Chronobiology International最新文献_第10页

A modified at-home methodology for measuring dim light melatonin onset timing in healthy adults. 一种用于测量健康成人昏暗光线下褪黑激素起效时间的改进的家庭方法。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-01 Epub Date: 2025-05-05 DOI: 10.1080/07420528.2025.2500404

Chris Xie Chen, Ran Wang, Forrest Tin Wai Cheung, Amy Wing Yin Ho, Chung Shun Ho, Ngan Yin Chan, Joey Wing Yan Chan, Wai Kai Hou, Suk-Yu Yau, Yan Liu, Tatia Mei Chun Lee, Shirley Xin Li, Yun Kwok Wing

{"title":"A modified at-home methodology for measuring dim light melatonin onset timing in healthy adults.","authors":"Chris Xie Chen, Ran Wang, Forrest Tin Wai Cheung, Amy Wing Yin Ho, Chung Shun Ho, Ngan Yin Chan, Joey Wing Yan Chan, Wai Kai Hou, Suk-Yu Yau, Yan Liu, Tatia Mei Chun Lee, Shirley Xin Li, Yun Kwok Wing","doi":"10.1080/07420528.2025.2500404","DOIUrl":"10.1080/07420528.2025.2500404","url":null,"abstract":"The goal of this study was to investigate whether a modified at-home dim light melatonin onset (DLMO) assessment would be comparable to the in-laboratory DLMO assessment. Fifty-five participants underwent the at-home DLMO, while 55 age- and sex-matched participants underwent the in-laboratory DLMO assessment. Each participant underwent 14 d of actigraphy monitoring with sleep diary, one overnight polysomnography (PSG), followed by another night for DLMO assessment, either in the laboratory or at home. The at-home DLMO and the in-laboratory DLMO were correlated to chronotype and habitual sleep wake time. DLMOs, compliance with the sampling time and dim lighting were compared between the two groups. The DLMOs were similar between at-home and in-laboratory assessments (Absolute threshold: 22:14 h at home and 22:30 h at in-laboratory, p = 0.18; Relative threshold: 21:42 h at home and 22:19 h at in-laboratory, p = 0.17). The earlier at-home DLMO and earlier in-laboratory DLMO were both moderately correlated to earlier chronotype and earlier sleep wake time. The compliance with the scheduled sampling time was slightly lower than that in the laboratory, while the compliance with dim lighting was comparable between the at-home group and the in-laboratory group. Our modified at-home assessment of DLMO is a feasible and valid alternative to the in-laboratory assessment.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"653-663"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin partially restores hepatic nocturnin oscillations in experimental models of MASLD. 褪黑素在MASLD实验模型中部分恢复肝夜曲素振荡。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-01 Epub Date: 2025-05-02 DOI: 10.1080/07420528.2025.2496347

Shruti Kulshrestha, Rhydham Karnik, Aliasgar Vohra, Apeksha Joshi, Ranjitsinh Devkar

{"title":"Melatonin partially restores hepatic nocturnin oscillations in experimental models of MASLD.","authors":"Shruti Kulshrestha, Rhydham Karnik, Aliasgar Vohra, Apeksha Joshi, Ranjitsinh Devkar","doi":"10.1080/07420528.2025.2496347","DOIUrl":"10.1080/07420528.2025.2496347","url":null,"abstract":"Melatonin, a pleiotropic neurohormone, is recognized for its hepatoprotective role in metabolic dysfunction-associated steatotic liver disease (MASLD) triggered by diet and/or chronodisruption. Nocturnin (Noct), a circadian clock output regulating hepatic lipid metabolism, has an unclear role in MASLD. This study explores circadian oscillations of Noct in MASLD and its synergy with melatonin. Differential gene expression analysis identified key lipogenic genes (HNF-4A and SCD) as targets of Noct enzymatic activity. Male C57BL/6J mice were subjected to high-fat-high-fructose (H) diet with or without chronodisruption (CD) for 16 weeks. Noct mRNA peaked at ZT12 in Control and H groups, while CD and HCD groups showed peaks at ZT6, alongside increased % relative amplitude, cumulative expression, and shifted Centre of Gravity (CoG). Melatonin treatment in H, CD, and HCD groups significantly reduced Noct amplitude and cumulative expression. In OA-treated HepG2 cells, Noct mRNA and protein levels rose at 36 h and 32 h, respectively, with CoG shifts. Melatonin reduced Noct mRNA but increased protein levels while correcting rhythmicity. Collectively, MASLD induces elevation and phase shifts in hepatic Noct expression, and melatonin demonstrates corrective effects on Noct circadian phasing, underscoring its therapeutic potential. .","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"664-677"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic markers of adverse lifestyle identified among evening and night shift workers in two UK population-based studies: Generation Scotland and Understanding Society. 在两项基于英国人群的研究中，在夜班工人和夜班工人中发现了不良生活方式的表观遗传标记：苏格兰一代和理解社会。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.1080/07420528.2025.2493208

Paige M Hulls, Daniel L McCartney, Yanchun Bao, Rosie M Walker, Frank de Vocht, Richard M Martin, Caroline L Relton, Kathryn L Evans, Meena Kumari, Riccardo E Marioni, Rebecca C Richmond

{"title":"Epigenetic markers of adverse lifestyle identified among evening and night shift workers in two UK population-based studies: Generation Scotland and Understanding Society.","authors":"Paige M Hulls, Daniel L McCartney, Yanchun Bao, Rosie M Walker, Frank de Vocht, Richard M Martin, Caroline L Relton, Kathryn L Evans, Meena Kumari, Riccardo E Marioni, Rebecca C Richmond","doi":"10.1080/07420528.2025.2493208","DOIUrl":"10.1080/07420528.2025.2493208","url":null,"abstract":"Epigenetic changes in the form of DNA methylation (DNAm) may act as biological markers of risk factors or adverse health states. In two cohort studies, Generation Scotland (GS) (n = 7,028) and Understanding Society (UKHLS) (n = 1,175), we evaluated associations between evening or night shift work and four lifestyle factors (body mass index, smoking, alcohol, education) through linear regression using both conventionally measured phenotypes and DNA methylation-based scores proxying the phenotypes. DNA methylation-based measures of biological ageing were also generated using six established \"epigenetic clocks.\" Meta-analysis of GS and UKHLS results was conducted using inverse-variance weighted fixed effects. Evening/night shift work was associated with higher BMI (0.79; 95%CI 0.02, 1.56; p = 0.04) and lower education ( - 0.18; - 0.30, - 0.07; p = 0.002). There was weak evidence of association between evening/night shift work and DNAm scores for smoking (0.06, - 0.03, 0.15; p = 0.18) and education ( - 0.24; - 0.49, 0.01; p = 0.06) in fully adjusted models (adjusted for age, sex, methylation principal components and phenotypic measures). Two of the epigenetic age measures demonstrated higher age acceleration among evening/night shift workers (0.80; 0.42, 1.18; p < 0.001 for GrimAge and 0.46; 0.00, 0.92; p = 0.05 for PhenoAge). In over 8,000 participants from two cohort studies, evening/night shift work was associated with both phenotypic and DNA methylation-based measures of higher BMI and lower education. DNAm predictors of smoking and ageing were also related to evening/night shift work. Epigenetic measures may provide insights into the health and lifestyle profiles of night shift workers.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"561-571"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of chronotype characteristics on cardiovascular health behaviors in school-age children: A cross-sectional study. 学龄儿童时型特征对心血管健康行为的影响：一项横断面研究

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-01 Epub Date: 2025-04-21 DOI: 10.1080/07420528.2025.2493218

Gamzegül Altay, Mehtap Metin Karaaslan

{"title":"The effect of chronotype characteristics on cardiovascular health behaviors in school-age children: A cross-sectional study.","authors":"Gamzegül Altay, Mehtap Metin Karaaslan","doi":"10.1080/07420528.2025.2493218","DOIUrl":"10.1080/07420528.2025.2493218","url":null,"abstract":"This study aimed to investigate the effect of chronotype characteristics on cardiovascular health behaviors in school-age children. This descriptive, correlational, and cross-sectional study involved 424 school-age children aged 10-12. Participants completed the Morningness-Eveningness Scale for Children (MESC) and the Cardiovascular Health Behavior Scale for Children (CHBSC). The results were analyzed using descriptive statistics and multivariate regression analysis, adhering to ethical principles throughout the study. The mean MESC and CHBSC scores for the children were 28.37 ± 5.20 and 57.04 ± 11.34, respectively. 53.8% of the children exhibited moderate cardiovascular health behaviors, while 79% had a moderate chronotype. A moderate negative correlation was observed between MESC and CHBSC scores (r = -0.39, p < 0.01), with the MESC explaining 16% of the variance in cardiovascular health behaviors. The MESC influenced cardiovascular health behaviors and its subscales nutrition, exercise, sedentary lifestyle, self-love, and stress subscales. Most school-age children display intermediate chronotype characteristics and cardiovascular health behaviors. Children with an evening chronotype demonstrated lower levels of cardiovascular health behaviors. Chronotype characteristics had the most negative impact on the sedentary lifestyle aspect of cardiovascular health behaviors. Furthermore, chronotype plays a significant role in explaining the key factors influencing cardiovascular health behaviors.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"572-580"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of chrononutrition, chronotype and sleep behavior variabilities on adiposity traits and appetite sensations among students and staff of a Malaysian university. 时间营养、时间型和睡眠行为变异对马来西亚一所大学师生肥胖特征和食欲感觉的影响。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-05-01 Epub Date: 2025-04-28 DOI: 10.1080/07420528.2025.2495161

Yee-How Say, Mimi Shamirah Nordin, Alvin Lai Oon Ng

{"title":"The effects of chrononutrition, chronotype and sleep behavior variabilities on adiposity traits and appetite sensations among students and staff of a Malaysian university.","authors":"Yee-How Say, Mimi Shamirah Nordin, Alvin Lai Oon Ng","doi":"10.1080/07420528.2025.2495161","DOIUrl":"10.1080/07420528.2025.2495161","url":null,"abstract":"We investigated the association of chrononutrition, sleep behavior, and chronotype with adiposity and appetite sensations among 220 Malaysian adults (M/F = 57/163; aged 22.02 ± 5.19). Meal times, dietary intake, and appetite sensations (before and after meals) were recorded for two weekdays and one weekend. Sleep behavior was tracked objectively via activity wristband, chronotype was assessed by the Morningness-Eveningness Questionnaire, and anthropometrics/body compositions were measured. Overall participants had significantly later breakfast, lunch, eating midpoint, wake up time, sleep duration, compared to weekdays. Those who belonged to the delay eating jetlag group had significantly higher weekday, but lower weekend eating windows. Larger caloric intake later in the day was significantly associated with lower body mass and adiposity. Delay lunch jetlag class was significantly associated with higher waist-hip ratio. Delayed morning and afternoon chrononutrition behaviors were associated with higher hunger and eating thoughts, and lower fullness sensations pre- and post-meals. Morningness was associated with lower satisfaction and fullness sensations post-breakfast, but higher same sensations pre-dinner. In conclusion, larger caloric intake later in the day and advanced lunch jetlag led to lower adiposity, while delayed chrononutrition behaviours were associated with higher pre- and post-meal appetite sensations.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"581-594"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balanced time perspective as a factor mitigating the negative consequences of sleep disruptions in the perinatal period. 平衡的时间观是减轻围产期睡眠中断的负面影响的一个因素。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-04-01 Epub Date: 2025-04-16 DOI: 10.1080/07420528.2025.2490499

Małgorzata Sobol, Agata Błachnio, Margherita Calderan, Giorgia Degasperi, Giovanna Mioni, Inna Hryhorchuk, Elżbieta Plucińska, Janusz Stasiniewicz, Jan Kwapiński, Konrad Jankowski, Nicola Cellini

{"title":"Balanced time perspective as a factor mitigating the negative consequences of sleep disruptions in the perinatal period.","authors":"Małgorzata Sobol, Agata Błachnio, Margherita Calderan, Giorgia Degasperi, Giovanna Mioni, Inna Hryhorchuk, Elżbieta Plucińska, Janusz Stasiniewicz, Jan Kwapiński, Konrad Jankowski, Nicola Cellini","doi":"10.1080/07420528.2025.2490499","DOIUrl":"10.1080/07420528.2025.2490499","url":null,"abstract":"One of the basic causes of depressive symptoms is problems with adaptation to the changing conditions of current life. A period of life in which major changes occur in pregnancy and postpartum. These changes are primarily related to circadian rhythm disturbances. In adapting to living conditions, the attitude to time is of fundamental importance. The aim of the present study was to examine associations between circadian rhythms disruptions, time perspective, and perinatal depressive symptoms among 37 women at three time points: in the first and third trimesters of pregnancy and after delivery. Objective measures of sleep-wake behavior were obtained, including three 1-week actigraphy recordings. Self-reported disruptions in circadian rhythms were evaluated using the Biological Rhythms Interview of Assessment in Neuropsychiatry. The Zimbardo Time Perspective Inventory and the Dark Future Scale were used to assess balanced time perspective. The Edinburgh Postnatal Depression Scale was used to measure perinatal depressive symptoms. Balanced time perspective was a moderator of the relationship between sleep efficiency, measured using actigraphs, and self-reported disruptions in circadian rhythms. Moreover, the less balanced time perspective, the more disruptions in circadian rhythms and the more depressive symptoms women reported. The results suggest that balanced time perspective may function as a protective factor, mitigating the adverse effects of sleep disturbances during pregnancy and after childbirth.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"528-539"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep characteristics in association with risk of sporadic anovulation among eumenorrheic women. 痛经妇女睡眠特征与散发性无排卵风险的关系

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1080/07420528.2025.2481165

Joshua R Freeman, Brian W Whitcomb, Elizabeth R Bertone-Johnson, Louise M O'Brien, Galit L Dunietz, Alexandra C Purdue-Smithe, Keewan Kim, Robert M Silver, Enrique F Schisterman, Sunni L Mumford

{"title":"Sleep characteristics in association with risk of sporadic anovulation among eumenorrheic women.","authors":"Joshua R Freeman, Brian W Whitcomb, Elizabeth R Bertone-Johnson, Louise M O'Brien, Galit L Dunietz, Alexandra C Purdue-Smithe, Keewan Kim, Robert M Silver, Enrique F Schisterman, Sunni L Mumford","doi":"10.1080/07420528.2025.2481165","DOIUrl":"10.1080/07420528.2025.2481165","url":null,"abstract":"Few studies have evaluated sleep characteristics, including social jetlag, with ovulatory dysfunction, which may be an indicator of subfertility and poor metabolic health. Our objective was to evaluate whether sleep characteristics, including sleep duration, chronotype, social jetlag, sleep latency, nocturnal awakenings, and shift work, were associated with risk of anovulation among eumenorrheic women. Participants had a history of pregnancy loss and regular menstrual cycles, but no history of infertility. Typical sleep characteristics were self-reported at baseline. Participants were followed up to the cycle of conception or up to six menstrual cycles. Fertility monitor data and reproductive hormone concentrations were used to assess anovulation. We used generalized estimating equations with log-Poisson distributions to estimate relative risks (RR). The study is registered at clinicaltrials.gov (NCT00467363). Sleep duration, social jetlag, sleep latency, and nocturnal awakenings were not associated with anovulation. Later chronotype was associated with greater anovulation risk (3rd vs. 2nd tertile RR: 1.33, 95% CI: 1.05-1.68; per 1-hour increase RR: 1.05 95% CI 1.00-1.11). The RR for rotating work was 1.14 (95% CI: 0.90-1.46) and for night shift work was 1.22 (95% CI: 0.98-1.52). These results suggest that later chronotype and potentially shift work may be related to menstrual cycle dysfunction.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"500-510"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morning-evening differences in the post-illumination pupillary response are associated with seasonal mood changes. 光照后瞳孔反应的早晚差异与季节性情绪变化有关。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-04-01 Epub Date: 2025-04-10 DOI: 10.1080/07420528.2025.2490496

Benjamin Amendolara, Lindsay Miller, Srimaye Samudrala, Michael J McCarthy

{"title":"Morning-evening differences in the post-illumination pupillary response are associated with seasonal mood changes.","authors":"Benjamin Amendolara, Lindsay Miller, Srimaye Samudrala, Michael J McCarthy","doi":"10.1080/07420528.2025.2490496","DOIUrl":"10.1080/07420528.2025.2490496","url":null,"abstract":"Changes in light availability during the winter may lead to individuals experiencing seasonal changes in mood, sleep and appetite, and in the most severely affected, seasonal affective disorder (SAD). By virtue of later activity schedules and less morning light exposure, people with evening chronotype may show higher levels of seasonal mood variation. Light information is transmitted from the eye to the brain through intrinsically photosensitive retinal ganglion cells (iPRGC), neurons that help coordinate circadian and seasonal rhythms. The post-illumination pupillary response (PIPR) is an observable physiological proxy measure of iPRGC activity in humans. Past work has shown that sensitivity of iPRGC to light measured by PIPR is associated with chronotype and seasonal changes in mood, sleep and behavior. However, the sensitivity of IPRGC to light may itself vary across the day, and how these changes in light sensitivity relate to seasonal mood variation and chronotype remains poorly unstudied. To estimate morning-evening differences in iPRGC light sensitivity, we used a pupillometer to measure PIPR following blue light pulses in the morning and evening 12 h apart in 20 community volunteers. Participant chronotype was assessed using the Basic Language Morningness Scale. Seasonal mood variation was assessed using the Seasonal Pattern Assessment Questionnaire. PIPR was significantly larger in the evening compared to the morning. After adjusting for age and sex, morning PIPR was associated with seasonal mood variation. We did not find any association between PIPR and chronotype. Our work supports the hypothesis that iPRGC sensitivity influences seasonal mood variation and that PIPR shows morning-evening differences. Morning light may be relevant to the development of SAD.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"520-527"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronotype and synchrony effects in human cognitive performance: A systematic review. 人类认知表现中的时型和同步性效应：系统综述。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-04-01 Epub Date: 2025-04-28 DOI: 10.1080/07420528.2025.2490495

Satyam Chauhan, Martina Vanova, Umisha Tailor, Maheen Asad, Kaja Faßbender, Ray Norbury, Ulrich Ettinger, Veena Kumari

{"title":"Chronotype and synchrony effects in human cognitive performance: A systematic review.","authors":"Satyam Chauhan, Martina Vanova, Umisha Tailor, Maheen Asad, Kaja Faßbender, Ray Norbury, Ulrich Ettinger, Veena Kumari","doi":"10.1080/07420528.2025.2490495","DOIUrl":"10.1080/07420528.2025.2490495","url":null,"abstract":"Chronotype is a proxy for various intra-individual rhythms (e.g. sleep-wake cycles) which fluctuate throughout the day. The extent to which chronotype modulates cognitive performance remains unclear. Here, we systematically reviewed studies to determine the influence of chronotype on its own, and/or in interaction with time of day (ToD; optimal/non-optimal), in cognitive function in healthy adults. Following PRISMA guidelines, data searches were conducted in PubMed and Web of Science databases (11 March 2024), yielding 65 studies (53 in adults aged 18-45 y; 11 comparing adults aged 18-32 and 50-95 y; one involving only morning type adults aged 60-76 y). Most of the reviewed studies (>80%) indicated no main effect of chronotype on cognitive function. There was evidence from 29 (45.31%) of 64 studies involving adults aged 18-45 y of a synchrony effect (i.e. superior performance at optimal ToD) in morning and/or evening types, mostly in attention, inhibition, and memory. In older adults, there was evidence of a synchrony effect from 10 (83.33%) of 12 studies, especially on tasks involving fluid abilities. Limited evidence suggested higher activation of inhibition-related brain regions at optimal ToD in both chronotypes, and synchrony effects being impacted by certain exogenous factors known to affect arousal and performance (e.g. task complexity, lighting conditions). Our findings highlight the need to carefully consider age along with endogenous and exogenous sources of intra-individual variations in arousal while determining synchrony effect in cognitive functions. Not acknowledging these synchrony effects may also result in exaggerated cognitive deficits especially in the elderly.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"463-499"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian antidepressant treatments in depression: A systematic review and meta-analysis. 抑郁症的昼夜抗抑郁治疗：系统回顾和荟萃分析。

IF 2.2 4区医学

Chronobiology International Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1080/07420528.2025.2478127

Chuying Li, Pengpeng Cao, Yuhao Li, Shuo Zhang, Ye Zhang, Zheng Xu, Bei An, Ruixin Yong

{"title":"Circadian antidepressant treatments in depression: A systematic review and meta-analysis.","authors":"Chuying Li, Pengpeng Cao, Yuhao Li, Shuo Zhang, Ye Zhang, Zheng Xu, Bei An, Ruixin Yong","doi":"10.1080/07420528.2025.2478127","DOIUrl":"10.1080/07420528.2025.2478127","url":null,"abstract":"The purpose of the present study was to explore whether maximum efficacy treatments would be dependent on the time of day at which antidepressants were taken. Databases were searched for randomized experiments or randomized controlled trials involving interventions of any antidepressants taken at a particular time of the day. Out of 10 348 screened articles, 10 studies were included in the meta-analyses. The optimal time of maximum efficacies in 5 out of 15 drugs in the 10 studies was at zeitgeber time (ZT) 2, including fluoxetine, sertraline, citalopram, doxepin, and agomelatine. The best therapeutic effects of mirtazapine, trazodone, and agomelatine were at ZT10, while maximum efficacies of venlafaxine and fluvoxamine were at ZT6 and ZT13, respectively. The optimal time of melatonin administration was the period of treatment dependence. We found antidepressants with different mechanisms might have same or different optimal administration times. These findings may guide evidence-based antidepressant treatment choices with optimal dosing time. More prospective randomized trials or randomized experiments are demanded to establish recommendations for optimal circadian timing of depression based on zeitgeber time. It would be of interest to further evaluate this time-selection as a potential viable novel therapeutic in future research.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"452-462"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0