for Statistics region. Additionally, we calculated hospitalisation rates adjusted for asthma prevalence and the female-to-male ratio in asthma hospital admissions per age group, considering the female-to-male ratio in the overall population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2012 and 2016, there were 92,084 asthma hospital admissions in mainland Spain and 7717 in mainland Portugal. There was a trend for a higher-than-average rate of asthma-related hospitalisations in the Northern regions of both countries. Women had a hospitalisation rate that was 3.2 times higher than men. Age was associated with higher risk for asthma hospitalisation, with individuals aged 65 and older displaying a hospitalisation rate 4.5 times higher than those under 65. Additionally, while hospitalisations in women aged &lt;65 years were 2.3 times more likely than in men of the same age, hospitalisations in women aged ≥65 years were 3.5 times higher than in men aged ≥65 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests that marked regional inequities in asthma hospital admissions exist in Spain and Portugal. Additionally, women are particularly at risk of hospitalisation due to asthma, and such risk increases with age.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnic differences in depression and anxiety among adults with atopic eczema: Population-based matched cohort studies within UK primary care","authors":"Elizabeth I. Adesanya,&nbsp;Alasdair Henderson,&nbsp;Joseph F. Hayes,&nbsp;Alexandra Lewin,&nbsp;Rohini Mathur,&nbsp;Amy Mulick,&nbsp;Caroline Morton,&nbsp;Catherine Smith,&nbsp;Sinéad M. Langan,&nbsp;Kathryn E. Mansfield","doi":"10.1002/clt2.12348","DOIUrl":"10.1002/clt2.12348","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Evidence demonstrates that individuals with atopic eczema (eczema) have increased depression and anxiety; however, the role of ethnicity in these associations is poorly understood. We aimed to investigate whether associations between eczema and depression or anxiety differed between adults from white and minority ethnic groups in the UK.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used UK Clinical Practice Research Datalink GOLD to conduct matched cohort studies of adults (≥18 years) with ethnicity recorded in primary care electronic health records (April 2006-January 2020). We matched (age, sex, practice) adults with eczema to up to five adults without. We used stratified Cox regression with an interaction between eczema and ethnicity, to estimate hazard ratios (HRs) for associations between eczema and incident depression and anxiety in individuals from white ethnic groups and a pooled minority ethnic group (adults from Black, South Asian, Mixed and Other groups).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified separate cohorts for depression (215,073 with eczema matched to 646,539 without) and anxiety (242,598 with eczema matched to 774,113 without). After adjusting for matching variables and potential confounders (age, sex, practice, deprivation, calendar period), we found strong evidence (<i>p</i> &lt; 0.01) of ethnic differences in associations between eczema and depression (minority ethnic groups: HR = 1.33, 95% CI = 1.22,1.45; white ethnic groups: HR = 1.15, 95% CI = 1.12,1.17) and anxiety (minority ethnic groups: HR = 1.41, 95% CI = 1.28,1.55; white ethnic groups: HR = 1.17, 95% CI = 1.14,1.19).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Adults with eczema from minority ethnic groups appear to be at increased depression and anxiety risk compared with their white counterparts. Culturally adapted mental health promotion and prevention strategies should be considered in individuals with eczema from minority ethnic groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey study on antibiotic prescription practices for acute asthma exacerbations: An European academy of allergy and clinical immunology task force report","authors":"Anne-Lotte Redel,&nbsp;Wojciech Feleszko,&nbsp;Alessandra Arcolaci,&nbsp;Francesca Cefaloni,&nbsp;Marina Atanaskovic-Markovic,&nbsp;Gert-Jan Braunstahl,&nbsp;Cristina Boccabella,&nbsp;Matteo Bonini,&nbsp;Aspasia Karavelia,&nbsp;Eefje Louwers,&nbsp;Norbert Mülleneisen,&nbsp;Liam O'Mahony,&nbsp;Laura Pini,&nbsp;Anna Rapiejko,&nbsp;Esmeralda Shehu,&nbsp;Milena Sokolowska,&nbsp;Eva Untersmayr,&nbsp;Gerdien Tramper-Stranders,&nbsp;EAACI Task Force on Conscious and Rational use of Antibiotics in Allergic Diseases","doi":"10.1002/clt2.12345","DOIUrl":"10.1002/clt2.12345","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Guidelines recommend treating asthma exacerbations (AAEs) with bronchodilators combined with inhaled and/or systemic corticosteroids. Indications for antibiotic prescriptions for AAEs are usually not incorporated although the literature shows antibiotics are frequently prescribed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate the antibiotic prescription rates in AAEs and explore the possible determining factors of those practices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A digital survey was created to determine the antibiotic prescription rates in AAEs and the influencing factors for the prescription practices. The survey was distributed among European academy of allergy and clinical immunology (EAACI) members by mass emailing and through regional/national societies in the Netherlands, Italy, Greece, and Poland. Furthermore, we retrieved local antibiotic prescription rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 252 participants completed the survey. Respondents stated that there is a lack of guidelines to prescribe antibiotics in AAEs. The median antibiotic prescription rate in this study was 19% [IQR: 0%–40%] and was significantly different between 4 professions: paediatrics 0% [IQR: 0%–37%], pulmonologists 25% [IQR: 10%–50%], general practitioners 25% [IQR: 0%–50%], and allergologists 17% [IQR: 0%–33%]) (<i>p</i> = 0.046). Additional diagnostic tests were performed in 71.4% of patients before prescription and the most common antibiotic classes prescribed were macrolides (46.0%) and penicillin (42.9%). Important clinical factors for health care providers to prescribe antibiotics were colorised/purulent sputum, abnormal lung sounds during auscultation, fever, and presence of comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In 19% of patients with AAEs, antibiotics were prescribed in various classes with a broad range among different subspecialities. This study stresses the urgency to compose evidence-based guidelines to aim for more rational antibiotic prescriptions for AAE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early exposure to maternal stress and risk for atopic dermatitis in children: A systematic review and meta-analysis","authors":"Yuan Ai,&nbsp;Jichong Huang,&nbsp;Ting Ting Zhu","doi":"10.1002/clt2.12346","DOIUrl":"10.1002/clt2.12346","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The incidence of atopic dermatitis (AD) in children is increasing. Early exposure to stress factors may be associated with the AD development. This study aimed to summarize studies that reported an association between stress exposure and AD development in later life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and findings</h3>\u0000 \u0000 <p>A comprehensive literature search was performed using online databases (PubMed, EMBASE, PsycINFO, and Web of Science) for articles published up to May 1, 2023. Eligible studies were screened and selected based on the inclusion criteria. We incorporated cohort or case-control studies published in English which explored the relationship between stress experienced by parents or children and AD. The pooled odds ratio (OR) was calculated according to the type of stress using a random-effects model. Twenty-two studies were included. AD was related to maternal distress (OR 1.29, 95% Confidence Interval [CI]: 1.13–1.47), maternal anxiety (OR 1.31, 95% CI: 1.18–1.46), and negative life events (OR 2.00, 95% CI: 1.46–2.76). Maternal depression during pregnancy was associated with AD (OR 1.21, 95% CI: 1.09–1.33), whereas no significant association was found for postpartum depression. Research on stress experienced by paternal or children is scare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Early maternal stress may potentially elevate the risk of AD in their offspring. Importantly, rigorously designed studies are required to corroborate the link between maternal stress and AD in children. These studies should aim to gather insights about the impact of stress during specific trimesters of pregnancy, postnatal stress, and paternal stress, and to identify potential prevention strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed neutrophil shedding of CD62L in patients with chronic rhinosinusitis with nasal polyps and asthma: Implications for Staphylococcus aureus colonization and corticosteroid treatment","authors":"Maryam Jafari,&nbsp;Eduardo I. Cardenas,&nbsp;Sandra Ekstedt,&nbsp;Julia Arebro,&nbsp;Marianne Petro,&nbsp;Agnetha Karlsson,&nbsp;Eric Hjalmarsson,&nbsp;Daniel Arnarson,&nbsp;Monika Ezerskyte,&nbsp;Susanna Kumlien Georén,&nbsp;Lars Olaf Cardell","doi":"10.1002/clt2.12347","DOIUrl":"10.1002/clt2.12347","url":null,"abstract":"&lt;p&gt;Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the sinonasal mucosa that is often accompanied by local &lt;i&gt;Staphylococcus aureus&lt;/i&gt; colonization,&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; as well as comorbid asthma.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Although both CRSwNP and asthma are associated with a type 2 inflammatory profile, a growing body of literature indicates that neutrophils can also contribute to the pathophysiology of these diseases. For instance, shedding of CD62L (L-selectin) is commonly used as a marker of neutrophil activation,&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; and we have previously shown that neutrophils isolated from nasal polyps of patients with CRSwNP are characterized by low CD62L and high CD16 (FcγRIII) surface expression.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Moreover, we have also shown that inhaled allergen provocation results in CD62L shedding in circulating neutrophils from patients with allergic asthma.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; However, the response of circulating neutrophils to bacterial stimuli has not been characterized in patients with both CRSwNP and asthma in comparison with healthy controls.&lt;/p&gt;&lt;p&gt;In this study, we isolated blood neutrophils from 19 patients with CRSwNP and comorbid asthma, as well as 20 healthy controls, and assessed their phenotype at baseline and in response to &lt;i&gt;S. aureus&lt;/i&gt; enterotoxin A (SEA). A detailed description of the methods used can be found in Supporting Information S1, and the main characteristics of all study participants are summarized in Table 1. Freshly isolated blood neutrophils from healthy controls and patients with CRSwNP and comorbid asthma had a similar baseline surface expression of CD62L and CD16 (Figure S1), which confirms our previous findings in other cohorts of patients with CRSwNP or asthma.&lt;span&gt;&lt;sup&gt;4, 5&lt;/sup&gt;&lt;/span&gt; Notably, most patients included in our study received inhaled corticosteroids (ICS) (Table S1), and a previous study suggests that ICS can impact the baseline surface expression of CD62L in unstimulated neutrophils.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; Nevertheless, the study by Pasternak et al. also determined that ICS have no impact on CD62L expression when administered via active inhaler, and our patients received ICS exclusively via active inhaler.&lt;/p&gt;&lt;p&gt;Interestingly, in vitro stimulation with SEA for 2 h resulted in a marked decrease in CD62L surface expression in neutrophils from healthy controls, but not in neutrophils from patients with CRSwNP and asthma (Figure 1A,B). No significant changes in the neutrophil activation markers CD11b, CD66b or IL-1β were detected in either study group at this timepoint (Figure S2). Nevertheless, neutrophils from both study groups had a similar decrease in CD62L surface expression 4 h post-stimulation (Figure 1C,D), as well as a similar increase in CD66b surface expression at this timepoint (Figure S3A–C). In addition, neutrophils from healthy controls had an increase in CD11b and IL-1β expression 4 h post-stimulation, while ne","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions for asthma prevention and management across the life course: Umbrella review","authors":"Xunliang Tong,&nbsp;Xinyue Zhang,&nbsp;Mengyuan Wang,&nbsp;Zijun Wang,&nbsp;Fawu Dong,&nbsp;Enying Gong,&nbsp;Torsten Zuberbier,&nbsp;Yanming Li","doi":"10.1002/clt2.12344","DOIUrl":"10.1002/clt2.12344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The impact of non-pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence regarding the effectiveness of various NPIs throughout the life course.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic search and screening of reviews that examined the effectiveness of various NPIs on asthma prevention and control in the Cochrane Library, PubMed, Embase, and Ovid databases. Data extraction was performed by considering the type of NPIs and the life course stages of the target population. Recommendations were provided by considering the quality of review assessed using the AMSTAR2 tool and the consistency of findings across reviews.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 145 reviews and mapped the evidence on the impact of 25 subtypes of NPIs on asthma prevention and control based on five stages of life course. Reviews indicated a shift of focus and various impacts of major NPIs on asthma prevention and control across life courses, while a few types of NPIs, such as physical exercise, appeared to be beneficial in children, adolescents and adults. Consistent and high-level evidence was observed only for psychological intervention on asthma control and quality of life among adults and older adults. Potential benefit with high-level evidence was reported on certain NPIs, such as vitamin D in reducing risk of developing asthma in offsprings in the prenatal stage, digital health interventions in improving asthma control from childhood to older adulthood, and breathing exercise in improving quality of life, asthma-related symptoms and lung function in adulthood and older adulthood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study emphasizes the significance of delivering NPIs to improve asthma prevention and management and highlights the heterogeneity regarding the impact of NPIs across life courses. High-quality research is urgently needed to further strengthen the evidence base of NPIs and tailored interventions should be considered in guideline development.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 3","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}