Chronobiology International最新文献

{"title":"Effects of therapy with local anesthetics (TLA) on heart rate variability (HRV) over 24 hours.","authors":"Stefan Weinschenk, Nurat Fitnat Topbas-Selcuki, Justus Benrath, Thomas Strowitzki, Manuel Feisst","doi":"10.1080/07420528.2025.2560963","DOIUrl":"https://doi.org/10.1080/07420528.2025.2560963","url":null,"abstract":"<p><p>Therapy with local anesthetics (TLA) is known to provide long-lasting pain relief, raising the question of whether these effects are mediated by changes in autonomic nervous system (ANS) regulation. To address this, we examined alterations in 24-h heart rate variability (HRV) following TLA treatment. Twenty-four patients undergoing TLA and 11 controls were monitored with Holter-ECG over 24 h. HRV parameters including mean heart rate (HR), root mean square of successive differences (RMSSD), stress index (SI), low- and high-frequency power, and total power were calculated in 15-min epochs. Changes were analyzed separately for the day and subsequent night, and the standard deviation of change between consecutive 15-min intervals was introduced as an additional parameter. TLA was associated with significant shifts in HRV within 24 h: HR and SI decreased, whereas RMSSD and low-frequency power increased, with effects most pronounced during the night. Moreover, the variability of changes between epochs was reduced across several parameters, particularly HR, RMSSD, and SI, suggesting a \"smoothing\" effect in HRV dynamics. These findings indicate that 24-h HRV monitoring can capture autonomic effects of TLA beyond its immediate analgesic action. The reduction of variability in HRV changes introduces a novel metric for assessing ANS modulation, offering new insight into the mechanisms and therapeutic potential of TLA.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronobiological effects of morning and evening exercise on biochemical responses in elite boxers.","authors":"Murat Ozan, Yunus Öztaşyonar, Yusuf Buzdağli, Nurcan Kılıç Baygutalp, Furkan Öğet, Neslihan Yüce, Fatma Necmiye Kaci, Adem Savaş, Fatih Baygutalp","doi":"10.1080/07420528.2025.2556835","DOIUrl":"https://doi.org/10.1080/07420528.2025.2556835","url":null,"abstract":"<p><p>This study aimed to investigate the chronobiological effects of exercise timing, specifically morning versus evening sessions, on biochemical responses in elite boxers. While both high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) protocols were applied, the primary focus was to examine how the time-of-day influences markers of muscle damage, oxidative stress, and hormonal activity. Twenty-one elite male boxers completed four exercise sessions, two HIIT and two MICT, conducted in the morning and evening on separate days. Venous blood samples were collected immediately after each exercise session and again one-hour post-exercise. A 3 × 2 × 2 mixed-design ANOVA with repeated measures was used to analyze the effects of exercise type, time of day, and sampling time on biochemical markers. Significant differences were observed in all muscle and cardiac output biomarkers (LDH, CK, CK-MB, TnT, MB) across sampling times (rest, immediately post-exercise, and one-hour post-exercise). Additionally, CK levels showed a significant difference based on the time of day, with higher values recorded in evening sessions. Regarding oxidative stress parameters, a significant three-way interaction (exercise type × time of day × sampling time) was observed for malondialdehyde (MDA), a serum oxidant marker. IL-6 levels differed significantly by both time of day, with higher levels observed in morning sessions and sampling time, with elevated concentrations immediately after and 1 hour after exercise compared to rest. A significant interaction between time of day and sampling time was also detected for IL-6. Based on the findings of this study, both HIIT and MICT appear to induce more favorable biochemical responses when performed in the morning. Morning exercise sessions were associated with reduced markers of muscle damage, oxidative stress, and pro-inflammatory activity compared to evening sessions. Therefore, morning exercise may be recommended to optimize recovery, minimize physiological strain, and support overall athletic performance in elite athletes.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-20"},"PeriodicalIF":1.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of chronotype on mental health and subjective well-being: The mediating role of emotion regulation strategies.","authors":"Joanna Gorgol-Waleriańczyk","doi":"10.1080/07420528.2025.2563609","DOIUrl":"https://doi.org/10.1080/07420528.2025.2563609","url":null,"abstract":"<p><p>Multiple studies have shown that individuals with an evening chronotype tend to report greater mental health problems, such as higher levels of depression and reduced well-being, compared to those with a morning chronotype. The adverse outcomes associated with eveningness appear to be linked to a combination of biological, social, and psychological factors. In the present study, the relationship between chronotype and two emotion regulation strategies: cognitive reappraisal and expressive suppression was invastigated. Furthermore, it was explored whether these strategies mediate the association between chronotype and indicators of mental health and well-being. Participants completed the Composite Scale of Morningness (CSM), and based on the established chronotype cut-off criteria, 76 individuals were classified as morning types and 81 as evening types. The total sample consisted of 157 participants (107 women, 50 men), aged 19-42 years (<i>M</i> ± <i>SD</i>: 25.12 ± 4.53). All participants completed questionnaires assessing emotion regulation strategies, depressive symptoms, life satisfaction, and positive and negative affect. Results show that evening types scored lower in cognitive reappraisal and well-being, and higher in expressive suppression and depressive symptoms. Controlling for age and gender, significant mediation effects were found, showing that the relationship between chronotype and depressive symptoms and between chronotype and subjective well-being might stem from lower cognitive reappraisal and higher expressive suppression among evening types. These findings suggest that adaptive emotion regulation strategies can positively impact well-being and reduce depressive symptoms, especially among evening types and highlight the importance of targeted interventions to improve emotion regulation strategies in this population.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mating rhythm of the African fig fly is predominantly controlled by light-dark cycles.","authors":"Sukriti Mishra, Nisha Sharma, Sunil Kumar Singh, Shahnaz Rahman Lone","doi":"10.1080/07420528.2025.2561848","DOIUrl":"https://doi.org/10.1080/07420528.2025.2561848","url":null,"abstract":"<p><p>The African fig fly, <i>Zaprionus indianus</i>, is an invasive pest of global concern, infesting over 80 crop species - including high-value fruits such as figs, strawberries, and guavas - and driving significant economic losses. Its ecological success is closely linked to circadian-regulated mating behavior, which enhances reproductive efficiency and fosters adaptability to diverse environments. Like the popular model organism <i>Drosophila melanogaster</i>, <i>Z. indianus</i> exhibits robust locomotor rhythms. A key feature of the circadian clock is its ability to anticipate predictable events, such as light-dark transitions, by gradually increasing or decreasing activity in advance. Mating rhythm is uniquely synchronized to light cycles: mating peaks show anticipation of both lights-on and lights-off transitions, with lights-off anticipation persisting even under long photoperiods (16-h light:8-h dark), suggesting circadian control. Remarkably, <i>Z. indianus</i> rapidly adapts to simulated jetlag, underscoring its plasticity in shifting environments. A critical distinction from <i>D. melanogaster</i> is its persistently low mating activity under constant darkness, indicating an obligate light dependence for mating. This reliance on light cues, combined with circadian plasticity and rapid environmental acclimation, likely underpins its capacity to colonize ecologically diverse regions and expand its geographic range. These insights into <i>Z. indianus</i>'s mating rhythm not only advance understanding of its invasive success but also offer actionable targets for disrupting its reproductive cycles, informing strategies to curb its spread and mitigate agricultural damage.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythm of melatonin secretion and associated factors of patients in the ICU: A prospective cohort study.","authors":"Jingjing Li, Shining Cai, Xiao Liu, Jinghua Mei, Wenyan Pan, Joseph M Latour, Ming Zhong, Yuxia Zhang","doi":"10.1080/07420528.2025.2552861","DOIUrl":"https://doi.org/10.1080/07420528.2025.2552861","url":null,"abstract":"<p><p>Circadian rhythm of melatonin secretion disturbance is common in patients in the intensive care unit (ICU) and may contribute to poor patient prognoses. The aim of this study was to explore the melatonin secretion rhythm in critically ill patients and to identify factors influencing the melatonin secretion rhythm. This was a prospective cohort study conducted in the surgical ICU of a tertiary hospital in Shanghai, China, between February 2022 and December 2022. Patients were enrolled if they were conscious, > 18years, had an expected ICU stay longer than 24 h, and were postoperative. Patient observations started on the first day of admission. ICU light and noise level, baseline characteristics, average night-time interruptions, pain level, use of analgesics and sedation, feeding, duration of mechanical ventilation, leukocyte and procalcitonin (PCT) level, surgical procedures and disease information were observed. We defined melatonin rhythmicity by calculating melatonin acrophase and amplitude. Serum melatonin was collected at 3:00, 8:00, and 16:00 on the first three days after admission. There were 190 ICU patients included in this study. The melatonin acrophase was abnormal in 100 (52.6%) patients. Use of analgesics (<i>p</i> = 0.002) and average night-time interruptions (<i>p</i> = 0.011) were independently related to the melatonin acrophase. Melatonin amplitude was associated with age and average night-time interruptions (<i>p</i> = 0.018 and <i>p</i> = 0.048, respectively). Clinical staff should routinely assess patients' pain levels using validated assessment tools and implement a combination of non-pharmacological and pharmacological pain control interventions. To optimize the ICU environment at night, non-urgent medical procedures should be limited to only those necessary. These approaches may help ICU patients maintain their circadian rhythm and potentially improve their overall recovery.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian fluctuations in saliva biochemical composition: A pilot study.","authors":"Carla P Lozano, Natalia García-Manríquez, Karla Gambetta-Tessini, Rodrigo A Giacaman","doi":"10.1080/07420528.2025.2556828","DOIUrl":"https://doi.org/10.1080/07420528.2025.2556828","url":null,"abstract":"<p><p>Saliva serves as a valuable, non-invasive diagnostic tool, yet the influence of circadian rhythms on its biochemical composition remains unclear. This study evaluated circadian fluctuations in unstimulated whole saliva, focusing on pH, total protein, glucose, and organic and inorganic ions. Eight healthy, caries-free adults provided unstimulated saliva samples at six time points (7:00 AM, 11:00 AM, 3:00 PM, 7:00 PM, 11:00 PM, and 3:00 AM) across a 24-hour period, on three separate days. Participants followed a standardized Mediterranean diet for three days before and during sampling. Saliva was analyzed for pH, total protein (bicinchoninic acid assay), and various biochemical markers using a calibrated reflectometer. Statistical analyses were performed using repeated measures ANOVA (<i>p</i> <0.05). No significant circadian variations were observed for calcium, phosphate, peroxide, salivary pH, or total protein (<i>p</i> >0.05). However, lactate, nitrate, nitrite, ammonium, and glucose exhibited significant circadian fluctuations (<i>p</i> <0.05), with distinct peaks at specific times. Circadian rhythm had a limited impact on the overall biochemical profile of unstimulated saliva in young, healthy adults. However, specific analytes exhibited significant fluctuations, highlighting the need for standardized sampling protocols in saliva-based diagnostics. Understanding circadian influences on saliva composition may improve the reliability of saliva as a diagnostic biofluid for oral and systemic conditions.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of sleep duration and quality with risk of incident obesity, diabetes, and metabolic syndrome: Results from the Midlife in the United States study.","authors":"Christopher Coleman, Gregory Grosicki, Satya S Jonnalagadda, Jessica Kiel, Yong Zhu","doi":"10.1080/07420528.2025.2556840","DOIUrl":"https://doi.org/10.1080/07420528.2025.2556840","url":null,"abstract":"<p><p>Understanding how sleep affects the risk of incident chronic conditions in midlife may reinforce the importance of a healthy sleep pattern for healthy aging and cardiometabolic health. The objective of the study was to examine associations of sleep duration and quality with incident obesity, diabetes and metabolic syndrome in mid-aged adults. Participants without obesity (<i>n</i> = 381), diabetes (<i>n</i> = 509), or metabolic syndrome (<i>n</i> = 487) from the Biomarker Projects in Midlife in the United States study were examined separately for baseline sleep duration and quality and their associations with incident obesity, diabetes, or metabolic syndrome after an average follow-up of 12 years. There was no significant association between baseline sleep duration and any of the incident conditions at follow-up (<i>p</i> > 0.05 for all). However, participants with poor baseline sleep quality had a higher risk of incident obesity (odds ratio (OR) = 1.798, 95% confidence interval (CI)=(1.001, 3.229), <i>p</i> = 0.0497) and incident diabetes (OR = 2.499, 95% CI=(1.160, 5.383), <i>p</i> = 0.0194) at follow-up than those with good sleep quality. There was no significant association between sleep quality and incident metabolic syndrome (OR = 0.881, 95% CI=(0.547, 1.420), <i>p</i> = 0.6031). In conclusion, sleep quality was associated with incident obesity and diabetes; maintaining a healthy sleep pattern in midlife may help reduce risk for these chronic conditions.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toluquinol modulates <i>NR1D1</i> and circadian rhythm in lung cancer cells: Implications for circadian medicine.","authors":"Nidhi Nagariya, Vihas Vasu, Kaushalkumar Chaudhari, Aparna Golani, Jyoti Vihas Thaikoottathil, Hetal Roy","doi":"10.1080/07420528.2025.2556834","DOIUrl":"https://doi.org/10.1080/07420528.2025.2556834","url":null,"abstract":"<p><p>Lung cancer remains one of the most fatal cancers, with cigarette smoke (CS) exposure being a major risk factor due to its role in triggering oxidative stress. Disruption of circadian rhythms, increasingly common in modern lifestyles, has also been linked to cancer progression. Targeting both oxidative imbalance and circadian disruption may offer a more effective therapeutic approach. Toluquinol (TQ), a compound derived from marine fungi, has shown promising anti-tumor activity and potential relevance in circadian-based cancer strategies. The current study investigated the role of TQ as a potential circadian medicine in modulating the dysregulated circadian-regulatory gene expression in the CS-exposed NCI-H23 lung adenocarcinoma cell line. Among the core circadian regulatory genes, <i>NR1D1</i> plays a crucial role as a transcriptional repressor, involved in maintaining the circadian rhythm, regulating redox homeostasis, and modulating inflammation. Dysregulation of <i>NR1D1</i> has been linked to cancer progression and poor prognosis in lung cancer. This study offers valuable insights into the impact of CS on <i>NR1D1</i> gene regulation and its role in lung cancer development, which is mediated through disrupted redox balance and inflammation, while highlighting the potential therapeutic role of TQ in mitigating this process.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-23"},"PeriodicalIF":1.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light exposure impact on cardiac autonomic control before and following exercise.","authors":"Thais C Marin, Gustavo F Oliveira, Luan M Azevêdo, Tiago Peçanha, Saurabh S Thosar, José Cipolla-Neto, Cláudia L M Forjaz, Leandro C Brito","doi":"10.1080/07420528.2025.2556841","DOIUrl":"https://doi.org/10.1080/07420528.2025.2556841","url":null,"abstract":"<p><p>We aimed to investigate whether bright light (BL) exposure affects sympathovagal activity in controlling heart rate (HR) before and after exercise. Eighteen healthy men (28 ± 4 years) underwent two experimental conditions: one under BL (5000 lux) and another under dim light (DL < 8 lux). In both conditions, subjects performed an aerobic exercise bout (cycle ergometer, 30 min at 50-60% of HRreserve). HR (electrocardiography) and respiratory rate (piezoelectric belt) were initially assessed at baseline light (500 lux). Measurements were repeated before and 10 min after the exercise in both light conditions, BL and DL. Cardiac autonomic modulation was evaluated using spectral analysis of HR variability. Before exercise, DL did not change HR but decreased low- to high-frequency ratio of HR variability (LF/HF_RR, DL = -0.35 ± 0.43 vs. BL = +0.00 ± 0.55, <i>p</i> < 0.01). From pre- to post-exercise, HR increased similarly, while LF/HF_RR increase was greater in DL than BL (+1.12 ± 0.87 vs. +0.60 ± 0.98, <i>p</i> = 0.04). Contrary to our hypothesis, in healthy men, BL did not exacerbate HR and cardiac sympathovagal balance. However, DL exposure decreased pre-exercise cardiac sympathovagal balance, a difference that no longer persisted postexercise.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daylight spectrum and intensity reduction and its impact on melatonin, cortisol, alpha-amylase, sleep parameters and sleepiness in humans.","authors":"Katarína Kováčová, Zuzana Dzirbíková, Lucia Grácová, Marek Turlík, Peter Hartman, Tomáš Bacigál, Peter Hanuliak, Andrea Vargová, Jozef Hraška, Katarína Stebelová","doi":"10.1080/07420528.2025.2556842","DOIUrl":"https://doi.org/10.1080/07420528.2025.2556842","url":null,"abstract":"<p><p>Light serves as the main synchroniser of the circadian system. The amount of light and its spectral distribution throughout the day influence hormonal secretion and sleep-wake regulation. There is a knowledge gap regarding the impact of the spectrum and intensity reduction of short-wavelength light during the day on circadian system outputs. In the present study, 23 participants spent 5 working days in the reference office with full-spectrum lighting. In the experimental week, participants spent five working days in the office with reduced intensity and short-light spectrum up to 500 nm. We measured melatonin, cortisol, and salivary alpha-amylase (sAA) activity in morning and evening saliva under dim light or light exposure (LE) and sleep by wrist actigraphy. Daylight impacted sleep quality only in females. The melatonin did not differ due to a changed daylight, but the LE had a stronger suppressive effect during the experimental week. The cortisol in the morning was higher in females, with no differences between weeks. To conclude, modified daylight has an impact on sleep quality without significant hormonal or sAA changes. LE before sleep can influence melatonin and sleep quality depending on the previous light history with high interindividual differences.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-19"},"PeriodicalIF":1.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}