Clinical and Translational Allergy最新文献

{"title":"Clinical and biological characteristics associated with bronchial or pulmonary abnormalities on chest CT imaging in patients with systemic mastocytosis","authors":"Raphael Vallière, Cristina Bulai Livideanu, Thomas Villeneuve, Grégoire Prévot, Laurent L. Reber, Laurent Guilleminault","doi":"10.1002/clt2.12387","DOIUrl":"10.1002/clt2.12387","url":null,"abstract":"<p>To the Editor,</p><p>Mastocytosis is a heterogeneous group of diseases characterized by a numerical increase and accumulation of clonal mast cells in various organ systems. In systemic mastocytosis, the severity varies from indolent to aggressive mastocytosis, the latter being associated with a worse prognosis.<span><sup>1</sup></span> Although the lungs are known to be rich in mast cells, comorbid respiratory diseases have only been sporadically suggested as associated with SM in case reports.<span><sup>2-4</sup></span> To our knowledge, no data are available on chest CT scans in patients with SM.</p><p>The aim of our study is to determine clinical and biological characteristics associated with bronchial or pulmonary abnormalities on chest CT scans in patients with SM.</p><p>A retrospective observational study was carried out at Toulouse University Hospital Center from 2003 to 2022 using our mastocytosis registry. All patients with (1) a diagnosis of SM based on bone marrow biopsy according to criteria published elsewhere<span><sup>1</sup></span> and (2) a CT scan image available in their medical record were included. This study was conducted in accordance with French ethics requirements (RC31/17/0095) and the guidelines of the National Commission for Data Protection and Liberties (CNIL number: 2206723 v 0).</p><p>Chest CT scans were evaluated by two physicians blinded to the patients' clinical and functional details. The two observers easily established a consensus about the predominant chest CT scan pattern according to the definitions of the Fleischner Society.<span><sup>5</sup></span></p><p>Continuous data were expressed as median and interquartile range and categorical data as number of patients and percentages. An increased risk of a predominant pattern on chest CT scan was assessed for aggressive versus indolent SM and serum tryptase ≥20 μg/L versus <20 μg/L. For this analysis, we used a multivariable logistic regression with a calculation of adjusted odds ratios (aORs) with a 95% confidence interval. aORs were adjusted on the following covariates: age, sex and smoking status. We were not able to determine aOR if the CT scan abnormality was absent in the control group.</p><p>A total of 103 patients with SM were included in the study (Table 1). Of them, 60.2% were females and the median age was 54 [40–60]. Mastocytosis was indolent in 70 (73%) patients, cKit mutation was found in 91 (85%) patients and median serum tryptase was 15 [30–51] µg/l. A predominant chest CT scan pattern was observed in 36 (35.0%) patients. The lung lesions were as follows: nodules (<i>n</i> = 11), emphysema (<i>n</i> = 9), bronchiectasis (<i>n</i> = 6), bronchial wall thickening (<i>n</i> = 6) and interstitial lung diseases (<i>n</i> = 4).</p><p>According to the multivariable analysis, an increased risk of emphysema was observed for aggressive mastocytosis compared to indolent mastocytosis (aOR 5.0 [95% CI: 1.1–27.6]) (Figure 1). An increased risk of bronchi","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being born in autumn or winter is associated with asthma and allergic rhinitis in Finland","authors":"Riikka Hänninen,&nbsp;Aada Murtomäki,&nbsp;Fanni Svärd,&nbsp;Aarno Dietz,&nbsp;Paulus Torkki,&nbsp;Jari Haukka,&nbsp;Mikko Nuutinen,&nbsp;Sanna Toppila-Salmi","doi":"10.1002/clt2.12383","DOIUrl":"10.1002/clt2.12383","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Our population-based study has previously shown that being born in winter or spring was associated with adult-onset asthma. The aim was to study if season of birth (SOB) is associated with airway allergy and related diseases: NSAID exacerbated respiratory disease (N-ERD), asthma, allergic rhinitis (AR), nonallergic rhinitis (NAR), chronic rhinosinusitis with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) in Finland.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A randomly sampled retrospective registry-based follow-up data (<i>n</i> = 74,868) of patients visiting Hospital District of Helsinki and Uusimaa (HUS) in Finland was used. The birth date, sex, visit date and comorbidities were collected from electronic health record data during visits from 2005 to 2019.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean (SD, range) age of the sample was 34.53 (25.47, 0–102) years, with 48.7 % being men. We divided the whole population in four groups based on the season they were born (SOB-groups). When observing these four SOB-groups, the proportion of those having asthma was 43.1%, 42.1%, 41.1%, 42.7%, in winter, spring, summer, and autumn SOB-groups, respectively. The proportion of those having AR was 12.6%, 12.0%, 10.7%, 12.1%, respectively. When having summer as a reference, being born in any other time of year was significantly associated with AR and, being born in autumn or winter was associated with asthma. No significant association was observed in CRS or N-ERD or NAR groups in adjusted models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study suggests that early life immunological events may have a role a role in pathogenesis of asthma and AR. As no association was observed between SOB and CRSsNP, CRSwNP, N-ERD or NAR, further studies on this are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab induces a significant decrease of food specific immunoglobulin E levels in pediatric atopic dermatitis patients","authors":"Lisa P. van der Rijst,&nbsp;Michelle S. Hilbrands,&nbsp;Nicolaas P. A. Zuithoff,&nbsp;Marjolein S. de Bruin-Weller,&nbsp;André C. Knulst,&nbsp;Thuy-My Le,&nbsp;Marlies de Graaf","doi":"10.1002/clt2.12381","DOIUrl":"10.1002/clt2.12381","url":null,"abstract":"&lt;p&gt;To the Editor,&lt;/p&gt;&lt;p&gt;Atopic dermatitis (AD) and food allergy (FA) are common chronic diseases that have a major impact on quality of life and socio-economic burden.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; AD is strongly associated with the development of immunoglobulin E (IgE)-mediated FA.&lt;span&gt;&lt;sup&gt;3-5&lt;/sup&gt;&lt;/span&gt; The associated immune response involves allergen specific T helper type 2 cells inducing a pro-inflammatory cytokine release, including interleukin (IL)-4 and IL-13, thereby causing initiation of B cell immunoglobulin class switching to specific IgE (sIgE).&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Dupilumab, a human monoclonal antibody that is approved for treatment of (moderate to) severe AD in children from the age of 6 months, blocks the IL-4 and IL-13 signaling pathway.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; Spekhorst et al. showed that dupilumab induces a profound decrease in sIgE levels of several food allergens in adult AD patients with comorbid FA, highlighting the positive effect of blocking IL-4 and IL-13 signaling on sIgE levels.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; As FA often develops at a young age, and the effect of dupilumab on food sIgE levels in pediatric patients remains unclear, it is of particular interest to evaluate the effect of dupilumab in this young patient population. Therefore, the aim of this study was to investigate the effect of dupilumab on food sIgE levels of 10 common allergens in food allergic pediatric patients with moderate to severe AD.&lt;/p&gt;&lt;p&gt;Pediatric AD patients (aged 4–17 years) treated with dupilumab with a suggestive clinical history of FA for peanut, hazelnut, cashew nut, pistachio, almond, walnut, hen's egg, cow's milk, kiwi, and/or apple with a corresponding positive sIgE (≥0.35 kU/L) at the start of treatment (baseline), were included. Patients who were never exposed to specific food allergens, due to severe IgE-mediated reactions to other food allergens (e.g., hazelnut, leading to avoidance of other nuts) or to parental anxiety (e.g., due to severe parental FA), with a corresponding positive sIgE, were also included. sIgE levels were measured at baseline and at least once during 1 year of follow-up. Data were extracted from the prospective BioDay registry between August 2019 and July 2023. A covariance pattern model was used to analyze the development of (s)IgE values over time. All analyses were performed for each food separately using a covariance pattern model (detailed explanation of methods is described in Supporting Information S1).&lt;/p&gt;&lt;p&gt;A total of 36 pediatric patients with a mean age of 12.5 (standard deviation ±3.6) years were included (Table 1). A total of 120 FAs, with 1008 corresponding sIgE samples, were identified (Table S1). Peanut (18.3%) and hazelnut (16.7%) were the most common foods to which patients were sensitized. Results of baseline food sIgE levels stratified by severity of FA are shown in Table S2. Two (5.6%) patients discontinued dupilumab treatment at a mean treatment duration of 16.5 weeks.&lt;/p&gt;&lt;p&gt;A significa","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"House dust mite immunotherapy: A real-world, prescription data-based analysis","authors":"R. Mösges,&nbsp;H. Richter,&nbsp;A. Sager,&nbsp;J. Weber,&nbsp;T. Müller","doi":"10.1002/clt2.12382","DOIUrl":"10.1002/clt2.12382","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>House dust mite (HDM) sensitisation can contribute to the development of allergic rhinoconjunctivitis (AR) or allergic asthma (AA). As treatment, allergen immunotherapy (AIT) is a promising approach, since it aims building immunotolerance against allergens, therewith establishing long-term efficacy. The evaluation of AIT has been investigated in many randomised controlled trials, whereas few real-world evidence studies are available.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from the longitudinal prescription data base IQVIA™ LRx. Data on initial AIT prescriptions against HDM from January 2009 to December 2013 was analysed regarding treatment (subcutaneous AIT with either depigmented polymerised allergen extract [dSCIT] or other allergens [oSCIT], or sublingual immunotherapy [SLIT]) and treatment duration. Treatment groups were compared with a control group of AR patients not receiving AIT. Data on symptomatic medication was collected until February 2017 and progression of AR and AA was compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data of 7260 patients with AIT prescriptions and of 21,780 control patients was analysed. AIT was associated with a significant decrease of AR medication intake compared with control (dSCIT: −34.0%, <i>p</i> &lt; 0.0001; oSCIT: −25.7%, <i>p</i> &lt; 0.0001; SLIT: −37.7%, <i>p</i> = 0.0026). In asthmatics, SCIT was associated with a significant decrease of asthma medication compared with control (dSCIT: −45.2%, <i>p</i> &lt; 0.0001; oSCIT: −32.9%, <i>p</i> &lt; 0.0001). Further, a significantly reduced likelihood for onset of asthma medication was demonstrated in patients treated with SCIT compared with controls (dSCIT OR: 0.759, <i>p</i> = 0.0476; oSCIT OR: 0.815, <i>p</i> = 0.0339).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Real-world data analyses indicate that AIT, particularly given via a subcutaneous route, reduces the need of medication against AR and AA and might delay the onset of asthma medication in patients with AR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of skin prick test and prick-to-prick test with fruits and vegetables in the diagnosis of food allergy","authors":"Severina Terlouw,&nbsp;Frank E. van Boven,&nbsp;Monika Borsboom-van Zonneveld,&nbsp;Tineke de Graaf-in ’t Veld,&nbsp;Roy Gerth van Wijk,&nbsp;Paul L. A. van Daele,&nbsp;Maurits S. van Maaren,&nbsp;Jac H. S. A. M. Kuijpers,&nbsp;Sharon Veenbergen,&nbsp;Nicolette W. de Jong","doi":"10.1002/clt2.12375","DOIUrl":"10.1002/clt2.12375","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Prick-to-prick (PTP) test with fresh food is accepted as a reliable tool for measuring sensitization to fruits and vegetables. Not all fruits and vegetables are available throughout the year. The objective of this study was to investigate whether skin prick test (SPT) performed with frozen juice of fruits and vegetables (FJFV) is a good alternative to PTP tests performed with fresh fruits and vegetables (FFV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adult patients suspected of having a food allergy to fruits and/or vegetables were included. A questionnaire was used to score symptoms after consumption of apple, kiwi, peach, tomato, and carrot. SPTs with FJFV, and PTP tests with FFV were performed. Intra-class correlation coefficients (ICC) between the SPT and PTP test results were calculated. The sensitivity and specificity of both diagnostic tests towards food allergen specific symptoms (FASS) were calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-six patients were included. FASS was positive in 75% for apple, 53% for kiwi, 44% for peach, 25% for tomato, and 22% for carrot. ICC between SPT and PTP test results were moderate for apple (0.72) and kiwi (0.71), strong for peach (0.75) and tomato (0.89), and very strong for carrot (0.94). Sensitivity was equal for the SPT and PTP tests for apple (0.93), peach (0.81), and carrot (1.00), and comparable for kiwi (0.50 resp. 0.70), and tomato (0.44 resp. 0.56). Specificity was equal for apple (0.33), peach (0.15), and carrot (0.41), and comparable for kiwi (0.29 resp. 0.21) and tomato (0.80 resp. 0.72).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Results of SPT with FJFV and PTP test with FFV are comparable. SPT with FJFV is a good alternative in the daily practice of the allergists.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11226404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of detection of aluminium-reactive T-lymphocytes in patients with SCIT-induced granulomas","authors":"Stine Skovbo Hoffmann,&nbsp;Jesper Elberling,&nbsp;Jeanne Duus Johansen,&nbsp;Lars Heede Blom","doi":"10.1002/clt2.12378","DOIUrl":"10.1002/clt2.12378","url":null,"abstract":"&lt;p&gt;Aluminium contact allergy is mainly seen in children with itching vaccination granulomas following immunization with aluminium-adsorbed vaccines, but may also occur in adults following allergen-specific subcutaneous immunotherapy, SCIT, as these vaccines too are aluminium-adsorbed.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Traditional method of determining sensitization to aluminium is patch testing, an in vivo skin test considered the gold standard for detecting contact allergy.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Still, it has the disadvantage of only detecting the allergic response in the skin, and not systemic reactions. In adults there is a great risk of false-negative patch test results even though new recommendations on a higher aluminium concentration, rising from 2% to 10% aluminium chloride hexahydrate (AlCl&lt;sub&gt;3&lt;/sub&gt;H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;6&lt;/sub&gt;), has been implemented.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;An alternative to patch testing is the blood in vitro lymphocyte proliferation test (LPT), also known as the lymphocyte transformation test (LTT), which we investigated using a well-established LPT protocol. This has previously been shown to detect and characterize metal-specific cells and was used to detect circulating aluminium-specific proliferation. The LPT test is based on a single blood sample and has mostly been used to detect drug hypersensitivity. Still, its role in detecting metal allergy is expanding,&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; with recent studies suggesting using the test as a supplement to the patch test when only a few allergens are to be investigated.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; Our study aimed to determine the diagnostic performance of LPT in adults with SCIT-induced vaccination granulomas, and to evaluate the association between LPT and patch test reactions.&lt;/p&gt;&lt;p&gt;We included six participants with SCIT-induced granulomas and 10 healthy controls. Inclusion of patients was limited by the small number of SCIT-recipients referred to our department.&lt;/p&gt;&lt;p&gt;Characteristics of the participants with SCIT-induced granulomas are shown in Table 1. All granulomas were long-lasting, and except for one participant with 2 granulomas, all had 3 or more palpable and itching granulomas, mainly on the upper arms but also on the flanks. The control group were matched for age and sex, and did not undergo patch testing, but had no history of post-vaccination granulomas, contact dermatitis, contact allergy, or other skin diseases, had never received SCIT and not been vaccinated with an aluminium-adsorbed vaccine within the last year.&lt;/p&gt;&lt;p&gt;Participants with granulomas were all patch tested with AlCl&lt;sub&gt;3&lt;/sub&gt;H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;6&lt;/sub&gt; 2% (before 2021) or 10% mixed in petrolatum and applied under Finn chambers, an aluminium Finn chamber and an empty plastic chamber as control (8 mm; Smartpractice, Phoenix, AZ, USA), all applied on the upper back and secured with Scanpor&lt;sup&gt;®&lt;/sup&gt; tape (Norgesplaster, Vennesla, Norway). Application time was 2 days, and patch test reactions we","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airborne pollen exposure and risk of hospital admission for allergic rhinitis in Beijing: A time-stratified case-crossover study","authors":"Yuhui Ouyang,&nbsp;Jun Yang,&nbsp;Jingxuan Zhang,&nbsp;Yun Yan,&nbsp;Shengzhi Sun,&nbsp;Jiajia Wang,&nbsp;Xiaobo Li,&nbsp;Rui Chen,&nbsp;Luo Zhang","doi":"10.1002/clt2.12380","DOIUrl":"10.1002/clt2.12380","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Airborne pollen is a crucial risk factor in allergic rhinitis (AR). The severity of AR symptoms can vary based on pollen type and concentration. This study aimed to estimate the association between exposure to different pollen types and AR risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We obtained data from patients admitted to the Beijing Tongren Hospital for AR, and data on pollen concentration, meteorological factors, and fine particulate matter (PM_2.5) from 13 districts in Beijing from 2016 to 2019. We used a time-stratified case-crossover study design and calculated odds ratios (ORs) related to the risk of AR associated with a 10 grain/1000 mm² increase in total pollen concentrations for specific pollen types. A stratified analysis was conducted to assess whether the associations were varied by age and sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The OR of AR associated with a 10 grain/1000 mm² increase in the 7-day average pollen concentration was 1.014 (95% CI: 1.014, 1.015), 1.076 (95% CI: 1.070, 1.082), 1.024 (95% CI: 1.023, 1.025), 1.042 (95% CI: 1.039, 1.045), 1.142 (95% CI: 1.137, 1.147), 1.092 (95% CI: 1.088, 1.097), 1.046 (95% CI: 1.035, 1.058), and 1.026 (95% CI: 1.024, 1.028) for total pollen, Ulmus, Cupressaceae, Populus, Fraxinus, Pinus, Betula, and Artemisia, respectively. Both tree pollen (Ulmus, Cupressaceae, Populus, Fraxinus, Betula, and Pinus) and weed pollen (Artemisia, Chenopodium, and Humulus) were correlated with an increased risk of AR. These associations remained consistent across distinct subgroups defined by both age and sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Exposure to pollen from trees and weeds might be associated with an increased risk of AR. This research provides valuable scientific support for both clinical practitioners and patients with AR regarding the hazards of pollen exposure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with the SQ tree sublingual immunotherapy tablet is safe and well tolerated in real-life","authors":"Oliver Pfaar,&nbsp;Hendrik Wolf,&nbsp;Rainer Reiber,&nbsp;André Knulst,&nbsp;Kirsten Sidenius,&nbsp;Mika J. Mäkelä,&nbsp;Sverre Steinsvåg,&nbsp;Christer Janson,&nbsp;Leonard van der Zwan,&nbsp;Elena Uss,&nbsp;Peter Arvidsson,&nbsp;Kathrin Borchert,&nbsp;Helena Himmelhaus,&nbsp;Eike Wüstenberg","doi":"10.1002/clt2.12373","DOIUrl":"10.1002/clt2.12373","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The SQ tree sublingual immunotherapy (SLIT)-tablet is authorised for treatment of allergic rhinoconjunctivitis with or without asthma in trees of the birch homologous group in 21 European countries. The primary objective of this study was to explore the safety in real-life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a prospective, non-interventional post-authorisation safety study (EUPAS31470), adverse events (AEs) and adverse drug reactions (ADRs) at first administration and follow-up visits, symptoms, medication use, and pollen food syndrome were recorded by physicians in 6 European countries during the first 4–6 months of treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ADRs with the SQ tree SLIT-tablet were reported in 57.7% of 1069 total patients (median age 36.0 years, 53.7% female) during the entire observation period (severity, mild-to-moderate: 70.1%, severe: 4.7%, serious: 0.7%) and in 45.9% after first administration. ADRs were not increased with pollen exposure at first administration. With coadministration of the SQ tree and grass SLIT-tablet AEs were reported in 73.8% of patients and in 52.8% with the SQ tree SLIT-tablet alone. Nasal and eye symptoms improved in 86.9% and 80.9% of patients and use of symptomatic medication in 76.0%. PFS with symptoms was reported in 43.0% of patients at baseline and in 4.3% at the individual last visit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results of this non-interventional safety study with the SQ tree SLIT-tablet confirm the safety profile from placebo-controlled clinical trials and support effectiveness in real-life according to the published efficacy data. Safety was not impaired by pollen exposure at first administration or co-administration with other SLIT-tablets.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe asthmatic airways have distinct circadian clock gene expression pattern associated with WNT signaling","authors":"Nguyen Quoc Vuong Tran,&nbsp;Minh Khang Le,&nbsp;Yuki Nakamura,&nbsp;Atsuhito Nakao","doi":"10.1002/clt2.12379","DOIUrl":"10.1002/clt2.12379","url":null,"abstract":"&lt;p&gt;To the Editor,&lt;/p&gt;&lt;p&gt;The circadian clock, which consists of a network of approximately 30 clock genes, enables organisms to coordinate physiological processes including airway function in synchrony with the changing 24-h environment.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Asthma is characterized by a marked day–night variation in symptoms and laboratory parameters in the airways, suggesting that the airway circadian clock underpins the pathology of asthma.&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt; However, the basic question, “do asthmatic airways have normal or altered circadian clock activity?” remains unanswered. This study analyzed the expression profiles of circadian clock genes and their potential significance in asthmatic airways using a public database of patients with asthma.&lt;/p&gt;&lt;p&gt;Gene expression data from bronchial epithelial brushing samples of patients with mild/moderate and severe asthma and healthy subjects were obtained from five publicly available NCBI-GEO datasets (GSE41861, GSE43696, GSE63142, GSE67472, and GSE89809). Two bronchial epithelial brushing sample datasets of COPD patients (GSE20257 and GSE37147) and two peripheral blood sample datasets of patients with asthma (GSE69683 and GSE207751) were used as controls. Information of datasets analyzed in this study was summarized in Table S1.&lt;/p&gt;&lt;p&gt;Differential gene expression analysis of 34 circadian clock genes showed that &lt;i&gt;NR1D2&lt;/i&gt;, &lt;i&gt;PER2&lt;/i&gt;, and &lt;i&gt;PER3&lt;/i&gt; are downregulated in bronchial epithelial samples from patients with asthma, apparently in those from severe asthma in four of the five datasets (4/5) compared with normal subjects (Figure 1A,B, Figure S1A, Table S2). Considering the lack of information on the timing of sampling, we conducted a sensitivity analysis for gene expression using relative amplitude data for &lt;i&gt;NR1D2&lt;/i&gt;, &lt;i&gt;PER2&lt;/i&gt;, and &lt;i&gt;PER3&lt;/i&gt; from CircaDB, a database of circadian gene expression profile.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Even after accounting for diurnal variations, the differences in &lt;i&gt;PER2&lt;/i&gt; expression remained significant in 3/5 datasets, while for &lt;i&gt;NR1D2&lt;/i&gt; and &lt;i&gt;PER3&lt;/i&gt;, significance was observed in only 2/5 datasets (Figure 1C, Figure S1B). Corroborating our findings, a previous study using time-matched bronchial brushing samples showed that the expression of &lt;i&gt;NR1D2&lt;/i&gt; and &lt;i&gt;PER2&lt;/i&gt; was reduced in asthma patients, as determined by Real-time PCR.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Importantly, in bronchial epithelial tissue, dimension reduction by principal component analysis and t-distributed stochastic neighbor embedding using the expression of &lt;i&gt;NR1D2&lt;/i&gt;, &lt;i&gt;PER2&lt;/i&gt;, and &lt;i&gt;PER3&lt;/i&gt; showed distinct clustering between healthy subjects and patients with severe asthma (Figure 1D, Figure S1C). For comparison, we performed the same exploration on two peripheral blood sample datasets of patients with asthma and two bronchial epithelial brushing sample datasets of COPD patients. The distinct cluster was not seen in blood sample analyses from asthma pat","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 7","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic status and different forms of rhinitis in Swedish adults","authors":"Muwada Bashir Awad Bashir,&nbsp;Teet Pullerits,&nbsp;Linda Ekerljung,&nbsp;Helena Backman,&nbsp;Göran Wennergren,&nbsp;Hannu Kankaanranta,&nbsp;Bright I. Nwaru","doi":"10.1002/clt2.12374","DOIUrl":"10.1002/clt2.12374","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rhinitis encompasses diverse forms. Each form has distinct pathophysiology and clinical manifestations and may be influenced by differential risk factors. The association between socioeconomic status (SES) and different forms of rhinitis remains poorly understood. Our aim was to examine SES variations in allergic rhinitis, chronic rhinitis, and chronic rhinosinusitis in adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on a 2016 postal questionnaire survey within the West Sweden Asthma Study, we analyzed data from 36,213 subjects aged 16–75 years. The measures of SES were levels of education and occupation. Adjusted logistic regression was used to examine associations between SES and the rhinitis outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Attaining a secondary school and tertiary education, compared to a primary school, were associated with increased risk of allergic rhinitis (secondary OR 1.33, 95% CI 1.22–1.45; tertiary 1.54, 1.41–1.69) and chronic rhinitis (secondary 1.18, 1.08–1.29; tertiary 1.17, 1.06–1.28). The influence of occupation was consistent with respect to allergic rhinitis. For instance, compared to the lowest occupational skill level, the highest level (OR 1.24, 95% CI 1.04–1.48) and the lower high occupation levels (1.24, 1.04–1.49) were associated with an increased risk of allergic rhinitis. No significant link was found between education and chronic rhinosinusitis or between occupation levels and risk of either chronic rhinitis or chronic rhinosinusitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Individuals with higher education and those at higher occupational levels may be at higher risk of having different forms of rhinitis than those at lower education and occupation levels. Assessment of rhinitis burden via SES can be one strategy to develop preventive strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"14 6","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}