Chronobiology International最新文献

{"title":"Effect of prolonged exposure to different lighting conditions on MPTP-induced motor dysfunction and cognitive performance in male rats.","authors":"Hamideh Rahmati, Seyedeh Masoumeh Seyedhosseini Tamijani, Hamed Ghazvini, Behzad Garmabi, Ali Siahposht-Khachaki, Saba Niknamfar, Raheleh Rafaiee","doi":"10.1080/07420528.2025.2529343","DOIUrl":"10.1080/07420528.2025.2529343","url":null,"abstract":"<p><p>Circadian rhythm disruption has been increasingly implicated in neurodegenerative diseases, including Parkinson's disease (PD). While motor impairments in PD are well-established, the impact of chronic circadian misalignment on both motor and cognitive dysfunctions remains underexplored. This study investigates the effect of prolonged exposure to different lighting conditions on MPTP-induced motor and cognitive deficits in a rat model. A total of 100 adult male Wistar rats were divided into five groups with different light-dark cycle conditions: standard 12-h light/12-h dark (12 L:12D), constant light (24 L), constant darkness (24D), 20-h light/4-h dark (20 L:4D), and 4-h light/20-h dark (20D:4 L). After 60 d of exposure to these conditions, each group was further divided into Parkinsonian (MPTP-treated) and non-Parkinsonian (saline-treated) subgroups. MPTP hydrochloride (25 µg/kg) was administered intranasally to induce Parkinsonism. Behavioral assessments, including the beam balance test, open field test, Y-maze test, and shuttle box test, were conducted to evaluate motor coordination and cognitive function. Immunohistochemical analyses of α-synuclein (α-syn) accumulation in the substantia nigra (SNc) and tyrosine hydroxylase (TH) expression in the suprachiasmatic nucleus (SCN) were performed. Data were analyzed using t test, one-way ANOVA and Tukey's post hoc test. MPTP administration significantly impaired motor function, as evidenced by increased crossing time in the beam balance test (<i>p</i> < 0.001) and reduced locomotor activity in the open field test (<i>p</i> < 0.01). Prolonged exposure to different lighting conditions further exacerbated these deficits, particularly in the 24 L and 20 L:4D groups (<i>p</i> < 0.0001). Cognitive assessments revealed that MPTP-treated rats exhibited marked deficits in working memory (Y-maze, <i>p</i> < 0.05) and associative learning (shuttle box, <i>p</i> < 0.01), with the most severe impairments observed in groups subjected to extreme light-dark alterations. Immunohistochemical analyses demonstrated significantly increased α-syn accumulation in the SNc (<i>p</i> < 0.0001) and decreased TH expression in the SCN (<i>p</i> < 0.001), particularly in MPTP-treated rats under photoperiod disruption. Chronic photoperiod disruption exacerbates MPTP-induced motor dysfunction, cognitive impairment, and neurodegeneration. Targeting circadian regulation may offer a potential therapeutic approach for mitigating neurodegenerative progression in PD.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1080-1095"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Arabic version of the reduced Horne-Östberg morningness-eveningness questionnaire (rMEQ).","authors":"Roni Chaaya, Rebecca Cattan, Christele Lahoud, Debora Tornquist, Felipe Barreto Schuch, Georges Merhi, Georges-Junior Kahwaji, Rachele Lahoud, Hanna Mattar, Sahar Obeid, Souheil Hallit, Feten Fekih-Romdhane","doi":"10.1080/07420528.2025.2525465","DOIUrl":"10.1080/07420528.2025.2525465","url":null,"abstract":"<p><p>Individual differences in sleep-wake cycles give rise to \"morningness-eveningness.\" The assessment of morningness-eveningness is essential for understanding these preferences, and the Reduced Morningness-Eveningness Questionnaire (rMEQ) has been developed for this purpose. The purpose of this study was to examine the Arabic rMEQ's psychometric properties in terms of validity, reliability and measurement invariance across sex groups. A population-based sample of 330 Arabic-speaking participants from Lebanon, comprising 67.3% females with a mean age of 21.75 ± 2.43 years (range: 18-33), were recruited for this study. The participants were asked to fill out an online questionnaire consisting of the Arabic versions of the rMEQ, Pittsburgh Sleep Quality Index (PSQI), and the Lebanese Anxiety Scale (LAS). Confirmatory factor analysis (CFA) indicated a modest fit for the one-factor model of the rMEQ. Internal reliability was good, with ω = .75 and α = .70. Additionally, cross-sex invariance analysis showed support for configural, metric, and scalar invariance, with no significant differences in rMEQ scores between males and females. Concurrent validity revealed significant moderate correlations between higher rMEQ scores and lower depression, better sleep quality, and lower anxiety. The Arabic version of the rMEQ demonstrated adequate psychometric properties in a Lebanese adult population. The CFA results support a one-factor model of the Arabic rMEQ, similarly as in the case of other language versions. Overall, the Arabic rMEQ appears to be a valid and reliable tool for evaluating morningness-eveningness in Arabic-speaking adults, with potential applications in cross-cultural chronotype studies.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1060-1071"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian and light-induced regulation of the expression of core clock proteins in common carp.","authors":"Mikolaj Mazur, Karolina Marzec, Tomasz Kantyka, Magdalena Markowska, Magdalena Chadzinska, Lukasz Pijanowski","doi":"10.1080/07420528.2025.2539415","DOIUrl":"https://doi.org/10.1080/07420528.2025.2539415","url":null,"abstract":"<p><p>The unique circadian clock system of fish consists of central and peripheral pacemakers that are directly regulated by light. The functioning of this clock machinery is based on cyclic changes in the expression of clock proteins that form transcriptional-translational loops. In this study, we performed an analysis of the circadian changes in Cry1, Cry2 and Clock protein levels in the nervous system, immune system and other peripheral organs of common carp. Protein-level analyses revealed that Cry1, Cry2 and Clock proteins show diurnal expression patterns in both central and peripheral tissues, with tissue-specific variations. We have shown that both Cry variants may play important roles in the clock mechanism, but their importance appears to be organ specific, with Cry2 and Cry1 likely playing important roles in central and peripheral oscillators, respectively. However, further genetic analysis will be required to clearly define the role of these proteins in the carp clock mechanism. We have found that the central oscillator function in carp is primarily performed by the retina, which is characterized by strong endogenous rhythmicity of activity. We have also observed that light availability clearly modulates the circadian clock mechanism in fish and probably indirectly other physiological functions by regulating the expression of key proteins that determine clock activity. Post-translational modifications of clock proteins, which are crucial for their functionality, affect their circadian rhythmicity.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and circadian disruption in humans: Is there a rationale for metabolic disorders?","authors":"Mariana Romanenko, Madeline Bartsch, Liubov Piven, Andreas Hahn, Mattea Müller","doi":"10.1080/07420528.2025.2536521","DOIUrl":"https://doi.org/10.1080/07420528.2025.2536521","url":null,"abstract":"<p><p>Circadian disruption, arising from behaviors such as shift work and sleep deprivation, is increasingly prevalent and associated with metabolic disorders, including obesity, type 2 diabetes, and cardiovascular disease. The gut microbiome plays a crucial role in metabolic homeostasis by producing metabolites - such as short-chain fatty acids, secondary bile acids, and microbial-associated molecular patterns - that influence nutrient absorption, immune responses, and host metabolism in alignment with circadian rhythms. This review explores how circadian disruptors influence the human gut microbiome, focusing on changes in microbial composition, diversity, and functionality, and their implications for metabolic health. Preclinical studies demonstrate that circadian disruptions alter microbial composition, reduce rhythmicity, and impair functionality, contributing to metabolic disorders. However, human studies often report inconsistent findings, with microbial functionality appearing more sensitive to disruptions than composition. Eating patterns affect both the gut microbiome and circadian alignment; their optimization could realign microbial and host rhythms to promote metabolic homeostasis. Future research should focus on longitudinal and interventional studies using advanced methodologies, such as real-time intestinal gas measurements, to capture dynamic microbial activity in humans. Understanding microbial responses to circadian disruptors could inform therapeutic strategies targeting host-microbe interactions to improve metabolic health.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-21"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between morning heart rate variability and ambulatory blood pressure characteristics in young adults.","authors":"Ann Claire E Blalock, James E Brown, Joseph D Vondrasek, Brett L Cross, Gregory J Grosicki, Andrew A Flatt","doi":"10.1080/07420528.2025.2538578","DOIUrl":"https://doi.org/10.1080/07420528.2025.2538578","url":null,"abstract":"<p><p>We aimed to quantify associations between resting heart rate variability (HRV) and ambulatory blood pressure (BP) characteristics in young adults. Thirty-two apparently healthy young adults (50% male) were included in the study. Short-term HRV was obtained via electrocardiography in the laboratory following an overnight fast to determine the mean RR interval, standard deviation of normal RR intervals (SDNN), and root-mean square of successive differences (RMSSD). Participants left the laboratory wearing an ambulatory BP monitor for 24 h to determine awake, asleep, and overall systolic and diastolic BP, and asleep BP dipping ratios. In males, higher SDNN and RMSSD were associated with lower asleep systolic and diastolic BP, and greater systolic BP dipping, with SDNN also associated with diastolic BP dipping (<i>Ps</i> <0.05). In females, higher mean RR, RMSSD, and SDNN were associated with lower awake diastolic BP, and RMSSD with lower overall diastolic BP (<i>Ps</i> <0.05). Our findings indicate potential sex differences in how cardiac-autonomic function associates with BP regulation throughout the day. In males, HRV showed stronger associations with nocturnal BP characteristics, whereas in females, HRV associations were more pronounced with daytime BP.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are 24-hour variations in food intake and subjective food perceptions different between day and night shift workers?","authors":"Nowane Borges Alves Silva Morais, Catarina Mendes Silva, Milena Ferreira Ramos, Gabriela Pereira Teixeira, Cibele Aparecida Crispim","doi":"10.1080/07420528.2025.2534007","DOIUrl":"https://doi.org/10.1080/07420528.2025.2534007","url":null,"abstract":"<p><p>Shift workers have an increased likelihood of developing obesity and metabolic disorders, and the dietary intake during nighttime seems to increase the risk of these conditions. Nevertheless, it remains unclear if hunger, food preferences, and satiety differ between night workers and day workers. This study aimed to compare the daily patterns of dietary intake and subjective dietary perceptions among day and night workers. A total of 60 workers participated in this study (30-day workers and 30-night workers). Dietary intake was assessed using a daily food record for a full working day, along with a Numerical Rating Scale (ranging from 0 to 10) used to measure subjective feelings of food satisfaction (appetite, hunger, and satiety) after each meal. Night workers showed a stronger preference for vegetables during the evening snack (<i>p</i> < 0.001) and a greater appetite for meat, eggs, and savory foods during the morning snack (<i>p</i> < 0.001 and <i>p</i> = 0.007, respectively) compared to day workers. In conclusion, night workers demonstrated different food perceptions compared to day workers.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional differences in the physique of Japanese children: Investigating the influence of seasonal variations in effective day length.","authors":"Masana Yokoya, Yukito Higuchi","doi":"10.1080/07420528.2025.2540049","DOIUrl":"https://doi.org/10.1080/07420528.2025.2540049","url":null,"abstract":"<p><p>In the physique of Japanese children may arise from photoperiodic responses. This study aimed to investigate whether the geographical distribution of height and weight in Japanese pre-adolescent children (aged 13 years) can be explained by seasonal variations in effective day length (defined as the duration of daylight with an illuminance of 5000 lX or more). Using the average height and weight of 13-year-old boys and girls in 1993, 2007, and 2020 by prefecture as response variables, and the variation in monthly averages of effective day length over the past 13 years by prefecture as explanatory variables, we conducted a Partial Least Squares (PLS) regression analysis. The regional differences in height and weight were associated with two components of effective day length that exhibited seasonal fluctuations. The scores and loading vectors of these components suggested that, in both summer and winter, short days led to height gain and inhibited weight gain through activation of thyroid hormone-like activity, whereas long days inhibited height gain, promoted weight gain, and induced suppression of thyroid hormone-like activity. The results suggested that the short days of winter particularly contribute to height growth, while the long days of summer are more likely to contribute to weight gain.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent dietary patterns and methyl-donor nutrient intakes in relation to blood leukocyte DNA methylation of circadian genes.","authors":"Jennifer T Lee, Jaclyn M Goodrich, Dana C Dolinoy, Karen E Peterson, Martha M Téllez-Rojo, Alejandra Cantoral, Libni A Torres-Olascoaga, Edward A Ruiz-Narváez, Erica C Jansen","doi":"10.1080/07420528.2025.2532796","DOIUrl":"10.1080/07420528.2025.2532796","url":null,"abstract":"<p><p>Dietary composition may impact circadian rhythms, potentially through DNA methylation of circadian genes. However, research among adolescents remains limited. Cross-sectional association of three dietary patterns, derived from principal component analysis of energy-adjusted food groups, and five energy-adjusted methyl-donor nutrients (folate, methionine, riboflavin, and vitamins B6 and B12) on DNA methylation of 18 circadian-related genes in 526 adolescents was examined. DNA methylation levels at CpG sites were quantified from blood leukocytes using the Illumina Infinium Methylation EPIC BeadChip, with false discovery rate adjustments (<i>q ≤ 0.20</i>). Linear regression was used, adjusting for age, sex, maternal education, smoking status, batch effects, and cell-type proportions. Correlations between CpG sites and gene expression data (RNA-seq) of the corresponding genes were evaluated. Riboflavin was negatively associated with cg06337557 (<i>MTNR1B</i>) and cg02076826 (<i>RORA</i>). Vitamin B6 was positively associated with cg09615953 (<i>PER3</i>) and negatively with cg06337557 (<i>MTNR1B</i>). In males, the <i>Breakfast</i> pattern was negatively associated with cg13146553 (<i>RORA</i>), and riboflavin was positively associated with cg06487986 (<i>PER3</i>). No significant associations were found for the <i>Plant-based & lean proteins</i> pattern, folate, methionine, or vitamin B12. DNA methylation of the 18 clock genes were not correlated with gene expression data of the corresponding genes. Dietary patterns and methyl-donor nutrients may influence core clock and melatonin-related genes, with potential sex-specific relationships.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morningness-eveningness scale for children: Difficulties in establishing reference score intervals by age and sex throughout adolescence.","authors":"Jeanny Joana Rodrigues Alves de Santana, Jefferson Souza Santos, Fernando Mazzilli Louzada, Sabine Pompeia","doi":"10.1080/07420528.2025.2532798","DOIUrl":"https://doi.org/10.1080/07420528.2025.2532798","url":null,"abstract":"<p><p>As adolescents become older, they tend to prefer sleeping and waking later due to biological maturation and social/environmental changes. Higher evening preferences relate to risks of developing physical and mental ill-health and/or academic underachievement. To identify individuals who are more vulnerable to these negative outcomes, prior studies have mostly established percentile cutoff scores in questionnaires of morningness-eveningness (M-E) preferences, a method that leads to biased estimates, and/or used linear statistical methods, which do not consider that M-E can fit other types of distribution. We reanalyzed cross-sectional data of 1815 10-18-year-old Brazilians who filled in the most popular circadian preference scale, the M-E Scale for Children (MESC). Age/sex MESC sum raw score differences were analyzed using correlations, general linear models and 44 different curve fittings based on fractional polynomials and exponential data transformation. We found a very slight correlation and general linear increase in eveningness with age, but none of the 44 tested curve fit patterns reliably explained score changes across ages, being highly variable at all ages. Hence, establishing MESC reference score intervals by age/sex is of little practical value. We discuss other factors combined with MESC scores that may help identify adolescents at risk of circadian-related problem.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>NR1D1 (REVERBalpha)</i> may be novel candidate gene for coronary artery disease in men: Differential effects of <i>NR1D1</i> polymorphisms by gender.","authors":"Rukiye Yesil, Cagatay Aydogan, Gulcin Ozkara, Bengu Tokat, Ahmet Yildiz, Abdullah Omer Ebeoglu, Mehmet Fatih Seyhan, Oguz Ozturk, Hulya Yilmaz-Aydogan","doi":"10.1080/07420528.2025.2532797","DOIUrl":"https://doi.org/10.1080/07420528.2025.2532797","url":null,"abstract":"<p><p>Circadian rhythms are strongly linked to cardiometabolic syndromes such as coronary artery disease (CAD). <i>NR1D1(REVERBalpha)</i> regulates lipid metabolism and circadian clock. This study investigated possible associations between the <i>NR1D1</i> rs2314339 C > T and rs72836608 C > A polymorphisms and metabolic parameters in 126 CAD patients and 125 controls. Allelic discrimination was performed by Real-Time PCR using TaqMan Genotyping Assays. The rs2314339-CC and rs72836608-AA genotypes were associated with an increased risk of CAD (<i>p</i> < 0.05), which varied according to cardiovascular risk factors. The rs72836608-A allele and rs2314339-CC genotypes were associated with an increased risk of CAD in healthy-weight, non-diabetic, normolipidemic, and male patients (<i>p</i> < 0.05). Additionally, the rs72836608-A allele was associated with an elevated risk of CAD in patients with hypertension (<i>p</i> = 0.016). Subgroup analysis by gender showed that the rs72836608-A allele (<i>p</i> = 0.018), the rs2314339-CC genotype (<i>p</i> = 0.008), hyperlipidemia (<i>p</i> = 0.001), hypertension (<i>p</i> = 0.001), and type 2 diabetes mellitus (T2DM) (<i>p</i> = 0.001) were associated with an increased risk of CAD in men. Nevertheless, the presence of hypertension (<i>p</i> = 0.008), hyperlipidemia (<i>p</i> = 0.025), and T2DM (<i>p</i> = 0.001) were significantly associated with CAD risk in the females. Multivariate regression analysis revealed that the rs72836608-A allele (<i>p</i> = 0.034), male gender (<i>p</i> = 0.01), hyperlipidemia (<i>p</i> = 0.008), hypertension (<i>p</i> = 0.001), and T2DM (<i>p</i> = 0.001) were associated with an increased risk for CAD in the overall cohort. The findings suggest that both polymorphisms may be associated with an increased risk of CAD, particularly in men, and may be influenced by factors including age and other cardiovascular risk factors.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}