Clinical and Experimental Otorhinolaryngology最新文献

{"title":"Trends in the Age-Adjusted Incidence of Head and Neck Cancer in South Korea Over the Past 20 Years.","authors":"Jae Hoon Cho, Jeffrey D Suh, Young Chang Lim","doi":"10.21053/ceo.2024.00346","DOIUrl":"10.21053/ceo.2024.00346","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to calculate the age-adjusted incidence rate of head and neck cancer (HNC) in South Korea from 1999 to 2020 and to analyze HNC incidence trends while excluding the effects of population aging.</p><p><strong>Methods: </strong>Data were obtained from the Cancer Registration Statistics Program. All 12 types of HNCs were analyzed. Crude incidence rates and the number of new cases from 1999 to 2020 were presented by sex and age group. Age-adjusted incidence rates were calculated using the World Standard Population (World Health Organization [WHO] 2000-2025), and trends were assessed.</p><p><strong>Results: </strong>Although the crude incidence rates of all HNCs increased steadily from 1999 to 2020, the absolute values remained low in most cases, at less than 2 per 100,000. The male-to-female ratio was 1 or higher for all HNCs except thyroid cancer, and 10 or higher for laryngeal and hypopharyngeal cancers. Age-adjusted incidence trends showed a gradual increase for tongue cancer, tonsil cancer, major salivary gland cancer, and thyroid cancer, a decrease for laryngeal cancer, and no significant change for the remaining HNCs.</p><p><strong>Conclusion: </strong>Excluding the effects of population aging, tongue cancer, tonsil cancer, major salivary gland cancer, and thyroid cancer have increased in South Korea over the past 20 years, while laryngeal cancer has decreased.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"180-187"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the Treatment of Laryngeal Cancer from the Korean Society of Head and Neck Surgery.","authors":"Jeon Yeob Jang, Geun-Jeon Kim, Sang-Yeon Kim, Min-Su Kim, Dong Kun Lee, Minsu Kwon, Dongbin Ahn, Myung Jin Ban, Young Kang, Ho-Ryun Won, Jae Won Chang, Dong Won Lee, Ki Nam Park, Yeon Soo Kim, Ah Ra Jung, Jungirl Seok, Hye Ran Lee, Sung-Chan Shin, Chang Myeon Song, Gil Joon Lee, Jihye Kwak, Soo Yeon Jung, Bo Hae Kim, Dong-Hyun Lee, Nayeon Choi, Eun Kyung Jung, Yong Tae Hong, Hyun-Bum Kim, Seung Hoon Han, Su Il Kim, Ji Won Kim, Yoon-Jong Ryu, Heejin Kim, Sung Joon Park, Hanaro Park, Eun-Jae Chung, Seung-Kuk Baek, Jun-Ook Park, Kwang-Jae Cho","doi":"10.21053/ceo.2025.00009","DOIUrl":"10.21053/ceo.2025.00009","url":null,"abstract":"<p><strong>Objectives: </strong>Effective treatment of laryngeal cancer requires clinical decision-making that balances survival outcomes with the preservation of essential functions, such as voice and swallowing. This study, led by the Clinical Practice Guideline Committee of the Korean Society of Head and Neck Surgery, aims to establish evidence-based recommendations to guide surgeons in optimizing treatment decisions for patients with laryngeal cancer.</p><p><strong>Methods: </strong>A literature search was performed in the PubMed, Embase, Cochrane Library, and KoreaMed databases by a literature search expert and subsequently reviewed by a panel of 39 committee experts. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method was employed to assess the quality of evidence and develop and report the recommendations. The strength of each recommendation reflects the guideline panel's confidence that the benefits of an intervention outweigh its risks for the target population. After drafting the guidelines, Delphi questionnaires were distributed to members of the Korean Society of Head and Neck Surgery and an external reviewer panel.</p><p><strong>Results: </strong>In total, 15 evidence-based recommendations are provided, addressing six critical aspects of laryngeal cancer treatment: early-stage treatment, treatment of locally advanced cancer, neck management, adjuvant therapy, swallowing rehabilitation, and salvage treatment for recurrent tumors.</p><p><strong>Conclusion: </strong>The guidelines provide evidence-based, validated recommendations to support clinicians in making optimal treatment decisions for laryngeal cancer.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"89-108"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Efficacy of the Body Roll Test for Lateral Canal Benign Paroxysmal Positional Vertigo: A Randomized Controlled Study.","authors":"Hyun Jin Lee, Yun-Jung Yang, Sung Goo Yoo, Eun-Ju Jeon","doi":"10.21053/ceo.2024.00296","DOIUrl":"10.21053/ceo.2024.00296","url":null,"abstract":"<p><strong>Objectives: </strong>Lateral canal benign paroxysmal positional vertigo (LC-BPPV) is diagnosed using the head roll test (HRT), which involves rotating the head to mobilize particles within the lateral canal, inducing nystagmus. The body roll test (BRT) is conducted by rolling both the body and head simultaneously, offering the advantage of safely achieving the correct rotational angle in both directions. This study evaluates the diagnostic utility of the BRT.</p><p><strong>Methods: </strong>A randomized controlled study was conducted. In total, 43 patients with LC-BPPV symptoms were enrolled and randomly divided into two groups. In group A (n=21), the HRT was administered first, followed by the BRT after a 5-minute interval. In contrast, group B (n=22) received the BRT first, followed by the HRT after 5 minutes. Participants wore Fresnel glasses, which allowed for the observation of nystagmus in sitting, bowing, and lying down positions. We recorded the direction, latency, and duration of the nystagmus.</p><p><strong>Results: </strong>The distribution of nystagmus types was 18:25 (geotropic: apogeotropic). There was no significant difference in age, sex, or type of nystagmus between the two groups. The findings from the HRT aligned with those from the BRT for 32 (74.4%) of the participants. No statistical differences were noted in the diagnosis of the affected side or in the type of nystagmus (geotropic vs. apogeotropic) between the HRT (n=32) and BRT (n=32) (P>0.05). The diagnostic rates in the first (n=31) and second tests (n=33) were similar, showing no significant difference and consistent results regarding the type of LC-BPPV. Additionally, there were no significant differences in postural discomfort and pain scores between these groups.</p><p><strong>Conclusion: </strong>BRT and HRT demonstrate comparable diagnostic efficacy for LC-BPPV. BRT offers a viable alternative, especially for patients whose conditions preclude the use of HRT, and may improve diagnostic accuracy when combined with HRT.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"134-142"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Hearing Impairment in Newborns Using Targeted Genomic Sequencing: A Large Pilot Cohort Study.","authors":"Pei-Hsuan Lin, Yu-Ting Chiang, Cheng-Yu Tsai, Chia-Huei Chu, Chia-Cheng Hung, Yi-Ning Su, Wei-Chung Hsu, Tien-Chen Liu, Chuan-Jen Hsu, Po-Nien Tsao, Chen-Chi Wu","doi":"10.21053/ceo.2024.00275","DOIUrl":"10.21053/ceo.2024.00275","url":null,"abstract":"<p><strong>Objectives: </strong>State-run newborn hearing screening (NBHS) programs have limitations in identifying children with mild or late-onset sensorineural hearing impairment (SNHI). Given that over 50% of pediatric SNHI cases are linked to genetic causes, the increasing accessibility of high-throughput, low-cost genomic sequencing may help address these shortcomings. This study investigates the feasibility of integrating a next-generation sequencing (NGS)-based genomic screening protocol into conventional NBHS and examines its potential benefits and challenges.</p><p><strong>Methods: </strong>A total of 8,261 newborns underwent simultaneous NBHS and NGS-based genomic screening targeting 46 deafness genes in this prospective study. The subjects' genotypes were determined, and those with conclusive genetic diagnoses received audiological assessments.</p><p><strong>Results: </strong>Conclusive genetic diagnoses were confirmed in 164 subjects, with 112 carrying variants in GJB2 and MTRNR1 and 52 carrying variants in other deafness genes. Notably, 126 of these subjects passed the NBHS, suggesting that an additional 1.5% (126/8,261) of children at risk for SNHI, who would have been missed by conventional physiological screening, can be identified through targeted genomic screening in the general population. Furthermore, one subject's father, who carried a COL4A5 variant, and three paternal relatives of another subject carrying an EDNRB variant (previously undiagnosed) were identified with Alport and Waardenburg syndromes, respectively, underscoring the familial benefits of this approach.</p><p><strong>Conclusion: </strong>Targeted genomic sequencing in newborns may serve as a valuable complement to conventional NBHS by identifying children at risk for SNHI and enabling early diagnosis in families with non-syndromic mimics.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"152-161"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies towards development of regenerative medicine approaches for olfactory disorders.","authors":"Do Hyun Kim, Michael Wang, Sarah Kim, David W Jang, Tiffany Ko, Bradley J Goldstein","doi":"10.21053/ceo.2025-00065","DOIUrl":"https://doi.org/10.21053/ceo.2025-00065","url":null,"abstract":"<p><p>Olfactory loss impacts >12% of the population and increases with aging. Multiple conditions can cause loss of smell (hyposmia or anosmia), including post-viral damage from COVID-19 or influenza, head injuries, sinusitis, or neurodegenerative conditions such as Alzheimer's or Parkinson's disease. While treatments including surgery, anti-inflammatories or olfactory training may be of benefit in specific cases, there is an unmet need for effective therapies for many common causes of olfactory dysfunction, especially those thought to be due to damage to the olfactory neurons that have failed to recover spontaneously. Regenerative medicine approaches, to either stimulate re-growth of sensory neural structures or to replace them via cell-based therapies, have been a subject of interest for many neurologic disorders, including olfactory loss. Here, we summarize the normal regenerative properties of the peripheral olfactory system and focus on current research strategies, along with barriers to be addressed for successful translational applications. A major unmet need for the field involves establishment of well-accepted culture models to expand and differentiate olfactory stem or progenitor cells from rodents and humans, for both in vitro assays and potential material for cell-based therapies.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioresistance mechanism in head and neck cancer.","authors":"QuocKhanh Nguyen, Bon Seok Koo","doi":"10.21053/ceo.2025-00029","DOIUrl":"https://doi.org/10.21053/ceo.2025-00029","url":null,"abstract":"<p><p>Head and neck cancer (HNC) is not only one of the deadliest malignant tumors but also a major burden on patient quality of life due to its proximity to various organs at risk. Radiotherapy is a treatment option for HNC because of its ability to eliminate cancer cells while preserving the organs. However, the development of radioresistance has severely hindered its therapeutic efficacy, often resulting in poor prognosis and treatment failure. Therefore, a better understanding of the mechanisms of radioresistance can help develop new treatment strategies to reduce recurrence rates and improve survival outcomes. We have summarized the main mechanisms associated with radioresistance in HNC from the perspectives of cancer cells and the tumor microenvironment. Moreover, we explored the radiation-sensitizing options currently available to overcome radioresistance in HNC.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Korean Society of Pediatric Otorhinolaryngology (KSPO) and the 10th Asia-Pacific Pediatric Otolaryngology Society (APPOS) Conference 2025 in Seoul.","authors":"Gi Jung Im, Seok Hyun Cho","doi":"10.21053/ceo.2025.00062","DOIUrl":"https://doi.org/10.21053/ceo.2025.00062","url":null,"abstract":"","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into Reponses to Caloric and head impulse stimulation in Lateral Semicircular Canal Benign Paroxysmal Positional Vertigo.","authors":"Seong Hoon Bae, Sang Hyun Kwak, Jeon Mi Lee, Ji Hyuk Han, Dae Bo Shim, Sung Huhn Kim","doi":"10.21053/ceo.2024-00365","DOIUrl":"https://doi.org/10.21053/ceo.2024-00365","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the pathophysiology of persistent geotropic direction-changing positional nystagmus (pGeo DCPN) by analyzing the caloric responses and clinical course in patients with pGeo DCPN and other variants of lateral semicircular canal benign paroxysmal positional vertigo (LSCC BPPV).</p><p><strong>Methods: </strong>In this case-control prospective study, 101 patients diagnosed with pGeo DCPN (pGeo group, N=34), persistent apogeotropic (pApo) DCPN (pApo group, N=40), or transient geotropic (tGeo) DCPN (tGeo group, N=27) involving the LSCC were enrolled. The video head impulse test (vHIT) and caloric test were performed on the day of diagnosis. If one or both of the tests.</p><p><strong>Results.: </strong>were abnormal, a follow-up test was performed after the disappearance of nystagmus. Differences in the tests.</p><p><strong>Results.: </strong>and clinical course were compared and analyzed across each type of LSCC BPPV.</p><p><strong>Results: </strong>The mean disease duration was significantly longer in patients with pGeo (23.0 days) than those with pApo (8 days) and tGeo (9 days) (p<0.005). All enrolled patients showed normal vHIT gain. Patients with pGeo demonstrated the highest canal paresis (CP) value (vs. pApo: p = 0.002 and vs. tGeo: p < 0.001) and a higher frequency of abnormal CP (61.8%) compared to pApo (22.5%) and tGeo (11.1%) groups. CP was predominantly ipsilesional (85.7%) in patients with pGeo. Follow-up caloric tests showed decreased CP in 72.7% of patients with pGeo, with 36.4% showing normalized CP after the disappearance of nystagmus.</p><p><strong>Conclusion: </strong>In Conclusion, the clinical course, caloric test, and vHIT results in patients with different types of LSCC BPPV in this study implied a distinct pathophysiology for each type. The deflection of the cupula by buoyancy in pGeo DCPN could plausibly lead to CP while preserving vHIT integrity.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nrf2: A Promising Therapeutic Target for Glucocorticoid-Resistant Chronic Rhinosinusitis.","authors":"Yue Wang, Yi Yang","doi":"10.21053/ceo.2024.00373","DOIUrl":"https://doi.org/10.21053/ceo.2024.00373","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic rhinosinusitis (CRS) presents a challenge for otolaryngologists due to its complex management and high recurrence rates. Glucocorticoids (GCs) are extensively utilized for their potent anti-inflammatory effects in managing various inflammatory conditions and also play a pivotal role in treating CRS. Certain patients exhibit insensitivity to GC therapy, leading to GC resistance (GCR). Oxidative stress is one causative factor for GCR development, while the Nrf2 signaling pathway emerges as a critical cellular defense mechanism against oxidative stress-induced damage. Exploring the Nrf2 signaling pathway is promising for advancing our understanding of GC sensitivity and its application in treating CRS. This article overviews the relationship between GC sensitivity and the Nrf2 signaling pathway and potential Nrf2-related drugs. Studies have shown that Nrf2 activators, used alone or in combination with GCs, more effectively inhibit the release of inflammatory factors and oxidative stress damage than GC monotherapy, making them a promising new target for CRS treatment.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of dupilumab as an adjuvant treatment after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps: a retrospective cohort analysis.","authors":"Chin-Nung Liu, Te-Huei Yeh, Chih-Feng Lin, Yi-Tsen Lin","doi":"10.21053/ceo.2024.00310","DOIUrl":"https://doi.org/10.21053/ceo.2024.00310","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high recurrence rate following endoscopic sinus surgery (ESS). The role of adjunctive biologic therapy remains to be fully elucidated. This study aims to assess the efficacy of dupilumab in conjunction with ESS for patients with CRSwNP.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of type 2 CRSwNP patients who underwent ESS. The study compared those who received postoperative dupilumab to those who underwent standard care. Changes in the Lund-Kennedy endoscopic score (LKES) and nasal polyp score (NPS) were recorded, and linear mixed models (LMMs) were utilized for primary outcome analysis.</p><p><strong>Results: </strong>The study enrolled 49 CRSwNP patients, with 22 patients in the dupilumab group. Postoperative LKES and NPS decreased in both groups. LMM showed significant improvement in LKESs (B = -0.61, 95% CI: -0.90 to -0.31, P < 0.001) and more pronounced improvement in NPSs (B = -0.14, 95% CI: -0.25 to -0.02, P = 0.025) in the dupilumab group from pre- to post-operation measurements compared to control group.</p><p><strong>Conclusion: </strong>In comparison to ESS alone, the adjunctive use of dupilumab in the postoperative period was associated with greater reductions in both nasal polyp scores and endoscopic scores.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}