Chronobiology International最新文献

{"title":"Reliability and validity of a smartwatch with a photoplethysmograph: Comparison with a Holter electrocardiograph.","authors":"Chieko Tan, Tomoya Tamei, Atsue Ishii, Nobue Arimoto, Hideyuki Shiotani","doi":"10.1080/07420528.2026.2669593","DOIUrl":"10.1080/07420528.2026.2669593","url":null,"abstract":"<p><p>Although consumer-grade smartwatches with a photoplethysmograph (PPG) can measure heart rate, their reliability and validity in healthy participants under free-living conditions remain unclear. Therefore, this study compared the heart rates measured by a smartwatch with PPG and a clinically accepted Holter electrocardiograph in healthy adult participants under completely free-living conditions. Ten participants wore a Holter recorder on their left chest and a Garmin vivosmart 5 on their non-dominant wrist simultaneously for 72-96 h. Averages were calculated every 2 min from the data obtained, and timestamps were used for alignment. Agreement between the measurements taken by the two devices was verified using intraclass correlation and Bland-Altman analyses. Error trends for Garmin vivosmart 5 were examined using linear regression analysis. The overall intraclass correlation coefficient range was 0.819-0.937 (mean: 0.902), indicating strong agreement. The mean bias was 1.16 bpm, and the mean limit of agreement was ±12.4 (7.87-20.6) bpm. Furthermore, the linear regression line intercept was negative for all participants, indicating that Garmin vivosmart 5 tended to underestimate the heart rate; however, the slope was positive and close to 0. Overall, the smartwatch maintained a certain accuracy level under fluctuating heart rates and demonstrated reasonable reliability during sleep or daily activities.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1350-1358"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory and phytochemical indices as predictors of sleep quality, chronotype, and psychological health in adults.","authors":"Elif Ulug, Nesli Ersoy, Aylin Acikgoz Pinar","doi":"10.1080/07420528.2026.2669597","DOIUrl":"10.1080/07420528.2026.2669597","url":null,"abstract":"<p><p>The dietary pattern might impact physiological and psychological health. Therefore, the present study aims to examine the associations of dietary phytochemical index (DPI) and dietary inflammatory index (DII) with chronotype, sleep, and psychological health in adults. This cross-sectional study included 628 healthy adults aged 19-64 y (mean age: 25.9 ± 9.7 y). Data on anthropometrics, physical activity, chronotype (Morningness-Eveningness Questionnaire (MEQ)), sleep quality (Pittsburgh Sleep Quality Index (PSQI)), and psychological status (Depression, Anxiety, and Stress Scale-21 (DASS-21)) were collected. Dietary intake was assessed using a validated semi-quantitative Food Frequency Questionnaire. The DPI was calculated using two different methods, one developed by McCarty and the other by Bahadoran et al. while the DII was computed based on the method developed by Shivappa et al. In the adjusted models, the DPI (according to McCarty) was positively associated with MEQ scores and negatively associated with PSQI and DASS-21 subscale scores, and increasing DPI was associated with significantly decreased odds of exhibiting mid- or evening chronotypes and poor sleep quality (<i>p</i> < 0.05). Although DPI (according to Bahadoran et al.) was positively associated with MEQ total score (<i>p</i> < 0.05), no significant associations were observed in the risk estimates for chronotype, sleep quality, and DASS-21 scores after adjustment (<i>p</i> > 0.05). Moreover, in the adjusted models, DII was not significantly associated with chronotype, sleep quality, or any DASS-21 sub-group (<i>p</i> > 0.05). A higher dietary phytochemical index was associated with a higher morningness tendency, better sleep quality, and lower levels of depression, anxiety, and stress. These findings underscore the potential link between an anti-inflammatory, phytochemical-rich dietary pattern, and psychological and physiological well-being.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1373-1384"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations of sleep midpoint and sleep midpoint variability with the mental health of young adult college students.","authors":"John Richmond T Sy, Ruth K Brombach, Jacqueline J Leete, Kelly N Kim, Daniel J Taylor, Alisa Huskey, Ethan A Olson, Kiley Pauck, Sarah E Emert, Kenneth Bottrill, Jessica R Dietch","doi":"10.1080/07420528.2026.2671355","DOIUrl":"10.1080/07420528.2026.2671355","url":null,"abstract":"<p><p>Mental health continues to be a growing concern among young adult college students. Prior research has shown that later sleep midpoint and greater sleep midpoint variability were associated with worse mental health, but these studies primarily focused on adolescents and middle- to older-aged adults. The lack of exploration into sleep midpoint and mental health in young adults creates a unique gap in the literature. Therefore, the present study aimed to investigate the longitudinal associations between sleep midpoint and mental health among young adult college students. College students (<i>N</i> = 256) between the ages of 18-26 from two universities recorded their sleep patterns and mental health (PHQ-2, GAD-2, and PSS-4) using electronic daily diaries over 2 weeks. Linear mixed-effects modeling was used to identify how within- and between-person sleep midpoints were associated with mental health outcomes among college students. Between participants, later sleep midpoint was robustly associated with depression (<i>B</i> = 0.19, <i>SE</i> = 0.05, <i>p</i> < 0.001), anxiety (<i>B</i> = 0.21, <i>SE</i> = 0.06, <i>p</i> < 0.001), and stress (<i>B</i> = 0.33, <i>SE</i> = 0.13, <i>p</i> = 0.008). Greater sleep midpoint variability was correlated with worse depressive symptoms (<i>r</i> = 0.14, <i>p</i> = 0.03). Intervention studies need to determine whether addressing sleep timing and sleep regularity could improve young adult mental health.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1424-1430"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype and health outcomes in shift-working healthcare professionals: Associations with eating attitudes, depressive symptoms, and quality of life.","authors":"Gökçe Kavak Sinanoğlu, Mustafa Sinanoğlu","doi":"10.1080/07420528.2026.2670681","DOIUrl":"10.1080/07420528.2026.2670681","url":null,"abstract":"<p><p>Shift work is an essential component of healthcare systems but induces chronic circadian misalignment through disruption of the sleep - wake cycle, nocturnal light exposure, and desynchronization between endogenous biological rhythms and environmental time cues. Such misalignment has been associated with adverse physical and psychological health outcomes. Chronotype, reflecting intrinsic circadian phase preference, has been proposed as a potential modifier of individual responses to shift work; however, its role among shift-working healthcare professionals remains incompletely understood. This cross-sectional study investigated the associations between chronotype and health-related quality of life, depressive symptoms, and eating attitudes among 278 healthcare professionals engaged in rotating shift schedules. Chronotype was assessed using the Morningness - Eveningness Questionnaire and categorized as morning, intermediate, or evening type. Physical and mental health - related quality of life were evaluated using the SF-36, yielding Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Depressive symptoms and eating attitudes were assessed using validated questionnaires. Group differences were examined using non-parametric tests, and multivariable analyses were performed to adjust for sociodemographic variables and explore non-linear effects. Significant differences in physical health - related quality of life were observed across chronotype groups. Evening-type participants demonstrated lower PCS scores compared with morning and intermediate types (<i>p</i> < 0.05), particularly in the Role Physical (RP) domain. However, in multivariable regression analyses, chronotype was not a significant independent predictor of PCS, whereas age and marital status remained significant. No significant differences were observed between chronotype groups in depressive symptoms, eating attitudes, or MCS scores (all <i>p</i> > 0.05). In conclusion, chronotype may be associated with differences in physical health - related quality of life among shift-working healthcare professionals; however, these associations appear to be influenced by sociodemographic and contextual factors rather than representing a direct relationship. These findings underscore the complexity of circadian adaptation in shift work and highlight the need for further longitudinal research.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1385-1392"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-night eating, poor sleep quality, and emotional eating: Stronger predictors of overweight and obesity than social jetlag and eating jetlag.","authors":"Hande Gül Ulusoy Gezer, Alperen Onur İşler, Seda Hanife Oguz, Erdem Karabulut, Neslişah Rakıcıoğlu","doi":"10.1080/07420528.2026.2674044","DOIUrl":"10.1080/07420528.2026.2674044","url":null,"abstract":"<p><p>Social jetlag (SJL) and eating jetlag (EJL) have been proposed as behavioral indicators of circadian misalignment; however, evidence linking these indicators to obesity remains inconsistent. This cross-sectional, case-control study examined whether higher SJL and EJL levels were associated with increased odds of overweight or obesity. A total of 444 adults (<i>n</i> = 211 with a healthy body weight and <i>n</i> = 233 with overweight/obesity) were included. Sleep quality, chronotype, and night eating behaviors were assessed using the Pittsburgh Sleep Quality Index (PSQI), Morningness-Eveningness Questionnaire (MEQ), and Night Eating Questionnaire (NEQ), respectively. Cognitive restraint, uncontrolled eating, and emotional eating were evaluated using the Three-Factor Eating Questionnaire (TFEQ). Circadian misalignment was measured using SJL, sleep-corrected SJL (SJLsc), EJL, and meal-specific jetlag metrics. Individuals with higher body mass index were older and more likely to exhibit morning chronotype characteristics, whereas evening types demonstrated greater SJLsc. Neither SJL nor EJL emerged as independent predictors of overweight/obesity, suggesting that weekly variability in sleep or eating timing may play a limited role in this population. Poor sleep quality, emotional eating, and the timing of the last eating event, rather than variability in meal timing, were associated with obesity. Weight management interventions should prioritize absolute meal timing, unhealthy eating behaviors, and sleep quality.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1451-1462"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between chrononutrition variables and hypertension in adults.","authors":"Jinrong Yang, Pucheng Mei, Hongfang Yang, Changsi Wang, Qi Nie, Lin Zhu, Wei Yang, Ping Wu, Hongfei Ma, Li Zhou","doi":"10.1080/07420528.2026.2667408","DOIUrl":"10.1080/07420528.2026.2667408","url":null,"abstract":"<p><p>Associations between chrononutrition variables (time of first meal, time of last meal and eating window) and hypertension remain unclear. This study aimed to examine associations between chrononutrition variables and hypertension. In this cross-sectional study, chrononutrition variables, including time of first meal, time of last meal, and eating window, were collected via face-to-face interviews. Blood pressure was measured using a standardized protocol, and hypertension was defined as measured blood pressure ≥140/90 mmHg, self-reported physician diagnosis, or antihypertensive medication use. Logistic regression models were used to assess the associations between chrononutrition variables and hypertension. Stratified analyses were performed to examine the association between time of first meal and hypertension across subgroups. Among 1,588 adults, a later time of first meal was initially associated with a lower prevalence of hypertension, but this association was attenuated and became non-significant after adjustment for wake time and sleep time. No significant associations were observed for time of last meal or eating window. No significant association was observed between chrononutrition variables and hypertension after adjustment for wake time and sleep time.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1343-1349"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in circadian rhythm changes between myopic and non-myopic college students over 2 years.","authors":"Zhong Guan, Tingting Li, Liwei Zou, Yajuan Yang, Fangbiao Tao, Xiaoyan Wu, Shuman Tao","doi":"10.1080/07420528.2026.2723199","DOIUrl":"https://doi.org/10.1080/07420528.2026.2723199","url":null,"abstract":"<p><p>This study aimed to characterize and compare the differences in circadian rhythm changes during 2 years between college students with myopia and non-myopia based on a longitudinal cohort study. Wake-up time and bedtime were obtained through a self-administered questionnaire. Chronotype was assessed using the reduced Morningness-Eveningness Questionnaire (rMEQ). Circadian rhythm timing was determined by dim-light melatonin onset (DLMO), measured through hourly saliva collection from 21:00 to 01:00. A total of 450 college students (146 [32.4%] males) with a mean age of 18.65 ± 1.05 years were included, of whom 353 (78.4%) students had myopia. Compared with non-myopic individuals, myopic students slept later, woke up earlier, and exhibited lower rMEQ scores at baseline. Over the 2-year follow-up, both groups showed significantly earlier bedtimes, later wake-up times, and higher rMEQ scores. Only myopic students demonstrated a 45-minute delay in DLMO after the 2-year follow-up. After adjusting for potential confounders, linear mixed-effects models showed that myopic individuals had later bedtimes and earlier wake-up times. These findings indicate significant circadian rhythm changes in individuals with myopia, suggesting the potential of targeted sleep rhythm interventions on preventing myopia.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural variation of the pineal gland in shift workers from neuroimaging evidence.","authors":"Youjin Kim, Heeju Son, Chae Jung Park, Joon Yul Choi, Wanhyung Lee","doi":"10.1080/07420528.2026.2674041","DOIUrl":"10.1080/07420528.2026.2674041","url":null,"abstract":"<p><p>Night work disrupts the circadian system, alters melatonin signaling, and is associated with sleep and mental health disturbances. The pineal gland is central to circadian regulation. However, structural neuroimaging evidence of pineal adaptation to chronic circadian disruption in humans remains limited. This cross-sectional neuroimaging study included 110 healthcare workers, 32 night workers and 78 day workers. High-resolution T1- and T2-weighted magnetic resonance imaging was used to quantify total pineal gland volume, parenchymal volume, and cyst prevalence. Circadian-related sleep disturbance was assessed using the General Sleep Disturbance Scale. Associations with night-work exposure and sleep domains were examined using nonparametric statistical methods. Total and parenchymal pineal volumes did not differ between both workers. However, the pineal cyst prevalence was higher among night workers. Within the night-work group, a greater pineal parenchymal volume correlated positively with sleep-maintenance disturbance. Pineal volume increased during early night-work exposure and subsequently stabilized with longer exposure. Night work was associated with distinct pineal structural features, potentially reflecting morphological adaptations of the human circadian system to chronic disruption. These preliminary findings suggest that pineal morphology could serve as a circadian strain structural marker, but longitudinal studies incorporating direct circadian and hormonal measures are required to establish its biomarker potential.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1444-1450"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and cognitive disengagement syndrome as sequential mediators linking chronotype to ADHD symptom dimensions in adults with attentional complaints.","authors":"Beyza Erdogan Akturk, Omer Kaptanoglu, Meltem Insel Kaptanoglu","doi":"10.1080/07420528.2026.2710230","DOIUrl":"10.1080/07420528.2026.2710230","url":null,"abstract":"<p><p>Evening chronotype is overrepresented in adults with attention-deficit/hyperactivity disorder (ADHD), yet how circadian preference relates to specific symptom dimensions remains unclear. Cognitive Disengagement Syndrome (CDS; formerly Sluggish Cognitive Tempo), characterized by daydreaming, mental fogginess, and hypoarousal, is considered distinct from ADHD despite overlap and may be relevant to associations among chronotype, sleep, and attentional symptoms. This cross-sectional study tested an a priori serial mediation model in 100 treatment-seeking adults with attentional complaints and no prior ADHD diagnosis or pharmacotherapy. Participants completed the Morningness-Eveningness Questionnaire, Pittsburgh Sleep Quality Index, Barkley Adult Sluggish Cognitive Tempo Rating Scale, and Adult ADHD Self-Report Scale (ASRS-v1.1). Eveningness was associated with poorer sleep quality, and poorer sleep quality with higher CDS symptoms. CDS was strongly associated with both inattention and hyperactivity/impulsivity. The serial indirect effects through sleep quality and CDS were significant for both dimensions, whereas simple indirect effects were not. The full models explained 50.0% and 21.3% of the variance in inattention and hyperactivity/impulsivity, respectively. Supplementary analyses localized this effect to the Daydreaming rather than Sluggishness subdimension. Findings were robust to age- and sex-adjustment. These findings suggest sleep quality and CDS are clinically relevant correlates of ADHD symptom dimensions, though longitudinal confirmation is needed.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1463-1474"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.","authors":"Amber S Kleckner, Yuanyuan Zhou, Yancy Diaz-Mercado, Jin-Oh Hahn, Ian R Kleckner, Shijun Zhu","doi":"10.1080/07420528.2026.2669594","DOIUrl":"10.1080/07420528.2026.2669594","url":null,"abstract":"<p><p>Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms in cancer survivorship. This study examined associations between various rest-activity rhythm parameters and cancer-related fatigue and quality of life. Adult cancer survivors (<i>n</i> = 31) were enrolled in a 12-week randomized clinical trial of individualized nutrition counseling with or without time-restricted eating. Participants wore actigraphy watches continuously for 3-7 days at baseline, 6 weeks, and 12 weeks. Rest-activity parameters were derived using cosinor models, traditional non-parametric methods, and probabilistic hidden Markov models (HMMs). Participants completed the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire, including physical, social, emotional, and functional well-being subscales; fatigue; and a quality-of-life total score. Mixed models revealed that stronger rest-activity rhythms were generally associated with lower fatigue and greater well-being in several dimensions. Specifically, intradaily variability and the HMM-derived rhythm index were positively associated with emotional well-being (<i>p</i> = 0.040 and <i>p</i> = 0.037, respectively, medium effect sizes). Earlier daily activity peaks, identified through both parametric and non-parametric methods, were linked to greater emotional well-being (e.g. cosinor peak time and emotional well-being, <i>p</i> = 0.006, large effect size; start hour of the most active 10 hours, <i>p</i> = 0.004, large effect size). There was no effect of group (time-restricted eating vs. control) on any of the rest-activity parameters. Findings suggest that rest-activity rhythm parameters, including those derived from novel HMMs, may serve as useful biomarkers of fatigue and various dimensions of well-being, supporting further research in larger samples and potential clinical application.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1359-1372"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}