Clinical and Translational Allergy最新文献

{"title":"Bifidobacterium animalis subsp. lactis A6 alleviates perennial allergic rhinitis in adults by inhibiting serum total IgE and IL-13: A randomized, double-blind, placebo-controlled trial","authors":"Langrun Wang,&nbsp;Shiwen Zhou,&nbsp;Huiyu Chen,&nbsp;Chao Zhang,&nbsp;Meiwen Sun,&nbsp;Qi Zhang,&nbsp;Yinghua Liu,&nbsp;Shaoqi Shi,&nbsp;Shaoyang Ge,&nbsp;Juan Chen,&nbsp;Yanling Hao,&nbsp;Yong Zhang,&nbsp;Bing Fang,&nbsp;Jingjing He,&nbsp;Ran Wang","doi":"10.1002/clt2.70064","DOIUrl":"https://doi.org/10.1002/clt2.70064","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The evidence regarding the efficacy of probiotics in improving allergic rhinitis (AR) remains inconsistent. This study aimed to evaluate the potential effects of <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> A6 (A6) on perennial AR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A randomized, double-blind, placebo-controlled trial was conducted involving 70 adults with perennial AR receiving either probiotic (A6, 5 × 10¹⁰ CFU/sachet per day) or placebo intervention for 8 weeks. Nasal symptoms and quality of life (QoL) were recorded using total nasal symptom scores (TNSS) and the rhinitis quality of life questionnaire (RQLQ). Blood eosinophil count, total immunoglobulin E (IgE), allergen-specific IgE, and immunological parameters were also assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 8 weeks of intervention, the probiotic group showed a statistically significant greater reduction in TNSS total score compared with the placebo group [−3.11 (3.53) vs. −1.29 (3.34), <i>p</i> = 0.029, Cohen's <i>d</i> = 0.68]. Similar results were noted for serum total IgE and interleukin-13 (IL-13). Comparable findings were seen for RQLQ score only at week 4 but not at week 8.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In conclusion, A6 could statistically significantly alleviate rhinitis symptoms and improve QoL in adults with perennial AR. The effect size, as measured by Cohen's <i>d</i>, suggests that A6 may provide clinically meaningful benefits for AR patients to a certain degree.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Trial Registration</h3>\u0000 \u0000 <p>Chictr.org.cn Identifier no. ChiCTR2200064158.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations with food allergy-related psychological distress in a global sample of adults, children and caregivers","authors":"S. E. M. Purser,&nbsp;C. J. Jones,&nbsp;J. L. P. Protudjer,&nbsp;L. J. Herbert,&nbsp;C. Screti,&nbsp;C. Roleston,&nbsp;E. Mattacola,&nbsp;H. A. Brough,&nbsp;C. Warren,&nbsp;L. Polloni,&nbsp;A. F. Santos,&nbsp;R. Gupta,&nbsp;M. J. Marchisotto,&nbsp;R. C. Knibb","doi":"10.1002/clt2.70071","DOIUrl":"https://doi.org/10.1002/clt2.70071","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Food allergy (FA) impacts health-related quality of life and mental health. Understanding what variables are associated with psychological distress can help healthcare providers direct patients to appropriate support. As part of the study, Global Access to Psychological Services (GAPS) for FA and associations with FA-related psychological distress were explored in adults with FA and caregivers of children with FA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants completed online surveys in seven languages. Participants reported the types of FA-related distress they or their child experienced, along with demographic and FA-related information. Associations with distress were analysed using regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>N</i> <i>=</i> 1329 adults with FA and <i>N</i> = 1373 caregivers of children with FA from 27 countries participated. Of the 21 different types of distress selected, anxiety about an allergic reaction was the most common (62.5% adults; 72.6% caregivers). Females reported significantly more types of distress than males (<i>p</i> &lt; 0.001). There were significant differences between countries (all <i>p</i> &lt; 0.05-0.001); participants in Australia, Brazil, Canada, and the United Kingdom consistently reported more types of distress than European countries or the United States. In regression models, country of residence, number of FAs, and symptoms were significantly associated with distress. Additional associations included adrenaline autoinjector (AAI) prescription, being female, anaphylaxis and comorbidities in adults; in caregivers having a younger child, longer time elapsed since FA diagnosis, being female, AAI prescription and anaphylaxis; and in children being older and living longer with FA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>FA-related distress is experienced differently across countries. Understanding associations with types of distress can help direct healthcare services and psychological support to where it is needed most.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of CT-P39, an omalizumab biosimilar, in chronic spontaneous urticaria: 16-week follow-up study","authors":"Clive Grattan,&nbsp;Yevgeniya Dytyatkovska,&nbsp;Michał Springer,&nbsp;Maria Ratkova,&nbsp;Borislava Krusheva,&nbsp;Izabella Krupa-Borek,&nbsp;Grazyna Pulka,&nbsp;Marta Chełmińska,&nbsp;Adam Reich,&nbsp;Sunghyun Kim,&nbsp;Yunju Bae,&nbsp;Suyoung Kim,&nbsp;Sewon Lee,&nbsp;Eunjin An,&nbsp;Jeong Eun Park,&nbsp;Jieun Ka,&nbsp;Jongho Kim,&nbsp;Sarbjit S. Saini","doi":"10.1002/clt2.70069","DOIUrl":"https://doi.org/10.1002/clt2.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A double-blind, randomized Phase 3 study (NCT04426890) confirmed that CT-P39 and European Union-approved reference omalizumab (ref-OMA) were comparable in terms of efficacy, quality of life (QoL), pharmacokinetics (PK), pharmacodynamics (PD), safety, and immunogenicity up to week 24. Here, we report results from the 16-week follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included two 12-week treatment periods (TPs) and a 16-week off-treatment follow-up period. In TP1, 619 patients with chronic spontaneous urticaria (CSU) were randomized to CT-P39 300 mg, ref-OMA 300 mg, CT-P39 150 mg, or ref-OMA 150 mg. A total of 579 patients continued into TP2, in which patients treated with ref-OMA 300 mg were rerandomized to CT-P39 300 mg or to continue on ref-OMA 300 mg; patients initially randomized to CT-P39 300 mg continued this regimen; and patients initially randomized to CT-P39 or ref-OMA 150 mg increased their dose to 300 mg. Efficacy, PK, PD, QoL, safety, and immunogenicity were assessed during the follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Improvements in efficacy outcomes observed in the TPs gradually decreased during the follow-up period, but did not return to baseline values. Omalizumab serum concentrations that had increased during treatment subsequently decreased during the follow-up period. After completing treatment at week 24, total and free immunoglobulin E levels returned toward baseline levels. No clinically meaningful differences in QoL, safety, or immunogenicity outcomes were observed across the treatment groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Follow-up results support the biosimilarity of CT-P39 and ref-OMA in terms of efficacy, PK, PD, QoL, safety, and immunogenicity in patients with CSU.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in type 2 and non-type 2 endotypes in chronic rhinosinusitis with nasal polyps: A prospective trial","authors":"Stijn Bogaert,&nbsp;Elisabeth Rheindorf,&nbsp;Stefan Dazert,&nbsp;Stefan Volkenstein,&nbsp;Lisa Knipps,&nbsp;Jonas Jae-Hyun Park,&nbsp;Oliver Pfaar","doi":"10.1002/clt2.70070","DOIUrl":"https://doi.org/10.1002/clt2.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In current clinical practice, primary diffuse chronic rhinosinusitis with nasal polyps (CRSwNP) is classified into two endotypes: type 2 and non-type 2. Previous studies on sinonasal health-related quality of life (HRQoL) in CRS have primarily focused on differences between phenotypes. This study aimed to compare HRQoL between the two endotypes in patients with CRSwNP.</p>\u0000 \u0000 <p>The type 2 endotype had a higher median nasal polyp score (NPS) than non-types (4 and 2, respectively), but this difference did not reach significance. Loss of smell was associated with NPS, and facial pain/pressure was inversely correlated with age. Age was significantly associated with loss of smell, but only in non-type 2 CRSwNP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a prospective, monocentric study conducted between 2018 and 2023 on CRSwNP patients referred for surgery. Health-related quality of life was assessed using the German standardized SNOT-20 questionnaire. Type 2 was defined according to the updated EPOS/EUFOREA 2023 criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 122 patients with CRSwNP were included, 113 (92.6%) of whom were classified as type 2. Type 2 was associated with a significantly worse SNOT-20 German Adapted Version score. Two of the four cardinal symptoms of CRS—loss of smell and rhinorrhea—were significantly more severe and prevalent in the type 2 endotype, with loss of smell being very specific. The most prevalent symptom in both endotypes was nasal obstruction, with no difference between both endotypes.</p>\u0000 \u0000 <p>The type 2 endotype had a higher median nasal polyp score (NPS) than non-types (4 and 2, respectively), but this difference did not reach significance. Loss of smell was associated with NPS, and facial pain/pressure was inversely correlated with age. Age was significantly associated with loss of smell, but only in non-type 2 CRSwNP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Type 2 CRSwNP has a more severe impact on HRQoL compared with non-type 2 CRSwNP. Hyposmia, rhinorrhea, and potentially NPS may offer endotypic and pathophysiological insights.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of asthma in individuals with eosinophilic esophagitis: Population-based cohort study with sibling analyses","authors":"Niki Mitselou,&nbsp;Amiko Uchida,&nbsp;Bjorn Roelstraete,&nbsp;Erik Melén,&nbsp;John J. Garber,&nbsp;Jonas F. Ludvigsson","doi":"10.1002/clt2.70068","DOIUrl":"https://doi.org/10.1002/clt2.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>There are limited data on the relationship between eosinophilic esophagitis (EoE) and asthma. We aimed to assess the risk of asthma in EoE patients compared with matched controls and siblings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Through the ESPRESSO study, a Swedish nationwide population-based histopathology cohort, we identified EoE patients diagnosed between 1989 and 2017 (<i>n</i> = 1146) and up to 5 age- and sex-matched controls (<i>n</i> = 5022). Cox regression generated hazard ratios (HRs) for developing asthma. We compared EoE patients with sibling controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age at EoE diagnosis was 42 years. During a median follow-up of 3.8 years, 140 EoE patients (28.1/1000 person-years) and 174 controls (7.2/1000 person-years) developed asthma (HR = 3.96; 95% confidence interval [CI] = 3.16–4.96, <i>p</i> &lt; 0.001). An increased risk of asthma was seen in the first 10 years after EoE diagnosis but not thereafter. EoE patients diagnosed in childhood or young adulthood were at a particularly high risk of asthma (HR = 4.74; 95% CI = 2.93–7.67, <i>p</i> &lt; 0.001 and HR = 5.84; 95% CI = 3.68–9.29, <i>p</i> &lt; 0.001, respectively). Compared with their non-EoE siblings, EoE patients were at a 5-fold increased risk of asthma (HR = 4.97; 95% CI = 3.13–7.92, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EoE patients are at an increased risk of asthma compared with the general population, which is unlikely to be entirely explained through unmeasured intrafamilial factors given that the positive association remained in sibling analyses. Physicians caring for EoE should have a high awareness of concomitant asthma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between telomere length and atopic dermatitis among school-age children","authors":"Hsin-Yi Huang,&nbsp;Kun-Hua Sheen,&nbsp;Chi-Yen Hung,&nbsp;Ju Chang-Chien,&nbsp;Shih-Ling Wang,&nbsp;Chia-Hua Ho,&nbsp;Hui-Ju Tsai,&nbsp;Tsung-Chieh Yao","doi":"10.1002/clt2.70066","DOIUrl":"https://doi.org/10.1002/clt2.70066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atopic dermatitis is a common chronic skin disease in children. Whether telomere length is associated with atopic dermatitis remains unclear. This population-based case-control study aimed to investigate the association between telomere length and atopic dermatitis in school-age children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this cross-sectional analysis, we included 1084 singleton term-born children (608 males; mean age 6.4 years) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren cohort. Telomere length was measured using quantitative real-time polymerase chain reaction, log-transformed and was analyzed in quartiles. The main outcome was atopic dermatitis defined as having physician-diagnosed atopic dermatitis and the presence of atopic dermatitis in the last 12 months. Regression analyses were used to assess the relationship between telomere length and atopic dermatitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Telomere length was significantly inversely associated with childhood atopic dermatitis after adjusting for child's age, sex, overweight or obesity, birth season, childhood allergic diseases, environmental tobacco smoke, parental history of allergic diseases, parental educational level, and breastfeeding status (<i>p</i>__trend = 0.01). Specifically, when telomere length was classified into quartiles, children in the shortest (fourth) telomere length quartile had a 1.88-fold higher probability of atopic dermatitis compared to those in the longest (first) quartile (95% confidence interval: 1.13–3.14). Stratified analyses showed that the associations were stronger in males and non-breastfed children, with no significant associations observed in females or breastfed children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides new evidence suggesting an association between shorter telomere length and atopic dermatitis in school-age children.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All change, 2025","authors":"Clive Grattan,&nbsp;Jean Bousquet","doi":"10.1002/clt2.70063","DOIUrl":"https://doi.org/10.1002/clt2.70063","url":null,"abstract":"&lt;p&gt;Professor Oliver Pfaar took over as Editor-in-Chief of Clinical and Translational Allergy (CTA) in April 2025 with Professor Maria Escribese as deputy editor. The journal was founded by Professor Jan Lötvall in 2011 when open access publication of scientific papers on the web to a worldwide readership without restriction to subscription journals was an innovation. Dr Clive Grattan was appointed in 2012 to lead the development of this new initiative of the European Academy of Allergy and Clinical Immunology (EAACI). Professor Jean Bousquet was appointed Co-editor in Chief in 2016.&lt;/p&gt;&lt;p&gt;The primary aim of CTA is to communicate applied science and clinical research in the field of allergy to daily clinical practice in the English language. The most frequently published article types are original articles, reviews, position articles and letters to the editor. The impact factor has increased from 3.239 at launch in 2016 to 4.6 in 2023. Publication impact is also reflected in altmetrics scores and social media dissemination. The number of manuscript submissions has increased steadily, with a year-on-year increase in 2023 of 8.8%. The acceptance rate of 34.9% in 2023 was comparable to other Allergy and Clinical Immunology journals. Submitted and published manuscripts come from across the globe. CTA migrated from BioMed Central to Wiley in 2021 to align with its two sister journals in the EAACI portfolio; Allergy and Paediatric Allergy and Immunology. Having a single publisher has facilitated the transfer of submitted manuscripts between the EAACI journals via Editor Driven Referral. This represented 29% of total submissions to CTA in 2023. The number of accesses and downloads has increased year-on-year.&lt;/p&gt;&lt;p&gt;The cost of open access publishing falls to the author or institution rather than the journal owner and its publisher but, in return, the copyright belongs to the copyright holder who is free to read, share and download their work immediately on publication. Different schemes are available to support the cost, including contracts between publishers, funders and research institutions. Waivers or discounts on the article processing charges (APC) are available through Wiley for low-income countries. EAACI offers discounted APCs for members.&lt;/p&gt;&lt;p&gt;Highly cited early publications in CTA including Diagnostic tools in Rhinology EAACI position paper (2011), mechanisms of allergen-specific immunotherapy (2012), diagnosis and management of non-IgE mediated cow's milk allergy in infancy – a UK primary care practical guide (2013), fungal allergy in asthma – state of the art and research needs (2014) and the role of IL-33 and mast cells in allergy and inflammation (2015) showpiece the breadth and quality of its content. Emerging technologies for predictive medicine in rhinitis and asthma across the life cycle have been an important innovation in generating large amounts of real world data in rhinitis, rhinosinusitis and asthma by engaging patients and their","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"20 years of the socioeconomic impact of atopic dermatitis and alopecia areata from around the globe","authors":"Katarina Stevanovic,&nbsp;Manuel Pereira,&nbsp;Ophélie Nguyen,&nbsp;Ingrid van Hofman,&nbsp;Cathrin Meesch,&nbsp;Torsten Zuberbier","doi":"10.1002/clt2.70061","DOIUrl":"https://doi.org/10.1002/clt2.70061","url":null,"abstract":"<p>Atopic dermatitis (AD) and alopecia areata (AA) represent chronic inflammatory diseases characterized by heterogeneous immune-mediated mechanisms, including subtypes that may interconnect the two diseases, as well as other comorbidities. AD is globally recognized as the most common inflammatory skin disease and AA is an autoimmune disease, causing non-scarring hair loss. In both diseases the quality of life (QoL) is decreased, out-of-pocket expenses on alternative therapies and camouflage endeavours is high, increased productivity loss/absenteeism at work or school, and high healthcare costs are significant. These diseases are not life threatening but result in a substantial socioeconomic impact, which so far has been difficult to quantify on the global scale. This qualitative review that includes literature published between 2004 and 2024 evaluates the current alignment between available healthcare resources and the comprehensive needs of these patients. Currently available data indicates that the socioeconomic impact of AD and AA is evidently high, meanwhile there is data lacking from most countries in Africa, Scandinavia and East Europe, the Middle East, South Asia, and parts of Latin America. Global studies with standardized methodology are necessary to assess the socio-economic impact of these conditions.</p>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnosis of lipid transfer protein allergy—Discriminating between sensitisation and allergy","authors":"B. Olivieri,&nbsp;G. Scadding,&nbsp;I. J. Skypala","doi":"10.1002/clt2.70065","DOIUrl":"https://doi.org/10.1002/clt2.70065","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sensitisation to Lipid Transfer Proteins (LTP), usually ascertained by undertaking a test to the peach LTP allergen Pru p 3, is common but does not always indicate LTP allergy. Improving the diagnostic process would ensure the correct diagnosis and management of this complex condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the diagnostic value of Pru p 3 and other LTP component allergens in UK adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective review was undertaken of adults referred to the Allergy Unit at the Royal Brompton &amp; Harefield Hospitals (RBHT) London (UK), between 2012 and 2022 who were sensitised to Pru p 3. Those with a final diagnosis of LTP allergy were compared to those sensitized to Pru p 3 but not diagnosed with LTP allergy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 285 patients with a positive Pru p 3, 157 (55%) were diagnosed with LTP allergy. LTP allergic patients were more likely to have a higher level of Pru p 3, and a lower level of total IgE. The ratio of Pru p 3:total IgE was the most accurate diagnostic marker of LTP allergy, with a receiver operating characteristics AUC of 0.880. A diagnosis of LTP allergy was also significantly associated with sensitisation to the LTP in peanut (Ara h 9, <i>p</i> &lt; 0.001), and hazelnut (Cor a 8, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sensitisation to Pru p 3 may not always indicate an LTP allergy. Our data suggests that the Pru p 3:total IgE ratio, and sensitisation to Ara h 9 and Cor a 8 can support the diagnosis of LTP allergy in individuals sensitised to Pru p 3.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Requalification of patients with severe asthma for biological therapy—Practical ‘ReQuaBi’ rate decision scheme based on the analytical model","authors":"Alicja Majos,&nbsp;Anna Ben Drissi,&nbsp;Maciej Kupczyk,&nbsp;Michał Panek","doi":"10.1002/clt2.70059","DOIUrl":"https://doi.org/10.1002/clt2.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with severe asthma experience decreased quality of life due to fixed airway obstruction, hospitalisations and potential fatalities. However, to date, the requalification of severe asthma patients eligible for biological therapy in daily clinical practice remains unstudied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of the study was to prepare a universal decision-making algorithm for requalifying patients for biological therapy based on available clinical data obtained from a leading reference centre in Poland.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All severe asthma patients treated with biologics since 2013 at the Internal Medicine, Asthma and Allergy Department (Medical University of Lodz, Poland), were analysed. The analysis included demographic (age, sex), pre-treatment (reported at qualification: oral glucocorticosteroids use, total IgE serum level, peripheral blood eosinophilia, co-morbidities: atopic dermatitis, chronic allergic rhinitis or sinusitis) and treatment-related data (treatment time, current treatment status, reason for early termination of therapy, year of discontinuation, rediagnostics, requalification).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Rediagnostics were performed in only 4.76% of all requalifications. The following additional data were used to requalify patients: blood eosinophilia (<i>n</i> = 63; 100.00% of requalifications), atopic comorbidities (<i>n</i> = 30; 47.62%) and total IgE serum level (<i>n</i> = 8; 12.70%). Kaplan–Meier curve analysis of all source data revealed the longevity of maintenance as follows: the highest for mepolizumab, then omalizumab, benralizumab, dupilumab and tezepelumab (<i>p</i> = 0.016). Based on the results, requalification model ‘ReQuaBi’, was constructed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The most important criteria for selecting a biological agent in requalification are peripheral blood eosinophilia, followed by comorbidities and IgE levels. In most cases, extensive additional re-diagnosis may not be necessary.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 5","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}