{"title":"The circadian rhythm of human body temperature - Clinical implications and review of the literature.","authors":"Ivayla I Geneva","doi":"10.1080/07420528.2025.2511268","DOIUrl":"10.1080/07420528.2025.2511268","url":null,"abstract":"<p><p>Human body temperature remains an essential vital sign that had been used to judge our health given its strong correlation with human disease. Body temperature is also a manifestation of our circadian rhythm, with a predictable rise during the day peaking in the evenings and steady decrease during the night reaching a minimum around the time of awakening. Yet, the rhythm is believed to be endogenous and to exist independently of any external stimuli, including day light. Human illnesses such as infections, autoimmune conditions, and cancer had been associated with a disruption in the circadian rhythm. This is of significant clinical interest because measurements of the specific disruptions of the rhythm appear to carry diagnostic and prognostic value. This is a review of the literature with a focus on the determinants of human body temperature and the circadian rhythm of body temperature. The last section provides potential new research avenues in our search for chronotherapy clinical applications.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"945-958"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between chronotype and central sensitization in patients with non-specific low back pain.","authors":"Aslı Çalışkan Uçkun, Nesibe Doğan, Buğra İnce, Şeniz Akçay, Taciser Kaya, Altınay Göksel Karatepe","doi":"10.1080/07420528.2025.2515990","DOIUrl":"10.1080/07420528.2025.2515990","url":null,"abstract":"<p><p>Low back pain is a leading cause of disability, with over 85% of cases classified as non-specific (NSLBP). Beyond mechanical causes, central sensitization (CS) has been recognized as a key mechanism in chronic pain. This study investigated the relationship between chronotype (morning, intermediate, evening) and CS severity in NSLBP patients, and whether chronotype is associated with pain intensity and disability. A total of 131 patients (aged 18-65) were assessed using the Morningness-Eveningness Questionnaire (MEQ), Central Sensitization Inventory (CSI), Pain Catastrophizing Scale (PCS), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), Visual Analogue Scale (VAS), and Roland-Morris Disability Questionnaire (RMDQ). Three-way ANCOVA (controlling for age, gender, and occupation) revealed that evening-type individuals had significantly higher CSI, PCS, BDI, PSQI, and RMDQ scores (all <i>p</i> < 0.05). Hierarchical regression analysis showed that evening chronotype (β = 0.193, <i>p</i> = 0.004), pain catastrophizing (β = 0.508, <i>p</i> < 0.001), and depressive symptoms (β = 0.435, <i>p</i> < 0.001) were independent predictors of CS severity. These findings suggest that eveningness is associated with more severe central sensitization and adverse psychosocial outcomes in NSLBP. Chronotype may play a role in pain modulation and should be considered in assessment and management strategies.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"913-920"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prevalence of morningness-eveningness in university-level students of North-East India: Impact on their sleep physiology and metabolic processes.","authors":"Ankita Bhattacharjee, Arijit Chakraborty","doi":"10.1080/07420528.2025.2511259","DOIUrl":"10.1080/07420528.2025.2511259","url":null,"abstract":"<p><p>Differences in circadian timing among individuals and the time of day are potential biological sources that might impact student's activities. As previous studies have reported that young adults are more susceptible to sleep deprivation, so the goal of the present study was to investigate the prevalence of chronotype, and its associations between circadian preferences, sleep and its physiological implications, cognitive performances and metabolic profiles among university-level students in the north-eastern parts of the Indian subcontinent. Majority of the students fall in intermediate chronotype in our study with the evening chronotypes having poor sleep quality, leading to low cognitive function that in turn causes periods of anxiety and stress which was reflected in salivary cortisol levels. The evening chronotypes also exhibited lower nocturnal melatonin levels compared to morning types and had difficulty in falling to sleep with elevated oral temperatures. Elevated BMI status and frequencies of fast-food intake were also high in evening chronotypes, which may increase the chances of obesity in them and also prone to hyperglycemia as indicated by higher fasting blood sugar and salivary amylase levels. The metabolic profiles were also altered in late chronotypes as evidenced by low thyroid hormone profiles and higher triglyceride levels. Our study reports intermediate chronotypes along with evening types are at the risk of developing sleep deprived disorders in the future, and it is important that researchers should develop tailored sleep interventions that consider demographic, psychological, and socio-behavioral factors contributing to poor sleep quality, excessive daytime sleepiness, and short sleep duration among students.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"840-863"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraindividual variability in sleep patterns and behavioral problems among preschool children: The role of bedtime and total sleep time variability.","authors":"Tomoki Nakatani, Norihisa Tamura","doi":"10.1080/07420528.2025.2515979","DOIUrl":"10.1080/07420528.2025.2515979","url":null,"abstract":"<p><p>Sleep stability is critical for early childhood development, yet many children experience variability in sleep patterns that may affect behavioral health. This study examines the impact of intra-individual variability (IIV) in sleep on behavioral issues in young children, independent of average nighttime sleep duration reported via BISQ. A sample of 306 children aged 1.5 to 5 years was recruited through the Health and Social Welfare Division, A City. Caregivers reported sleep patterns using daily activity logs, and behavioral problems were assessed using the Child Behavior Checklist 1½-5. Main sleep measures included total sleep time and weekly standard deviations of bedtime, wake time, and total sleep time, reflecting sleep IIV. Logistic regression analyses adjusted for confounding factors (e.g. child age, birth order, maternal age at birth) indicated that higher IIV in bedtime was significantly associated with increased internalizing problems, while greater IIV in total sleep time was linked to externalizing problems. Both indicators of IIV were also associated with overall behavioral problems, independent of average nighttime sleep duration. These findings underscore the relevance of consistent sleep-wake rhythms for emotional and behavioral stability in early childhood and indicate that addressing sleep IIV could support efforts to foster healthier behavioral development.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"905-912"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Line Victoria Moen, Tarjei L Rysstad, Jenny-Anne S Lie, Fred Haugen, Dagfinn Matre
{"title":"Validation of the Norwegian version of the Munich ChronoType Questionnaire for shift workers (MCTQ<sup>Shift</sup>).","authors":"Line Victoria Moen, Tarjei L Rysstad, Jenny-Anne S Lie, Fred Haugen, Dagfinn Matre","doi":"10.1080/07420528.2025.2523514","DOIUrl":"https://doi.org/10.1080/07420528.2025.2523514","url":null,"abstract":"<p><p>Chronotype may play a role in the association between shift work and health risks. An important and widely used questionnaire for measuring chronotype is the Munich Chronotype Questionnaire for Shift workers (MCTQ<sup>Shift</sup>); however, it has neither been validated nor is it available in Norwegian or any other Scandinavian language. Therefore, we translated the MCTQ<sup>Shift</sup> into Norwegian and assessed its validity against subjective and objective sleep measures. We adhered to established methodological guidelines to translate the questionnaire. The final Norwegian version was administered to 60 workers (85% responders) on a three-shift schedule (21.7% women, median age 28 y) at an industrial plant. Sleep duration and mid-sleep from the MCTQ<sup>Shift</sup> were compared with sleep diary and a multisensory sleep tracker (the Oura ring). Construct and criterion validity were evaluated. Sleep duration measured by the MCTQ<sup>Shift</sup> was highly correlated (<i>r</i> > 0.6) with sleep duration calculated from both the Oura ring and sleep diaries after morning shifts. On free days, the MCTQ<sup>Shift</sup> correlated moderately with the sleep diary but weakly with the Oura ring. Mid-sleep correlations from MCTQ<sup>Shift</sup> compared to the Oura ring data were high (<i>r</i> > 0.7) for sleep periods after morning and night shifts, and moderate (<i>r</i> = 0.5) sleep periods between free days following morning shift. Bland-Altman analyses indicated that the MCTQ<sup>Shift</sup> overestimated sleep duration and underestimated mid-sleep, with the largest discrepancies on free days after morning shifts. Night shifts showed the most pronounced outliers. The Norwegian MCTQ<sup>Shift</sup> shows promising validity for assessing sleep habits in shift workers, particularly on workdays. However, reduced accuracy on free days after morning shifts suggests limitations in capturing sleep patterns across all shift types.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of different feeding times on the structure of the intestinal flora of <i>Rana dybowskii</i> tadpole.","authors":"Wandi Xu, Hongyue Shi, Yingdong Li","doi":"10.1080/07420528.2025.2519308","DOIUrl":"10.1080/07420528.2025.2519308","url":null,"abstract":"<p><p>Feeding time is a critical factor influencing the growth, feeding efficiency, and health of animals. This study aimed to investigate the impact of different feeding times on the gut microbiome composition in <i>Rana dybowskii</i> tadpoles over a 50-d period. Using 16S rRNA sequencing, we analyzed the gut microbiome at four feeding times: 6:00, 12:00, 18:00, and 24:00. Our results revealed that tadpoles fed at 12:00 and 18:00 grew significantly faster than those fed at 6:00 and 24:00. The highest microbial abundance and diversity were observed in the 12:00 feeding group. Additionally, three probiotic bacteria-<i>Akkermansia muciniphila</i>, <i>Bacteroides ovatus</i>, and <i>Butyricicoccus pullicaecorum</i>-were identified as dominant species in this group. These findings suggest that feeding time not only influences the composition and structure of the intestinal microbiota in <i>R. dybowskii</i> tadpoles but also affects their growth performance. These results highlight the importance of feeding time in improving tadpole health and farming efficiency.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The importance of social jet lag in obstructive sleep apnea syndrome (OSAS).","authors":"Mehmet Hakan Bilgin, Pınar Guzel Ozdemir","doi":"10.1080/07420528.2025.2521349","DOIUrl":"https://doi.org/10.1080/07420528.2025.2521349","url":null,"abstract":"","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-2"},"PeriodicalIF":2.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ying Wu, Lijuan Dong, Xiaofang Jiang, Xinhong Li, Juan Han, Hongmei Lin
{"title":"Mental health and well-being in Chinese nurses: Relationship with psychological flexibility and night shifts.","authors":"Ying Wu, Lijuan Dong, Xiaofang Jiang, Xinhong Li, Juan Han, Hongmei Lin","doi":"10.1080/07420528.2025.2507226","DOIUrl":"https://doi.org/10.1080/07420528.2025.2507226","url":null,"abstract":"<p><p>The purpose of this study was to investigate whether the relationship between mental health and well-being among Chinese nurses could be mediated by factors such as night shift frequency and psychological flexibility. A total of 421 nurses were selected from 10 Grade secondary public hospitals in Shanghai, China. The 12-item General Health Questionnaire (GHQ-12) was used to assess mental health status. Additionally, psychological flexibility and well-being were assessed using the Chinese version of Personalized Psychological Flexibility Index and Chinese version of the 5-item WHO Well-Being Index, respectively. Correlation analysis showed that psychological flexibility was positively associated with well-being (<i>r</i> = 0.220, <i>p</i> < 0.05) and negatively correlated with mental health issues (<i>r</i> = ‒0.225, <i>p</i> < 0.05). Night shift frequency was linked to mental health issues (<i>r</i> = 0.276, <i>p</i> < 0.05) and lower psychological flexibility (<i>r</i> = ‒0.165, <i>p</i> < 0.05). Structural equation modeling demonstrated that age had direct positive effects on psychological flexibility (β = 0.130) and mental health (β = 0.541), while night shift frequency directly worsened mental health (β = 0.618) and reduced psychological flexibility (β = ‒0.198). Psychological flexibility significantly influenced both mental health (β = ‒0.674) and well-being (β = 0.418), with indirect effects on well-being (β = 0.268). Mental health was the strongest predictor of well-being (β = 0.718). These findings highlight the importance of psychological flexibility, night shifts and age in nurses' mental health well-being, though the study's cross-sectional design limits causal inferences.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing the relationship between different sleep traits and retinal neurodegenerative diseases: A bidirectional Mendelian randomization study.","authors":"Yijie Lu, Yao Tan, Kai Jin, Wei Xiong","doi":"10.1080/07420528.2025.2509631","DOIUrl":"10.1080/07420528.2025.2509631","url":null,"abstract":"<p><p>his bidirectional Mendelian randomization (MR) study assessed causal relationships between sleep traits (chronotype, sleep duration, insomnia) and retinal neurodegenerative diseases (RNDs), including open-angle glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). Using genome-wide association study data and inverse variance weighting, we found chronotype significantly increased DR risk (OR: 1.60, <i>p</i> = 0.023). Reverse MR showed AMD was inversely associated with short sleep duration and chronotype. Sensitivity analyses supported result robustness. Mediation analysis identified six traits potentially linking chronotype to DR. These findings suggest sleep-related traits may be modifiable risk factors in RNDs, offering insights for early prevention and intervention.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"784-794"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arcady A Putilov, Evgeniy G Verevkin, Dmitry S Sveshnikov, Zarina V Bakaeva, Elena B Yakunina, Olga V Mankaeva, Vladimir I Torshin, Elena A Trutneva, Michael M Lapkin, Zhanna N Lopatskaya, Roman O Budkevich, Elena V Budkevich, Marina P Dyakovich, Olga G Donskaya, Alexandra N Puchkova, Vladimir B Dorokhov
{"title":"Estimation of sleep shortening and sleep phase advancing in response to advancing risetimes on weekdays.","authors":"Arcady A Putilov, Evgeniy G Verevkin, Dmitry S Sveshnikov, Zarina V Bakaeva, Elena B Yakunina, Olga V Mankaeva, Vladimir I Torshin, Elena A Trutneva, Michael M Lapkin, Zhanna N Lopatskaya, Roman O Budkevich, Elena V Budkevich, Marina P Dyakovich, Olga G Donskaya, Alexandra N Puchkova, Vladimir B Dorokhov","doi":"10.1080/07420528.2025.2509629","DOIUrl":"10.1080/07420528.2025.2509629","url":null,"abstract":"<p><p>Since the circadian clocks cannot directly respond to the signals of social clocks, earlier risetimes on weekdays lead to loss of certain amount of sleep. However, these clocks can partly reduce this loss by advancing sleep phase due to advancing the pattern of 24-h exposure to light caused by earlier risetimes. In an <i>in silico</i> study, a model of sleep-wake regulation was applied to show that the difference between earlier and later weekday risers in weekday risetime is equal to the sum of differences between them in sleep loss and sleep phase advance that can be measured as their differences in weekend-weekday gap in risetime and in weekend risetimes, respectively. Such differences in sleep loss and sleep phase advance were estimated from bed- and risetimes self-reported for weekdays and weekends by 4940 university students and lecturers subdivided into subsamples with different weekday risetimes and chronotypes. We also estimated, for these subsamples, the percentages of weekday sleep insufficiency and circadian misalignment determined as a less than 6 hours in bed on weekdays and a larger than 3-h weekend-weekday gap in risetime, respectively. Additionally, advance phase shifts of the circadian clocks were predicted by model-based simulations of self-reported sleep times.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"770-783"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}