Being born in autumn or winter is associated with asthma and allergic rhinitis in Finland

IF 4.6 2区医学 Q2 ALLERGY

Clinical and Translational Allergy Pub Date : 2024-07-19 DOI:10.1002/clt2.12383

Riikka Hänninen, Aada Murtomäki, Fanni Svärd, Aarno Dietz, Paulus Torkki, Jari Haukka, Mikko Nuutinen, Sanna Toppila-Salmi

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Abstract

Background

Our population-based study has previously shown that being born in winter or spring was associated with adult-onset asthma. The aim was to study if season of birth (SOB) is associated with airway allergy and related diseases: NSAID exacerbated respiratory disease (N-ERD), asthma, allergic rhinitis (AR), nonallergic rhinitis (NAR), chronic rhinosinusitis with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) in Finland.

Methods

A randomly sampled retrospective registry-based follow-up data (n = 74,868) of patients visiting Hospital District of Helsinki and Uusimaa (HUS) in Finland was used. The birth date, sex, visit date and comorbidities were collected from electronic health record data during visits from 2005 to 2019.

Results

The mean (SD, range) age of the sample was 34.53 (25.47, 0–102) years, with 48.7 % being men. We divided the whole population in four groups based on the season they were born (SOB-groups). When observing these four SOB-groups, the proportion of those having asthma was 43.1%, 42.1%, 41.1%, 42.7%, in winter, spring, summer, and autumn SOB-groups, respectively. The proportion of those having AR was 12.6%, 12.0%, 10.7%, 12.1%, respectively. When having summer as a reference, being born in any other time of year was significantly associated with AR and, being born in autumn or winter was associated with asthma. No significant association was observed in CRS or N-ERD or NAR groups in adjusted models.

Conclusions

The study suggests that early life immunological events may have a role a role in pathogenesis of asthma and AR. As no association was observed between SOB and CRSsNP, CRSwNP, N-ERD or NAR, further studies on this are warranted.

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在芬兰，秋季或冬季出生与哮喘和过敏性鼻炎有关。

研究背景我们基于人群的研究曾表明，出生在冬季或春季与成人哮喘发病有关。我们的目的是研究出生季节（SOB）是否与气道过敏及相关疾病有关：芬兰的非甾体抗炎药加重的呼吸道疾病（N-ERD）、哮喘、过敏性鼻炎（AR）、非过敏性鼻炎（NAR）、有鼻息肉的慢性鼻炎（CRSwNP）和无鼻息肉的慢性鼻炎（CRSsNP）：方法：采用随机抽样的回顾性登记随访数据（n=74,868），这些数据来自芬兰赫尔辛基和乌西马医院区（HUS）。从2005年至2019年就诊期间的电子健康记录数据中收集了患者的出生日期、性别、就诊日期和合并症：样本的平均年龄（SD，范围）为34.53（25.47，0-102）岁，其中48.7%为男性。我们根据出生季节将整个人群分为四组（SOB 组）。在观察这四个季节组时，冬季、春季、夏季和秋季季节组的哮喘患者比例分别为 43.1%、42.1%、41.1% 和 42.7%。患有急性哮喘的比例分别为 12.6%、12.0%、10.7% 和 12.1%。以夏季为参照，在一年中的任何其他时间出生都与哮喘有显著相关性，而在秋季或冬季出生则与哮喘相关。在调整模型中，CRS、N-ERD 或 NAR 组均未观察到明显的相关性：结论：这项研究表明，生命早期的免疫事件可能在哮喘和哮喘的发病机制中起一定作用。由于未观察到 SOB 与 CRSsNP、CRSwNP、N-ERD 或 NAR 之间存在关联，因此有必要对此进行进一步研究。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.