Self-reported accidental allergic reactions among patients with challenge-verified food allergy

IF 4.6 2区医学 Q2 ALLERGY

Clinical and Translational Allergy Pub Date : 2025-06-18 DOI:10.1002/clt2.70067

Sebastian Vigand Svendsen, Annemarie Schaeffer Senders, Athamaica Ruiz Oropeza, Annmarie Lassen, Carsten Bindslev-Jensen, Charlotte G. Mortz

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Abstract

Background

Food allergy affects up to 6% of the population and emergency department visits due to accidental food-allergic reactions are increasing. This study evaluated accidental allergic reactions outside the hospital and the number of hospitalizations in food allergic patients as well as the pattern before and after the diagnosis of food allergy by oral food challenge (OFC).

Methods

An electronic questionnaire concerning accidental allergic reactions was sent to 785 patients with challenge verified peanuts, hazelnuts, cow's milk and/or hen's egg allergies at the Allergy Centre, Odense University Hospital, Denmark.

Results

In total, 51% (402/785) responded. Among the 357 who reported at least one accidental allergic reaction, 51.5% (184/357) reported a total of six or less reactions, whereas 22.4% (80/357) had experienced a total of ≥21 reactions. Skin symptoms were commonly reported by children/adolescents (n = 277), whereas symptoms from all other organ systems were more frequently reported by adults (n = 80). In total, 61.6% (220/357) experienced at least one accidental allergic reaction, requiring immediate medical attention, which decreased from 77.3% (170/220) before to 55% (121/220) after establishment of the food allergy diagnosis by OFC. A concomitant proportional increase in the number of hospitalizations was identified (63.5% (108/170) to 72.7% (88/121)). Limitations: We had no exact data on the timing of the accidental allergic reactions for the individual allergens.

Conclusion

Accidental food-allergic reactions are common and often severe. After the diagnostic OFC, the number of patients with reactions decreased, and the proportion of hospitalizations increased, indicating improved disease and healthcare management.

Abstract Image

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食物过敏患者自我报告的意外过敏反应

食物过敏影响了高达6%的人口，由于意外的食物过敏反应而到急诊室就诊的人数正在增加。本研究评估了食物过敏患者院外意外过敏反应和住院次数，以及口服食物激发法（OFC）诊断食物过敏前后的模式。方法对丹麦欧登塞大学医院过敏反应中心785例花生、榛子、牛奶和/或鸡蛋过敏患者进行意外过敏反应电子问卷调查。结果总有效率为51%（402/785）。在报告至少一次意外过敏反应的357人中，51.5%（184/357）报告了总共6次或更少的反应，而22.4%（80/357）报告了总共≥21次反应。儿童/青少年通常报告皮肤症状（n = 277），而成人更常报告其他器官系统的症状（n = 80）。总共有61.6%（220/357）的患者至少经历过一次意外过敏反应，需要立即就医，这一比例从OFC建立食物过敏诊断前的77.3%（170/220）下降到55%（121/220）。住院人数也随之呈比例增加（63.5%（108/170）至72.7%(88/121)）。局限性：我们没有关于个别过敏原意外过敏反应时间的确切数据。结论意外食物过敏反应是常见且严重的。诊断性OFC后，出现反应的患者数量减少，住院比例增加，表明疾病和医疗保健管理得到改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.