Chronobiology International最新文献

{"title":"Differences in circadian rhythm changes between myopic and non-myopic college students over 2 years.","authors":"Zhong Guan, Tingting Li, Liwei Zou, Yajuan Yang, Fangbiao Tao, Xiaoyan Wu, Shuman Tao","doi":"10.1080/07420528.2026.2723199","DOIUrl":"https://doi.org/10.1080/07420528.2026.2723199","url":null,"abstract":"<p><p>This study aimed to characterize and compare the differences in circadian rhythm changes during 2 years between college students with myopia and non-myopia based on a longitudinal cohort study. Wake-up time and bedtime were obtained through a self-administered questionnaire. Chronotype was assessed using the reduced Morningness-Eveningness Questionnaire (rMEQ). Circadian rhythm timing was determined by dim-light melatonin onset (DLMO), measured through hourly saliva collection from 21:00 to 01:00. A total of 450 college students (146 [32.4%] males) with a mean age of 18.65 ± 1.05 years were included, of whom 353 (78.4%) students had myopia. Compared with non-myopic individuals, myopic students slept later, woke up earlier, and exhibited lower rMEQ scores at baseline. Over the 2-year follow-up, both groups showed significantly earlier bedtimes, later wake-up times, and higher rMEQ scores. Only myopic students demonstrated a 45-minute delay in DLMO after the 2-year follow-up. After adjusting for potential confounders, linear mixed-effects models showed that myopic individuals had later bedtimes and earlier wake-up times. These findings indicate significant circadian rhythm changes in individuals with myopia, suggesting the potential of targeted sleep rhythm interventions on preventing myopia.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural variation of the pineal gland in shift workers from neuroimaging evidence.","authors":"Youjin Kim, Heeju Son, Chae Jung Park, Joon Yul Choi, Wanhyung Lee","doi":"10.1080/07420528.2026.2674041","DOIUrl":"10.1080/07420528.2026.2674041","url":null,"abstract":"<p><p>Night work disrupts the circadian system, alters melatonin signaling, and is associated with sleep and mental health disturbances. The pineal gland is central to circadian regulation. However, structural neuroimaging evidence of pineal adaptation to chronic circadian disruption in humans remains limited. This cross-sectional neuroimaging study included 110 healthcare workers, 32 night workers and 78 day workers. High-resolution T1- and T2-weighted magnetic resonance imaging was used to quantify total pineal gland volume, parenchymal volume, and cyst prevalence. Circadian-related sleep disturbance was assessed using the General Sleep Disturbance Scale. Associations with night-work exposure and sleep domains were examined using nonparametric statistical methods. Total and parenchymal pineal volumes did not differ between both workers. However, the pineal cyst prevalence was higher among night workers. Within the night-work group, a greater pineal parenchymal volume correlated positively with sleep-maintenance disturbance. Pineal volume increased during early night-work exposure and subsequently stabilized with longer exposure. Night work was associated with distinct pineal structural features, potentially reflecting morphological adaptations of the human circadian system to chronic disruption. These preliminary findings suggest that pineal morphology could serve as a circadian strain structural marker, but longitudinal studies incorporating direct circadian and hormonal measures are required to establish its biomarker potential.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1444-1450"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and cognitive disengagement syndrome as sequential mediators linking chronotype to ADHD symptom dimensions in adults with attentional complaints.","authors":"Beyza Erdogan Akturk, Omer Kaptanoglu, Meltem Insel Kaptanoglu","doi":"10.1080/07420528.2026.2710230","DOIUrl":"10.1080/07420528.2026.2710230","url":null,"abstract":"<p><p>Evening chronotype is overrepresented in adults with attention-deficit/hyperactivity disorder (ADHD), yet how circadian preference relates to specific symptom dimensions remains unclear. Cognitive Disengagement Syndrome (CDS; formerly Sluggish Cognitive Tempo), characterized by daydreaming, mental fogginess, and hypoarousal, is considered distinct from ADHD despite overlap and may be relevant to associations among chronotype, sleep, and attentional symptoms. This cross-sectional study tested an a priori serial mediation model in 100 treatment-seeking adults with attentional complaints and no prior ADHD diagnosis or pharmacotherapy. Participants completed the Morningness-Eveningness Questionnaire, Pittsburgh Sleep Quality Index, Barkley Adult Sluggish Cognitive Tempo Rating Scale, and Adult ADHD Self-Report Scale (ASRS-v1.1). Eveningness was associated with poorer sleep quality, and poorer sleep quality with higher CDS symptoms. CDS was strongly associated with both inattention and hyperactivity/impulsivity. The serial indirect effects through sleep quality and CDS were significant for both dimensions, whereas simple indirect effects were not. The full models explained 50.0% and 21.3% of the variance in inattention and hyperactivity/impulsivity, respectively. Supplementary analyses localized this effect to the Daydreaming rather than Sluggishness subdimension. Findings were robust to age- and sex-adjustment. These findings suggest sleep quality and CDS are clinically relevant correlates of ADHD symptom dimensions, though longitudinal confirmation is needed.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1463-1474"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.","authors":"Amber S Kleckner, Yuanyuan Zhou, Yancy Diaz-Mercado, Jin-Oh Hahn, Ian R Kleckner, Shijun Zhu","doi":"10.1080/07420528.2026.2669594","DOIUrl":"10.1080/07420528.2026.2669594","url":null,"abstract":"<p><p>Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms in cancer survivorship. This study examined associations between various rest-activity rhythm parameters and cancer-related fatigue and quality of life. Adult cancer survivors (<i>n</i> = 31) were enrolled in a 12-week randomized clinical trial of individualized nutrition counseling with or without time-restricted eating. Participants wore actigraphy watches continuously for 3-7 days at baseline, 6 weeks, and 12 weeks. Rest-activity parameters were derived using cosinor models, traditional non-parametric methods, and probabilistic hidden Markov models (HMMs). Participants completed the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire, including physical, social, emotional, and functional well-being subscales; fatigue; and a quality-of-life total score. Mixed models revealed that stronger rest-activity rhythms were generally associated with lower fatigue and greater well-being in several dimensions. Specifically, intradaily variability and the HMM-derived rhythm index were positively associated with emotional well-being (<i>p</i> = 0.040 and <i>p</i> = 0.037, respectively, medium effect sizes). Earlier daily activity peaks, identified through both parametric and non-parametric methods, were linked to greater emotional well-being (e.g. cosinor peak time and emotional well-being, <i>p</i> = 0.006, large effect size; start hour of the most active 10 hours, <i>p</i> = 0.004, large effect size). There was no effect of group (time-restricted eating vs. control) on any of the rest-activity parameters. Findings suggest that rest-activity rhythm parameters, including those derived from novel HMMs, may serve as useful biomarkers of fatigue and various dimensions of well-being, supporting further research in larger samples and potential clinical application.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1359-1372"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating effect of sleep hygiene between morningness-eveningness preferences and psychological distress among a sample of Lebanese adults.","authors":"Nada Akiki, Souheil Hallit, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Sahar Obeid, Feten Fekih-Romdhane, Rabih Hallit","doi":"10.1080/07420528.2026.2670688","DOIUrl":"10.1080/07420528.2026.2670688","url":null,"abstract":"<p><p>Our study explored the mediating effect of sleep hygiene between morningness-eveningness preferences and psychological distress among a sample of Lebanese adults. A total of 948 Lebanese participants were enrolled in this cross-sectional study (mean age 26.93 ± 10.23 years). A self-administered survey was dispersed using the snowball sampling technique. The survey consisted of socio-demographic characteristics along with the following Arabic validated instruments: The Morningness-Eveningness Questionnaire (MEQ), the Patient-Health Questionnaire (PHQ-4), and the Sleep Hygiene Index (SHI). Statistical analysis was performed using SPSS v.27 with mediation analysis via PROCESS MACRO v.42 Model 4. Sleep hygiene fully mediated the relationship between morningness-eveningness preferences and psychological distress. Greater morningness preferences were significantly associated with better sleep hygiene (i.e. lower sleep hygiene scores). In turn, poor sleep hygiene (i.e. higher sleep hygiene scores) was significantly associated with higher psychological distress. The direct association between morningness and psychological distress was not statistically significant. Our study offered insight on important connections between sleep hygiene, morningness-eveningness preferences, and psychological distress within the Lebanese context. These results highlight the necessity of promoting healthy sleep behaviors and chronobiological awareness to improve mental health in this population.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1401-1410"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global bibliometric trends in shrimp chronobiology: From behavioral rhythms to precision aquaculture frontiers.","authors":"Rafael Queiroz-Anjos","doi":"10.1080/07420528.2026.2674043","DOIUrl":"10.1080/07420528.2026.2674043","url":null,"abstract":"<p><p>The global expansion of intensive shrimp farming confronts a physiological paradox: while production systems become increasingly technological, management protocols often disregard the temporal dimension of crustacean physiology. This study presents a comprehensive bibliometric analysis of shrimp chronobiology based on 197 Scopus-indexed publications (1943-2026). Network analysis reveals a conceptual transition from descriptive ecological studies (1950s-1990s) focused on tidal rhythms and catchability to a contemporary molecular frontier (2015-2025) driven by transcriptomics, clock gene expression, and immune-circadian interactions. Keyword co-occurrence analysis identified four structural clusters: Production/Feeding, Behavior/Locomotion, Molecular Physiology, and Toxicology. Analysis of the most-cited and recent articles demonstrates that while light and feeding have been validated as primary zeitgebers, a critical knowledge gap persists regarding circadian regulation of osmotic stress. Despite the dominance of inland low-salinity farming, none of the top-ranked studies investigated rhythmic osmoregulation. We identify the lack of research on circadian regulation of osmotic stress as a significant knowledge gap and propose a research agenda integrating chronobiology into precision aquaculture to optimize metabolic efficiency and disease resistance.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1332-1342"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting energy expenditure and substrate oxidation do not differ between night and day shift workers: A real-life study.","authors":"Kely R C Teixeira, Luana Thomazetto Rossato, Flávia M S de Branco, Jordane A Mendes, Luciana A de Medeiros, Thúlio M Cunha, Laura Cristina Tibiletti Balieiro, Erick P de Oliveira, Cibele A Crispim","doi":"10.1080/07420528.2026.2670685","DOIUrl":"10.1080/07420528.2026.2670685","url":null,"abstract":"<p><p>This cross-sectional study investigated differences in resting energy expenditure (REE), respiratory quotient (RQ), and substrate utilization between night and day shift workers. A total of 62 male workers (30-night shift, 32 d shifts), aged 21 to 62 y, were assessed for anthropometric measurements, sleep parameters, social jetlag, and daytime sleepiness. Indirect calorimetry was used to evaluate REE, RQ, and carbohydrate and fat oxidation. Linear regression models and Generalized Estimating Equations (GEE) were applied, adjusting for potential confounders. Night shift workers exhibited lower RQ and carbohydrate oxidation and higher fat oxidation compared to day shift workers after adjusting for age. However, after further adjustment for workload, no significant differences in REE were observed (night: 1843.31 [1737.21-1931.42] kcal/day; day: 1732.74 [1639.58-1825.91] kcal/day, <i>p</i> = 0.133), RQ (night: 0.88 [0.86-0.91]; day: 0.90 [0.88-0.93], <i>p</i> = 0.331), or substrate oxidation rates - carbohydrate oxidation (g/min: night: 0.20 [0.18-0.23]; day: 0.21 [0.19-0.24], <i>p</i> = 0.583) and fat oxidation (g/min: night: 0.04 [0.03-0.06]; day: 0.03 [0.02-0.04], <i>p</i> = 0.134) - between night and day shift workers. Night shift work does not differ from day shift work in terms of REE and substrate oxidation. Further longitudinal studies with larger samples are needed to confirm these findings.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1393-1400"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147867024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of chronotype on nutritional status and eating behaviors among university students of Pakistan.","authors":"Aqsa Naseem, Mahpara Safdar","doi":"10.1080/07420528.2026.2674039","DOIUrl":"10.1080/07420528.2026.2674039","url":null,"abstract":"<p><p>Chronotype reflects individual differences in circadian rhythm-related behaviors, including food consumption and sleep pattern. University students often follow irregular schedules, increasing the risk of unhealthy eating behaviors and obesity. This cross-sectional study aimed to examine chronotype prevalence and its association with eating behaviors and nutritional status among Pakistani university students. Chronotype was assessed using the Morningness Eveningness Questionnaire (MEQ). Eating behavior was evaluated using a 3-d dietary recall, while anthropometry, physical activity (IPAQ), and sleep habits were also recorded. Pearson chi-square, one-way ANOVA, Pearson correlation was applied. Among 345 students, 63.2% were males and 36.8% were females, with chronotype distributed as 57.1% intermediate, 26.4% morning, and 16.5% evening. Evening chronotypes exhibited unhealthy eating behaviors including meal skipping, delayed meal timings, unhealthy snacking and the lowest breakfast energy (<i>p</i> ≤ 0.05). Morning chronotypes showed a higher intake of fruit and milk, whereas evening chronotypes, particularly males had lower intake of fiber, magnesium, iron, zinc, phosphorus (<i>p</i> ≤ 0.05). However, there was no significant association between chronotype and nutritional status (<i>p</i> ≥ 0.05). In conclusion, chronotype influenced students' eating behaviors, highlighting the need to consider circadian preferences when promoting healthy dietary habits and long-term metabolic health.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1431-1443"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning approaches in predicting circadian rhythm sleep-wake disorders: A review.","authors":"Trina Sengupta, Archana Gaur, Sakthivadivel Varatharajan","doi":"10.1080/07420528.2026.2667404","DOIUrl":"10.1080/07420528.2026.2667404","url":null,"abstract":"<p><p>Circadian rhythm sleep-wake disorders (CRSWDs) arise from misalignment between an individual's sleep-wake timing and endogenous circadian physiology, with substantial consequences for sleep health and overall well-being. In the era of sleep-omics and digital phenotyping, machine learning (ML) offers powerful tools for modelling complex, high-dimensional circadian data; however, its application to CRSWD prediction remains under developed. This systematic review aims to synthesize current evidence on the use of ML approaches for circadian phase estimation and CRSWD classification in humans. We have conducted a systematic search of PubMed, ScienceDirect, PsycINFO, Cochrane Library, and Google Scholar for studies published between January 2011 and May 2025. Eligible studies focused on sighted adults where ML algorithms predicted circadian phase or classified CRSWDs. Data sources included sleep diaries, actigraphy, genomics, and biological markers. To maintain model homogeneity and account for physiological differences, studies involving pediatric populations, neurodegenerative comorbidities, or blind individuals were excluded. A total of 22 studies met the inclusion criteria. Across studies, ML models demonstrated promise for circadian phase estimation and CRSWD classification using diverse data modalities, including wearable-derived time-series data and multimodal features. However, the evidence base remains limited by small sample sizes, methodological heterogeneity, limited external validation, and inconsistent reporting standards. Overall, current findings suggest that while ML-based approaches hold significant potential for advancing CRSWD detection and personalized circadian medicine, more robust, standardized, and generalizable models are required. Future research should prioritize larger multimodal datasets, transparent validation strategies, and clinically translatable tools to support scalable CRSWD screening and diagnosis.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1316-1331"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Earlier bedtime misalignment is associated with increased severity of chemotherapy-induced hot flashes in premenopausal women with breast cancer.","authors":"Sun Hyung Lee, Sanghyup Jung, Geun Hui Won, Jaehyun Kim, Saim Jung, Chan-Woo Yeom, Kwang-Min Lee, Kyung-Lak Son, Jang-Il Kim, Sook Young Jeon, Han-Byoel Lee, Bong-Jin Hahm, Joon Sung Shin","doi":"10.1080/07420528.2026.2723196","DOIUrl":"https://doi.org/10.1080/07420528.2026.2723196","url":null,"abstract":"<p><p>Chemotherapy-induced hot flashes (CIHFs), a vasomotor symptom that has been demonstrated to impair the quality of life in breast cancer patients, have been associated with circadian rhythms. While circadian misalignment has been shown to contribute to chemotherapy-related adverse effects, the link between bedtime misalignment (BM) and these effects remains unclear. The objective of this study was to evaluate BM based on objective measurements and determine whether CIHF severity differs according to BM. A total of 35 premenopausal women with breast cancer awaiting chemotherapy were evaluated for BM using actigraphy. Participants were categorized into the earlier misaligned group (\"going to bed earlier than preferred bedtime\") and the aligned/later misaligned group (\"going to bed at or later than preferred bedtime\"). CIHF was assessed using 7-day diaries at baseline, at one month post-chemotherapy (T1), and at nine months post-chemotherapy. The habitual bedtime (p = 0.032) and the degree of BM (p < 0.001) measured by actigraphy differed between the earlier misaligned group and the aligned/later misaligned group. The earlier misaligned group reported significantly higher burden of CIHF, including total hot flash score (p = 0.004), daytime and nighttime sweating scores (both p < 0.001), and daytime hot flash frequency (p = 0.007) compared with the aligned/later misaligned group at T1. Premenopausal women whose habitual bedtime was earlier than their preferred bedtime experienced greater burden of CIHF. Our findings indicate the potential for BM to contribute to vasomotor vulnerability in patients with breast cancer. Further studies are needed to elucidate the mechanisms by which BM contributes to CIHF.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}