Chronobiology International最新文献

{"title":"Multivariate associations between sleep patterns and self-regulation in adolescence: Canonical correlation analysis across ABCD and NCANDA cohorts.","authors":"Tommy Gunawan, Ty Brumback, Brant P Hasler, Qingyu Zhao, Susan F Tapert, Alejandro D Meruelo","doi":"10.1080/07420528.2026.2685032","DOIUrl":"10.1080/07420528.2026.2685032","url":null,"abstract":"<p><p>Adolescence involves pronounced changes in sleep timing and duration that have been linked to executive functioning, impulsivity, and risk behaviors, yet evidence for generalizable sleep - self-regulation associations remains limited. We used regularized canonical correlation analysis to examine multivariate relationships between sleep and self-regulation across two independent cohorts. In the Adolescent Brain Cognitive Development study (<i>n</i> = 11,143), later chronotype and shorter sleep duration were associated with higher impulsivity, particularly urgency and deficits in planning and perseverance (<i>r</i> = 0.21, permutation <i>p</i> < 0.001), with minimal contribution from delay discounting. Social jetlag showed weak loadings. In the National Consortium on Alcohol and Neurodevelopment in Adolescence cohort (<i>n</i> = 831), only one canonical function was statistically significant (<i>r</i> = 0.15, <i>p</i> = 0.011), characterized by later chronotype and greater social jetlag, with minimal contribution from sleep duration and primary loadings on impulsivity-related measures. Applying the ABCD-derived sleep - self-regulation pattern to NCANDA produced a small but nonzero association, driven primarily by social jetlag and delayed sleep timing, with minimal influence of sleep duration. These findings provide multivariate evidence linking delayed sleep timing and circadian misalignment to adolescent self-regulation, though effect sizes attenuate across cohorts. Longitudinal work is needed to clarify predictive pathways and inform sleep-focused interventions during this vulnerable developmental period.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1661-1675"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability and heart rate fragmentation among shift workers: The Multi-Ethnic Study of Atherosclerosis.","authors":"Mussammat Snigdha Sowrin, Ana Espinosa, Susan R Heckbert, Susan Redline, Gerben Hulsegge, Barbara N Harding","doi":"10.1080/07420528.2026.2679138","DOIUrl":"10.1080/07420528.2026.2679138","url":null,"abstract":"<p><p>Night shift work is linked with cardiovascular disease (CVD), although underlying mechanisms remain unclear. Heart rate variability (HRV) is a well-established biomarker, but heart rate fragmentation (HRF) may offer additional insights. We conducted a study to compare heart rate metrics, including HRV and HRF, across different types of shift schedules, and to evaluate the influence of sleep duration. In this cross-sectional study, we included 845 participants (mean age 64; 51% women) from the Multi-Ethnic Study of Atherosclerosis Sleep study. Heart rate metrics were compared between the day shift (reference), night/rotating shift, and other shift workers using adjusted linear regression. HRV was measured from overnight bipolar (Electrocardiogram) ECG. HRV (log transformed) and HRF values were reported as % difference with 95% confidence intervals (CIs). Analyses were stratified by sleep duration (short <7 h, recommended 7-<9 h, and long ≥9 h), and tested for interaction. Night/rotating shift workers had higher HRF than day shift workers, particularly a greater percentage of normal-to-normal intervals in alternation segments (PAS) (% difference 11.9, 95% CI 1.8, 22.0). We found differences based on sleep duration for PAS. The difference was most pronounced in workers with short sleep (% difference 20.4, 95% CI 3.0 to 37.9), somewhat smaller in those with recommended sleep (% difference 14.2, 95% CI -1.0 to 29.5), and reversed in long sleepers (% difference -10.8, 95% CI -32.4 to 10.8; interaction <i>p</i> = 0.06) Interaction terms were assessed at <i>p</i> < 0.10. HRV metrics showed minimal differences and no consistent patterns across shift groups. Night shift work is related to higher HRF, and sleep duration influences these findings, which may reflect circadian misalignment and autonomic dysregulation.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1600-1608"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/07420528.2026.2685905","DOIUrl":"10.1080/07420528.2026.2685905","url":null,"abstract":"","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"I-III"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype and daily social connectedness: Insights from a 30-day diary study.","authors":"Seweryn Nogalski, Radosław Rogoza","doi":"10.1080/07420528.2026.2678282","DOIUrl":"10.1080/07420528.2026.2678282","url":null,"abstract":"<p><p>Chronotype refers to individual preferences regarding the timing of activity and rest within the circadian cycle. Previous research has demonstrated its associations with various aspects of social functioning. The present study examines how chronotype is related to daily feelings of social connectedness. A total of <i>N</i> = 224 participants (<i>M</i> = 47.66, <i>SD</i> = 17.57) were recruited. At baseline, participants completed the Morningness-Eveningness-Stability-Scale improved (MESSi), followed by 30 consecutive days of social connectedness assessments using a short version of the UBC State Social Connection Scale (UBC-SSCS). Analyses revealed that higher morning affect was associated both with higher overall levels and lower day-to-day variability in social connectedness. In contrast, higher distinctness was related to lower average levels of social connectedness and greater fluctuations across days. No significant associations were found between eveningness and social connectedness. These findings highlight the importance of morning affect, and crucially, circadian stability in contributing to individuals' perceived connection with others.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1547-1559"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and joint associations of chronotype and social jetlag with depressive symptoms in adults with overweight and obesity: Evidence from NHANES (2017-2023).","authors":"Jie Feng, Xiaoqi Huang, Xiaojie Yang, Ruiyuan Tao, Jingsi Wen","doi":"10.1080/07420528.2026.2679136","DOIUrl":"10.1080/07420528.2026.2679136","url":null,"abstract":"<p><p>This study aimed to examine the independent and joint associations of chronotype and social jetlag with depression among adults with overweight and obesity. Data from the National Health and Nutrition Examination Survey (NHANES) among US adults were used. Sleep was assessed through the Sleep Disorders Questionnaire, and depressive symptoms via the Patient Health Questionnaire. Body mass index was calculated from objectively measured height and weight. Generalised additive models and multi-level modelling were employed. A total of 5,816 adults (mean age: 45.0 ± 12.9 y; 47.5% male) with overweight or obesity were included in this analysis. Independently, evening chronotypes showed higher depression scores and odds compared with morning type. Moderate and high social jetlag were associated with lower depression scores and reduced depression odds compared to low social jetlag. Joint analyses revealed that among individuals with neutral and evening chronotypes across the week, those experiencing moderate social jetlag had lower odds of depressive symptoms compared to those with low social jetlag (neutral type: odds ratio [OR] = 0.63; 95% confidence interval [CI]: 0.41, 0.99; evening type: OR = 0.53; 95% CI: 0.37, 0.74). These associations varied between weekday and weekend chronotypes. Moderate social jetlag demonstrated protective effects against depression in adults with overweight and obesity, particularly among evening chronotypes across the week, morning types on weekdays, and neutral and evening types on weekends. These findings suggest that sleep schedule flexibility between weekdays and weekends, potentially reflecting weekend catch-up sleep, may mitigate depression risk in this population, especially for individuals with evening preferences.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1590-1599"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of social isolation on stress, neuroinflammation, endocrine dysregulation, and antioxidant defense in mice exposed to rotational shiftwork/jetlag.","authors":"Madhumita Mishra, Rajesh Gupta, Muniyandi Singaravel","doi":"10.1080/07420528.2026.2681615","DOIUrl":"10.1080/07420528.2026.2681615","url":null,"abstract":"<p><p>Circadian disruption and social isolation are increasingly prevalent stressors in modern societies, each known to impair behavioral and physiological homeostasis. However, their concurrent influence remains poorly characterized. This study investigated the effects of social isolation and chronic circadian misalignment on affective behavior, neuroinflammatory signaling, endocrine function, and antioxidant defense in male AKR mice. Animals were housed either in groups or isolation under a stable 12:12 h light-dark cycle or subjected to six successive 8 h phase delays or advances every fourth day, modeling rotational shiftwork/jetlag exposure. Behavioral analyses revealed that isolated mice displayed pronounced anhedonia and anxiety-like behavior across all lighting regimens, with maximal impairment under phase advances. Molecular and biochemical assessments revealed significant elevations in pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) in the prefrontal cortex, hippocampus, and serum, accompanied by reduced melatonin levels, elevated corticosterone, and decreased antioxidant enzyme activity (SOD, CAT). These effects were observed across lighting conditions, indicating that circadian disruption and social isolation independently contribute to neuroendocrine stress, inflammation, and oxidative imbalance. Collectively, the results underscore the importance of social synchrony in maintaining circadian and physiological stability and highlight the impact of concurrent social and temporal desynchronization on health risks associated with chronic shiftwork/jetlag.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1624-1641"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose circadian rhythm disruption is associated with preeclampsia.","authors":"Rafael Bravo, Kyung Hyun Lee, Sarah A Nazeer, Jocelyn A Cornthwaite, Baha Sibai, Michal Fishel Bartal, Claudia Pedroza","doi":"10.1080/07420528.2026.2682481","DOIUrl":"10.1080/07420528.2026.2682481","url":null,"abstract":"<p><p>Preeclampsia is a leading cause of maternal death during pregnancy, and the role of circadian rhythms in predicting preeclampsia is not well understood. We aimed to determine whether glucose circadian rhythm disruption is associated with preeclampsia and can be used to predict this disorder. We analyzed a dataset of 92 pregnant individuals recruited with Continuous Glucose Monitoring (CGM). To study rhythmicity, we performed a cosinor analysis using the packages <i>cosinor</i> and <i>cosinor2</i>, and we calculated the non-parametric circadian rhythm variables using the <i>nparACT</i> package in R. Furthermore, we performed multiple-component cosinor analysis to detect internal oscillations and identify glucose postprandial peaks using the package <i>CosinorPy</i> in Python. Seventy-one participants (20 women with preeclampsia) had sufficient data for studying glucose circadian rhythmicity and performing all the chronobiological analyses. All the participants exhibited a significant circadian rhythm in their glucose oscillation. We developed a model including the time difference between the first postprandial peak and the last one, L5 start-time, and age that was predictive for preeclampsia. Patients diagnosed with preeclampsia from this model had a reduced amplitude and less robust glucose rhythmicity. We conclude that identifying abnormal glucose circadian rhythm during pregnancy may help to anticipate pregnancy-related disorders like preeclampsia.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1651-1660"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of chronotype and sleep habits with smartphone and tablet addiction among children: A cross-sectional study.","authors":"Kiavash Mokhtarpour, Tayebeh Mohtashami, Behzad Garmabi","doi":"10.1080/07420528.2026.2678271","DOIUrl":"10.1080/07420528.2026.2678271","url":null,"abstract":"<p><p>Excessive use of smartphones and tablets has become increasingly common among children, contributing to adverse physical and mental health outcomes. Evening chronotype and inadequate sleep habits have been identified as potential risk factors. However, despite growing concerns, there is limited evidence on the relationship between chronotype, sleep patterns, and digital device addiction in children. In this cross-sectional study, 213 Iranian schoolchildren aged 4-11 years were assessed using validated Persian versions of three standardized instruments: the Children's Chronotype Questionnaire (CCTQ), the Children's Sleep Habits Questionnaire (CSHQ), and the Smartphone and Tablet Addiction Questionnaire. This is the first study in Iran to employ the CCTQ to examine the association between chronotype and smartphone addiction in children. Data analysis included descriptive statistics, Spearman's correlation, stepwise regression, and Kruskal-Wallis tests. Sleep problems and smartphone/tablet addiction were significantly more prevalent in children with an evening chronotype, followed by those with a neutral chronotype, and were lowest in those with a morning chronotype. In addition, the M/E and CSHQ scores were positively associated with smartphone/tablet addiction scores, whereas later sleep onset time on scheduled days showed a negative association. Specifically, each one-unit increase in the M/E score was linked to a 0.75-point increase in the average addiction score (β = 0.75, SE = 0.17, <i>p</i> < 0.01), and each one-unit increase in the CSHQ score corresponded to a 0.35-point increase (β = 0.35, SE = 0.13, <i>p</i> < 0.05). Conversely, each one-unit delay in sleep onset time on scheduled days was associated with a 0.15-point decrease in the average addiction score (β = -0.15, SE = 0.09, <i>p</i> < 0.05). Children with an evening chronotype appear more susceptible to both poor sleep habits and smartphone/tablet addiction. These findings, in line with previous research on adolescents and adults, support the notion that circadian misalignment plays a pivotal role in technology-related behavioral risks. Early identification of chronotype and the implementation of strategies to promote healthier sleep schedules may be beneficial for fostering healthier sleep patterns and more balanced device use among children.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1538-1546"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating architecture components and their associations with BMI in urban and rural Ghanaian mothers, fathers, children, and adolescents, assessed using a wearable camera: A cross-sectional study.","authors":"Sorochi Anyaibe, Alex K Anderson, Christabel A Domfe, Edward Sazonov, Tonmoy Ghosh, Gary Frost, Matilda Steiner-Asiedu, Mingui Sun, Wenyan Jia, Tom Baranowski, Benny Lo, Megan A McCrory","doi":"10.1080/07420528.2026.2674741","DOIUrl":"10.1080/07420528.2026.2674741","url":null,"abstract":"<p><p>Eating architecture - timing, frequency, and size of meals and snacks - affects metabolism, but data from low-middle-income countries (LMICs) are scarce. We examined eating architecture (timing, frequency, and size of eating occasions) among Ghanaian households and its relationship with BMI. Thirty rural and 30 urban Ghanaian households participated. A wearable camera on eyeglasses captured dietary intake over 2 weekdays and 1 weekend day. Custom software was used for nutritional analysis and identifying eating episodes. Meals were distinguished from snacks by time, context, and items consumed. Eating frequencies were 2.4-2.7 x/d, and eating windows were 6.5-9.5 h/d. Children ate more frequently than other household members and had longer eating windows than fathers. Eating and energy intake peaked at 8:00 h and 12:00 h, respectively. Only 56% of urban and 72% of rural members snacked. Meal energy was similar across locations, but snack energy was higher among urban versus rural households, positively associated with BMI among urban mothers. Ghanaian eating architecture varied by location, household member, and differed from high-income countries. Only the size component of eating architecture, namely snack energy, was associated with BMI, and only in urban mothers. Our findings highlight the need to address nutritional disparities in Ghana and other LMICs.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1524-1537"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L5 onset as a proxy for circadian phase in infants.","authors":"Rebeca Buest de Mesquita Silva, Adrielle Holler Pykocz, Hanna Victoria Leal, Mario Andre Leocadio-Miguel, Fernando Mazzilli Louzada, Cpapi Group","doi":"10.1080/07420528.2026.2681616","DOIUrl":"10.1080/07420528.2026.2681616","url":null,"abstract":"<p><p>Chronotype is commonly assessed using the mid-sleep point as an indicator of circadian phase. In infants, however, this assessment typically relies on actigraphy, and most available sleep-scoring algorithms have been developed and validated for adolescents and adults, limiting their applicability in early childhood. The aim of this study was to examine the relationship between the mid-sleep point and L5 onset, a nonparametric measure derived from rest-activity rhythms that reflects the start of the least active 5-h period. A total of 502 nights from 81 six-month-old infants were analyzed. Sleep onset and offset were determined by visual inspection of actograms, and the mid-sleep point was subsequently calculated. A positive correlation was observed between mid-sleep point and L5 onset (<i>r</i> = 0.22, <i>p</i> < 0.001). Linear mixed-effects models indicated significant associations both between infants (β = 0.63, <i>p</i> < 0.001) and within infants (β = 0.10, <i>p</i> < 0.001). These findings suggest that L5 onset may serve as a practical proxy for circadian phase in 6-month-old infants, offering an alternative to sleep parameters derived from algorithms not specifically validated for this age group.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1518-1523"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}