Clinical and Experimental Otorhinolaryngology最新文献

{"title":"Relationship of Sudden Sensorineural Hearing Loss With History of Chronic Periodontitis.","authors":"So Young Kim, Hyo Geun Choi, Joo-Hee Kim, Dae Myoung Yoo, Kyeongmin Han, Na-Eun Lee, Mi Jung Kwon, Ho Suk Kang","doi":"10.21053/ceo.2024.00297","DOIUrl":"10.21053/ceo.2024.00297","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic periodontitis (CP) has been linked to an increased risk of sudden sensorineural hearing loss (SSNHL). This study aimed to delineate the causal relationships between CP and SSNHL.</p><p><strong>Methods: </strong>Data from participants aged 40 years or older in the Korean National Health Insurance Service-Health Screening Cohort from 2002 through 2019 were used. Data for 13,769 patients with SSNHL were collected and matched with those for 55,076 control participants based on demographic and socioeconomic variables. The incidence of CP before the onset of SSNHL was recorded. The odds ratios (ORs) for SSNHL based on CP history were calculated using conditional logistic regression. ORs were analyzed according to the frequency of CP, specifically ≥1, ≥2, and ≥3 clinic visits for CP within 1 year and ≥1 visit within 2 years. Sensitivity analyses were also conducted for all covariables.</p><p><strong>Results: </strong>The patients with SSNHL had a higher mean number of CP visits (0.71 within 1 year and 1.34 within 2 years) compared with control participants. CP was associated with increased odds of SSNHL, with an OR of 1.14 (95% CI, 1.10-1.19) for ≥1 CP visit, an OR of 1.09 (95% CI, 1.03-1.15) for ≥2 visits, and an OR of 1.09 (95% CI, 1.02-1.17) for ≥3 visits within 1 year. Furthermore, having experienced at least 1 visit for CP within 2 years was associated with 1.15 times greater odds of SSNHL (95% CI, 1.10-1.19). Higher rates of SSNHL were also observed in the subgroups of participants with underweight, overweight, and age ≥65 years, as well as those with comorbidities.</p><p><strong>Conclusion: </strong>CP was linked to an elevated incidence of SSNHL. Individuals with comorbidities, advanced age, or abnormal body weight were more likely to exhibit both CP and SSNHL.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"225-233"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Korean Society of Pediatric Otorhinolaryngology (KSPO) and the 10th Asia-Pacific Pediatric Otolaryngology Society (APPOS) Conference 2025 in Seoul.","authors":"Gi Jung Im, Seok Hyun Cho","doi":"10.21053/ceo.2025.00062","DOIUrl":"10.21053/ceo.2025.00062","url":null,"abstract":"","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"201-203"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Dupilumab as an Adjuvant Treatment After Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps: A Retrospective Cohort Analysis.","authors":"Chin-Nung Liu, Te-Huei Yeh, Chih-Feng Lin, Yi-Tsen Lin","doi":"10.21053/ceo.2024.00310","DOIUrl":"10.21053/ceo.2024.00310","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrates a high recurrence rate following endoscopic sinus surgery (ESS). The role of adjunctive biologic therapy remains incompletely understood. This study aims to assess the efficacy of dupilumab when used in conjunction with ESS for patients with CRSwNP.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of type 2 CRSwNP patients who underwent ESS. The study compared patients receiving postoperative dupilumab with those receiving standard care. Changes in the Lund-Kennedy endoscopic score (LKES) and nasal polyp score (NPS) were recorded, and linear mixed models (LMMs) were employed for the primary outcome analysis.</p><p><strong>Results: </strong>The study enrolled 49 CRSwNP patients, with 22 patients in the dupilumab group. Postoperative LKES and NPS decreased in both groups. LMM analysis revealed a significant improvement in LKES (B=-0.61; 95% CI, -0.90 to -0.31; P<0.001) and a more pronounced improvement in NPS (B=-0.14; 95% CI, -0.25 to -0.02; P=0.025) in the dupilumab group compared to controls from preoperative to postoperative measurements.</p><p><strong>Conclusion: </strong>Compared to ESS alone, the adjunctive use of dupilumab in the postoperative period was associated with greater reductions in both NPS and endoscopic scores.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"271-279"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon Eustachian Tuboplasty in Chronic Suppurative Otitis Media and Dilatory Eustachian Tube Dysfunction: A Randomized Controlled Trial.","authors":"Hye Ah Joo, Sung-Min Park, Yehree Kim, Dong Kyu Lee, Yun Ji Lee, Yeonjoo Choi, Woo Seok Kang, Joong Ho Ahn, Jong Woo Chung, Won-Ho Chung, Ja-Won Koo, Hong Ju Park","doi":"10.21053/ceo.2024.00281","DOIUrl":"10.21053/ceo.2024.00281","url":null,"abstract":"<p><strong>Objectives: </strong>Balloon eustachian tuboplasty (BET) is an emerging treatment for dilatory eustachian tube (ET) dysfunction, yet its efficacy in patients with chronic suppurative otitis media (COM) combined with ET dysfunction remains unclear. This trial aimed to evaluate the efficacy and safety of BET versus medical management (MM) alone in adult patients with COM and chronic dilatory ET dysfunction, as defined by a failed Valsalva maneuver.</p><p><strong>Methods: </strong>This prospective, multicenter, randomized controlled trial enrolled 116 participants (121 ears) between January 2021 and June 2023. Participants were randomly assigned (1:1) to receive either BET combined with MM or MM alone (fluticasone furoate nasal steroid spray). The primary short-term outcome was the normalization of the Valsalva maneuver at 8 weeks, while secondary outcomes included improvements in Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) scores and reductions in the air-bone gap (ABG) measured at 8 weeks. Adverse events were monitored in both groups throughout the follow-up period.</p><p><strong>Results: </strong>Of the 116 participants (121 ears), 60 participants (62 ears) received BET and 56 participants (59 ears) received MM alone. There were no significant differences in demographics, baseline characteristics, ETDQ-7 scores, bone conduction thresholds, or ABG between the groups. In the BET group, 46.8% of ears (29/62) achieved a successful Valsalva maneuver compared with 15.3% of ears (9/59) in the MM-only group (P<0.001). The BET group exhibited greater subjective symptom improvement, with an average ETDQ-7 score reduction of -6.2±9.4 compared to -2.6±8.6 in the MM-only group (P=0.028). Additionally, the ABG decreased more significantly in the BET group (-5.8±11.4 dB HL) than in the MM-only group (-1.2±10.5 dB HL) (P=0.023). No serious procedure- or device-related adverse events were observed during the 8-week follow-up.</p><p><strong>Conclusion: </strong>This trial demonstrates that BET combined with MM is superior to MM alone in treating dilatory ET dysfunction in patients with COM, while also maintaining a favorable safety profile.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"234-241"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Anosmia in Middle Age, But Not in Older Adulthood, Increases Alzheimer Dementia Risk.","authors":"Jin Kook Kim, Jae Hoon Cho","doi":"10.21053/ceo.2024.00345","DOIUrl":"10.21053/ceo.2024.00345","url":null,"abstract":"<p><strong>Objectives: </strong>Many studies have reported that patients with anosmia exhibit an increased incidence of dementia later in life. However, most of these studies have focused exclusively on individuals aged 65 or older, leaving a gap in research on middle-aged subjects (40-65 years).</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using Korea's National Health Insurance claims data. The study targeted participants aged 40 years and above by randomly selecting 40% of individuals who underwent the 2009 national health check-up. The cohort was divided into two groups: the anosmia group (n=8,023), comprising individuals diagnosed with anosmia between 2006 and 2008, and the control group (n=2,680,534), consisting of the remaining participants. Subsequently, we followed the participants to monitor the occurrence of Alzheimer and vascular dementia from 2011 to 2020.</p><p><strong>Results: </strong>After adjusting for various factors, the incidence of Alzheimer dementia was significantly higher in the anosmia group compared to the control group (hazard ratio [HR], 1.15; 95% CI, 1.04-1.28). Stratification by age revealed that the risk of developing dementia was significantly elevated in anosmia patients under 65 years (HR, 1.28; 95% CI, 1.07-1.54), whereas no significant increase was observed in those over 65 years (HR, 1.10; 95% CI, 0.97-1.24). Vascular dementia was not statistically associated with anosmia.</p><p><strong>Conclusion: </strong>A diagnosis of anosmia in middle age increases the risk of developing Alzheimer dementia, while no such increase is observed in older individuals.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"264-270"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to Develop Regenerative Medicine Approaches for Olfactory Disorders.","authors":"Do Hyun Kim, Michael Wang, Sarah Kim, David W Jang, Tiffany Ko, Bradley J Goldstein","doi":"10.21053/ceo.2025-00065","DOIUrl":"10.21053/ceo.2025-00065","url":null,"abstract":"<p><p>Olfactory loss affects more than 12% of the population, with prevalence increasing in aging individuals. Multiple conditions can lead to a loss of smell (hyposmia or anosmia), including post-viral damage from coronavirus disease 2019 (COVID-19) or influenza, head injuries, sinusitis, or neurodegenerative conditions such as Alzheimer or Parkinson disease. Although treatments like surgery, anti-inflammatory medications, or olfactory training can be beneficial in certain cases, there remains an unmet need for effective therapies addressing many common causes of olfactory dysfunction. This is particularly true for cases attributed to damage of olfactory neurons that fail to spontaneously recover. Regenerative medicine approaches, aimed at either stimulating the regrowth of sensory neural structures or replacing them through cell-based therapies, have attracted considerable interest for treating various neurological disorders, including olfactory loss. Here, we summarize the intrinsic regenerative capabilities of the peripheral olfactory system, focusing on current research strategies and the existing barriers that must be overcome for successful translational applications. A major unmet need in this field involves the establishment of reliable and widely accepted culture models for expanding and differentiating olfactory stem or progenitor cells from rodents and humans, both for use in vitro assays and as potential material for cell-based therapies.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"204-209"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic utility of albumin-to-alkaline phosphatase ratio in head and neck cancer: A systematic review and metaanalysis.","authors":"Yun-Ting Wang, Adarsh Kudva, Yen-Ting Lu, Liang-Tseng Kuo, Chia-Hsuan Lai, Yuan-Hsiung Tsai, Chun-Ta Liao, Ku-Hao Fang, Chung-Jan Kang, Ethan I Huang, Cheng-Ming Hsu, Geng-He Chang, Ming-Shao Tsai, Yao-Te Tsai","doi":"10.21053/ceo.2025-00034","DOIUrl":"https://doi.org/10.21053/ceo.2025-00034","url":null,"abstract":"<p><p>The prognostic value of pretreatment albumin-to-alkaline phosphatase ratio (AAPR) in head and neck cancer (HNC) remains controversial. This meta-analysis investigated AAPR's predictive potential for survival outcomes in HNC patients. We conducted a comprehensive literature search across EMBASE, Cochrane Library, and PubMed databases through July 30, 2024. Eight studies comprising 1737 HNC patients were analyzed using random-effects models. The analysis revealed that lower AAPR values were significantly correlated with worse overall survival (HR = 2.08), progression-free survival (HR = 2.00), and disease-free survival (HR = 2.18). Sensitivity analyses confirmed result robustness, with no significant publication bias detected. These findings suggest that pretreatment AAPR could serve as a valuable and cost-effective prognostic indicator in HNC, potentially aiding clinicians in risk stratification and treatment decision-making. However, additional validation studies are warranted to confirm its clinical applicability.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter Regarding \"Positional Obstructive Sleep Apnea and Periodic Limb Movements During Sleep: A Large Multicenter Study\".","authors":"Yun Jin Kang, Chan-Soon Park, Hyun-Woo Shin","doi":"10.21053/ceo.2025-00116","DOIUrl":"https://doi.org/10.21053/ceo.2025-00116","url":null,"abstract":"<p><p>We appreciate the thoughtful comments regarding our study on the relationship between positional obstructive sleep apnea (POSA), OSA severity, and periodic limb movements during sleep (PLMS). In our large multicenter analysis, PLMS prevalence decreased with increasing OSA severity and was significantly higher in patients with POSA, particularly those with severe OSA. While our findings align with previous reports, differences among studies-such as that of Budhiraja et al.- may reflect variation in confounder control, including medication use, which was not captured in our retrospective, anonymized dataset. We acknowledge that iron-related laboratory parameters, including serum ferritin, were not available due to the nature of the dataset. Nonetheless, iron deficiency remains an important consideration in PLMS pathophysiology. Future prospective studies should include detailed clinical, pharmacologic, and laboratory data to clarify these associations. We thank the correspondent for the opportunity to address these important points.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of the GABAergic neural circuit in salicylate-induced tinnitus: from the inferior colliculus to the medial geniculate body.","authors":"Xu-Yuan Peng, Jiang Wang, Ming-Yue Gong, Li-Yuan Zhang, Min Zhang, Zhi-Bin Chen, Zheng-Quan Tang, Lei Cheng","doi":"10.21053/ceo.2025-00027","DOIUrl":"https://doi.org/10.21053/ceo.2025-00027","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the regulatory functions of gamma-aminobutyric acid (GABA)ergic neural circuits from the inferior colliculus (IC) to the medial geniculate body (MGB) in salicylate-induced tinnitus.</p><p><strong>Methods.: </strong>Mice were treated with salicylate to induce tinnitus, and tinnitus-like behaviors were evaluated via gap prepulse inhibition of acoustic startle. Using combined viral tracing methodologies, we identified and mapped the pathways and connections from the IC to the MGB. Moreover, we used Gq-coupled human M3 designer receptors exclusively activated by designer drugs (DREADDs) and Gi-coupled human M4 DREADDs, allowing targeted control of GABAergic neurons through excitation or suppression in the IC and MGB regions. Following the administration of Clozapine N-oxide, which can bind to the abovementioned specific receptors, we modulated these neural circuits to assess their impact on tinnitus severity in a mouse model.</p><p><strong>Results.: </strong>Our results indicated that mice exposed to salicylate exhibited tinnitus-like behavior. GABAergic neurons projecting retrogradely from the MGB to the IC are mainly concentrated in the external nucleus of the IC. After the administration of Clozapine N-oxide, the chemogenetic activation of IC-MGB GABAergic neurons aggravated salicylate-induced tinnitus. Our study revealed that activation of GABAergic neurons between the IC and MGB was effective in inducing tinnitus perception, even in the absence of salicylate. However, chemogenetic inhibition of the IC-MGB GABAergic circuit did not reverse salicylate-induced tinnitus.</p><p><strong>Conclusion.: </strong>This finding suggests that activation of the IC-MGB GABAergic neural circuit may contribute to tinnitus generation, but through a mechanism that is distinct from salicylate-induced tinnitus. This study provided novel insights into the mechanisms underlying tinnitus.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications and Future Perspectives of Large Language Models in Otolaryngology-Head and Neck Surgery: A Comprehensive Survey.","authors":"Junyong Ahn, Bong Gyun Kang, Munyoung Chang, Sungroh Yoon","doi":"10.21053/ceo.2025-00121","DOIUrl":"https://doi.org/10.21053/ceo.2025-00121","url":null,"abstract":"<p><p>Since the release of ChatGPT, large language models (LLMs) have rapidly expanded into professional domains, including the medical field. These models, trained on vast text corpora, including the medical literature, have demonstrated impressive capabilities in tasks such as clinical decision support, research assistance, and education. This review focuses on the applications of LLMs in otolaryngology and head and neck surgery (ENT). We analyzed 25 studies published between January 2022 and March 2025 in ENT journals ranked in the top 25% based on the 2023 edition of the Journal Citation Reports (Q1). Moreover, we categorized them by use case and examined the models, datasets, and evaluation methods employed. Despite the growing adoption of LLMs in the ENT field, several challenges remain, including limited model diversity, inconsistent evaluations, and insufficient accuracy and fairness. We also contextualized LLM research trends within a broader medical domain. We highlighted five key areas for advancing clinical-grade LLMs: robust evaluation frameworks, external source-based generation, multimodal integration, agent-based reasoning, and model explainability. Our findings provide ENT clinicians and researchers with a practical foundation for understanding, evaluating, and applying LLMs or advanced versions of LLMs (e.g., Large Multimodal Models, Agents) in clinical and research settings.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}