{"title":"Assessing the relationship between different sleep traits and retinal neurodegenerative diseases: A bidirectional Mendelian randomization study.","authors":"Yijie Lu, Yao Tan, Kai Jin, Wei Xiong","doi":"10.1080/07420528.2025.2509631","DOIUrl":null,"url":null,"abstract":"<p><p>his bidirectional Mendelian randomization (MR) study assessed causal relationships between sleep traits (chronotype, sleep duration, insomnia) and retinal neurodegenerative diseases (RNDs), including open-angle glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). Using genome-wide association study data and inverse variance weighting, we found chronotype significantly increased DR risk (OR: 1.60, <i>p</i> = 0.023). Reverse MR showed AMD was inversely associated with short sleep duration and chronotype. Sensitivity analyses supported result robustness. Mediation analysis identified six traits potentially linking chronotype to DR. These findings suggest sleep-related traits may be modifiable risk factors in RNDs, offering insights for early prevention and intervention.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"784-794"},"PeriodicalIF":2.2000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronobiology International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07420528.2025.2509631","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
his bidirectional Mendelian randomization (MR) study assessed causal relationships between sleep traits (chronotype, sleep duration, insomnia) and retinal neurodegenerative diseases (RNDs), including open-angle glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). Using genome-wide association study data and inverse variance weighting, we found chronotype significantly increased DR risk (OR: 1.60, p = 0.023). Reverse MR showed AMD was inversely associated with short sleep duration and chronotype. Sensitivity analyses supported result robustness. Mediation analysis identified six traits potentially linking chronotype to DR. These findings suggest sleep-related traits may be modifiable risk factors in RNDs, offering insights for early prevention and intervention.
他的双向孟德尔随机化（MR）研究评估了睡眠特征（时间类型、睡眠持续时间、失眠）与视网膜神经退行性疾病（RNDs）之间的因果关系，包括开角型青光眼、年龄相关性黄斑变性（AMD）和糖尿病性视网膜病变（DR）。使用全基因组关联研究数据和反向方差加权，我们发现时间类型显著增加DR风险（OR: 1.60, p = 0.023）。反向磁共振显示AMD与短睡眠时间和睡眠类型呈负相关。敏感性分析支持结果的稳健性。中介分析确定了6个可能与睡眠类型相关的特征，这些发现表明睡眠相关特征可能是rnd的可改变风险因素，为早期预防和干预提供了见解。
期刊介绍：
Chronobiology International is the journal of biological and medical rhythm research. It is a transdisciplinary journal focusing on biological rhythm phenomena of all life forms. The journal publishes groundbreaking articles plus authoritative review papers, short communications of work in progress, case studies, and letters to the editor, for example, on genetic and molecular mechanisms of insect, animal and human biological timekeeping, including melatonin and pineal gland rhythms. It also publishes applied topics, for example, shiftwork, chronotypes, and associated personality traits; chronobiology and chronotherapy of sleep, cardiovascular, pulmonary, psychiatric, and other medical conditions. Articles in the journal pertain to basic and applied chronobiology, and to methods, statistics, and instrumentation for biological rhythm study.
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