Chronobiology International最新文献_第6页

Interaction of Clock gene variants and behavioral parameters influences adiposity-related traits. Clock 基因变异和行为参数的相互作用影响脂肪相关特征。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI: 10.1080/07420528.2024.2433592

Adil Anwar Bhatti, Sobia Rana, Narjis Fatima

{"title":"Interaction of Clock gene variants and behavioral parameters influences adiposity-related traits.","authors":"Adil Anwar Bhatti, Sobia Rana, Narjis Fatima","doi":"10.1080/07420528.2024.2433592","DOIUrl":"10.1080/07420528.2024.2433592","url":null,"abstract":"Obesity, a major health concern, is influenced by an individual's genetic makeup and lifestyle factors (eating, sedentary lifestyle, and sleep disruptions) that affect circadian clock and metabolism. This study investigates the impact of Clock gene variants rs6843722 and rs4864548 on obesity measures in the Pakistani population. Genetic-behavior interaction studies have focused on Western populations, overlooking South Asians. We included 306 overweight/obese and 306 normal-weight controls, matched for age and gender. Anthropometric measures (BMI, waist circumference, waist-to-height ratio, and body fat percentage) were taken using standard procedures while behavioral data (dietary and sleep-related behaviors, shiftwork, and physical activity) was collected by questionnaire. Genotyping was performed by Taqman assays. Data was analyzed using SPSS 19.0. Rank-based inverse normal transformation was executed for quantitative non-normal variables. The linear regression revealed that both Clock gene variants interacted significantly with dietary and sleep-related behaviors and low physical activity, impacting adiposity measures regardless of age and gender. Shiftwork interacted specifically with rs6843722, increasing body fat percentage. This study indicates that Clock gene variants, when interacting with lifestyle factors, play a substantial role in increasing obesity risk highlighting the link between lifestyle choices and disturbances in circadian rhythms controlled by Clock gene variations, ultimately leading to obesity.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1545-1555"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety in emerging adults: The role of chronotype, emotional competence, and sleep quality. 新成人的焦虑：时间型、情绪能力和睡眠质量的作用。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1080/07420528.2024.2429661

Susan M J Morris, Georgios K Kountouriotis

引用次数: 0

Chronobiological perspectives and meteorological associations in symptomatic popliteal artery aneurysms. 无症状腘动脉瘤的时间生物学观点和气象学关联。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-11-06 DOI: 10.1080/07420528.2024.2422867

Maria Elisabeth Leinweber, Amun Georg Hofmann, Thomas Karl, Roushanak Shayesteh-Kheslat, Michael Engelhardt, Thomas Schmandra, Barbara Weis-Müller, Thomas Schmitz-Rixen, Georg Jung

{"title":"Chronobiological perspectives and meteorological associations in symptomatic popliteal artery aneurysms.","authors":"Maria Elisabeth Leinweber, Amun Georg Hofmann, Thomas Karl, Roushanak Shayesteh-Kheslat, Michael Engelhardt, Thomas Schmandra, Barbara Weis-Müller, Thomas Schmitz-Rixen, Georg Jung","doi":"10.1080/07420528.2024.2422867","DOIUrl":"10.1080/07420528.2024.2422867","url":null,"abstract":"The potential influence of circadian rhythm, seasonal variations, and alterations in meteorological parameters has been studied across various vascular events. However, there is a lack of evidence on the potential chronobiological impacts on thromboembolic events related to the most common peripheral aneurysm, the popliteal artery aneurysm (PAA). Data was obtained from a German PAA registry and the German Meteorological Service (Deutscher Wetterdienst). In this observational cohort study seasonality and chronobiology as well as associations with meteorological parameters of symptomatic PAA were investigated. In a multivariate logistic regression analysis, it was further analyzed whether meteorological parameters could distinguish asymptomatic from symptomatic patients in the registry. Of 1200 registered PAA, n = 142 PAA presented with acute limb ischemia between February 2011 and September 2022. More symptomatic patients (57.0%) presented to the hospital between January and June than in the second half of the year with a nadir in the fall season. Symptom onset was predominantly in the morning hours (39.5%). Atmospheric pressure and humidity values from the index dates diverged from a normal distribution showing a bimodal (\"double-peak\") configuration. Most patients developed symptoms after a reduction in temperatures compared to 1 or 2 d prior to the index date. However, we found evidence for an interaction between age and temperature difference, where the effects of a decreasing temperature fade with increasing age. Facing the complexity of individual-environment interactions, further investigations are needed to determine whether meteorological parameters are true risk modifiers or surrogates for seasonal differences and altered behaviors.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1442-1453"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The appropriate and inappropriate uses of saliva melatonin measurements. 唾液褪黑激素测量的适当和不适当用途。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-11-12 DOI: 10.1080/07420528.2024.2428197

David J Kennaway

{"title":"The appropriate and inappropriate uses of saliva melatonin measurements.","authors":"David J Kennaway","doi":"10.1080/07420528.2024.2428197","DOIUrl":"10.1080/07420528.2024.2428197","url":null,"abstract":"Melatonin is produced in the pineal gland under very tight control through the influences of light and the suprachiasmatic nucleus. As such, melatonin circulates in the blood at levels <3 pg/ml during the day and is only actively secreted at night reaching levels of approximately 100 pg/ml. As a consequence of binding to plasma proteins, free melatonin appears in saliva at approximately one third the plasma concentration. Measurement of melatonin is technically challenging because of these very low concentrations and while a number of commercial immunoassay kits are available and mass spectrometry assay methods have been published, not all are fit for purpose and can lead to unreliable conclusions. In this review I discuss the aspects of pineal melatonin production that saliva melatonin reflects, the factors influencing melatonin production or metabolism, saliva collection and analysis methods. Examples are provided of the appropriate use of saliva melatonin measurements; Dim Light Melatonin Onset (DLMO) assessment, impact of light on melatonin and the monitoring of rhythms prior to specific treatments. Examples of inappropriate use of saliva melatonin measurements are also provided including the use of poorly validated assays, morning saliva collections, attempts to stimulate melatonin, and linking specific illnesses to saliva melatonin levels.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1351-1364"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupted rest-activity circadian rhythms are associated with all-cause mortality in patients with chronic kidney diseases. 休息-活动昼夜节律紊乱与慢性肾病患者的全因死亡率有关。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.1080/07420528.2024.2414045

Youngdeok Kim, Jisu Kim, Richard Inho Joh, Jonathan D Kenyon, Natalie J Bohmke, Jason M Kidd, Michelle L Gumz, Karyn A Esser, Danielle L Kirkman

{"title":"Disrupted rest-activity circadian rhythms are associated with all-cause mortality in patients with chronic kidney diseases.","authors":"Youngdeok Kim, Jisu Kim, Richard Inho Joh, Jonathan D Kenyon, Natalie J Bohmke, Jason M Kidd, Michelle L Gumz, Karyn A Esser, Danielle L Kirkman","doi":"10.1080/07420528.2024.2414045","DOIUrl":"10.1080/07420528.2024.2414045","url":null,"abstract":"Circadian rhythms are important biological contributors to health. Rest activity rhythms (RAR) are emerging as biomarkers of circadian behavior that are associated with chronic disease when abnormal. RAR have not yet been characterized in chronic kidney diseases (CKD). Leveraging the National Health and Nutrition Examination Survey (2011-2014), patients with CKD (n = 1114; Mean [95% CI]: Age, 50 [58-61] y; 52% female) were compared with non-CKD individuals (n = 5885; Age, 47 [46-48] y; 52% female). Actigraphy data were processed for RAR parameters including rhythmic strength (amplitude), the rhythm adjusted mean (mesor), the timing of peak activity (acrophase), activity regularity (inter-daily stability), and activity fragmentation (intra-daily variability). Cox regression was performed to assess RAR parameters for the prediction of all-cause mortality. Compared to non-CKD adults, patients with CKD had a lower rhythmic amplitude and mesor, and exhibited greater fragmentation and less day-to-day stability in RAR (ps < 0.001). Among CKD patients, a lower rhythmic amplitude (HR [95% CI]: 0.88 [0.82-0.96]; p < 0.001), a lower rhythm adjusted mean (0.87 [0.81-0.95]; p = 0.002), and a higher daily activity fragmentation (1.87 [1.10-3.18]; p = 0.023) were associated with an increased risk of all-cause mortality. Patients with CKD showed dampened rhythmic amplitudes and greater fragmentation of activity that were associated with a higher risk of all-cause mortality. These findings demonstrate a relationship between circadian disruption and prognosis in patients with CKD.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1399-1410"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relevance of high glycaemic index breakfast for heart rate variability among collegiate students with early and late chronotypes. 高血糖指数早餐对早熟和晚熟大学生心率变异性的影响

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-11-21 DOI: 10.1080/07420528.2024.2428203

Bettina Krueger, Bianca Stutz, Rasmus Jakobsmeyer, Claus Reinsberger, Anette E Buyken

{"title":"Relevance of high glycaemic index breakfast for heart rate variability among collegiate students with early and late chronotypes.","authors":"Bettina Krueger, Bianca Stutz, Rasmus Jakobsmeyer, Claus Reinsberger, Anette E Buyken","doi":"10.1080/07420528.2024.2428203","DOIUrl":"10.1080/07420528.2024.2428203","url":null,"abstract":"Plasma glucose spikes affect cardiac autonomic modulation resulting in a decrease of heart rate variability (HRV). We hypothesize that a later chronotype or a higher morning plasma melatonin level is associated with larger decreases of HRV following an early high glycaemic index (GI) breakfast. In persons with an early (n = 21) or a late (n = 15) chronotype who consumed a high GI breakfast at 7 a.m. glucose data were continuously monitored. Time domain HRV parameters were calculated from blood volume pulses derived by wireless wrist worn multisensor. HRV changes (values after minus values before breakfast) were associated with chronotype by multivariable linear regression adjusted for age, sex and baseline levels. Morning plasma melatonin levels were determined from samples drawn on the run-in day. Time domain parameters indicate a higher HRV before high GI breakfast in both chronotypes. A later chronotype tended to be associated with smaller decreases of mean interbeat intervals (p = 0.08) only; no associations were seen with morning melatonin levels. This exploratory analysis in a small sample provides a first indication that in young healthy adults later chronotype might be associated with reduced ANS activation following a high GI breakfast. Future studies should elucidate whether this indicates parasympathetic or sympathetic inhibition.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1389-1398"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using actigraphy to assess chronotype: Simpler is better. 使用行为记录仪评估时型：越简单越好

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-11-21 DOI: 10.1080/07420528.2024.2428196

Yuxian Wei, Shuo Wang, Wendong Wang, Xu Lei

{"title":"Using actigraphy to assess chronotype: Simpler is better.","authors":"Yuxian Wei, Shuo Wang, Wendong Wang, Xu Lei","doi":"10.1080/07420528.2024.2428196","DOIUrl":"10.1080/07420528.2024.2428196","url":null,"abstract":"Actigraphy provides a unique method for objectively measuring sleep activity patterns, but confusion remains about how to use actigraphy data to determine chronotype. To determine the most suitable parameter, this study made a systematic comparison of actigraphy-derived parameters: the average midpoint of sleep of all record days (aMS-acti), cosine parameter (Bathyphase), and non-parametric parameter (L5-mid) in terms of the consistency with subjective chronotype parameters, test-retest reliability, and external validity. More importantly, we proposed multiple Munich Chronotype Questionnaire (MCTQ)-based actigraphy parameters: considering the difference between weekday (MSW-acti) with weekends (MSF-acti) and the sleep debt (MSFsc-acti). The study collected 5 days of actigraphy and scale data from 1,055 young adults, 138 of whom participated in the retest 2 years later. The results showed that, in terms of consistency with subjective chronotype, aMS-acti generally performed better than other actigraphy parameters. In addition, aMS-acti had the highest test-retest reliability and was more closely related to the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Self-Rating Depression Scale (SDS). The results suggest that the simplest parameter (aMS-acti) is superior to traditional cosine and non-parametric parameters and MCTQ-derived parameters for short-term assessment of chronotype.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1469-1479"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of the time of day on metabolic responses to exercise in adults: A systematic and meta-analysis review. 一天中的时间对成人运动代谢反应的影响：系统性和荟萃分析综述。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.1080/07420528.2024.2419867

Anas Dighriri, Maha Timraz, Nur Dania Rosaini, Faris F Aba Alkhayl, James G Boyle, Greig Logan, Stuart R Gray

{"title":"The impact of the time of day on metabolic responses to exercise in adults: A systematic and meta-analysis review.","authors":"Anas Dighriri, Maha Timraz, Nur Dania Rosaini, Faris F Aba Alkhayl, James G Boyle, Greig Logan, Stuart R Gray","doi":"10.1080/07420528.2024.2419867","DOIUrl":"10.1080/07420528.2024.2419867","url":null,"abstract":"The aim of the current study is to investigate whether the time of day at which exercise is performed affects metabolic, glucose and insulin responses to exercise in adults. Databases were searched for randomised controlled (parallel and crossover) trials with participants aged from 18 to 65 year, an intervention of any exercise carried out at a specific time of the day and compared to any exercise carried out at a different time of the day. From 2458 screened articles, 12 studies were included in the systematic review of which 5 studies were included in the meta-analyses which compared 24 h continuous glucose monitoring (CGM) data, between morning and afternoon/evening exercise, on the day exercise was performed (SMD = 0.12 [-0.22-0.46] p = 0.76) and the day after exercise (SMD = -0.02 [-0.36-0.33] p = 0.94. Similar findings were observed in the wider systematic review with a general unclear risk of bias and a low certainty in these data. The results indicate that there is no clear effect of the time of the day on metabolic responses to exercise and exercise at any time of day should be the goal of public health strategies.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1377-1388"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The moderating role of protective factors in shift work disorder and health outcomes: A cross-sectional study. 保护性因素在轮班工作失调和健康结果中的调节作用：一项横断面研究。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.1080/07420528.2024.2419851

Rachael Harris, Sean P A Drummond, Tracey L Sletten, Alexander P Wolkow

{"title":"The moderating role of protective factors in shift work disorder and health outcomes: A cross-sectional study.","authors":"Rachael Harris, Sean P A Drummond, Tracey L Sletten, Alexander P Wolkow","doi":"10.1080/07420528.2024.2419851","DOIUrl":"10.1080/07420528.2024.2419851","url":null,"abstract":"This study investigated whether sleep-specific (e.g. chronotype) and traditional (e.g. resilience) protective factors were associated with reduced shift work disorder (SWD) risk and explored their role as moderators in the relationship between SWD risk and health. Shift workers (n = 126) participated in a cross-sectional study evaluating SWD risk (i.e. low vs. high; SWD-screening Questionnaire), mental health (Patient Health Questionnaire-9; Generalized Anxiety Disorder Questionnaire-7), physical health (Subjective Health Complaints Inventory), sleep (Pittsburgh Sleep Quality Index; Insomnia Severity Index; Epworth Sleepiness Scale), and protective factors (Resilience Scale; Social Provisions Scale; Survey of Perceived Organizational Support; Short Impulsive Behavior Scale; Circadian Type Inventory; reduced-Morningness-Eveningness Questionnaire). Logistic regressions revealed lower sleep languidity was associated with reduced odds (OR = 0.88 [0.79,0.96]) for having high SWD risk. Multiple regression analyses showed in shift workers with high social support or morningness, having high SWD risk was not associated with increased depression symptoms, or insomnia severity and poor sleep quality, respectively. Finally, in those with high or medium levels of perceived organizational support, high SWD risk was not associated with increased gastrointestinal and allergy complaints. Longitudinal research with larger samples is needed to confirm the moderating role of protective factors in the relationship between SWD risk and health.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1492-1502"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of family meals with sleep and quality of life in Japanese preschool and elementary school children: A cross-sectional study. 家庭膳食与日本学龄前儿童和小学生睡眠和生活质量的关系：横断面研究

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1080/07420528.2024.2422868

Yun-Peng Lo, Yu Tahara, Inn-Kynn Khaing, Seiko Mochida, Naomichi Makino, Yuki Nozawa, Akiko Furutani, Tatsuhiko Kubo, Shigenobu Shibata

{"title":"Association of family meals with sleep and quality of life in Japanese preschool and elementary school children: A cross-sectional study.","authors":"Yun-Peng Lo, Yu Tahara, Inn-Kynn Khaing, Seiko Mochida, Naomichi Makino, Yuki Nozawa, Akiko Furutani, Tatsuhiko Kubo, Shigenobu Shibata","doi":"10.1080/07420528.2024.2422868","DOIUrl":"10.1080/07420528.2024.2422868","url":null,"abstract":"Sleep is crucial for children's health and eating habits. The decline in family meals has raised concerns about its impact on children. Previous research indicated associations between family meals and psychological health and dietary habits, but their relationship with sleep behavior is less understood. This study examined the association between family meals (breakfast and dinner), sleep patterns, and quality of life among Japanese preschoolers and elementary school students (1st to 3rd grade). The cross-sectional study involved 6,177 children aged 3-8 years in Japan. Mothers completed an online survey on family meal habits, sleep patterns, and the KINDL-R questionnaire to assess quality of life. Results showed that family meals were associated with sleep behaviors and KINDL scores. Multiple regression analysis indicated that family breakfast was associated with earlier bedtime and wake-up time, shorter weekend sleep duration, reduced social jet lag, and a morning chronotype, as detected by the Munich ChronoType Questionnaire. Family dinners were linked to later sleep and wake-up times and an evening chronotype. Family breakfast and dinner were associated with higher KINDL scores, with dinner having a stronger positive impact. These findings underscore the significance of family meals in associating sleep patterns and quality of life among Japanese children.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1430-1441"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0