Clinical and Experimental Otorhinolaryngology最新文献

{"title":"Guidelines for the Treatment of Laryngeal Cancer from the Korean Society of Head and Neck Surgery.","authors":"Jeon Yeob Jang, Geun-Jeon Kim, Sang-Yeon Kim, Min-Su Kim, Dong Kun Lee, Minsu Kwon, Dongbin Ahn, Myung Jin Ban, Young Kang, Ho-Ryun Won, Jae Won Chang, Dong Won Lee, Ki Nam Park, Yeon Soo Kim, Ah Ra Jung, Jungirl Seok, Hye Ran Lee, Sung-Chan Shin, Chang Myeon Song, Gil Joon Lee, Jihye Kwak, Soo Yeon Jung, Bo Hae Kim, Dong-Hyun Lee, Nayeon Choi, Eun Kyung Jung, Yong Tae Hong, Hyun-Bum Kim, Seung Hoon Han, Su Il Kim, Ji Won Kim, Yoon-Jong Ryu, Heejin Kim, Sung Joon Park, Hanaro Park, Eun-Jae Chung, Seung-Kuk Baek, Jun-Ook Park, Kwang-Jae Cho","doi":"10.21053/ceo.2025.00009","DOIUrl":"10.21053/ceo.2025.00009","url":null,"abstract":"<p><strong>Objectives: </strong>Effective treatment of laryngeal cancer requires clinical decision-making that balances survival outcomes with the preservation of essential functions, such as voice and swallowing. This study, led by the Clinical Practice Guideline Committee of the Korean Society of Head and Neck Surgery, aims to establish evidence-based recommendations to guide surgeons in optimizing treatment decisions for patients with laryngeal cancer.</p><p><strong>Methods: </strong>A literature search was performed in the PubMed, Embase, Cochrane Library, and KoreaMed databases by a literature search expert and subsequently reviewed by a panel of 39 committee experts. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method was employed to assess the quality of evidence and develop and report the recommendations. The strength of each recommendation reflects the guideline panel's confidence that the benefits of an intervention outweigh its risks for the target population. After drafting the guidelines, Delphi questionnaires were distributed to members of the Korean Society of Head and Neck Surgery and an external reviewer panel.</p><p><strong>Results: </strong>In total, 15 evidence-based recommendations are provided, addressing six critical aspects of laryngeal cancer treatment: early-stage treatment, treatment of locally advanced cancer, neck management, adjuvant therapy, swallowing rehabilitation, and salvage treatment for recurrent tumors.</p><p><strong>Conclusion: </strong>The guidelines provide evidence-based, validated recommendations to support clinicians in making optimal treatment decisions for laryngeal cancer.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"89-108"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Efficacy of the Body Roll Test for Lateral Canal Benign Paroxysmal Positional Vertigo: A Randomized Controlled Study.","authors":"Hyun Jin Lee, Yun-Jung Yang, Sung Goo Yoo, Eun-Ju Jeon","doi":"10.21053/ceo.2024.00296","DOIUrl":"10.21053/ceo.2024.00296","url":null,"abstract":"<p><strong>Objectives: </strong>Lateral canal benign paroxysmal positional vertigo (LC-BPPV) is diagnosed using the head roll test (HRT), which involves rotating the head to mobilize particles within the lateral canal, inducing nystagmus. The body roll test (BRT) is conducted by rolling both the body and head simultaneously, offering the advantage of safely achieving the correct rotational angle in both directions. This study evaluates the diagnostic utility of the BRT.</p><p><strong>Methods: </strong>A randomized controlled study was conducted. In total, 43 patients with LC-BPPV symptoms were enrolled and randomly divided into two groups. In group A (n=21), the HRT was administered first, followed by the BRT after a 5-minute interval. In contrast, group B (n=22) received the BRT first, followed by the HRT after 5 minutes. Participants wore Fresnel glasses, which allowed for the observation of nystagmus in sitting, bowing, and lying down positions. We recorded the direction, latency, and duration of the nystagmus.</p><p><strong>Results: </strong>The distribution of nystagmus types was 18:25 (geotropic: apogeotropic). There was no significant difference in age, sex, or type of nystagmus between the two groups. The findings from the HRT aligned with those from the BRT for 32 (74.4%) of the participants. No statistical differences were noted in the diagnosis of the affected side or in the type of nystagmus (geotropic vs. apogeotropic) between the HRT (n=32) and BRT (n=32) (P>0.05). The diagnostic rates in the first (n=31) and second tests (n=33) were similar, showing no significant difference and consistent results regarding the type of LC-BPPV. Additionally, there were no significant differences in postural discomfort and pain scores between these groups.</p><p><strong>Conclusion: </strong>BRT and HRT demonstrate comparable diagnostic efficacy for LC-BPPV. BRT offers a viable alternative, especially for patients whose conditions preclude the use of HRT, and may improve diagnostic accuracy when combined with HRT.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"134-142"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Hearing Impairment in Newborns Using Targeted Genomic Sequencing: A Large Pilot Cohort Study.","authors":"Pei-Hsuan Lin, Yu-Ting Chiang, Cheng-Yu Tsai, Chia-Huei Chu, Chia-Cheng Hung, Yi-Ning Su, Wei-Chung Hsu, Tien-Chen Liu, Chuan-Jen Hsu, Po-Nien Tsao, Chen-Chi Wu","doi":"10.21053/ceo.2024.00275","DOIUrl":"10.21053/ceo.2024.00275","url":null,"abstract":"<p><strong>Objectives: </strong>State-run newborn hearing screening (NBHS) programs have limitations in identifying children with mild or late-onset sensorineural hearing impairment (SNHI). Given that over 50% of pediatric SNHI cases are linked to genetic causes, the increasing accessibility of high-throughput, low-cost genomic sequencing may help address these shortcomings. This study investigates the feasibility of integrating a next-generation sequencing (NGS)-based genomic screening protocol into conventional NBHS and examines its potential benefits and challenges.</p><p><strong>Methods: </strong>A total of 8,261 newborns underwent simultaneous NBHS and NGS-based genomic screening targeting 46 deafness genes in this prospective study. The subjects' genotypes were determined, and those with conclusive genetic diagnoses received audiological assessments.</p><p><strong>Results: </strong>Conclusive genetic diagnoses were confirmed in 164 subjects, with 112 carrying variants in GJB2 and MTRNR1 and 52 carrying variants in other deafness genes. Notably, 126 of these subjects passed the NBHS, suggesting that an additional 1.5% (126/8,261) of children at risk for SNHI, who would have been missed by conventional physiological screening, can be identified through targeted genomic screening in the general population. Furthermore, one subject's father, who carried a COL4A5 variant, and three paternal relatives of another subject carrying an EDNRB variant (previously undiagnosed) were identified with Alport and Waardenburg syndromes, respectively, underscoring the familial benefits of this approach.</p><p><strong>Conclusion: </strong>Targeted genomic sequencing in newborns may serve as a valuable complement to conventional NBHS by identifying children at risk for SNHI and enabling early diagnosis in families with non-syndromic mimics.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"152-161"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into Reponses to Caloric and head impulse stimulation in Lateral Semicircular Canal Benign Paroxysmal Positional Vertigo.","authors":"Seong Hoon Bae, Sang Hyun Kwak, Jeon Mi Lee, Ji Hyuk Han, Dae Bo Shim, Sung Huhn Kim","doi":"10.21053/ceo.2024-00365","DOIUrl":"https://doi.org/10.21053/ceo.2024-00365","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the pathophysiology of persistent geotropic direction-changing positional nystagmus (pGeo DCPN) by analyzing the caloric responses and clinical course in patients with pGeo DCPN and other variants of lateral semicircular canal benign paroxysmal positional vertigo (LSCC BPPV).</p><p><strong>Methods: </strong>In this case-control prospective study, 101 patients diagnosed with pGeo DCPN (pGeo group, N=34), persistent apogeotropic (pApo) DCPN (pApo group, N=40), or transient geotropic (tGeo) DCPN (tGeo group, N=27) involving the LSCC were enrolled. The video head impulse test (vHIT) and caloric test were performed on the day of diagnosis. If one or both of the tests.</p><p><strong>Results.: </strong>were abnormal, a follow-up test was performed after the disappearance of nystagmus. Differences in the tests.</p><p><strong>Results.: </strong>and clinical course were compared and analyzed across each type of LSCC BPPV.</p><p><strong>Results: </strong>The mean disease duration was significantly longer in patients with pGeo (23.0 days) than those with pApo (8 days) and tGeo (9 days) (p<0.005). All enrolled patients showed normal vHIT gain. Patients with pGeo demonstrated the highest canal paresis (CP) value (vs. pApo: p = 0.002 and vs. tGeo: p < 0.001) and a higher frequency of abnormal CP (61.8%) compared to pApo (22.5%) and tGeo (11.1%) groups. CP was predominantly ipsilesional (85.7%) in patients with pGeo. Follow-up caloric tests showed decreased CP in 72.7% of patients with pGeo, with 36.4% showing normalized CP after the disappearance of nystagmus.</p><p><strong>Conclusion: </strong>In Conclusion, the clinical course, caloric test, and vHIT results in patients with different types of LSCC BPPV in this study implied a distinct pathophysiology for each type. The deflection of the cupula by buoyancy in pGeo DCPN could plausibly lead to CP while preserving vHIT integrity.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nrf2: A Promising Therapeutic Target for Glucocorticoid-Resistant Chronic Rhinosinusitis.","authors":"Yue Wang, Yi Yang","doi":"10.21053/ceo.2024.00373","DOIUrl":"https://doi.org/10.21053/ceo.2024.00373","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic rhinosinusitis (CRS) presents a challenge for otolaryngologists due to its complex management and high recurrence rates. Glucocorticoids (GCs) are extensively utilized for their potent anti-inflammatory effects in managing various inflammatory conditions and also play a pivotal role in treating CRS. Certain patients exhibit insensitivity to GC therapy, leading to GC resistance (GCR). Oxidative stress is one causative factor for GCR development, while the Nrf2 signaling pathway emerges as a critical cellular defense mechanism against oxidative stress-induced damage. Exploring the Nrf2 signaling pathway is promising for advancing our understanding of GC sensitivity and its application in treating CRS. This article overviews the relationship between GC sensitivity and the Nrf2 signaling pathway and potential Nrf2-related drugs. Studies have shown that Nrf2 activators, used alone or in combination with GCs, more effectively inhibit the release of inflammatory factors and oxidative stress damage than GC monotherapy, making them a promising new target for CRS treatment.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application and limitations of digitalized olfactory function test including threshold, discrimination, and identification subsets.","authors":"Hae Ryong Lee, Il-Youp Kwak, Kyung Soo Kim, Hyun Jin Min","doi":"10.21053/ceo.2024.00383","DOIUrl":"https://doi.org/10.21053/ceo.2024.00383","url":null,"abstract":"","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel EYA1 Splicing Mutation in a Chinese Family With Branchio-Oto Syndrome: A Functional Analysis and Reproductive Intervention","authors":"Chen Anhai, Jiang Lu, Nie Zequn, Song Jian, He Chufeng, Mei Lingyun, Liu Yalan","doi":"10.21053/ceo.2024.00304","DOIUrl":"10.21053/ceo.2024.00304","url":null,"abstract":"<p><strong>Objectives: </strong>Branchio-oto syndrome (BOS) is a group of autosomal dominant genetic diseases, multisystem disorders excluding renal anomalies. There are clinical heterogeneity and ethnic diversity in BOS, which reported in more studies in European populations than in Asian populations, with a prevalence rate of approximately 1/40000. As the most common disease-causing gene, the mutation types of EYA1 range from missense to various frameshift, splicing and nonsense variants. Although splicing mutations are one of the important factors in the disease, existed research has paid less attention to the novel mutations causing aberrant RNA splicing and their pathogenic mechanisms. Reproductive interventions that actively block the transmission of the disease to future generations have also not been reported.</p><p><strong>Methods: </strong>We had collected research samples from a three-generation Chinese family with BOS. Whole exome sequencing was applied for the screening of candidate causing gene. Minigene assay was performed to identify the aberrant splicing products, and molecular biology techniques were used to analyze the pathogenicity of potentially mistranslated proteins. pre-implantation genetic testing (PGT) has been employed to prevent hearing loss in this family based on SNP analysis.</p><p><strong>Results: </strong>A novel mutation EYA1:c.1598-2AG>TA was identified by whole-exome sequencing and classified as harmful refer to ACMG's evidence. An aberrant RNA splicing was verified and suggested that might prematurely terminates the translation of EYA1 protein, through the minigene assay. The EYA1 truncated protein presented unstable and difficultly translocated to the nucleus, also impaired EYA1-SIX1 interactions in cytological experiments. PGT helped the proband give birth to a healthy boy.</p><p><strong>Conclusion: </strong>A novel splicing variant of EYA1 gene was identified in this study, and the potential molecular pathogenic mechanism was elucidated by several functional experiments. On basis above findings, we successfully implemented the first instance of using PGT to ensure the birth of a healthy offspring free from this genetic disorder.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Versus Manual Electrode Insertion in Cochlear Implant Surgery: An Experimental Study.","authors":"Salman F Alhabib, Farid Alzhrani, Abdulrahman Alsanosi, Mariam Al-Amro, Abdulaziz Alballaa, Ibrahim Shami, Abdulrahman Hagr, Asma Alahmadi, Tahir Sharif, Maximilian Stichling, Marco Matulic, Masoud Zoka Assadi, Yassin Abdelsamad, Fida Almuhawas","doi":"10.21053/ceo.2024.00253","DOIUrl":"10.21053/ceo.2024.00253","url":null,"abstract":"<p><strong>Objectives: </strong>This experimental study compared the precision and surgical outcomes of manual versus robotic electrode insertions in cochlear implantation.</p><p><strong>Methods: </strong>The study was conducted on formalin-fixed cadaveric heads, with nine senior neurotologists performing both manual and robotic insertions.</p><p><strong>Results: </strong>The results showed no statistically significant differences between the two methods in terms of insertion angle, cochlear coverage, or electrode coverage. However, the robotic method demonstrated a significantly slower and more controlled insertion speed (0.1 mm/sec) compared to manual insertion (0.66±0.31 mm/sec), which is crucial for minimizing intra-cochlear force and pressures. Although robotic insertions resulted in fewer complications such as tip fold-over or scala deviation, there were instances of incomplete insertion.</p><p><strong>Conclusion: </strong>The robotic system provided a consistent and controlled insertion process, potentially standardizing cochlear implant operations and reducing outcome variability. The study concludes that robotic-assisted insertion offers significant advantages in controlling insertion speed and consistency, supporting the continued development and clinical evaluation of robotic systems for cochlear implant surgery.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"21-29"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Surgical Outcome of Canal-Tympanoplasty in Patients With Schuknecht Type B Congenital Aural Stenosis.","authors":"Yoonjae Lee, Moo Kyun Park, Jun Ho Lee, Sang-Yeon Lee, Myung-Whan Suh","doi":"10.21053/ceo.2024.00189","DOIUrl":"10.21053/ceo.2024.00189","url":null,"abstract":"<p><strong>Objectives: </strong>Congenital aural atresia (CAA) is a complex condition that manifests in various forms, including Schuknecht type B stenosis, which is characterized by a congenitally narrow bony external auditory canal (EAC). This study aims to evaluate the long-term surgical outcomes of canal-tympanoplasty in patients with Schuknecht type B CAA.</p><p><strong>Methods: </strong>The study included 21 ears diagnosed with Schuknecht type B CAA, all of which underwent canal-tympanoplasty. Reconstruction of the large EAC and tympanic membrane involved conchal flap meatoplasty, bony EAC drilling, ossicular reconstruction, and overlay tympanoplasty. Standard pure-tone audiometry was analyzed at multiple post-surgery time points: 3, 6, 12, and 24-60 months. Additionally, the incidence of postoperative complications was assessed.</p><p><strong>Results: </strong>The hearing outcomes of canal-tympanoplasty in this case series were satisfactory. Serviceable hearing was achieved in all patients after 3 months and was maintained in 85% of patients for 1 year. The air-bone gap improved from a preoperative average of 39.3±15.1 dB to 13.7±7.4 dB at 3 months, 16.4±10.5 dB at 6 months, 19.1±11.7 dB at 12 months, and 21.5±16.1 dB at 2-5 years postoperatively. Three patients required revision canal-tympanoplasty due to hearing deterioration, representing 14.3% of the cases. There were no instances of postoperative infection, facial nerve weakness, vertigo, deterioration of bone conduction thresholds, or complete restenosis of the EAC.</p><p><strong>Conclusion: </strong>Canal-tympanoplasty proved to be a satisfactory surgical intervention for patients with Schuknecht type B CAA. This procedure led to significant improvements in hearing outcomes, providing serviceable hearing that lasted for several years. Moreover, the risk of postoperative hearing deterioration and/or the need for revision surgery within 1 year was considered acceptable.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"14-20"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Complex Impact of Smoking Habits on Allergic Rhinitis: A National Cross-Sectional Study.","authors":"Jae-Min Shin, Yujin Jeong, Jaehyeong Kim, Juhyun Lee, Tae Hoon Kim","doi":"10.21053/ceo.2024.00202","DOIUrl":"10.21053/ceo.2024.00202","url":null,"abstract":"<p><strong>Objectives: </strong>Allergic rhinitis (AR) significantly impacts quality of life and incurs socioeconomic costs. The influence of smoking habits, including the use of conventional cigarettes (CCs) and electronic cigarettes (ECs), on the prevalence and management of AR remains a subject of debate. This study aims to explore the association between smoking status (CC and EC use) and the prevalence and management of AR among Koreans by analyzing data from the Korea National Health and Nutrition Examination Survey (KNHANES) VII (2018) and VIII (2019-2021).</p><p><strong>Methods: </strong>This cross-sectional study involved 22,290 participants aged 19 years and older from the KNHANES. Participants self-reported their smoking status, and urinary cotinine levels were measured to assess nicotine exposure. We employed statistical analyses, including logistic regression, to examine the relationships between smoking status, cotinine levels, and the prevalence and management of AR.</p><p><strong>Results: </strong>In univariable logistic regression analysis, EC users exhibited a 35.8% increased risk of AR compared to non-smokers, whereas CC users experienced a 27.7% reduced risk. Multivariable logistic regression analysis showed a 20.3% lower risk of AR among CC users; however, no significant association was observed for EC users. Higher cotinine levels (>500 ng/mL) were associated with a lower prevalence of AR. Specifically, heavy CC users with high cotinine levels demonstrated a 35% reduced risk of AR. Nonetheless, after adjusting for confounders, this association was no longer significant, indicating that other variables might influence this relationship.</p><p><strong>Conclusion: </strong>Smoking status is associated with the prevalence of AR in Koreans. Notably, heavy use of CCs is negatively correlated with the prevalence of AR.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"30-39"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}