Chronobiology International最新文献

{"title":"Assessing the relationship between different sleep traits and retinal neurodegenerative diseases: A bidirectional Mendelian randomization study.","authors":"Yijie Lu, Yao Tan, Kai Jin, Wei Xiong","doi":"10.1080/07420528.2025.2509631","DOIUrl":"10.1080/07420528.2025.2509631","url":null,"abstract":"<p><p>his bidirectional Mendelian randomization (MR) study assessed causal relationships between sleep traits (chronotype, sleep duration, insomnia) and retinal neurodegenerative diseases (RNDs), including open-angle glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). Using genome-wide association study data and inverse variance weighting, we found chronotype significantly increased DR risk (OR: 1.60, <i>p</i> = 0.023). Reverse MR showed AMD was inversely associated with short sleep duration and chronotype. Sensitivity analyses supported result robustness. Mediation analysis identified six traits potentially linking chronotype to DR. These findings suggest sleep-related traits may be modifiable risk factors in RNDs, offering insights for early prevention and intervention.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"784-794"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of sleep shortening and sleep phase advancing in response to advancing risetimes on weekdays.","authors":"Arcady A Putilov, Evgeniy G Verevkin, Dmitry S Sveshnikov, Zarina V Bakaeva, Elena B Yakunina, Olga V Mankaeva, Vladimir I Torshin, Elena A Trutneva, Michael M Lapkin, Zhanna N Lopatskaya, Roman O Budkevich, Elena V Budkevich, Marina P Dyakovich, Olga G Donskaya, Alexandra N Puchkova, Vladimir B Dorokhov","doi":"10.1080/07420528.2025.2509629","DOIUrl":"10.1080/07420528.2025.2509629","url":null,"abstract":"<p><p>Since the circadian clocks cannot directly respond to the signals of social clocks, earlier risetimes on weekdays lead to loss of certain amount of sleep. However, these clocks can partly reduce this loss by advancing sleep phase due to advancing the pattern of 24-h exposure to light caused by earlier risetimes. In an <i>in silico</i> study, a model of sleep-wake regulation was applied to show that the difference between earlier and later weekday risers in weekday risetime is equal to the sum of differences between them in sleep loss and sleep phase advance that can be measured as their differences in weekend-weekday gap in risetime and in weekend risetimes, respectively. Such differences in sleep loss and sleep phase advance were estimated from bed- and risetimes self-reported for weekdays and weekends by 4940 university students and lecturers subdivided into subsamples with different weekday risetimes and chronotypes. We also estimated, for these subsamples, the percentages of weekday sleep insufficiency and circadian misalignment determined as a less than 6 hours in bed on weekdays and a larger than 3-h weekend-weekday gap in risetime, respectively. Additionally, advance phase shifts of the circadian clocks were predicted by model-based simulations of self-reported sleep times.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"770-783"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between circadian type and physical activity as predictors of cognitive performance during simulated nightshifts: A randomised controlled trial.","authors":"Dayna Easton, Charlotte Gupta, Grace Vincent, Corneel Vandelanotte, Mitch Duncan, Philip Tucker, Lee Di Milia, Sally A Ferguson","doi":"10.1080/07420528.2025.2503866","DOIUrl":"10.1080/07420528.2025.2503866","url":null,"abstract":"<p><p>Nightshift is associated with impaired cognitive performance on many tasks, yet performance is also moderated by individual differences. We investigated the effect of circadian type (two factors: flexible-rigid, and languid-vigour), and the efficacy of a novel countermeasure, breaking up sitting with light-intensity physical activity, in the context of nightshift performance. Thirty-three healthy adults (age M ± SD: 24.3 ± 4.6 y; 19 females) participated in a sleep laboratory study over five consecutive simulated nightshifts (2200-0600 h). Sleep opportunities occurred at 0800-1700 h. Participants were randomised to a sedentary (SIT; <i>n =</i> 14), or \"breaking-up\" sitting (BREAK; <i>n =</i> 19) condition. BREAK participants completed 3 min of light-intensity walking every 30 min at 3.2 km/h, while SIT participants remained seated. Every 2 h during nightshift, participants completed the Psychomotor Vigilance Task (mean RRT), Stroop Task, and Digit Symbol Substitution Task. Participants completed the revised Circadian Type Inventory which categorises individuals on a rigid-flexible scale and a languid-vigorous scale (rigid; <i>n =</i> 12, flexible; <i>n =</i> 11; languid; <i>n =</i> 11, vigorous <i>n =</i> 13). Linear mixed models showed a significant 3-way interaction between Nightshifts (1-5), Condition (SIT, BREAK), and flexibility-rigidity for mean RRT (<i>p =</i> 0.03) only. Flexible types in the BREAK condition had better performance than rigid BREAK, rigid SIT, and flexible SIT over five nights, with performance marginally worse on the first night for all participants apart from rigid SIT. Linear mixed models showed a significant 2-way interaction between Nightshifts (1-5), and flexibility-rigidity for percentage accuracy on the Stroop task, and a significant 2-way interaction between Nightshifts (1-5), and languid-vigour for response time on the Stroop task. Accuracy worsened for rigid types, while response time on the Stroop task improved for languid types over five nights. No other significant differences were found. Breaking up sitting with light-intensity physical activity maintained sustained attention for flexible circadian types across all five experimental nightshifts. Both rigidity and languidity moderated trends in performance, though whether these differences have meaningful real-world implications must be explored further. Our results indicate that circadian type classifications should be accounted for in breaking up sitting interventions overnight.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"736-754"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abrupt change in the timing of the day/night negatively affects sleep behaviour and cognitive performance in diurnal zebra finches.","authors":"Ashwani Kumar, Mayank Kumar, Vatsala Tripathi, Abhilash Prabhat, Sanjay Kumar Bhardwaj","doi":"10.1080/07420528.2025.2506630","DOIUrl":"10.1080/07420528.2025.2506630","url":null,"abstract":"<p><p>We investigated the consequence of abrupt directional shifts in the timing of light (hence darkness) period on sleep behaviour, novel object exploration and cognitive performance in diurnal zebra finches maintained under an equinox (12:12h LD) photoperiod. To two cohorts of birds (<i>n</i> = 80), the timing of 12 h light-on (hence of the darkness) for a week was either advanced by 6 h by reducing the dark period or delayed by 6 h by lengthening the dark period, with controls maintained on LD cycle as before. The first cohort of birds were examined for the effects on 24 h activity and feeding behaviors, while the second cohorts of birds were examined for the effects on sleep, neophobia and cognitive performance; the latter two were tested by the novel object exploration and spatial learning, respectively. The abrupt LD cycle shifts negatively affected sleep behaviour and cognition, as evidenced by behavioral and gene expression assays. There was a significant decrease in the mRNA expression levels of gene coding for the tyrosine hydroxylase (<i>TH</i>, the regulatory enzyme of the dopamine synthesis), cAMP response element binding protein (<i>CREB</i>), and brain-derived neurotrophic factor (<i>BDNF</i>) in hippocampus and <i>TH</i> alone in midbrain. These results support growing evidence of negative effects on behaviour and advanced brain functions in a diurnal species exposed to abrupt shifts in 24 h LD cycles.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"693-705"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel index for actigraphic studies: The core sleep efficiency.","authors":"Letizia Galasso, Giovanna Calogiuri, Lucia Castelli, Antonino Mulè, Fabio Esposito, Angela Montaruli, Eliana Roveda, Andrea Caumo","doi":"10.1080/07420528.2025.2510508","DOIUrl":"10.1080/07420528.2025.2510508","url":null,"abstract":"<p><p>Sleep efficiency is a widely used indicator of sleep quality in actigraphy studies. Nevertheless, it is a composite metric integrating data derived from actigraphic recordings alongside information about bedtime and wake-up time, typically obtained from self-reported sleep logs. The aim of this report is to propose a novel sleep efficiency index, denoted as core sleep efficiency, that relies solely on actigraphic data and focuses on the quality of sleep after its onset. Using a database of actigraphic recordings obtained in 40 young subjects (22 ± 3 yrs, Mean±SD) and in 45 middle-aged subjects (63 ± 11 yrs, Mean±SD), we evaluated the interrelationship between the two metrics of sleep efficiency and investigated the extent of their correlation with other crucial actigraphic indicators of sleep quality, such as sleep onset latency, fragmentation index and mean activity score. We provided evidence suggesting that the novel index may be suitable for specifically assessing the quality of sleep once it has begun. We propose that the newly introduced core sleep efficiency has the potential to serve as a valuable adjunct to the classic sleep efficiency, thus enriching the parametric characterisation of sleep obtained through actigraphy.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"817-824"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morningness-Eveningness Questionnaire: Reliability and factorial structure of the full and reduced versions in Spanish adolescents.","authors":"José Luís Manjón-Caballero, Juan F Díaz-Morales","doi":"10.1080/07420528.2025.2509634","DOIUrl":"10.1080/07420528.2025.2509634","url":null,"abstract":"<p><p>This study analyzed the suitability of the Morningness-Eveningness Questionnaire (MEQ) for Spanish adolescents, focusing on reliability, structure, and age/sex invariance. 2,268 adolescents (49.1% girls, aged 12-17) participated. Four MEQ items were unsuitable, leading to a 15-item version (MEQ-15) with good reliability and fit to a bifactor model: general morningness-eveningness factor and awakening time, sleep time, and time of greatest efficiency factors. The reduced MEQ (rMEQ) also fit a one-factor model. Sex and age invariance were tenable for the general factor of MEQ-15 and rMEQ. Morningness declines during adolescence, with boys showing more morningness than girls. Both versions show good psychometric properties.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"808-816"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between chronotype and depressive symptoms among college students: Mediating roles of perceived stress and self-control.","authors":"Wanting Liu, Xinrui Zu, Junyu Huang, Shan Feng, Dongfang Wang","doi":"10.1080/07420528.2025.2506633","DOIUrl":"10.1080/07420528.2025.2506633","url":null,"abstract":"<p><p>This study aims to explore the longitudinal relationship between chronotype and depressive symptoms and the mediating roles of perceived stress and self-control among college students. A total of 11,010 college students completed two web-based surveys during 17 to 29 October 2023 (Time 1, T1) and 15 to 24 April 2024 (Time 2, T2), respectively. Participants completed the reduced version of morningness-eveningness questionnaire, the 10-item Perceived Stress Scale, the Brief Self-Control Scale, the 2-item Patient Health Questionnaire, and 3 items of the Youth Self-Rating Insomnia Scale. The results indicated that perceived stress (T1) and self-control (T2) serially mediate the relationship between morning chronotype (T1) and depressive symptoms (T2) (<i>β</i> =  -0.010, 95% CI: -0.012 to -0.009), after controlling for baseline sample characteristics, depressive symptoms (T1), and insomnia symptoms (T2). This longitudinal relationship was observed in both male (<i>β</i> =  -0.009, 95% CI: -0.012 to -0.006) and female (<i>β</i> =  -0.011, 95% CI: -0.013 to -0.009) participants. These findings enhance our understanding of the mechanisms by which chronotype affects college students' depressive symptoms, providing valuable insights for developing targeted interventions, such as stress-management workshops, to mitigate depression risk, especially among students with evening chronotypes.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"724-735"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive examination of circadian rhythm and tryptophan pathway parameters: Assessing their role in predicting bipolar disorder in patients, siblings, and controls.","authors":"Emine Yavuz Ataşlar, Kürşat Altınbaş","doi":"10.1080/07420528.2025.2509623","DOIUrl":"10.1080/07420528.2025.2509623","url":null,"abstract":"<p><p>The complex interplay between sleep, circadian rhythms, and tryptophan pathway metabolites in bipolar disorder (BD) remains poorly understood. This study examined these mechanisms in euthymic individuals with BD (n = 20), their unaffected siblings (n = 20), and healthy controls (n = 24). Subjective and objective sleep and circadian rhythm parameters were assessed using questionnaires and actigraphy, alongside plasma measurements of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), and quinolinic acid (QUIN). Compared to controls, both BD patients and siblings showed reduced sleep efficiency and increased wake after sleep onset. Patients had longer time in bed, whereas siblings had shorter total sleep time. Elevated KYN/TRP ratios were found in both groups. Higher 3-HAA levels predicted both BD and sibling status, while increased QUIN levels were specific to BD. Lasso regression identified 12 variables associated with BD and 6 with sibling status. These results suggest that altered tryptophan metabolism and circadian disruption may contribute to the pathophysiology of BD and familial risk, providing potential biomarkers for early identification and intervention.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"755-769"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clock and clock-related gene expression is light responsive in the Atlantic salmon (<i>Salmo salar</i>) embryo.","authors":"Marie Bue, Øivind Andersen, Helge Tveiten","doi":"10.1080/07420528.2025.2510505","DOIUrl":"10.1080/07420528.2025.2510505","url":null,"abstract":"<p><p>Light and photoperiod vary in a predictable manner throughout the daily and annual cycle that is utilized by organisms to direct processes of living. The aquaculture industry applies light to manipulate salmon development, but the effects have not yet been thoroughly investigated in early ontogeny. Here, salmon eggs and larvae were subjected to three different light regimes (continuous dark, continuous light and compressed simulated natural photoperiod [LD] to provide calendar time information). The expression of eight clock- and melatonin-related genes (<i>clock1a.2, arntl1a.2</i>, <i>per1b</i>, <i>per2a</i>, <i>cry3b</i>, <i>nr1d1a</i>, <i>aanat2b</i>, <i>mtnr1b</i>) was examined through one daily cycle before eyeing, after eyeing, and before start-feeding. <i>Clock1a.2</i> and <i>per2a</i> showed indications of being maternally deposited, and expression increased for most genes through development. All genes showed clear differences in expression between light regimes, and rhythmically expressed genes were more abundant and with stronger rhythms under LD regime. <i>Aanat2b</i> was rhythmically expressed before eyeing, and all genes were rhythmically expressed under LD at start-feeding. Interestingly, at this time, the positive, negative, and stabilizing arm of the clock peaked simultaneously along with the melatonin-related genes mid-photophase. These results implore greater attention to the lighting conditions used during early development, as different lightings could have lasting effects.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"679-692"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype impact on mating, desire for sex and sexual activity in humans.","authors":"Agnieszka Witek, Regina Grugel, Joanna Kasprowicz, Łukasz Pawelec","doi":"10.1080/07420528.2025.2501234","DOIUrl":"10.1080/07420528.2025.2501234","url":null,"abstract":"<p><p>Research on assortative mating by chronotype in previous years has yielded contradictory results. The aim of the study was to examine whether non-cohabiting partners in short-term relationships shared the same chronotype. A sample of 100 heterosexual couples completed the Composite Scale of Morningness (CSM) questionnaire and responded to additional questions. No evidence of assortative mating for chronotype was found, but there was a significant positive correlation between male and female time of waking up, time of greatest desire for sex and actual time of sexual activity. Additionally, female chronotype was significantly associated with the timing of peak sexual desire. Morning-type women declared the greatest desire for sex at 15:00-18:00 more frequently than evening-types. In case of actual sexual activity, men and women declared 21:00-00:00 most often, regardless of chronotype. It is likely that adapting to social schedules aligns activity timing across different chronotypes. They are performing their activities during which they get to know each other at similar times. While chronotype may not be critical in initiating relationships, it could influence the maintenance of long-term relationship satisfaction.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"706-715"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}