Clinical and Experimental Otorhinolaryngology最新文献

{"title":"Treatment Outcome of Olfactory Neuroblastoma: A Multicenter Study by the Korean Sinonasal Tumor and Skull Base Surgery Study Group.","authors":"Sang Duk Hong, Song I Park, Ji Heui Kim, Sung Jae Heo, Sung-Woo Cho, Tae-Bin Won, Hyun-Jin Cho, Dong Hoon Lee, Sue Jean Mun, Soo Kyoung Park, Yong-Wan Kim, Dong-Young Kim","doi":"10.21053/ceo.2023.00089","DOIUrl":"https://doi.org/10.21053/ceo.2023.00089","url":null,"abstract":"Due to the rarity of olfactory neuroblastoma (ONB), there is an ongoing debate about optimal treatment strategies, especially for early staged or locally advanced cases. Therefore, our study aims to explore experiences from multiple centers, focusing on factors that influence the oncological outcomes of ONB.","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"29 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139968719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair Cell Regeneration: From Animals to Humans.","authors":"Sung-Won Choi, Julia M Abitbol, Alan G Cheng","doi":"10.21053/ceo.2023.01382","DOIUrl":"10.21053/ceo.2023.01382","url":null,"abstract":"<p><p>Cochlear hair cells convert sound into electrical signals that are relayed via the spiral ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage caused by excessive noise, aging, and ototoxic agents. Non-mammals can regenerate lost hair cells by mitotic regeneration and direct transdifferentiation of surrounding supporting cells. However, in mature mammals, damaged hair cells are not replaced, resulting in permanent hearing loss. Recent studies have uncovered mechanisms by which sensory organs in non-mammals and the neonatal mammalian cochlea regenerate hair cells, and outlined possible mechanisms why this ability declines rapidly with age in mammals. Here, we review similarities and differences between avian, zebrafish, and mammalian hair cell regeneration. Moreover, we discuss advances and limitations of hair cell regeneration in the mature cochlea and their potential applications to human hearing loss.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Postoperative Benefits in Receptive and Expressive Language Development After Cochlear Implantation Under 9 Months of Age in Comparison to Implantation at Later Ages.","authors":"Seung Jae Lee, Heonjeong Oh, Kyu Ha Shin, Sung-Min Park, Yun Kyeong Kim, Do Hyun Jung, Jiyeon Yang, Yejun Chun, Min Young Kim, Jin Hee Han, Ju Ang Kim, Ngoc-Trinh Tran, Bong Jik Kim, Byung Yoon Choi","doi":"10.21053/ceo.2024.00011","DOIUrl":"10.21053/ceo.2024.00011","url":null,"abstract":"<p><strong>Objectives: </strong>The recent expansion of eligibility for cochlear implantation (CI) by the U.S. Food and Drug Administration (FDA) to include infants as young as 9 months has reignited debates concerning the clinically appropriate cut-off age for pediatric CI. Our study compared the early postoperative trajectories of receptive and expressive language development in children who received CI before 9 months of age with those who received it between 9 and 12 months. This study involved a unique pediatric cohort with documented etiology, where the timing of CI was based on objective criteria and efforts were made to minimize the influence of parental socioeconomic status.</p><p><strong>Methods: </strong>A retrospective review of 98 pediatric implantees recruited at a tertiary referral center was conducted. The timing of CI was based on auditory and language criteria focused on the extent of delay corresponding to the bottom 1st percentile of language development among age-matched controls, with patients categorized into very early (CI at <9 months), early (CI at 9-12 months) and delayed (CI at 12-18 months) CI groups. Postoperative receptive/expressive language development was assessed using the Sequenced Language Scale for Infants receptive and expressive standardized scores and percentiles.</p><p><strong>Results: </strong>Only the very early CI group showed significant improvements in receptive language starting at 3 months post-CI, aligning with normal-hearing peers by 9 months and maintaining this level until age 2 years. During this period (<2 years), all improvements were more pronounced in receptive language than in expressive language.</p><p><strong>Conclusion: </strong>CI before 9 months of age significantly improved receptive language development compared to later CI, with improvements sustained at least up to the age of 2. This study supports the consideration of earlier CI, beyond pediatric Food and Drug Administration labeling criteria (>9 months), in children with profound deafness who have a clear deafness etiology and language development delays (<1st percentile).</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"46-55"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Pathomics Model Using Machine Learning to Predict CXCL8 Expression and Prognosis in Head and Neck Cancer.","authors":"Weihua Wang, Suyu Ruan, Yuhang Xie, Shengjian Fang, Junxian Yang, Xueyan Li, Yu Zhang","doi":"10.21053/ceo.2023.00026","DOIUrl":"10.21053/ceo.2023.00026","url":null,"abstract":"<p><strong>Objectives: </strong>The necessity to develop a method for prognostication and to identify novel biomarkers for personalized medicine in patients with head and neck squamous cell carcinoma (HNSCC) cannot be overstated. Recently, pathomics, which relies on quantitative analysis of medical imaging, has come to the forefront. CXCL8, an essential inflammatory cytokine, has been shown to correlate with overall survival (OS). This study examined the relationship between CXCL8 mRNA expression and pathomics features and aimed to explore the biological underpinnings of CXCL8.</p><p><strong>Methods: </strong>Clinical information and transcripts per million mRNA sequencing data were obtained from The Cancer Genome Atlas (TCGA)-HNSCC dataset. We identified correlations between CXCL8 mRNA expression and patient survival rates using a Kaplan-Meier survival curve. A retrospective analysis of 313 samples diagnosed with HNSCC in the TCGA database was conducted. Pathomics features were extracted from hematoxylin and eosin-stained images, and then the minimum redundancy maximum relevance, with recursive feature elimination (mRMR-RFE) method was applied, followed by screening with the logistic regression algorithm.</p><p><strong>Results: </strong>Kaplan-Meier curves indicated that high expression of CXCL8 was significantly associated with decreased OS. The logistic regression pathomics model incorporated 16 radiomics features identified by the mRMR-RFE method in the training set and demonstrated strong performance in the testing set. Calibration plots showed that the probability of high gene expression predicted by the pathomics model was in good agreement with actual observations, suggesting the model's high clinical applicability.</p><p><strong>Conclusion: </strong>The pathomics model of CXCL8 mRNA expression serves as an effective tool for predicting prognosis in patients with HNSCC and can aid in clinical decision-making. Elevated levels of CXCL8 expression may lead to reduced DNA damage and are associated with a pro-inflammatory tumor microenvironment, offering a potential therapeutic target.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"85-97"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulation of TET2 contributes to nasal polypogenesis through HIF1","authors":"Yu Xu","doi":"10.21053/ceo.2023.01340","DOIUrl":"https://doi.org/10.21053/ceo.2023.01340","url":null,"abstract":"Background: Hypoxia-inducible factor (HIF) 1","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"1 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Revision Cochlear Implantation and Device Failure Profiles","authors":"Bokhyun Song, Subi Oh, Doyun Kim, Young Sang Cho, Il Joon Moon","doi":"10.21053/ceo.2023.00010","DOIUrl":"https://doi.org/10.21053/ceo.2023.00010","url":null,"abstract":"Objective. With rapid innovation in and expanding indications for cochlear implantation (CI), changes in the features of revision CI (RCI) appear to be emerging. This study aims to investigate the changes in RCI profile and discuss their clinical significance. Methods. A retrospective chart review was performed for all CIs performed at a tertiary medical institution between October 2001 and January 2023. The rate and reasons for RCI were evaluated and examined in terms of the manufacturer and device model. The Kaplan-Meier curve was used to examine the cumulative and device survival curves. In addition, the cumulative and device survivals were further analyzed based on age group, time period of primary CI, and manufacturer. Cox proportional hazards model was used to evaluate the association between RCI and manufacturers. Results. Among 1,430 CIs, 73 RCIs were conducted (5.1%). Device failure was the most common cause of RCI (40 of 73 RCIs [54.8%]), with an overall device failure rate of 2.8%, followed by flap-associated problems and migration (9 of 73 RCIs each [12.3%]). Flap retention problem appeared as a new cause in three cases (two CI 632 and one SYNCHRONY 2), and six electrode tip fold-over occurred (four CI 600 series and two CI 500 series). The 10-year overall cumulative and device survival rates were 93.4% and 95.8%, respectively. After excluding the models with recall issues, cumulative (P= 0.010) and device survival curves ( P= 0.001) revealed significant differences by manufacturer.","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"58 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of partial and superficial or total parotidectomies for superficial T1-2 primary parotid cancers","authors":"Seung Hoon Han, Jihae Lee, Jeong Wook Kang, Heejin Kim, Dong Jin Lee, Jin Hwan Kim, Il Seok Park","doi":"10.21053/ceo.2023.00014","DOIUrl":"https://doi.org/10.21053/ceo.2023.00014","url":null,"abstract":"Objective: This study aimed to compare the oncological outcomes of partial and superficial or total parotidectomies for superficial T1 or T2 primary parotid cancers and investigate their prognostic factors and recurrence patterns. Methods: The medical records of 77 patients with T1–2 primary parotid malignancies between May 2003 and March 2022 were retrospectively reviewed. Univariate and multivariate analyses were performed to evaluate the prognostic factors associated with overall survival, disease-free survival, and local and distant recurrences. Results: The average follow-up duration was 70.2 months (range,12–202 months). The 5-year overall and disease-free survival rates were 88.7% and 77.1%, respectively. Twenty-two patients underwent partial parotidectomy, and 55 underwent superficial or total parotidectomy. There were no significant differences in the disease recurrence ( p =0.320) and mortality rates ( p =0.884) of the partial and superficial or total parotidectomy groups. The mean duration of surgery was shorter and the overall complication rates were significantly lower for the partial group than for the superficial or total parotidectomy group ( p =0.049). Sixteen cases of recurrence occurred during the study period (20.8%). Univariate analyses showed that high-grade tumors ( p =0.006), lymphovascular invasion ( p =0.046), and regional lymph node metastasis ( p =0.010) were significant risk factors for disease recurrence. Multivariate analysis identified regional lymph node metastasis as an independent prognostic factor for disease recurrence ( p =0.027), and lymphovascular invasion as an independent prognostic factor for overall survival ( p =0.033). Conclusions: The conservative surgical approach of partial parotidectomy can yield oncologic outcomes comparable to superficial or total parotidectomies under careful patient","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"15 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of differences in nasal shapes and degree of changes with pairing analysis.","authors":"Younghac Kim, Joo Hyun Park, Minhae Park, Eunkyu Lee, Sang Duk Hong, Yong Gi Jung, Gwanghui Ryu, Hyo Yeol Kim","doi":"10.21053/ceo.2023.01137","DOIUrl":"https://doi.org/10.21053/ceo.2023.01137","url":null,"abstract":"This study aimed to analyze the differences in aging nasal morphometry and the degree of changes within an individual over at least ten-year period by pairing previous and recent three-dimensional reconstructed computed tomography (CT) images.","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"20 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138556177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Music-Based Auditory Training on Hearing-Impaired Elderly with Mild Cognitive Impairment.","authors":"Sihun Park, Kyoung Ho Park, Woojae Han","doi":"10.21053/ceo.2023.00815","DOIUrl":"https://doi.org/10.21053/ceo.2023.00815","url":null,"abstract":"The present study identifies the effect of music-based auditory training on the elderly with hearing loss and decreased cognitive ability, common conditions in the older population.","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"102 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138556021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive screening and hearing assessment in patients with chronic tinnitus","authors":"Alberto Bernal-Robledano, Patricia Perez-Carpena, Dimitris Kikidis, Birgit Mazurek, Stefan Schoisswohl, Susanne Staudinger, Berthold Langguth, Winfried Schlee, Jose Antonio Lopez-Escamez","doi":"10.21053/ceo.2023.00808","DOIUrl":"https://doi.org/10.21053/ceo.2023.00808","url":null,"abstract":"Objective: The study aims to assess the relationship between tinnitus and hyperacusis with cognitive impairment as indicated by the Montreal Cognitive Assessment (MoCA) tool.Methods: A multicentre cross-sectional study including individuals with chronic tinnitus from the","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":"46 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136281427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}