Chronobiology International最新文献_第3页

Longitudinal association between chronotype and depressive symptoms among college students: Mediating roles of perceived stress and self-control. 大学生时间型与抑郁症状的纵向关联：感知压力和自我控制的中介作用。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1080/07420528.2025.2506633

Wanting Liu, Xinrui Zu, Junyu Huang, Shan Feng, Dongfang Wang

{"title":"Longitudinal association between chronotype and depressive symptoms among college students: Mediating roles of perceived stress and self-control.","authors":"Wanting Liu, Xinrui Zu, Junyu Huang, Shan Feng, Dongfang Wang","doi":"10.1080/07420528.2025.2506633","DOIUrl":"10.1080/07420528.2025.2506633","url":null,"abstract":"This study aims to explore the longitudinal relationship between chronotype and depressive symptoms and the mediating roles of perceived stress and self-control among college students. A total of 11,010 college students completed two web-based surveys during 17 to 29 October 2023 (Time 1, T1) and 15 to 24 April 2024 (Time 2, T2), respectively. Participants completed the reduced version of morningness-eveningness questionnaire, the 10-item Perceived Stress Scale, the Brief Self-Control Scale, the 2-item Patient Health Questionnaire, and 3 items of the Youth Self-Rating Insomnia Scale. The results indicated that perceived stress (T1) and self-control (T2) serially mediate the relationship between morning chronotype (T1) and depressive symptoms (T2) (β = -0.010, 95% CI: -0.012 to -0.009), after controlling for baseline sample characteristics, depressive symptoms (T1), and insomnia symptoms (T2). This longitudinal relationship was observed in both male (β = -0.009, 95% CI: -0.012 to -0.006) and female (β = -0.011, 95% CI: -0.013 to -0.009) participants. These findings enhance our understanding of the mechanisms by which chronotype affects college students' depressive symptoms, providing valuable insights for developing targeted interventions, such as stress-management workshops, to mitigate depression risk, especially among students with evening chronotypes.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"724-735"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive examination of circadian rhythm and tryptophan pathway parameters: Assessing their role in predicting bipolar disorder in patients, siblings, and controls. 昼夜节律和色氨酸通路参数的综合检查：评估其在预测患者、兄弟姐妹和对照组双相情感障碍中的作用。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-06-01 Epub Date: 2025-05-29 DOI: 10.1080/07420528.2025.2509623

Emine Yavuz Ataşlar, Kürşat Altınbaş

{"title":"A comprehensive examination of circadian rhythm and tryptophan pathway parameters: Assessing their role in predicting bipolar disorder in patients, siblings, and controls.","authors":"Emine Yavuz Ataşlar, Kürşat Altınbaş","doi":"10.1080/07420528.2025.2509623","DOIUrl":"10.1080/07420528.2025.2509623","url":null,"abstract":"The complex interplay between sleep, circadian rhythms, and tryptophan pathway metabolites in bipolar disorder (BD) remains poorly understood. This study examined these mechanisms in euthymic individuals with BD (n = 20), their unaffected siblings (n = 20), and healthy controls (n = 24). Subjective and objective sleep and circadian rhythm parameters were assessed using questionnaires and actigraphy, alongside plasma measurements of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), and quinolinic acid (QUIN). Compared to controls, both BD patients and siblings showed reduced sleep efficiency and increased wake after sleep onset. Patients had longer time in bed, whereas siblings had shorter total sleep time. Elevated KYN/TRP ratios were found in both groups. Higher 3-HAA levels predicted both BD and sibling status, while increased QUIN levels were specific to BD. Lasso regression identified 12 variables associated with BD and 6 with sibling status. These results suggest that altered tryptophan metabolism and circadian disruption may contribute to the pathophysiology of BD and familial risk, providing potential biomarkers for early identification and intervention.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"755-769"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clock and clock-related gene expression is light responsive in the Atlantic salmon (Salmo salar) embryo. 时钟和时钟相关的基因表达在大西洋鲑鱼胚胎中具有光响应性。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-06-01 Epub Date: 2025-06-05 DOI: 10.1080/07420528.2025.2510505

Marie Bue, Øivind Andersen, Helge Tveiten

{"title":"Clock and clock-related gene expression is light responsive in the Atlantic salmon (Salmo salar) embryo.","authors":"Marie Bue, Øivind Andersen, Helge Tveiten","doi":"10.1080/07420528.2025.2510505","DOIUrl":"10.1080/07420528.2025.2510505","url":null,"abstract":"Light and photoperiod vary in a predictable manner throughout the daily and annual cycle that is utilized by organisms to direct processes of living. The aquaculture industry applies light to manipulate salmon development, but the effects have not yet been thoroughly investigated in early ontogeny. Here, salmon eggs and larvae were subjected to three different light regimes (continuous dark, continuous light and compressed simulated natural photoperiod [LD] to provide calendar time information). The expression of eight clock- and melatonin-related genes (clock1a.2, arntl1a.2, per1b, per2a, cry3b, nr1d1a, aanat2b, mtnr1b) was examined through one daily cycle before eyeing, after eyeing, and before start-feeding. Clock1a.2 and per2a showed indications of being maternally deposited, and expression increased for most genes through development. All genes showed clear differences in expression between light regimes, and rhythmically expressed genes were more abundant and with stronger rhythms under LD regime. Aanat2b was rhythmically expressed before eyeing, and all genes were rhythmically expressed under LD at start-feeding. Interestingly, at this time, the positive, negative, and stabilizing arm of the clock peaked simultaneously along with the melatonin-related genes mid-photophase. These results implore greater attention to the lighting conditions used during early development, as different lightings could have lasting effects.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"679-692"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronotype impact on mating, desire for sex and sexual activity in humans. 睡眠类型对人类交配、性欲望和性活动的影响。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-06-01 Epub Date: 2025-05-13 DOI: 10.1080/07420528.2025.2501234

Agnieszka Witek, Regina Grugel, Joanna Kasprowicz, Łukasz Pawelec

{"title":"Chronotype impact on mating, desire for sex and sexual activity in humans.","authors":"Agnieszka Witek, Regina Grugel, Joanna Kasprowicz, Łukasz Pawelec","doi":"10.1080/07420528.2025.2501234","DOIUrl":"10.1080/07420528.2025.2501234","url":null,"abstract":"Research on assortative mating by chronotype in previous years has yielded contradictory results. The aim of the study was to examine whether non-cohabiting partners in short-term relationships shared the same chronotype. A sample of 100 heterosexual couples completed the Composite Scale of Morningness (CSM) questionnaire and responded to additional questions. No evidence of assortative mating for chronotype was found, but there was a significant positive correlation between male and female time of waking up, time of greatest desire for sex and actual time of sexual activity. Additionally, female chronotype was significantly associated with the timing of peak sexual desire. Morning-type women declared the greatest desire for sex at 15:00-18:00 more frequently than evening-types. In case of actual sexual activity, men and women declared 21:00-00:00 most often, regardless of chronotype. It is likely that adapting to social schedules aligns activity timing across different chronotypes. They are performing their activities during which they get to know each other at similar times. While chronotype may not be critical in initiating relationships, it could influence the maintenance of long-term relationship satisfaction.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"706-715"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validating an Arabic translation of the Sleep, Circadian Rhythms, and Mood (SCRAM) questionnaire. 验证睡眠，昼夜节律和情绪（SCRAM）问卷的阿拉伯语翻译。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1080/07420528.2025.2510501

Hessa Abdulla Bugahoos, Ameena Duaij Albinjasim, Yasmin AlMashouk, Abdulmajeed Abdullah Alghamdi, Achraf Ammar, Hadeel Ghazzawi, Khaled Trabelsi, Jamie Byrne, Michael V Vitiello, Haitham Jahrami

{"title":"Validating an Arabic translation of the Sleep, Circadian Rhythms, and Mood (SCRAM) questionnaire.","authors":"Hessa Abdulla Bugahoos, Ameena Duaij Albinjasim, Yasmin AlMashouk, Abdulmajeed Abdullah Alghamdi, Achraf Ammar, Hadeel Ghazzawi, Khaled Trabelsi, Jamie Byrne, Michael V Vitiello, Haitham Jahrami","doi":"10.1080/07420528.2025.2510501","DOIUrl":"10.1080/07420528.2025.2510501","url":null,"abstract":"This study translated the Sleep, Circadian Rhythms, and Mood (SCRAM) questionnaire into Arabic and evaluated the psychometric properties and conceptual validity of the Arabic version. This process involved forward translation, back-translation, research team review, and pretesting of the Arabic SCRAM. A sample of 649 adults completed the Arabic SCRAM along with validation measures of sleep disturbances (Jenkins Sleep Scale: JSS) and depression severity (Patient Health Questionnaire: PHQ-9). Psychometric analyses included descriptive statistics, reliability analysis, test re-test, confirmatory factor analysis, and tests of convergent validity. The sample (77% female, mean age 26.31 years, range 18-47 years) demonstrated normal score distributions and adequate reliability on the Arabic SCRAM subscales. A three-factor structure was confirmed, aligning with the original English version. The Good Sleep and Depressed Mood subscales showed good convergence with the JSS and PHQ-9 scores, respectively. The Morningness subscale was not tested in the present research for convergent validity against other measures. The results provide preliminary support for a three-factor structure of the Arabic version of the SCRAM, with improved reliability indices (McDonald's ω ≈ 0.70) after removing three culturally non-optimal items; further validation is recommended before confirming these modifications.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"795-807"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronotype and sleep disturbances: A comparative analysis of sluggish cognitive tempo and attention deficit hyperactivity disorder. 时间类型和睡眠障碍：迟缓的认知节奏和注意缺陷多动障碍的比较分析。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1080/07420528.2025.2509625

Yadigar Düğüncü Terlemez, Nagihan Cevher Binici, Ali Evren Tufan, Çisel Yazan Songür, Fatma Sibel Durak

{"title":"Chronotype and sleep disturbances: A comparative analysis of sluggish cognitive tempo and attention deficit hyperactivity disorder.","authors":"Yadigar Düğüncü Terlemez, Nagihan Cevher Binici, Ali Evren Tufan, Çisel Yazan Songür, Fatma Sibel Durak","doi":"10.1080/07420528.2025.2509625","DOIUrl":"10.1080/07420528.2025.2509625","url":null,"abstract":"Recent investigations into Sluggish Cognitive Tempo (SCT), also known as Cognitive Disengagement Syndrome, have primarily focused on its association with ADHD. However, emerging evidence suggests SCT may be a distinct clinical entity, despite frequent co-occurrence with ADHD symptomatology. While ADHD studies have elucidated sleep patterns and chronotype preferences, SCT research has largely focused on ADHD-comorbid cases, providing limited data on community-based adolescents and adults. This study aims to investigate sleep disturbances and chronotype characteristics in individuals with pure SCT compared to those with ADHD and healthy controls within a clinical sample. We utilized the DSM-IV-based Disruptive Behavior Disorders Rating Scale (DBDRS-parent and teacher form), Barkley Sluggish Cognitive Tempo Scale (BSCTS), the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS), Children's Sleep Habit Questionnaire, and Children's Chronotype Questionnaire for the evaluation of children with SCT, ADHD, and healthy controls. Our findings revealed shorter sleep duration in ADHD (n: 67) children compared to both SCT (n: 50) and healthy controls (n: 50), with no significant difference between SCT and healthy controls (p < 0.001). Eveningness tendencies were highest in SCT but also elevated in ADHD compared to controls (p < 0.001). Additionally, daytime sleepiness was highest in SCT and higher in ADHD than controls (p < 0.001). Regression analyses demonstrated that SCT severity predicted both daytime sleepiness and eveningness.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"716-723"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global research trends on exercise and circadian rhythm: A bibliometric analysis. 运动与昼夜节律的全球研究趋势：文献计量学分析。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-30 DOI: 10.1080/07420528.2025.2501339

Yu Gu, Yongchao Xie, Wenduo Liu, Zilin Wang, Dong-Hun Seong, Sang Hyun Kim

{"title":"Global research trends on exercise and circadian rhythm: A bibliometric analysis.","authors":"Yu Gu, Yongchao Xie, Wenduo Liu, Zilin Wang, Dong-Hun Seong, Sang Hyun Kim","doi":"10.1080/07420528.2025.2501339","DOIUrl":"https://doi.org/10.1080/07420528.2025.2501339","url":null,"abstract":"Recent advancements in the field of exercise and circadian rhythms have brought attention to the potential for tailored exercise strategies based on individual biological rhythms, aiming to optimize both health and performance, yet there is a lack of bibliometric analysis within this specific area of research. This study seeks to provide an extensive insight into the knowledge structure and primary research focuses on the correlation between exercise and circadian rhythms using bibliometric analysis. Publications pertinent to exercise and circadian rhythms were sourced from the Web of Science Core Collection (WoSCC) database. Utilizing VOSviewer, CiteSpace, and the R package \"bibliometrix,\" a thorough bibliometric analysis was conducted. The analysis encompassed publications from 83 countries and 2025 institutions focusing on exercise and circadian rhythms. Leading contributors included the USA, England, France, Japan, and Germany, with an increasing number of publications annually. Notable institutions like Liverpool John Moores University, Univ Sfax, Brigham Women's Hosp, and Univ Milan ranked among the top contributors. Chronobiology International emerged as the most popular journal in this domain. These publications were attributed to 4402 authors, with Thomas Reilly and Greg Atkinson receiving the most citations, particularly Reilly being the most co-cited author. Dominant research topics included circadian rhythm, quality, skeletal muscle, and entrainment, while emerging hotspots comprised sports performance, mental health validity, older adults, and the sleep-wake cycle. This study marks the first comprehensive bibliometric analysis summarizing research trends and developments in exercise and circadian rhythms. This collection pinpoints the latest research frontiers and promising avenues, acting as a valuable resource for researchers investigating the connection between exercise and circadian rhythms.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring chronotype, sleep disturbances, and temperament in adolescents with attention deficit hyperactivity disorder. 探索青少年注意缺陷多动障碍的时型、睡眠障碍和气质。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-29 DOI: 10.1080/07420528.2025.2511269

İrem Cihanyurdu Erdem, Aliye Tuğba Bahadır

{"title":"Exploring chronotype, sleep disturbances, and temperament in adolescents with attention deficit hyperactivity disorder.","authors":"İrem Cihanyurdu Erdem, Aliye Tuğba Bahadır","doi":"10.1080/07420528.2025.2511269","DOIUrl":"10.1080/07420528.2025.2511269","url":null,"abstract":"This study aimed to explore sleep problems, chronotype, and temperament traits between adolescents with Attention Deficit Hyperactivity Disorder (ADHD) and healthy controls, and to examine how these variables relate within the ADHD group. One hundred and two adolescents with ADHD aged 11-17 recruited from Marmara University Pendik Training and Research Hospital Child and Adolescent Psychiatry Outpatient Clinic and 101 age and gender matched healthy controls participated in the study. Assessments included the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL), Junior Temperament and Character Inventory-Revised (J-TCI-R), Children's Chronotype Questionnaire (CCTQ), and Sleep Disturbance Scale for Children (SDSC). Adolescents with ADHD showed significantly higher rates of sleep disturbances and a greater prevalence of evening chronotype (63.7%) compared to controls. ADHD participants scored higher in novelty seeking and harm avoidance, while controls exhibited greater persistence and self-directedness. Notably, novelty seeking was pronounced in those with an evening chronotype and positively correlated with sleep disturbances, including difficulties initiating and maintaining sleep. Logistic regression analyses indicated that novelty seeking and age significantly predicted evening chronotype, while linear regression revealed that both novelty seeking and M/E scores predicted SDSC total scores. The findings underscore the clinical significance of addressing the interplay between chronotype, sleep disturbances, and temperament traits in adolescents with ADHD.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of chronotype on depression: The mediating roles of rumination and perceived stress. 时间类型对抑郁的影响：反刍和感知压力的中介作用。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-29 DOI: 10.1080/07420528.2025.2511263

Haowen Zou, Xumiao Wang, Ciqing Bao, Hao Sun, Qiudong Xia, Zhilu Chen, Hongliang Zhou, Rui Yan, LingLing Hua, Domenica Veniero, Qing Lu, Zhijian Yao

{"title":"Impact of chronotype on depression: The mediating roles of rumination and perceived stress.","authors":"Haowen Zou, Xumiao Wang, Ciqing Bao, Hao Sun, Qiudong Xia, Zhilu Chen, Hongliang Zhou, Rui Yan, LingLing Hua, Domenica Veniero, Qing Lu, Zhijian Yao","doi":"10.1080/07420528.2025.2511263","DOIUrl":"https://doi.org/10.1080/07420528.2025.2511263","url":null,"abstract":"Chronotype represents an independent risk factor for depression, yet the psychological mechanisms underlying this association remain unclear. Potential mediators may include social jetlag (SJL), sleep quality, rumination, and perceived stress. Thus, this China-based study enrolled 122 patients with Depressive Episode (DE) and 126 healthy Controls (HC), assessing participants using: the Beck Depression Inventory (BDI), Morningness-Eveningness Questionnaire (MEQ), Munich Chronotype Questionnaire (MCTQ), Pittsburgh Sleep Quality Index (PSQI), Ruminative Response Scale (RRS), and Perceived Stress Scale (PSS). Partial Spearman correlations examined relationships between BDI scores, chronotype, sleep quality, rumination, and perceived stress within each group. Mediation analyses employed MEQ scores as the independent variable and diagnostic status (DE vs HC) as the dependent variable, with moderated mediation analyses assessing age, sex, and work status influences. Results revealed significant indirect effects of chronotype on depression status through: sleep quality, symptom rumination, brooding, reflective pondering, PSS scores, perceived helplessness, and perceived self-efficacy. These mediating effects were moderated by sex or work status, but not age. The demonstrated association between evening chronotype and increased depression risk suggests that clinical interventions targeting sleep improvement, rumination reduction, and stress coping enhancement may be particularly beneficial for such individuals experiencing depressive symptoms.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population-level analysis of circadian variations in blood cells. 血细胞昼夜节律变化的人群水平分析。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-28 DOI: 10.1080/07420528.2025.2511266

Patricia Fuentes-Bullejos, David Melguizo-Melguizo, María Carmen Lorenzo-Lozano, Alfonso Luis Blázquez-Manzanera

{"title":"Population-level analysis of circadian variations in blood cells.","authors":"Patricia Fuentes-Bullejos, David Melguizo-Melguizo, María Carmen Lorenzo-Lozano, Alfonso Luis Blázquez-Manzanera","doi":"10.1080/07420528.2025.2511266","DOIUrl":"https://doi.org/10.1080/07420528.2025.2511266","url":null,"abstract":"Knowledge of circadian rhythms is crucial in laboratory medicine to understand disease pathophysiologies and improve patient diagnoses and treatments. Here, we aim to determine whether circadian variations in blood cells are present at a population level and assess whether these rhythms are consistent with those reported previously in individuals. In a retrospective observational study we employed blood sample data analyzed at a local emergency laboratory over a period of 7 years, including the number of blood cells, time of sample collection, and patient age (between 18 and 85 years). Data showing cell counts outside the normal range were excluded, yielding a dataset consisting of 189,635 individual data points from 164,982 different patients. Records were grouped into 30-min intervals to determine their temporal distribution and average wave. We detected a circadian rhythm in all studied blood cell types (p < 0.01), with all except neutrophils peaking during the resting phase and exhibiting minimum values during the activity phase. Results were confirmed through parametric and nonparametric analyses. To the best of our knowledge, this is the first report of a significant circadian rhythm in blood cells at population level. The observed temporal variations at population level are comparable to those previously described for individuals.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0