Clinical and Experimental Otorhinolaryngology最新文献

{"title":"Reprogramming Macrophage Phenotypes With Photobiomodulation for Improved Inflammation Control in ENT Organ Tissues.","authors":"Ken Woo, Yeon Soo Kim, Celine Abueva, Seung Hoon Woo","doi":"10.21053/ceo.2024.00286","DOIUrl":"10.21053/ceo.2024.00286","url":null,"abstract":"<p><p>Photobiomodulation (PBM), a noninvasive phototherapy that utilizes wavelengths between red and near-infrared light, has emerged as a promising approach for controlling inflammation by modulating macrophage polarization. This review investigates the therapeutic potential of PBM in treating ENT-specific inflammatory conditions, such as chronic rhinosinusitis and otitis media, focusing on its effects on macrophage phenotypes and evidence from preclinical studies. By promoting mitochondrial activity, increasing adenosine triphosphate production, and modulating reactive oxygen species, PBM has been shown to shift macrophages from a pro-inflammatory to an anti-inflammatory phenotype. Studies have demonstrated that PBM enhances tissue repair, reduces inflammatory markers, and promotes wound healing. Moreover, PBM facilitates the polarization of M2 macrophages, a crucial factor in resolving mucosal inflammation in the nasal, pharyngeal, and middle ear cavities, as well as restoring tissue homeostasis. The anti-inflammatory effects of PBM are attributed to its ability to influence several molecular mechanisms involved in inflammation regulation, particularly in ENT organ tissues, where recurrent inflammation can lead to chronic conditions such as otitis media or sinusitis. Furthermore, this review compares PBM to competing methods for reprogramming macrophages and treating inflammation, highlighting its advantages of minimal toxicity, simplicity, and precision in controlling ENT immune responses.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"1-13"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper Airway Collapsibility During Rapid Eye Movement Sleep Is Associated With the Response to Upper Airway Surgery for Obstructive Sleep Apnea.","authors":"Yung-An Tsou, Liang-Wen Hang, Eysteinn Finnsson, Jón S Ágústsson, Scott A Sands, Wan-Ju Cheng","doi":"10.21053/ceo.2024.00246","DOIUrl":"10.21053/ceo.2024.00246","url":null,"abstract":"<p><strong>Objectives: </strong>Endotype-based interventions have shown promise in the treatment of patients with obstructive sleep apnea, and upper airway surgery is a key therapeutic option. However, responses to surgery vary among patients with obstructive sleep apnea. This study aims to examine changes in endotypic traits following upper airway surgery and to explore their association with surgical outcomes.</p><p><strong>Methods: </strong>We prospectively recruited 25 patients with obstructive sleep apnea who visited a single sleep center for upper airway surgery. These patients underwent polysomnographic studies both before and after surgical intervention. During non-rapid eye movement and rapid eye movement sleep, we estimated endotypic traits-including collapsibility (Vpassive), arousal threshold, loop gain, and upper airway compensation-with the phenotyping using polysomnography method. Based on improvements in the apnea-hypopnea index, patients were classified as either responders or non-responders. We compared the preoperative endotypic traits between these groups using Mann-Whitney tests. Additionally, we compared changes in endotypic traits pre- and post-surgery between responders and non-responders using generalized linear mixed models.</p><p><strong>Results: </strong>We identified 12 responders and 13 non-responders. Compared to non-responders, responders exhibited improved collapsibility during rapid eye movement sleep (22.3 vs. -8.2%eupnea in Vpassive, P=0.01), and their arousal threshold decreased during non-rapid eye movement sleep (-22.4%eupnea, P=0.02). No endotypic trait predicted surgical response; however, the apnea-hypopnea index during rapid eye movement sleep was higher among responders than non-responders (51.8/hr vs. 34.4/hr, P=0.05).</p><p><strong>Conclusion: </strong>Upper airway surgery significantly reduced collapsibility during rapid eye movement sleep in responders. The target pathology for upper airway surgery is a compromised upper airway during rapid eye movement sleep.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"50-56"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Allergic Sensitization and Diseases in the Korean General Population Over a 9-Year Period.","authors":"Dong Hee Lee, Ji-Hyeon Shin","doi":"10.21053/ceo.2024.00209","DOIUrl":"10.21053/ceo.2024.00209","url":null,"abstract":"<p><strong>Objectives: </strong>The prevalence of allergic sensitization and diseases varies over time due to changes in climate, environment, and lifestyle. This study analyzed changes in sensitization to house dust mites (HDM) and dogs, as well as the prevalence of allergic diseases in the Korean general population over a 9-year period and identified contributing factors.</p><p><strong>Methods: </strong>This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey conducted in 2010 and 2019. Participants were aged ≥10 years, with the analysis stratified by adolescents (10-18 years) and adults (≥19 years). We evaluated the prevalence of allergic sensitization and diseases and examined links to clinicodemographic factors across the two survey years. Multivariate logistic regression was performed to evaluate the association between sensitization and clinicopathological factors.</p><p><strong>Results: </strong>In total, 4,084 participants (2010: n=2,019, 2019: n=2,065) were enrolled. In 2010, HDM sensitization was 36.9%, declining to 36.6% in 2019. Dog sensitization decreased from 6.1% in 2010 to 5.8% in 2019. There were no significant differences between the two years among total participants; however, dog sensitization increased significantly among adolescents (2010: 8.7% vs. 2019: 15.3%; P=0.027). In 2010, HDM sensitization was negatively associated with urban residence (odds ratio [OR], 0.76; 95% CI, 0.60-0.96) and apartment dwelling (OR, 0.78; 95% CI, 0.64-0.95) but was without significance in 2019. In adolescents, dog sensitization was strongly correlated with urban residence (OR, 8.06; 95% CI, 1.53-42.49) in 2010, whereas HDM sensitization was associated with obesity (OR, 2.02; 95% CI, 1.04-3.91) in 2019. In adults, heavy drinking was linked to dog sensitization (OR, 2.35; 95% CI, 1.20-4.62) in 2010 and HDM sensitization in 2019 (OR, 1.44; 95% CI, 1.03-2.02).</p><p><strong>Conclusion: </strong>The prevalence of HDM sensitization remained stable over 9 years, while dog sensitization increased in adolescents. The factors associated with sensitization differed between age groups and years. Understanding these trends and related factors in the general population can help healthcare providers develop new strategies to reduce allergic sensitization and diseases.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"40-49"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Trend in Age-Adjusted Incidence of Head and Neck Cancer in South Korea over the Past 20 Years.","authors":"Jae Hoon Cho, Jeffrey D Suh, Young Chang Lim","doi":"10.21053/ceo.2024.00346","DOIUrl":"https://doi.org/10.21053/ceo.2024.00346","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to calculate the age-adjusted incidence rate of head and neck cancer (HNC) in South Korea from 1999 to 2020 and investigate the incidence trend of HNC excluding the effect of population aging.</p><p><strong>Methods: </strong>Data were obtained from the Cancer Registration Statistics Program. All 12 types of HNCs were analyzed. For each HNC type, the crude incidence rate and number of new cases during 1999-2020 are presented according to sex and age group. Age-adjusted incidence rates were calculated based on the World Standard Population (WHO 2000-2025), and its trends were also measured.</p><p><strong>Results: </strong>Although the crude incidence rates of all HNCs have been steadily increasing from 1999 to 2020, the absolute values were very low in most cases, less than 2/100,000. The male-to-female ratio was 1 or higher for all HNCs except thyroid cancer, and 10 or higher for laryngeal cancer and hypopharyngeal cancer. The trend of age-adjusted incidence was a gradual increase for tongue cancer, tonsil cancer, major salivary gland cancer, and thyroid cancer, a decrease for laryngeal cancer, and no significant change for the remaining HNCs.</p><p><strong>Conclusion: </strong>Excluding the population aging effect, tongue cancer, tonsil cancer, major salivary gland cancer, and thyroid cancer among HNCs have been increasing in South Korea over the past 20 years, while laryngeal cancer has been decreasing.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of hearing aids in South Korea: a multistate Markov model analysis.","authors":"Heonjeong Oh, Chul Young Yoon, Junhun Lee, Young Joon Seo, Wankyo Chung, Moo Kyun Park","doi":"10.21053/ceo.2024.00255","DOIUrl":"https://doi.org/10.21053/ceo.2024.00255","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the cost-effectiveness of using hearing aids among individuals aged 50 and older with varying levels of hearing loss in South Korea.</p><p><strong>Methods: </strong>A state-transition Markov model was employed to assess the cost-effectiveness of hearing aid utilization from a societal perspective. We simulated a cohort of patients aged 50, tracking their progression through normal, mild, moderate, and severe stages of hearing loss until death or age 80. The incremental cost-effectiveness ratio (ICER) per quality-adjusted life year gained was determined using both published and calculated data on the costs and effectiveness of hearing aids.</p><p><strong>Results: </strong>The respective ICERs were $8,571 for men and $10,635 for women. These figures are significantly below the willingness-to-pay (WTP) threshold of $31,721, which corresponds to the per capita gross domestic product in 2020. The probabilities of cost-effectiveness were 83.6% for men and 73.4% for women at this WTP threshold. The lower ICERs observed in men can likely be attributed to the earlier onset of hearing loss and the rapid progression from normal, mild, moderate, and severe stages of hearing loss to death.</p><p><strong>Conclusion: </strong>Hearing aids represent a highly cost-effective intervention for adults aged 50 and older in Korea, regardless of the degree of hearing loss, even in mild cases. In light of the rapidly aging population, it would be prudent for government policymakers to consider the costeffectiveness of hearing aids in their decision-making processes.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of septal swell body reduction for patients with nasal airway obstruction: A systemic review and meta-analysis.","authors":"Ji-Sun Kim, Gulnaz Stybayeva, Se Hwan Hwang","doi":"10.21053/ceo.2024.00341","DOIUrl":"https://doi.org/10.21053/ceo.2024.00341","url":null,"abstract":"<p><strong>Background: </strong>The septal swell body (SSB), a distinct anatomical structure located in the anterior nasal septum, has been recognized as a significant contributor to nasal obstruction, impacting airflow dynamics and nasal resistance. This meta-analysis evaluated the impact of septal swell body volume reduction (SSBVR).</p><p><strong>Methods: </strong>A systematic review of studies from PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases was conducted through October 2024. Outcomes included changes in nasal obstruction scores, cross-sectional area, and nasal airway resistance pre- and post-SSBVR. Standardized mean differences (SMDs) were calculated, and the effectiveness of SSBVR combined with turbinate surgery was compared to turbinate surgery alone.</p><p><strong>Results: </strong>Seven studies involving 232 patients were analyzed. SSBVR significantly improved crosssectional area (SMD = -1.05, 95% CI [-1.88; -0.21]) and nasal airway resistance (SMD = -0.67, 95% CI [-0.89; -0.45]), while nasal obstruction scores demonstrated significant improvements over up to 12 months (SMD = 2.54, 95% CI [1.81; 3.26]). The addition of SSBVR to turbinate surgery resulted in greater improvement in nasal obstruction scores (SMD = 0.47, 95% CI [0.24; 0.70]) compared to turbinate surgery alone, though no significant differences were observed in crosssectional area or nasal airway resistance. Subgroup analyses revealed time-dependent improvements in nasal obstruction scores and variability in effectiveness based on treatment modality.</p><p><strong>Conclusion: </strong>: SSBVR significantly improves nasal obstruction and airflow metrics, with added benefits when combined with turbinate surgery. Further randomized trials are warranted to validate these findings and optimize treatment strategies.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic efficacy of body roll test for lateral canal BPPV: A randomized controlled study.","authors":"Hyun Jin Lee, Yun-Jung Yang, Sung Goo Yoo, Eun-Ju Jeon","doi":"10.21053/ceo.2024.00296","DOIUrl":"https://doi.org/10.21053/ceo.2024.00296","url":null,"abstract":"<p><strong>Background: </strong>Lateral semicircular canal BPPV (LC-BPPV) is diagnosed by the head roll test (HRT), in which the head is rotated to move particles in the lateral canal, causing nystagmus. The body roll test (BRT) is performed in a rolling position with the body and head together, which has the advantage of safely rotating the head at the correct angle in both directions. This study aims to assess the diagnostic utility of the body roll test (BRT).</p><p><strong>Methods: </strong>A randomized controlled study was conducted. A total of 43 enrolled patients with LCBPPV symptoms were randomly divided into two groups. In group A (n=21), the HRT was performed first followed by the BRT after 5 minutes. Conversely, the BRT was performed first in group B followed by the HRT after 5 minutes (n=22). Participants were fitted with Freznel glasses and observed for nystagmus in the sitting, bow, and lying down position. The direction, latency, and duration of nystagmus were recorded.</p><p><strong>Results: </strong>The type of nystagmus was 18:25 (geotropic: apogeotropic). No significant difference was found in age, sex, and nystagmus type between the two groups. The results of the HRT were consistent with those of the BRT for 32 (74.4%) participants. No statistical differences were observed in the diagnosis of the affected side and nystagmus type (geotropic vs. apogeotropic) between the HRT (n=32) and BRT (n=32) (P>0.05). The diagnosis rate in the first (n=31) and second tests (n=33) showed no significant difference and yielded similar results including the type of LC-BPPV. Moreover, no significant difference was found in postural discomfort and pain scores between these groups.</p><p><strong>Conclusion: </strong>BRT and HRT show similar diagnostic efficacy for LC-BPPV. BRT provides a practical alternative, particularly for patients with limitations that prevent HRT, and may enhance diagnostic accuracy when used together with HRT.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Risk Factors Associated with the Occurrence and Recurrence of Benign Paroxysmal Positional Vertigo in Koreans: A Nested Case-Control Study.","authors":"Jae Sang Han, Yun-Hee Lee, Ji Hyung Lim, Dong-Hee Lee, Sang Hyun Kwak, Jae-Hyun Seo","doi":"10.21053/ceo.2024.00207","DOIUrl":"https://doi.org/10.21053/ceo.2024.00207","url":null,"abstract":"<p><strong>Objectives: </strong>Benign paroxysmal positional vertigo (BPPV) is the most prevalent cause of vertigo. This study analyzes the risk factors involved in the occurrence and recurrence of BPPV.</p><p><strong>Methods: </strong>A database maintained by the Korean National Health Insurance Service (NHIS) was used to enroll 434,552 patients diagnosed with BPPV from 2011 to 2017. A propensity score was used to match participants with an equal number of control patients without BPPV by age, sex, residential status, and socioeconomic status. Recurrence of BPPV was defined as an occurrence of BPPV more than 90 days after treatment. Logistic regression was used to analyze the occurrence of BPPV, and Cox proportional hazards models were applied to analyze the risk factors for recurrence.</p><p><strong>Results: </strong>BPPV was 2.2 times more common in females, peaking between the ages of 50 and 59 years. The five-year BPPV recurrence rate was 39.8%, with a significant portion recurring within the first year. The incidence of BPPV was statistically significantly associated with several underlying medical conditions, including vitamin D deficiency, thyroid hormone abnormalities, head trauma, and disorders of the inner ear. Advanced age, female gender, rural residence, low socioeconomic status, and the presence of inner-ear diseases were notable risk factors for the recurrence of BPPV.</p><p><strong>Conclusion: </strong>Our study provides significant insight into the risk factors associated with both the occurrence and recurrence of BPPV, which appears to be linked to vitamin D levels, thyroid hormones, and estrogen. Conditions such as inner-ear disorders, head trauma, and otologic surgery were strongly associated with both the occurrence and recurrence of BPPV.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Assessment of Speech and Swallowing Function in Laryngopharyngeal Cancer Patients After J-Flap Reconstruction.","authors":"Yi-An Lu, Chung-Kan Tsao, Li-Jen Hsin, Hsiu-Feng Chuang, Tuan-Jen Fang","doi":"10.21053/ceo.2024.00109","DOIUrl":"10.21053/ceo.2024.00109","url":null,"abstract":"<p><strong>Objectives: </strong>A novel J-shaped anterolateral thigh (ALT) flap reconstruction technique was developed to simultaneously restore swallowing and speech functions in patients following total laryngopharyngectomy. This study aimed to assess the outcomes and surgical complications in patients who underwent J-flap reconstruction over time.</p><p><strong>Methods: </strong>Patients who underwent J-shaped ALT flap phonatory tube reconstruction were enrolled. Surgical morbidities and outcomes were evaluated every 3 months post-surgery for a period of 12 months or until death.</p><p><strong>Results: </strong>Of the 36 patients, 13 underwent circumferential pharyngeal wall resection (circumferential defect [CD] group), and 23 underwent partial resection (partial defect [PD] group). After 12 months, 97% of the patients were able to resume oral intake without the need for a nasogastric tube, and 50% achieved fluent speech using the reconstructed phonatory tube. The CD group experienced a higher rate of delayed healing than the PD group (30.8% vs. 0%, p=0.012). Additionally, the PD group showed significantly higher percentages of individuals consuming solid food at both the 3- and 12-month intervals than the CD group (81.0% vs. 23.1% and 78.9% vs. 40%, respectively).</p><p><strong>Conclusion: </strong>. This study investigated the progression of speech and swallowing functions over time after reconstruction of the voice tube with a J-flap. Using a J-shaped ALT flap phonatory tube effectively restored both speech and swallowing functions, providing long-term benefits, regardless of whether the defect was circumferential or partial.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"346-354"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video Head Impulse Test Coherence Predicts Vertigo Recovery in Sudden Sensorineural Hearing Loss With Vertigo.","authors":"Sheng-Chiao Lin, Ming-Yee Lin, Bor-Hwang Kang, Yaoh-Shiang Lin, Yu-Hsi Liu, Chi-Yuan Yin, Po-Shing Lin, Che-Wei Lin","doi":"10.21053/ceo.2024.00068","DOIUrl":"10.21053/ceo.2024.00068","url":null,"abstract":"<p><strong>Objectives: </strong>Labyrinthitis significantly reduces quality of life due to prolonged vestibular symptoms in patients experiencing sudden sensorineural hearing loss with vertigo (SSNHLV). This study employed a novel coherence analysis in the video head impulse test (vHIT) to explore vertigo outcomes in SSNHLV patients.</p><p><strong>Methods: </strong>A retrospective review was conducted on 48 SSNHLV patients who completed high-dose steroid treatment between December 2016 and April 2023. Additionally, 38 healthy volunteers were prospectively enrolled from November 2022 to April 2023 at our academic tertiary referral center. The magnitude-squared wavelet coherence between eye and head velocities during the vHIT was measured to assess correlations across frequency bands. Recovery from vertigo, determined by a visual analog scale (VAS) score of 0 at both 2 weeks and 2 months, was analyzed using multivariable Cox regression.</p><p><strong>Results: </strong>The mean VAS for patients with SSNHLV was 5.73±2.45. Higher coherent frequencies in the horizontal semicircular canal (SCC), posterior SCC, and the mean and minimal coherent frequencies of all three SCCs combined were significantly associated with early complete remission of vertigo 2 weeks posttreatment. In the multivariate analysis, the minimal coherent frequency among the three SCCs emerged as an independent factor (hazard ratio, 2.040; 95% CI, 1.776-2.304). Two months posttreatment, in addition to the previously significant parameters, abnormalities in the vestibulo-ocular reflex (VOR) in the posterior SCC, gains in the horizontal and posterior SCCs, total and overt saccades in the horizontal SCC, coherent frequency in the anterior SCC, and mean VOR gain of all three SCCs combined were also statistically significantly related to total relief from vertigo.</p><p><strong>Conclusion: </strong>The highest minimal coherent frequency among the three SCCs significantly contributed to earlier vertigo relief in patients with SSNHLV. Coherence analysis in vHIT may offer greater sensitivity than time series analysis for predicting the prognosis of vertigo.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"282-291"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}