Clinical and Translational Allergy最新文献

{"title":"Maternal Dietary Inflammatory Status and Serum Neopterin During Pregnancy: Influence on Infantile Atopic Eczema in the Offspring","authors":"Sarah El-Heis,&nbsp;Sarah R. Crozier,&nbsp;Evelyn X. Loo,&nbsp;Elizabeth H. Tham,&nbsp;Nicholas C. Harvey,&nbsp;Hazel M. Inskip,&nbsp;Southampton Women's Survey Study Group,&nbsp;Keith M. Godfrey","doi":"10.1002/clt2.70080","DOIUrl":"https://doi.org/10.1002/clt2.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A protective influence of maternal inflammatory status on infantile atopic eczema risk has been proposed, but few studies have investigated these potential links. We examined the associations between energy-adjusted dietary inflammatory index (E-DII) scores indicative of an inflammatory dietary pattern, maternal serum neopterin levels, a biomarker elevated in Th1 immune activation, and infantile risk of atopic eczema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Within the UK Southampton Women's Survey, mothers' diets were recorded using questionnaires at preconception, early and late pregnancy and E-DII scores derived. 3006 deliveries of live born infants with no major congenital growth abnormalities who were assessed for atopic eczema at 6 or 12 months (ascertained using the UK Working Party Diagnostic Criteria [<i>n</i> = 2955 and 2871, respectively]). A sub-sample of 497 mothers had serum neopterin measured in late pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Unadjusted analyses showed that higher E-DII in preconception and late pregnancy was associated with a lower risk of eczema at ages 6 and 12 months. After adjusting for maternal BMI, age, parity, education, smoking during pregnancy, breastfeeding duration and sex, higher E-DII in late pregnancy was associated with reduced risks of eczema at age 6 and 12 months (OR 0.89 [95% CI 0.81, 0.99], <i>p</i> = 0.03 and OR 0.91 [0.82, 1.00], <i>p</i> = 0.05, respectively). Consistent with this, higher maternal serum neopterin was associated with a lower risk of eczema at ages 6 months (OR 0.72 [0.51, 1.01], <i>p</i> = 0.05) and 12 months (OR 0.71 [0.53, 0.96], <i>p</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings suggest that a pro-inflammatory maternal diet and an inflammatory maternal environment during pregnancy may protect the developing infant from Th2 driven inflammation and lower the risk of infantile atopic eczema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>NCT04715945</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Exercise Improves Symptomatic Dermographism","authors":"Ragıp Ertaş,&nbsp;Muhammed Burak Yücel,&nbsp;Murat Türk,&nbsp;Şule Ketenci Ertaş,&nbsp;Emek Kocatürk,&nbsp;Melba Muñoz","doi":"10.1002/clt2.70083","DOIUrl":"https://doi.org/10.1002/clt2.70083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Short-term exercise may reduce disease activity in symptomatic dermographism (SD), but its prevalence and short- and long-term effects remain unclear and understudied. This study aims to assess the impact of both short-term and regular long-term exercise programs on disease activity in patients with SD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a short-term exercise test to assess the disease activity and the critical friction threshold (CFT) using the FricTest before (SDE1) and 10 min after (SDE2) this test on 34 SD patients. Afterward, we asked the patients to carry on a 1-month regular long-term exercise program according to the World Health Organization's physical activity recommendations. At the end of this 1-month period, we performed the short-term exercise test using the FricTest before (SDE3) and 10 min after (SDE4) the exercise test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Before a 1-month regular exercise program, 32 of 34 patients (94.1%) showed a reduction in the critical friction threshold after the short-term exercise test (SDE1; 1.95 ± 0.88 vs. SDE2; 0.81 ± 0.86). After a 1-month regular exercise program, 29 of 34 patients (85%) showed a reduction in SD symptoms with short-term exercise test and the FricTest scores were significantly decreased (SDE3; 1.57 ± 0.80 vs. SDE4; 1.01 ± 0.83). After the 1-month regular exercise program, a statistically significant increase was seen in the patients’ UCT scores and quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings show that short-term exercise improves SD symptoms, while long-term regular exercise programs reduce disease symptoms and improve UCT scores and quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Onset Asthma, But Not Aeroallergen Sensitization, Is Associated With Lung Function Impairment in Young Adulthood—A Prospective Cohort Study","authors":"Joakim Bunne,&nbsp;Linnea Hedman,&nbsp;Anders Bjerg,&nbsp;Matthew Perzanowski,&nbsp;Thomas Platts-Mills,&nbsp;Eva Rönmark","doi":"10.1002/clt2.70084","DOIUrl":"https://doi.org/10.1002/clt2.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Aeroallergen sensitization is a major factor in asthma, and asthma is associated with impaired lung function. The independent association between sensitization and lung function is unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine factors associated with lung function in adolescence, with special interests in sensitization and asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All schoolchildren in grade one and two (median age 8) in two municipalities in Northern Sweden were invited to a questionnaire survey of allergic diseases and skin prick tests to aeroallergens. This was repeated at ages 12 and, at 19 years also including spirometry and <i>n</i> = 1495 participated at all three occasions. Associations between risk factors and FEV₁, FVC and FEV₁/FVC were analysed by linear regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Aeroallergen sensitization was not associated with lung function, irrespective of age at onset, type or degree of sensitization. Early-onset asthma, both persistent (B −0.35, 95% CI –0.60 to −0.09) and in remission (B −0.43, 95% CI –0.74 to −0.12) was associated with lower FEV₁. Persistent asthma was associated with lower FEV₁/FVC (B −0.81, 95% CI –1.07 to −0.55), and remission with lower FVC (B −0.37, 95% CI –0.67 to −0.70). No interaction between asthma and sensitization was found. Maternal smoking in pregnancy was associated with lower FEV₁/FVC. Underweight at age 19 years was associated with lower FEV₁ and FVC and overweight was associated with higher FEV₁ and FVC, but lower FEV₁/FVC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Aeroallergen sensitization was not independently associated with lung function. Early onset asthma was strongly associated with lung function impairments in young adulthood and in sensitized and non-sensitized individuals alike.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Roles Between Eotaxin 1 and Eotaxin 2 in Asthmatic Airways","authors":"Soyoon Sim,&nbsp;Eun-mi Yang,&nbsp;Yoo Seob Shin,&nbsp;Seon Beom Kim,&nbsp;Youngwoo Choi,&nbsp;Hae-Sim Park","doi":"10.1002/clt2.70077","DOIUrl":"https://doi.org/10.1002/clt2.70077","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Eotaxins (EOTs), primarily expressed in airway epithelial cells (AECs), act as chemoattractants for eosinophils in asthma pathogenesis. Recent studies have suggested that EOTs have additional functions beyond chemotaxis. However, the distinct roles of EOTs remain incompletely understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Serum EOT1, EOT2, myeloperoxidase (MPO), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels were evaluated by ELISA and serum eosinophil cationic protein (ECP) levels were measured by ImmunoCAP in 79 adult asthmatics. Clinical characteristics were analyzed by inflammatory phenotype, disease severity, and serum EOT1/EOT2 levels. The functions of EOTs were investigated in vitro and ex vivo. For in vivo, EOT1 and EOT2 were intranasally administered to ovalbumin/lipopolysaccharide-induced asthmatic mice (BALB/c). To assess neutralization effects, anti-EOT1 or anti-EOT2 antibodies were intranasally administered.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Serum EOT1 and EOT2 levels were higher in patients with severe asthma (SA) than in those with non-SA. Serum EOT1 levels were associated with increased blood/sputum eosinophil counts and serum ECP levels, but not significantly correlated with FEV₁ (%) values. In contrast, serum EOT2 levels are correlated with higher serum MPO, MMP-9, and TIMP-1 levels but lower FEV₁ (%). In asthmatic mice, EOT1 increased eosinophil counts and IL-5 production, whereas EOT2 induced CXCL1 and MMP-9 production, junctional dysfunction and epithelial-to-mesenchymal transition in the lungs, which were attenuated by neutralizing EOTs using each antibody.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EOT1 promotes T2/eosinophilic inflammation, whereas EOT2 accelerates airway remodeling and lung function decline by activating neutrophils, providing a new insight into the distinct roles of EOTs in the pathogenesis of SA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a role of genetics in acute and chronic urticaria—A systematic review and meta-analysis","authors":"George N. Konstantinou,&nbsp;Indrashis Podder,&nbsp;Arunima Dhabal","doi":"10.1002/clt2.70072","DOIUrl":"https://doi.org/10.1002/clt2.70072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic urticaria (CU) is a heterogeneous skin disorder whose genetic drivers are incompletely defined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To systematically review and meta-analyse genetic and epigenetic factors that influence susceptibility and treatment response in acute and CU.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, PubMed, Scopus and Web of Science were searched from inception to 31 July 2024. Original human studies reporting genetic or epigenetic associations with any urticaria subtype were eligible. Random-effects meta-analyses were undertaken when at least three comparable datasets were available.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-one studies met the inclusion criteria. Associations were confirmed for HLA-B44 (pooled Odds Ratio 8.15, 95% Confidence Interval 1.61–41.29; <i>I</i>² = 86%) and vitamin-D-receptor polymorphisms FokI, TaqI and BsmI, each conferring a 1.5- to 2.1-fold increased risk. Variants in CRTH2, FcεR1α and C-reactive protein predicted antihistamine response, while FCER1G, IL-6, prostaglandin-endoperoxide synthase 2, CCL2 and TNF-pathway genes were over-expressed in lesional tissue, supporting an immune-mediated pathogenesis. Evidence for non-CSU subtypes, acute urticaria, epigenetic modifications and gene–environment interactions was limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CU displays an autoimmune-like genetic signature. HLA-B44 and vitamin D receptor variants are susceptibility markers, and pharmacogenetic signals enable personalised therapy. Longitudinal studies integrating environmental exposures and functional genomics are needed to translate these insights into precision care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of chronic urticaria profile as a key predictor of alexithymia: A cross-sectional study","authors":"Ivan Cherrez Ojeda,&nbsp;Simon Francis Thomsen,&nbsp;Ana M. Gimenez-Arnau,&nbsp;Jennifer Astrup Sørensen,&nbsp;Hermenio Lima,&nbsp;Kiran Godse,&nbsp;Carole Guillet,&nbsp;Luis Escalante,&nbsp;Astrid Maldonado,&nbsp;Gonzalo Federico Chorzepa,&nbsp;Blanca Morfin-Maciel,&nbsp;Jose Ignacio Larco Sousa,&nbsp;Erika de Arruda-Chaves,&nbsp;Abhishek De,&nbsp;Daria Fomina,&nbsp;Anant Patil,&nbsp;Roberta Jardim Criado,&nbsp;Luis Felipe Ensina,&nbsp;Solange O. R. Valle,&nbsp;Rosana Câmara Agondi,&nbsp;Herberto Chong Neto,&nbsp;Nelson Rosario,&nbsp;German Dario Ramon,&nbsp;Marco Faytong-Haro,&nbsp;Isabel Ogueta,&nbsp;Ivan Tinoco Moran,&nbsp;Jennifer Donnelly,&nbsp;Emek Kocatürk,&nbsp;Anna Zalewska-Janowska,&nbsp;Karla Robles-Velasco","doi":"10.1002/clt2.70075","DOIUrl":"https://doi.org/10.1002/clt2.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The relationship between chronic urticaria (CU) and alexithymia, a cognitive-affective impairment characterized by difficulty in identifying and expressing emotions, is complex and underexplored. This study aimed to identify predictors of alexithymia in CU patients by focusing on the impact of coexisting mental illnesses and antihistamine use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An online survey was distributed to specialized allergy and dermatology centers from 2021 to 2022. The survey included the TAS-20, UAS-7, UCT, CU-Q2oL, and demographic information. Participants were 18–80 years old, diagnosed with CU, and had no prior diagnosis of alexithymia. The final analysis included a total of 332 respondents from various countries. Regression models were used to investigate the relationship between clinical and demographic factors of patients with CU as key predictors of alexithymia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among CU patients, the main predictors of having alexithymia were: presenting mental (OR = 2.406, <i>p</i> &lt; 0.05) and cardiovascular comorbidities (OR = 2.085, <i>p</i> &lt; 0.05), active urticaria (as opposed to being urticaria-free), OR = 1.989, <i>p</i> &lt; 0.05, severe impact on quality of life (OR = 1.973, <i>p</i> &lt; 0.01), and the use of oral first-generation antihistamines (OR = 2.340, <i>p</i> &lt; 0.05). The duration of chronic urticaria diagnosis and other types of treatments (sg-AH use, omalizumab use, and corticosteroid use) do not appear to be significantly associated with alexithymia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alexithymia is closely linked to clinical and demographic variables among patients with CU. These findings suggest that comprehensive management of CU should include psychological assessment and support, especially for patients with alexithymia and those using fg-AH. Reducing the reliance on fg-AH and addressing mental health issues may improve outcomes for these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C1 inhibitor deficient hereditary angioedema is related to endothelial dysfunction in young adult and middle-aged patients","authors":"Gokce Gul Atay Sensoy,&nbsp;Derya Baykız,&nbsp;İlkim Deniz Toprak,&nbsp;Deniz Eyice Karabacak,&nbsp;Erdem Bektas,&nbsp;Derya Unal,&nbsp;Aslı Gelincik,&nbsp;Semra Demir","doi":"10.1002/clt2.70076","DOIUrl":"https://doi.org/10.1002/clt2.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hereditary angioedema (HAE) is a rare, autosomal dominantly inherited disease characterised by mucocutaneous oedema attacks. Vasoactive mediators and the endothelium play an important role in the pathogenesis of HAE. We aimed to evaluate the endothelial dysfunction in HAE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 35 C1 inhibitor deficient (C1-INH) HAE patients aged 18–50 years old without any risk factor that could cause endothelial dysfunction, and 25 sex- and age-matched healthy controls (HCs). Bilateral carotid intima-media thickness (CIMT), flow-mediated dilation (FMD) measurements, and transthoracic echocardiography (ECHO) imaging were performed. Demographic and clinical features of the patients were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The percentage of FMD (FMD [%]) in C1-INH HAE patients was significantly lower than in the HCs (<i>p</i> &lt; 0.001). There was no significant difference in the CIMT between C1-INH HAE patients and HCs. In addition, the findings of the ECHO were similar between the groups. C4 and C1 INH levels at diagnosis, gender, age, disease severity, presence of long-term prophylaxis treatment and attack frequency were not associated with FMD (%), whereas disease duration was correlated with lower FMD (%) (<i>r</i> = −0.480, <i>p</i> = 0.003).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The present study indicated the presence of structural endothelial dysfunction in C1-INH HAE in the absence of atherosclerosis. Moreover, the study revealed that endothelial dysfunction was associated with disease duration, irrespective of disease severity. Further studies are required in order to assess mortality and morbidity due to endothelial dysfunction in C1-INH HAE and to determine the molecular mechanisms underlying endothelial dysfunction in C1-INH HAE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LP-003, a novel high-affinity anti-IgE antibody for inadequately controlled seasonal allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled phase 2 clinical trial","authors":"Kai Guan,&nbsp;Shuang Liu,&nbsp;Yan Feng,&nbsp;Lisha Li,&nbsp;Xiaoming Zhu,&nbsp;Nai-Chau-Sun Bill,&nbsp;Haili Ma,&nbsp;Jie Yang,&nbsp;Cuicui Han,&nbsp;Heng Liu,&nbsp;Qingyu Wei,&nbsp;Haiyun Shi,&nbsp;Xueyan Wang","doi":"10.1002/clt2.70074","DOIUrl":"https://doi.org/10.1002/clt2.70074","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anti-IgE therapy can serve as an option for inadequately controlled seasonal allergic rhinitis (SAR) patients. LP-003, a novel anti-IgE antibody, is being tested as an add-on treatment for SAR. This trial aimed to evaluate whether LP-003 is effective and safe for SAR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This placebo-controlled double-blind phase 2 randomized clinical trial was conducted in 17 hospitals in China. SAR patients whose symptoms were inadequately controlled despite first-line treatment (nasal corticosteroids with or without oral antihistamine) in the previous two seasons were enrolled between July 6, 2023 and August 7, 2023. Participants were randomized in a ratio of 2:4:3 to receive subcutaneous injections of 100 mg LP-003, 200 mg LP-003 or placebo every 4 weeks for 2 doses. All patients received fluticasone propionate as standard-of-care (SoC). The main outcome was the mean total nasal symptom score (TNSS) during the peak pollen period (PPP). Secondary endpoints included a series of symptom and medication scores, quality of life assessments during PPP and pollen period (PP), immunogenicity and safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 180 participants were randomly assigned. The LP-003 + SoC treatment achieved a significantly lower TNSS compared with placebo + SoC (3.31 vs. 4.06, intergroup difference = −0.74, <i>p</i> = 0.0464). For key secondary outcomes, the LP-003 group also achieved significantly lower daily nasal symptom and rescue medication use scores (3.54 vs. 4.42, intergroup difference = −0.88, <i>p</i> = 0.0352), and daily ocular symptom and rescue medication use scores (1.66 vs. 2.19, intergroup difference = −0.54, <i>p</i> = 0.0245) compared to the placebo group. The suppression of free IgE was prevalent and persistent. There was no statistically significant difference in adverse events and severe adverse events between LP-003 and placebo groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings support LP-003 as a promising add-on option to the SoC for patients with moderate to severe SAR. Fixed dosage regimen and extensive suppression of free-IgE render it a cutting-edge advantage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported accidental allergic reactions among patients with challenge-verified food allergy","authors":"Sebastian Vigand Svendsen,&nbsp;Annemarie Schaeffer Senders,&nbsp;Athamaica Ruiz Oropeza,&nbsp;Annmarie Lassen,&nbsp;Carsten Bindslev-Jensen,&nbsp;Charlotte G. Mortz","doi":"10.1002/clt2.70067","DOIUrl":"https://doi.org/10.1002/clt2.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Food allergy affects up to 6% of the population and emergency department visits due to accidental food-allergic reactions are increasing. This study evaluated accidental allergic reactions outside the hospital and the number of hospitalizations in food allergic patients as well as the pattern before and after the diagnosis of food allergy by oral food challenge (OFC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An electronic questionnaire concerning accidental allergic reactions was sent to 785 patients with challenge verified peanuts, hazelnuts, cow's milk and/or hen's egg allergies at the Allergy Centre, Odense University Hospital, Denmark.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 51% (402/785) responded. Among the 357 who reported at least one accidental allergic reaction, 51.5% (184/357) reported a total of six or less reactions, whereas 22.4% (80/357) had experienced a total of ≥21 reactions. Skin symptoms were commonly reported by children/adolescents (<i>n</i> = 277), whereas symptoms from all other organ systems were more frequently reported by adults (<i>n</i> = 80). In total, 61.6% (220/357) experienced at least one accidental allergic reaction, requiring immediate medical attention, which decreased from 77.3% (170/220) before to 55% (121/220) after establishment of the food allergy diagnosis by OFC. A concomitant proportional increase in the number of hospitalizations was identified (63.5% (108/170) to 72.7% (88/121)). Limitations: We had no exact data on the timing of the accidental allergic reactions for the individual allergens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Accidental food-allergic reactions are common and often severe. After the diagnostic OFC, the number of patients with reactions decreased, and the proportion of hospitalizations increased, indicating improved disease and healthcare management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 gene expression signature in severe asthma associates with more advanced airway remodeling","authors":"Bogdan Jakiela,&nbsp;Karolina Górka,&nbsp;Iwona Gross-Sondej,&nbsp;Sławomir Mikrut,&nbsp;Krzysztof Okoń,&nbsp;Piotr Sadowski,&nbsp;Anna Andrychiewicz,&nbsp;Hanna Plutecka,&nbsp;Tomasz Stachura,&nbsp;Grażyna Bochenek,&nbsp;Stanisława Bazan-Socha,&nbsp;Krzysztof Sładek,&nbsp;Jerzy Soja","doi":"10.1002/clt2.70060","DOIUrl":"https://doi.org/10.1002/clt2.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Asthma is a heterogeneous disease with various inflammatory subtypes, including the type-2 (T2) endotype associated with airway eosinophilia. Severe asthma is linked to reduced ventilatory function due to airway structural changes. This study compared the extent of airway remodeling in different immunological endotypes of asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Severe asthma patients (<i>n</i> = 30) were stratified based on bronchial expression of T2 (e.g., <i>CST1</i>) and T3 (e.g., <i>IL1</i>7A) immunity genes as T2-high, T3-high, or low-inflammatory. We analyzed airway wall thickness using endobronchial ultrasound (EBUS), bronchial biopsy morphometry, and mRNA expression of remodeling genes. Bronchial epithelial cell cultures were used to assess cytokine responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>T2-high asthma patients showed lower predicted FEV1 (59 vs. 74 % in low-inflammatory variant, <i>p</i> = 0.049) and increased submucosa layer (L2) in EBUS (0.203 vs. 0.189 mm, <i>p</i> = 0.018). T2-high asthma patients also had increased airway smooth muscle (ASM) mass (∼2-fold, <i>p</i> = 0.018) and marginally thicker reticular basement membrane. T3-high asthma showed only a trend toward thicker L2 (<i>p</i> = 0.055). Only patients with an eosinophilic signature in endobronchial biopsy demonstrated increased expression of remodeling genes, including <i>TGFB1</i>. A profibrotic profile was also induced in bronchial epithelium stimulated in vitro with IL-13.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These data suggest that T2-signature in severe asthma is associated with increased ASM mass and more pronounced airway obstruction. Overexpression of remodeling genes primarily occurred in patients with signs of eosinophilic infiltration in the bronchial mucosa, suggesting that remodeling may progress with uncontrolled airway inflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}