Clinical and Experimental Otorhinolaryngology最新文献

筛选
英文 中文
Response to the Letter Regarding "Positional Obstructive Sleep Apnea and Periodic Limb Movements During Sleep: A Large Multicenter Study". 关于“体位性阻塞性睡眠呼吸暂停和睡眠中的周期性肢体运动:一项大型多中心研究”的回复。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-07-15 DOI: 10.21053/ceo.2025-00116
Yun Jin Kang, Chan-Soon Park, Hyun-Woo Shin
{"title":"Response to the Letter Regarding \"Positional Obstructive Sleep Apnea and Periodic Limb Movements During Sleep: A Large Multicenter Study\".","authors":"Yun Jin Kang, Chan-Soon Park, Hyun-Woo Shin","doi":"10.21053/ceo.2025-00116","DOIUrl":"https://doi.org/10.21053/ceo.2025-00116","url":null,"abstract":"<p><p>We appreciate the thoughtful comments regarding our study on the relationship between positional obstructive sleep apnea (POSA), OSA severity, and periodic limb movements during sleep (PLMS). In our large multicenter analysis, PLMS prevalence decreased with increasing OSA severity and was significantly higher in patients with POSA, particularly those with severe OSA. While our findings align with previous reports, differences among studies-such as that of Budhiraja et al.- may reflect variation in confounder control, including medication use, which was not captured in our retrospective, anonymized dataset. We acknowledge that iron-related laboratory parameters, including serum ferritin, were not available due to the nature of the dataset. Nonetheless, iron deficiency remains an important consideration in PLMS pathophysiology. Future prospective studies should include detailed clinical, pharmacologic, and laboratory data to clarify these associations. We thank the correspondent for the opportunity to address these important points.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of the GABAergic neural circuit in salicylate-induced tinnitus: from the inferior colliculus to the medial geniculate body. 水杨酸诱发耳鸣中gaba能神经回路的激活:从下丘到内侧膝状体。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-07-07 DOI: 10.21053/ceo.2025-00027
Xu-Yuan Peng, Jiang Wang, Ming-Yue Gong, Li-Yuan Zhang, Min Zhang, Zhi-Bin Chen, Zheng-Quan Tang, Lei Cheng
{"title":"Activation of the GABAergic neural circuit in salicylate-induced tinnitus: from the inferior colliculus to the medial geniculate body.","authors":"Xu-Yuan Peng, Jiang Wang, Ming-Yue Gong, Li-Yuan Zhang, Min Zhang, Zhi-Bin Chen, Zheng-Quan Tang, Lei Cheng","doi":"10.21053/ceo.2025-00027","DOIUrl":"https://doi.org/10.21053/ceo.2025-00027","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the regulatory functions of gamma-aminobutyric acid (GABA)ergic neural circuits from the inferior colliculus (IC) to the medial geniculate body (MGB) in salicylate-induced tinnitus.</p><p><strong>Methods.: </strong>Mice were treated with salicylate to induce tinnitus, and tinnitus-like behaviors were evaluated via gap prepulse inhibition of acoustic startle. Using combined viral tracing methodologies, we identified and mapped the pathways and connections from the IC to the MGB. Moreover, we used Gq-coupled human M3 designer receptors exclusively activated by designer drugs (DREADDs) and Gi-coupled human M4 DREADDs, allowing targeted control of GABAergic neurons through excitation or suppression in the IC and MGB regions. Following the administration of Clozapine N-oxide, which can bind to the abovementioned specific receptors, we modulated these neural circuits to assess their impact on tinnitus severity in a mouse model.</p><p><strong>Results.: </strong>Our results indicated that mice exposed to salicylate exhibited tinnitus-like behavior. GABAergic neurons projecting retrogradely from the MGB to the IC are mainly concentrated in the external nucleus of the IC. After the administration of Clozapine N-oxide, the chemogenetic activation of IC-MGB GABAergic neurons aggravated salicylate-induced tinnitus. Our study revealed that activation of GABAergic neurons between the IC and MGB was effective in inducing tinnitus perception, even in the absence of salicylate. However, chemogenetic inhibition of the IC-MGB GABAergic circuit did not reverse salicylate-induced tinnitus.</p><p><strong>Conclusion.: </strong>This finding suggests that activation of the IC-MGB GABAergic neural circuit may contribute to tinnitus generation, but through a mechanism that is distinct from salicylate-induced tinnitus. This study provided novel insights into the mechanisms underlying tinnitus.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications and Future Perspectives of Large Language Models in Otolaryngology-Head and Neck Surgery: A Comprehensive Survey. 大语言模型在耳鼻喉头颈外科中的应用及未来展望:一项综合调查。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-07-01 DOI: 10.21053/ceo.2025-00121
Junyong Ahn, Bong Gyun Kang, Munyoung Chang, Sungroh Yoon
{"title":"Applications and Future Perspectives of Large Language Models in Otolaryngology-Head and Neck Surgery: A Comprehensive Survey.","authors":"Junyong Ahn, Bong Gyun Kang, Munyoung Chang, Sungroh Yoon","doi":"10.21053/ceo.2025-00121","DOIUrl":"https://doi.org/10.21053/ceo.2025-00121","url":null,"abstract":"<p><p>Since the release of ChatGPT, large language models (LLMs) have rapidly expanded into professional domains, including the medical field. These models, trained on vast text corpora, including the medical literature, have demonstrated impressive capabilities in tasks such as clinical decision support, research assistance, and education. This review focuses on the applications of LLMs in otolaryngology and head and neck surgery (ENT). We analyzed 25 studies published between January 2022 and March 2025 in ENT journals ranked in the top 25% based on the 2023 edition of the Journal Citation Reports (Q1). Moreover, we categorized them by use case and examined the models, datasets, and evaluation methods employed. Despite the growing adoption of LLMs in the ENT field, several challenges remain, including limited model diversity, inconsistent evaluations, and insufficient accuracy and fairness. We also contextualized LLM research trends within a broader medical domain. We highlighted five key areas for advancing clinical-grade LLMs: robust evaluation frameworks, external source-based generation, multimodal integration, agent-based reasoning, and model explainability. Our findings provide ENT clinicians and researchers with a practical foundation for understanding, evaluating, and applying LLMs or advanced versions of LLMs (e.g., Large Multimodal Models, Agents) in clinical and research settings.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-port hairline approach thyroidectomy (SPHAT) in male patients: a retrospective analysis of cosmetic and surgical outcomes. 单孔发际线入路甲状腺切除术(SPHAT)在男性患者:美容和手术结果的回顾性分析。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-06-30 DOI: 10.21053/ceo.2025-00098
Ji Won Kim, Myung Woul Han
{"title":"Single-port hairline approach thyroidectomy (SPHAT) in male patients: a retrospective analysis of cosmetic and surgical outcomes.","authors":"Ji Won Kim, Myung Woul Han","doi":"10.21053/ceo.2025-00098","DOIUrl":"https://doi.org/10.21053/ceo.2025-00098","url":null,"abstract":"<p><strong>Background: </strong>While the concern for visible scars might traditionally be associated more with female patients, male patients are increasingly valuing cosmetic outcomes in surgical procedures. A single port robot thyroidectomy using only a hairline approach is feasible in female patients. The purpose of this study is to investigate the safety, utility, and cosmetic outcomes of single port hairline approach thyroidectomy (SPHAT), emphasizing its ability to minimize visible scarring in male patients.</p><p><strong>Materials and methods: </strong>Thirty-one male patients underwent by one surgeon using SPHAT between February 2020 and February 2024. We analyzed the operation time, complication rate, pain score (NRS score), and cosmetic results in male patients.</p><p><strong>Results: </strong>Twenty-seven cases were diagnosed with papillary thyroid carcinomas and 1 follicular thyroid carcinoma, 2 non-invasive follicular neoplasms with papillary-like nuclear features, and 1 follicular adenoma were found. The median age (range) of the patients was 62 (34-73) years. Hemithyroidectomies were performed in 28 cases and total thyroidectomies in 3 cases. Central neck dissection was performed in 26 cases. The median total operative time (range) was 89 (55-160) minutes, with a median console time of 49 (26-125) minutes. All patients were discharged without major complications on the second or third day after the operation. The postoperative pain NRS score were 3.71±1.56 on the day of surgery and 2.86±0.35 on the first postoperative day. At six months after surgery, cosmetic VAS satisfaction scale was a mean score of 8.51±1.62.</p><p><strong>Conclusion: </strong>SPHAT is also a viable and safe option for male patients, delivering excellent cosmetic outcomes.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Outcomes of the Inferior Meatus Augmentation Procedure with Autologous Costal Cartilage for Empty Nose Syndrome. 自体肋软骨下鼻道隆胸术治疗空鼻综合征疗效观察。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-06-25 DOI: 10.21053/ceo.2025-00107
Jang Wook Gwak, Yong Ju Jang
{"title":"Treatment Outcomes of the Inferior Meatus Augmentation Procedure with Autologous Costal Cartilage for Empty Nose Syndrome.","authors":"Jang Wook Gwak, Yong Ju Jang","doi":"10.21053/ceo.2025-00107","DOIUrl":"https://doi.org/10.21053/ceo.2025-00107","url":null,"abstract":"<p><strong>Objective: </strong>Empty nose syndrome (ENS) is a rare postoperative complication arising from turbinate surgery. Here, we report our clinical experience and comprehensive analysis of the inferior meatus augmentation procedure with autologous costal cartilage (IMAP-ACC) for ENS.</p><p><strong>Methods: </strong>We conducted a retrospective review of medical records of patients diagnosed with ENS and underwent IMAP-ACC at a tertiary referral center between November 2015 and November 2023. Symptom improvement was assessed by the Empty Nose Syndrome 6-Item Questionnaire (ENS6Q) score before and after the IMAP. Additionally, perioperative complications and revision surgery cases were investigated.</p><p><strong>Results: </strong>Out of the 32 patients that underwent IMAP-ACC, the clinical analysis included 20 patients (16 males, 4 females) with a mean age of 39.1 ± 11.5 years and mean follow-up of 61.2 ± 28.8 months. The mean ENS6Q score improved significantly from 17.5 ± 5.3 preoperatively to 9.1 ± 6.0 at the last follow-up (p<0.001). In the subgroup analysis of 16 patients whose early follow-up data were available, significant improvements were observed in the ENS6Q scores at both the early (7.8 ± 5.7) and long-term follow-up (8.6 ± 6.5) compared to the preoperative value (18.2 ± 5.6). Among 32 patients, nasal obstruction was the most common perioperative complication (34.4%), necessitating reoperation in four patients (12.5%). Most complications were managed well with a conservative approach.</p><p><strong>Conclusion: </strong>IMAP-ACC demonstrated its role as a valuable treatment option for patients with ENS, showing sustained effectiveness over a long-term follow-up period.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of angular insertion depth of a cochlear implant electrode array: 3D reconstruction versus spiral formulae. 人工耳蜗电极阵列角度插入深度的估计:三维重建与螺旋公式。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-06-25 DOI: 10.21053/ceo.2025-00043
Irumee Pai, Aditi Shetty, Gowri Pradeep, Charalampos Komninos, Christos Bergeles, Sebastien Ourselin, Steve Connor
{"title":"Estimation of angular insertion depth of a cochlear implant electrode array: 3D reconstruction versus spiral formulae.","authors":"Irumee Pai, Aditi Shetty, Gowri Pradeep, Charalampos Komninos, Christos Bergeles, Sebastien Ourselin, Steve Connor","doi":"10.21053/ceo.2025-00043","DOIUrl":"https://doi.org/10.21053/ceo.2025-00043","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective was to determine which of the following angular insertion depth (AID) estimation methods had the strongest correlation with the post-operative AID (AIDpost-op) of a lateral wall (LW) electrode: 1) Escudé formula based on the largest distance from the round window (RW) to the LW (distance A), 2) the elliptic-circular approximation (ECA) method based on both distance A and the perpendicular distance (distance B), 3) a 3D reconstruction method. The secondary objective was to evaluate the impact of using the actual electrode insertion length on the evaluation of the AID estimation methods.</p><p><strong>Methods: </strong>The study included 45 cochleae implanted with the Advanced Bionics SlimJ electrode, with all 16 active electrode contacts being intracochlear. Distance A, distance B and a 3D reconstruction along the LW using 3D Slicer were evaluated on pre-operative magnetic resonance imaging (MRI). The AIDpost-op and insertion length were assessed on post-operative cone beam computed tomography (CBCT). Two sets of estimated AID values were obtained: 1) assuming perfect 23 mm insertion length with the reference electrode at the RW (AID23mm), 2) with the actual insertion length (AIDinsertionlength). Spearman's Rank correlation coefficient assessed he association between the estimated AID values and AIDpost-op.</p><p><strong>Results: </strong>A moderately positive correlation was found between AID23mm and AIDpost-op for all three approaches, with no statistical difference among them (rs=0.410-0.579). When the analysis was repeated with AIDinsertionlength, the strength of the correlation with AIDpost-op improved significantly for all three, with the 3D reconstruction method having a stronger correlation (rs=.952) than the Escudé formula (rs=0.734) or ECA method (rs=0.787) (p<.001).</p><p><strong>Conclusion: </strong>The 3D reconstruction approach has the potential to improve prediction of AID of a LW electrode array compared to spiral formulae based on 2D cochlear dimensions. Accurate assessment of the actual insertion length is important for proper evaluation of AID estimation methods.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Affecting Visible Contamination of Positive Airway Pressure Devices in Patients with Obstructive Sleep Apnea. 影响阻塞性睡眠呼吸暂停患者气道正压通气器可见污染的因素。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-06-12 DOI: 10.21053/ceo.2025-00123
Il-Youp Kwak, Kyung Soo Kim, Hyun Jin Min
{"title":"Factors Affecting Visible Contamination of Positive Airway Pressure Devices in Patients with Obstructive Sleep Apnea.","authors":"Il-Youp Kwak, Kyung Soo Kim, Hyun Jin Min","doi":"10.21053/ceo.2025-00123","DOIUrl":"https://doi.org/10.21053/ceo.2025-00123","url":null,"abstract":"","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-occurrence of otologic disorders and benign paroxysmal positional vertigo: Systematic review and meta-analysis. 耳科疾病和良性阵发性位置性眩晕的共同发生:系统回顾和荟萃分析。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-06-09 DOI: 10.21053/ceo.2025-00030
Mustafa Karabulut, Sevgi Kutlu, Wolfgang Viechtbauer, Ali Melliti, Cem Meço, Alfarghal Mohamad, Osman Nuri Özgirgin, Anita Bhandari, Herman Kingma, Raymond van de Berg
{"title":"Co-occurrence of otologic disorders and benign paroxysmal positional vertigo: Systematic review and meta-analysis.","authors":"Mustafa Karabulut, Sevgi Kutlu, Wolfgang Viechtbauer, Ali Melliti, Cem Meço, Alfarghal Mohamad, Osman Nuri Özgirgin, Anita Bhandari, Herman Kingma, Raymond van de Berg","doi":"10.21053/ceo.2025-00030","DOIUrl":"https://doi.org/10.21053/ceo.2025-00030","url":null,"abstract":"<p><strong>Objective: </strong>To systematically investigate the co-occurrence of otologic disorders and benign paroxysmal positional vertigo (BPPV).</p><p><strong>Data sources: </strong>PubMed and Web of Science.</p><p><strong>Review methods: </strong>All original studies in English, from full-text clinical trials to case reports, involving participants ≥18 years old, were included. Two groups of article were identified: Group 1) studies reporting co-occurring otologic disorders in BPPV patients; Group 2) studies reporting co-occurring BPPV in patients with otologic disorders. The frequency of each condition was analyzed using descriptive statistics. Meta-analyses were performed using a random-effects model to estimate overall prevalence in both groups.</p><p><strong>Results: </strong>A total of 3407 studies were retrieved of which 68 articles were included in the analysis. In Group 1, 11.4% of BPPV patients (932/8157) had co-occurring otologic disorders (19 studies). The most commonly reported conditions were sudden sensorineural hearing loss (11.9%) and acute unilateral vestibulopathy/vestibular neuritis (5.0%). Meta-analyses showed pooled prevalences of 11.8% (95% CI: 3.1%- 35.7%) for sudden sensorineural hearing loss and 6.5% (95% CI: 3.7%-11.2%) for acute unilataral vestibulopathy/vestibular neuritis. In Group 2, 9.7% of patients with otologic disorders (1106/11457) had co-occurring BPPV (49 studies). Menière's disease was the most frequently reported disorder that resulted in co-occurring BPPV (10.2%). Meta-analyses showed pooled prevalences of 10.4% (95% CI: 6.2%-16.8%) for acute unilateral vestibulopathy/vestibular neuritis and 9.1% (95% CI: 4%-19.1%) for Menière's disease.</p><p><strong>Conclusion: </strong>The co-occurrence of otologic disorders and BPPV are prevalent. These findings demonstrate the need for mutual screening of BPPV and otologic disorders. Furthermore, these findings might help understanding the etiologies underlying BPPV.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Underlying Mechanisms of Obstructive Sleep Apnea: A Review. 阻塞性睡眠呼吸暂停的潜在机制综述。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-06-02 DOI: 10.21053/ceo.2025-00071
Yun Jin Kang, Chan-Soon Park
{"title":"Underlying Mechanisms of Obstructive Sleep Apnea: A Review.","authors":"Yun Jin Kang, Chan-Soon Park","doi":"10.21053/ceo.2025-00071","DOIUrl":"https://doi.org/10.21053/ceo.2025-00071","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper airway obstruction during sleep, leading to apnea and hypopnea. While anatomical factors such as upper airway collapsibility are significant contributors, emerging evidence underscores the role of non-anatomical mechanisms, including impaired pharyngeal muscle responsiveness, low arousal threshold, and high ventilatory loop gain. Interplay of these factors can cause respiratory instability, sleep fragmentation, and systemic complications. The pathophysiology of OSA is further influenced by obesity, aging, gender differences, and central nervous system dysfunction, contributing to cardiovascular and metabolic comorbidities. Advances in diagnostic techniques such as cephalometry and polysomnography, along with therapies including continuous positive airway pressure, mandibular advancement devices, and hypoglossal nerve stimulation highlight the need for personalized treatment approaches. Although surgical interventions targeting multi-level airway obstructions also show promise, they are limited by variable long-term efficacy. A comprehensive understanding of OSA's multifactorial mechanisms is crucial for improving diagnostic accuracy and tailoring management strategies. This review summarizes recent findings to elucidate the complex pathophysiology of OSA and emphasizes a multidimensional approach to optimize patient outcomes.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and Morphological Changes in the Olfactory Epithelium of Mouse Models with Upper Respiratory Inflammation and Olfactory Dysfunction. 上呼吸道炎症和嗅觉功能障碍小鼠模型嗅上皮的功能和形态变化。
IF 2.9 3区 医学
Clinical and Experimental Otorhinolaryngology Pub Date : 2025-05-26 DOI: 10.21053/ceo.2025-00003
Shin Hyuk Yoo, Jun-Sang Bae, Reiza Ventura, Eun Hee Kim, A Young Kim, Ji Hye Kim, Ji-Hun Mo
{"title":"Functional and Morphological Changes in the Olfactory Epithelium of Mouse Models with Upper Respiratory Inflammation and Olfactory Dysfunction.","authors":"Shin Hyuk Yoo, Jun-Sang Bae, Reiza Ventura, Eun Hee Kim, A Young Kim, Ji Hye Kim, Ji-Hun Mo","doi":"10.21053/ceo.2025-00003","DOIUrl":"https://doi.org/10.21053/ceo.2025-00003","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated behavioral tests and histological findings of allergic rhinitis (AR), chronic rhinosinusitis (CRS), and drug-induced anosmia murine models, comparing the results among groups.</p><p><strong>Methods: </strong>This study established total six animal model groups: control, ovalbumin (OVA) induced AR, OVA/poly(I:C) induced neutrophilic dominant rhinitis, OVA/staphylococcus enterotoxin B induced CRS, two anosmia models induced by 3-methylindole (3-MI) intraperitoneal injection and chronic ZnSO4 intranasal administration (n=5 in each group). Olfactory function was evaluated using an open-field food-finding test and a T-maze test one week after establishing the models. The results of the behavioral tests were analyzed using video analysis software (EthoVision XT), and the immunofluorescent staining was performed to evaluate the histologic changes of olfactory sensory neurons (OSNs) and olfactory basal cells.</p><p><strong>Results: </strong>OVA and OVA/poly(I:C) induced rhinitis groups showed increased food finding time compared with control and CRS groups in T-maze test. The two anosmia mouse models showed statistically significant differences from the other groups. There was a significant positive correlation between food-finding time and the two novel variables evaluated in this study: total distance moved and average velocity in both the open-field and T-maze tests. Histologically, there was a significant decrease in the number of mature and immature OSNs in the CRS and two anosmia models. Two rhinitis groups and CRS group showed significant changes in the number of immature OSNs. Additionally, there were changes in the basal cell marker (cytokeratin-5) in the 3-MI model.</p><p><strong>Conclusion: </strong>This study demonstrated significant differences in olfactory function and histological changes among various mouse models of upper airway inflammation and druginduced anosmia using histological analysis and behavioral test and can be used as a reference for future study on olfaction using mouse models.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信