Chronobiology International最新文献

{"title":"Objective rest-activity rhythm amplitude and lung function in US adults: A cross-sectional analysis of the 2011-2012 National Health and Nutrition Examination Survey.","authors":"Hui-Jie Wang, Ting Mo","doi":"10.1080/07420528.2026.2747176","DOIUrl":"https://doi.org/10.1080/07420528.2026.2747176","url":null,"abstract":"<p><p>This cross-sectional analysis of 4,150 US adults from the 2011-2012 NHANES examined associations between wrist-accelerometry-derived rest-activity rhythm metrics and respiratory outcomes spanning spirometry, exhaled nitric oxide, and self-reported respiratory symptoms and diagnoses. Relative amplitude (RA), interdaily stability, intradaily variability, M10, L5, and cosinor parameters were derived from hourly monitor-independent movement summary (MIMS) values. The co-primary outcomes were FEV₁ and FVC z-scores (GLI 2012); secondary outcomes included FEV₁/FVC, FeNO, and latent-class-derived respiratory phenotypes. Survey-weighted linear regression with progressive adjustment for demographics, socioeconomic factors, BMI, smoking, depression, and wear time was employed, with activity volume (M10 and total daily activity) addressed in dedicated sensitivity models. Each 1-SD increase in RA was associated with a 0.108 higher FEV₁ z-score (95% CI: 0.053-0.164; <i>p</i> < 0.001), with concordant signals for cosinor amplitude and M10. Each 1-SD increase in RA was also associated with a 0.120 higher FVC z-score (95% CI: 0.073-0.166; <i>p</i> < 0.001), a magnitude comparable to that for FEV₁. This association persisted in never-smokers, those without diagnosed respiratory disease, and after adjusting for total activity volume. No amplitude metric was associated with FEV₁/FVC or FeNO. Rhythm metrics did not independently distinguish respiratory phenotypes after full covariate adjustment. In conclusion, a stronger day-night activity contrast was associated with higher FEV₁ and FVC z-scores, but not with FEV₁/FVC, FeNO or adjusted respiratory phenotype membership, and this association was not attenuated by adjustment for M10 or total daily activity volume. Prospective studies with repeated accelerometry and post-bronchodilator spirometry are required to determine whether the day-night activity contrast has predictive value for lung-function decline.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-16"},"PeriodicalIF":2.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in research on the bidirectional relationship between circadian rhythm and depression: A bibliometric analysis.","authors":"Kui He, Kexin Cheng, Weihong Li","doi":"10.1080/07420528.2026.2747060","DOIUrl":"https://doi.org/10.1080/07420528.2026.2747060","url":null,"abstract":"<p><p>This study used VOSviewer and CiteSpace to conduct a bibliometric analysis of 444 publications on the relationship between circadian rhythms and depression, retrieved from the Web of Science Core Collection (January 2015 to April 2025). Publication numbers remained low until 2017 but increased markedly after 2018, with the United States contributing the largest share. Ian B. Hickie and Joanne S. Carpenter were the most prolific authors; the University of Pittsburgh and <i>Chronobiology International</i> were the most productive institution and journal, respectively. McClung, Dubocovich, and Logan were the top co-cited authors, while frequent keywords included \"expression,\" \"sleep,\" \"circadian rhythms,\" and \"melatonin.\" These findings underscore the growing importance of circadian rhythms in depression pathophysiology and therapy, with future research likely to focus on diagnosis, biomarker identification, individualized treatment, prognosis, and health management.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-17"},"PeriodicalIF":2.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond seasonality: Rethinking daylight exposure in adolescent sleep research.","authors":"Ariel M Lorenzo, Dan Jones A Blanco, Cris Jae D Muralla, Arnold O Fernandez, Lucky Ceasar S Lampitoc, Aldrin J Tinaza","doi":"10.1080/07420528.2026.2752973","DOIUrl":"https://doi.org/10.1080/07420528.2026.2752973","url":null,"abstract":"","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-2"},"PeriodicalIF":2.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing the effort: Chronobiological drivers of skeletal muscle adaptation and metabolic health.","authors":"Emrah Aykora, Gülfem Erbil, Damla Aykora","doi":"10.1080/07420528.2026.2750361","DOIUrl":"https://doi.org/10.1080/07420528.2026.2750361","url":null,"abstract":"<p><p>Exercise acts as a non-photic zeitgeber, resetting skeletal muscle circadian clocks that regulate metabolism, mitochondrial function, and insulin sensitivity. This review synthesizes current evidence on how exercise timing modulates skeletal muscle clock function and metabolic adaptation, with emphasis on divergent molecular pathways, sex-specific regulation, chrono-nutrition, and emerging evidence on immune-circadian interactions, myokine-mediated muscle-organ communication, and cellular stress responses. Exercise performed at different circadian phases activates distinct signaling networks despite identical mechanical workloads. Early active phase exercise, typically performed following an overnight fast, preferentially activates the AMPK-SIRT1-HIF1α axis, promoting lipid oxidation, metabolic stress sensing, and circadian phase advancement through PER/CRY modulation. Conversely, late phase exercise favors p38 MAPK-ATF2/CREB-PGC-1α signaling, enhancing mitochondrial biogenesis, oxidative phosphorylation, and Akt-AS160-GLUT4-mediated glucose disposal. Emerging evidence further suggests that circadian regulation of macrophage polarization, cGAS-STING signaling, contraction-induced myokine secretion, and proteostasis may contribute to time-dependent systemic adaptations, although direct human evidence remains limited. In addition, pronounced sexual dimorphism indicates that estrogen-mediated regulation of BMAL1/CLOCK signaling influences mitochondrial function and substrate selection. In conclusion, exercise timing represents an important regulator of metabolic health. Integrating circadian biology, nutritional timing, chronotype, sex, metabolic phenotype, and immune-metabolic context may facilitate the development of precision chrono-exercise strategies for metabolic and cardiometabolic disorders.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-20"},"PeriodicalIF":2.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging evidence suggests that circadian disruption and muscle wasting form a self-reinforcing loop.","authors":"Feifei Li, Chunhong Liu","doi":"10.1080/07420528.2026.2743668","DOIUrl":"https://doi.org/10.1080/07420528.2026.2743668","url":null,"abstract":"<p><p>Circadian disruption and skeletal muscle wasting frequently co-occur in critical illness, shift work, and aging. We propose a bidirectional self-reinforcing loop in which each process amplifies the other. Environmental disruption of the skeletal muscle clock impairs protein turnover and mitochondrial function, triggering atrophy. The resulting loss of muscle mass weakens peripheral clock output and disrupts systemic circadian rhythms. The forward arm is supported by genetic evidence, particularly from global <i>Bmal1</i> knockout models and human sleep-deprivation studies. The reverse arm is supported by correlative evidence from clinical observations and disease models. Chronotherapeutic interventions targeting this loop have shown preclinical efficacy and warrant clinical translation.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two seconds per day: Limitations of circadian burden metrics in the Permanent Daylight Saving Time debate.","authors":"José María Martín-Olalla, Jorge Mira","doi":"10.1080/07420528.2026.2745645","DOIUrl":"https://doi.org/10.1080/07420528.2026.2745645","url":null,"abstract":"","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-3"},"PeriodicalIF":2.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac fibrosis and heart failure: Metabolic stress, circadian dysregulation, and extracellular matrix remodeling.","authors":"Diyashi Deb, Sattwika Ray, Pravesh Sharma, Pawan Sharma, Kunal Sikder","doi":"10.1080/07420528.2026.2745644","DOIUrl":"https://doi.org/10.1080/07420528.2026.2745644","url":null,"abstract":"<p><p>Diabetes is a major risk factor for heart failure and drives a distinct cardiomyopathic phenotype characterized by oxidative stress, metabolic inflexibility, mitochondrial dysfunction, and progressive myocardial remodeling. Central to this process is cardiac fibrosis, marked by excessive extracellular matrix deposition, increased myocardial stiffness, and impaired mechanotransduction. Emerging evidence identifies circadian rhythm disruption as an under recognized modifier of diabetic cardiac fibrosis. The circadian clock regulates daily oscillations in myocardial metabolism, redox balance, inflammatory signaling, and extracellular matrix turnover, thereby maintaining cardiac homeostasis. However, modern urbanization has introduced chronic exposure to artificial light at night, particularly blue light from digital devices, which suppresses melatonin and desynchronizes central and peripheral clocks. In diabetes, loss of circadian regulation amplifies TGF-β signaling, Rho-A/ROCK-mediated mechanotransduction, oxidative stress, and myofibroblast transformation. Understanding how circadian misalignment accelerates profibrotic remodeling may reveal novel chronotherapeutic strategies to reduce cardiac fibrosis and heart failure risk.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-14"},"PeriodicalIF":2.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian misalignment and low-grade inflammation: Failure of temporal gating by the molecular clock.","authors":"Yujin Lee, Heon-Jeong Lee","doi":"10.1080/07420528.2026.2743662","DOIUrl":"https://doi.org/10.1080/07420528.2026.2743662","url":null,"abstract":"<p><p>Circadian misalignment, from shift work, recurrent sleep-wake disruption, or mistimed behavioral rhythms, tracks with cardiometabolic disease and low-grade systemic inflammation, yet no single account ties the molecular, animal, and human evidence together. This narrative review reads that evidence through one idea: temporal gating of innate immunity by the molecular clock. Clock components, chiefly REV-ERBα and BMAL1, confine NF-κB and NLRP3 inflammasome activity to defined circadian windows through transcriptional and metabolic routes. Misalignment then amounts to internal phase dissociation between central and peripheral clocks, letting inflammation fire at the wrong biological time. Controlled human protocols show that misalignment modestly raises 24-hour high-sensitivity C-reactive protein even when sleep loss is held constant, although cytokine responses are mixed rather than uniformly proinflammatory. Apparent inconsistencies, such as pathway-specific BMAL1 effects, variable biomarkers, and imperfect clock-targeting drugs, reflect biological and methodological heterogeneity and are only partly resolved at present. The mechanistic case for a contribution to chronic inflammation is considerably stronger than the quantitative human case, and causal inference remains incomplete. Behavioral realignment has the firmest translational support; clock-targeted drugs remain largely preclinical. Because low-grade inflammation also figures in mood disorders, mood disorders are discussed here as a hypothesis-generating translational exemplar rather than as evidence of a directly tested circadian-misalignment-inflammation-mood pathway. Standardized circadian-phase assessment and longitudinal human studies are needed.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing temporal patterns in trampoline‑associated injuries.","authors":"Randall T Loder","doi":"10.1080/07420528.2026.2739516","DOIUrl":"https://doi.org/10.1080/07420528.2026.2739516","url":null,"abstract":"<p><p>Injuries due to trampoline use are well described. The purpose of this study was to evaluate trampoline‑associated injuries presenting to US Emergency Departments (EDs) spanning a quarter century. National Electronic Injury Surveillance System (NEISS) data for the years 1998 through 2024 was used. There were an estimated 2,861,127 ED visits for trampoline‑associated injuries. The total number of ED visits remained relatively constant from 1998 through 2015 but then gradually increased. Those occurring at home peaked years 2003-2008 and then gradually decreased; those occurring at places of recreation/sport increased rapidly starting in 2014. The percentage of those over 55 years old and traumatic brain injuries demonstrated an increase over time. Injuries by month demonstrated an asymmetric distribution rising rapidly from January to May followed by a less rapid decrease from June to December. May 17 was the peak for those occurring at home and March 22 for those at places of recreation/sport. For those occurring at home, there was a rapid spring increase after the Daylight-Saving Time change. In conclusion, changes over time were demonstrated in trampoline‑associated injuries. Such evaluations can guide adjustments in injury prevention strategies and health care resource allocation. One possible prevention strategy is the use of public service announcements in early spring.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Martin-Olalla & Mira: Interpreting aggregate circadian burden.","authors":"Lara Weed, Jamie Zeitzer","doi":"10.1080/07420528.2026.2744598","DOIUrl":"https://doi.org/10.1080/07420528.2026.2744598","url":null,"abstract":"","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-3"},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}