Chronobiology International最新文献

{"title":"Circadian amplitude and CLOCK 3111 polymorphism predict morning leptin in Arctic residents, independent of photoperiod.","authors":"Denis Gubin, Sergey Kolomeichuk, Konstantin Danilenko, Oliver Stefani, Alexander Markov, Ivan Petrov, Kirill Voronin, Marina Mezhakova, Mikhail Borisenkov, Aislu Shigabaeva, Julia Boldyreva, Julianna Petrova, Larisa Alkhimova, Dietmar Weinert, Germaine Cornelissen","doi":"10.1080/07420528.2026.2693222","DOIUrl":"10.1080/07420528.2026.2693222","url":null,"abstract":"<p><p>This hypothesis-driven study tested whether circadian amplitudes of wrist temperature (WTA), physical activity (PAA), and light exposure measured by actigraphy predicted morning leptin in 64 Arctic residents, and whether the <i>CLOCK 3111</i> polymorphism (<i>rs1801260</i>) modulated these predictions. Actigraphy measures (circadian amplitudes of WT, PA, and light exposure) and morning leptin concentrations were assessed across seasons with contrasting photoperiods. Multivariate regression models identified leptin predictors. Post-hoc analyses examined WTA-leptin relationships, considering <i>CLOCK</i> 3111 genotype and an exploratory leptin threshold of 13 ng/mL. A multivariate analysis adjusted for the photoperiod revealed significant negative associations between leptin and WTA (<i>β</i> = -0.344), PAA (<i>β</i> = -0.323) and sleep efficiency (<i>β</i> = -0.265) that were retained after further adjustment for age, sex and indigeneity. In the fully adjusted model, a larger normalized amplitude of blue light exposure (NA BLE) was associated with increased WTA (<i>β</i> = 0.256) and lower leptin (<i>β</i> = -0.171). The <i>CLOCK</i> 3111 polymorphism modulated the WTA - leptin relationship, with a strong negative correlation in TT individuals (<i>r</i> = -0.509) and a non-significant trend towards a positive association in CC individuals (<i>r</i> = 0.282), Δ<i>r</i> = 0.791, <i>z</i> = 2.31, <i>p</i> = 0.021. In <i>CLOCK</i> 3111 TT individuals, those with a WTA <1°C had significantly higher odds (OR = 3.93, 95% CI: 1.69-9.17, <i>p</i> = 0.0015) and increased relative risk (RR = 2.70, 95% CI: 1.47-4.99, <i>p</i> = 0.0014) of having a morning leptin ≥13 ng/mL, compared to those with a WTA >1.5°C. Overall, the smaller circadian amplitude of WTA and PAA, the lesser sleep quality, and the smaller normalized amplitude of blue light exposure (NA BLE), independently of photoperiod, are associated with elevated leptin in Arctic residents. The <i>CLOCK 3111</i> polymorphism modulates the WTA-leptin relationship. For <i>CLOCK 3111</i> TT individuals, a small WTA (<1°C) may identify those at risk of elevated morning leptin (≥13 ng/mL), informing metabolic risk assessment in unique environments.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1891-1904"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148351044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late eating is associated with higher total energy intake and poorer adequacy of food groups in patients with non-communicable diseases.","authors":"Luciana Araújo Junqueira, Catarina Mendes Silva, Laura Cristina Tibiletti Balieiro, Walid Makin Fahmy, Luana Thomazetto Rossato, Maria Carliana Mota, Cibele Aparecida Crispim","doi":"10.1080/07420528.2026.2701136","DOIUrl":"10.1080/07420528.2026.2701136","url":null,"abstract":"<p><p>Late eating has been linked to adverse physiological and metabolic effects, suggesting that meal timing may affect dietary intake and weight management. This study investigated whether late eating is associated with energy intake, macronutrient distribution, and food group consumption among 792 patients (56.1 ± 12.45 years; 73.3% women) with obesity, hypertension, type 2 diabetes, or dyslipidemia attending public health clinics in Uberlândia, Brazil. Dietary intake was assessed by a 24-h recall, and participants were classified as early eaters (caloric midpoint ≤12:30 h) or late eaters (>12:30 h). After adjustment for confounders, a later caloric midpoint was positively associated with total energy (β = 0.09, <i>p</i> < 0.001), carbohydrate (β = 0.10, <i>p</i> = 0.03), and sweets intake (β = 0.13, <i>p</i> = 0.001), and negatively associated with milk and dairy consumption (β = -0.09, <i>p</i> = 0.01). Late eaters showed a higher odds of inadequate consumption of meat and eggs (OR = 1.5, 95% CI 1.1-1.9, <i>p</i> = 0.003), oils and fats (OR = 1.4, 95% CI 1.0-1.9, <i>p</i> = 0.01), and sweets (OR = 1.7, 95% CI 1.2-2.5, <i>p</i> = 0.003). These findings indicate that consuming a greater proportion of daily calories later in the day is associated with higher energy intake and poorer dietary quality, highlighting the potential importance of meal timing in nutritional counseling and metabolic health.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1959-1969"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of stocking density on growth, accelerometer-derived locomotor activity and circadian rhythms in lambs during suckling and fattening.","authors":"José-Alfonso Abecia, Raquel Abildgaard, Noemí Crespo","doi":"10.1080/07420528.2026.2697951","DOIUrl":"10.1080/07420528.2026.2697951","url":null,"abstract":"<p><p>This study assessed the impacts of stocking density on growth and locomotor activity (LA) of lambs in the suckling and fattening periods, integrating production variables with behavioural and circadian rhythm analyses. Lambs were reared under either high or low stocking densities (suckling period: high, 2.1; low, 7.3 m²/ewe; fattening period: high 1.4; low 2.6 m²/lamb), and growth performance was assessed separately for suckling and fattening periods. LA was recorded by accelerometers, and circadian rhythms were characterised by a 24-h cosinor analysis. In the suckling period, stocking density had a significant effect on amplitude and acrophase of LA. In the fattening period, lambs exhibited a robust circadian rhythm in LA at both densities, similar mean MESOR and acrophases; however, lambs housed at high density at both studied periods had a significantly higher amplitude than did lambs at low density. Differences between groups in growth performance observed in the suckling period tended to diminish in the fattening period, suggesting that compensatory growth occurred once nutritional constraints were removed. The results have demonstrated that stocking density influences LA in a phase-dependent manner and that circadian indicators provide complementary insights into the biological responses of lambs to housing conditions, beyond those obtained from growth performance alone.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1939-1947"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype, flexibility, and the impact of imposed sleep-wake schedules on circadian interpretation.","authors":"Efrem Kentiba, Victoria Drazdova, Dessalegn Wase Mola, Kesatie Legesse","doi":"10.1080/07420528.2026.2695194","DOIUrl":"10.1080/07420528.2026.2695194","url":null,"abstract":"","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1725-1727"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype and its association with eating behaviour and psychosocial well-being in shift workers: A systematic review.","authors":"Emmanuel Ngelayang Franky Giltelin, Nur Islami Mohd Fahmi Teng, Siti Nor Ismalina Isa, Norazmir Md Nor, Sofwatul Mokhtarah Maluin, Norsham Juliana","doi":"10.1080/07420528.2026.2703821","DOIUrl":"10.1080/07420528.2026.2703821","url":null,"abstract":"<p><p>Shift work is increasingly common in modern societies but is strongly associated with misalignments of natural circadian rhythms, which may negatively impact dietary behaviour and psychosocial well-being. Chronotype, an individual's natural sleep-wake preference, influences adaptation to shift work and its associated lifestyle challenges. This systematic review aimed to examine the relationship between chronotype on both eating behaviour and psychosocial well-being among shift workers. A systematic search was conducted in accordance with PRISMA 2020 guidelines. Literature searches were performed in Web of Science, Scopus, PubMed, and Cochrane from database inception until April 2026. Eligible studies included research involving adult shift workers reporting on chronotype in relation to eating behaviour and psychosocial aspects. Quality appraisal was performed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools. Twenty-nine studies met the inclusion criteria, comprising primarily nurses and healthcare workers, with additional representation from manufacturing and services sectors. Evening chronotypes consistently exhibited less healthy dietary habits, including irregular meal timing, skipping breakfast, delayed food intake, greater consumption of energy-dense foods, lower fibre intake, and higher alcohol use. Additionally, psychosocial outcomes showed similar patterns, with evening types reported significantly higher levels of depression, anxiety, stress, emotional exhaustion, and burnout compared to morning and intermediate types. Misalignment between chronotype and shift schedule further amplifies these effects, whereas alignment improved job satisfaction and well-being. Sleep disturbances, a contributing factor that can exacerbate psychosocial issues, were observed to be more common in evening types as compared to morning and intermediate types. Evening chronotype is a key vulnerability factor for both unhealthy eating habits and impaired psychosocial well-being among shift workers. Organisational strategies such as chronotype-sensitive scheduling, access to healthier food options, and tailored psychosocial support may mitigate these risks. Future longitudinal and interventional research is needed to establish causal pathways and to evaluate the effectiveness of chronotype-based workplace interventions.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1755-1768"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health and objective rest-activity rhythms and sleep health in U.S. Adults: Depression and overactive bladder as potential explanatory factors.","authors":"Miao Huang, Renjie Huang, Dongyan Wang","doi":"10.1080/07420528.2026.2693217","DOIUrl":"10.1080/07420528.2026.2693217","url":null,"abstract":"<p><p>This cross-sectional study examined whether cumulative adverse social determinants of health (SDOH) were associated with accelerometer-derived rest-activity rhythms and multidimensional sleep metrics, and whether depression and overactive bladder statistically accounted for part of the SDOH-relative amplitude association in exploratory pathway analyses. We analyzed 6,130 U.S. adults aged 20-80 y (mean age 49.5 y; 51.7% female) from NHANES 2011-2014. From wrist-worn 7-d accelerometer recordings, nonparametric rest-activity indices (interdaily stability, intradaily variability, and relative amplitude) and sleep parameters (duration, efficiency, timing irregularity, social jetlag, and catch-up sleep) were derived. A composite SDOH score (0-8) was constructed across economic, educational, healthcare, housing, and social domains. In fully adjusted survey-weighted linear regression, each 1-unit higher SDOH score was associated with lower relative amplitude (beta = -0.007; 95% CI, -0.008 to -0.005), greater rhythm fragmentation, shorter sleep duration, lower sleep efficiency, and more irregular sleep timing. Graded associations were observed across SDOH quartiles. At the component level, unpartnered status, unemployment, and food insecurity showed the most consistent inverse associations with rhythm robustness. Exploratory pathway analyses were consistent with small indirect associations through depression severity and overactive bladder. Overall, greater cumulative adverse SDOH burden was associated with less robust, more fragmented rest-activity rhythms and poorer multidimensional sleep health.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1862-1875"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective and objective sleep in relation to the work context, profession, age, and workload among helicopter emergency medical service (HEMS) workers.","authors":"Tine Almenning Flaa, Erik Zakariassen, Bjørn Bjorvatn, Ståle Pallesen, Anette Harris, Siri Waage","doi":"10.1080/07420528.2026.2689495","DOIUrl":"10.1080/07420528.2026.2689495","url":null,"abstract":"<p><p>Sleep is essential for cognitive function and performance. This is particularly evident in safety-critical professions such as Helicopter Emergency Medical Services (HEMS). The present study examined sleep among pilots and HEMS crew members (HCMs) during a 7-day duty period. Based on sleep diary and actigraphy, we assessed sleep in relation to work context, profession, age, and workload. Sleep diary data showed delayed sleep timing across the week, with reduced sleep duration (08:22 vs. 07:48, b = -0.55, <i>p</i> < 0.05) and increased sleep debt (-00:03 vs. 00:27, b = 0.57, <i>p</i> < 0.05) from first to last duty day. Furthermore, pilots went to bed later (00:38) than HCMs (00:19, b = 0.38, <i>p</i> < 0.05). Night missions were associated with reduced sleep duration (06:52 vs. 07:29, b = -0.52) and sleep efficiency (80% vs. 92%, b = -14.8), as well as increased wake time after sleep onset (01:26 vs. 00:11, b = 86.3) and sleep debt (00:29 vs. 00:01, b = 0.44), all <i>p</i> < 0.05. Older workers at busy bases accumulated more self-reported sleep debt (b = 0.86, <i>p</i> < 0.05). These findings highlight how operational demands and worker characteristics influence sleep among HEMS personnel, underscoring the need for strategies to optimize sleep.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1827-1840"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrono-modulated drug delivery systems for oncology: Mechanisms, translational evidence, and pharmaceutical innovations.","authors":"Santoshini Nayak, Rajat Kumar Kar, Prasanta Kumar Biswal, Ranjit Prasad Swain, Snehamayee Mohapatra","doi":"10.1080/07420528.2026.2687798","DOIUrl":"10.1080/07420528.2026.2687798","url":null,"abstract":"<p><p>Conventional chemotherapy is limited by severe systemic toxicity, suboptimal pharmacokinetics, and nonspecific drug distribution. Chrono-modulated drug delivery systems (CDDS) address these challenges by aligning drug release with circadian rhythms, thereby enhancing efficacy and minimizing adverse effects. This strategy capitalizes on temporal fluctuations in drug metabolism, DNA repair mechanisms, cell proliferation, and immune function to refine pharmacokinetic and pharmacodynamic profiles. This review synthesizes recent preclinical and emerging clinical studies exploring chronomodulated chemotherapy, with a focus on delivery-system design and translational feasibility. Technological innovations, including stimuli-responsive hydrogels, nano- and micro-carriers, 3D printed formulations, and programmable infusion devices, enable precise temporal drug release. Comparative evaluation of these platforms reveals improved therapeutic indices and reduced toxicity, underscoring the clinical promise of chronotherapy in oncology. However, significant obstacles remain, including limited clinical standardization, regulatory barriers for drug-device combinations, formulation complexity, and inter-patient chronotype variability. Future integration of wearable biosensors, AI, and adaptive trials is expected to accelerate clinical translation. Overall, this review positions chronomodulated drug delivery as a strategically mature yet clinically underutilized approach for advancing precision oncology.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1728-1754"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional exploration of sleep duration and inattention traits in the association between chronotype and self-esteem.","authors":"Madelon A Vollebregt, Anouk Scheres","doi":"10.1080/07420528.2026.2693226","DOIUrl":"10.1080/07420528.2026.2693226","url":null,"abstract":"<p><p>The current cross-sectional and observational online study investigated previously reported associations between chronotype, sleep duration, inattention traits, and self-esteem within one indirect-effect model in a general, mostly student, population. Chronotype was operationalized as a continuous μMCTQ-derived score, with higher values indicating later sleep timing and greater evening orientation. We found that chronotype and self-esteem were negatively related, with lower self-esteem observed in participants with later sleep timing. This association was statistically accounted for in part by reported inattention traits, irrespective of reported sleep duration. Participants with higher chronotype scores on average reported more inattention traits, and lower self-esteem. Age effects, found for chronotype score, sleep duration, and inattention traits, were controlled for. Because all variables were measured concurrently, these findings should not be interpreted as evidence that eveningness causes inattention or low self-esteem. Instead, they show that previously reported bivariate relationships are likely connected in the same correlational pattern. Longitudinal, experimental, or network approaches are needed to test temporal ordering, alternative explanations, and possible intervention targets.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1914-1923"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian and metabolic effects of light-phase time-restricted feeding with a Western-style diet in young female rats.","authors":"Vitória Felício Souto, Sandra Lopes de Souza, Fernando Wesley Cavalcanti de Araujo, João Carlos Fonseca da Silva, Marconi Camara Rodrigues, Pierre Castro Soares, Elizabeth do Nascimento","doi":"10.1080/07420528.2026.2687810","DOIUrl":"10.1080/07420528.2026.2687810","url":null,"abstract":"<p><p>Young adulthood is a critical period for the development of metabolic disorders. Time-restricted feeding (TRF) has been proposed as an intermittent fasting strategy to mitigate these effects. However, its impact when feeding occurs out of sync with the biological clock remains uncertain. This study aimed to investigate the effects of mistimed time-restricted feeding during the light phase on metabolic and circadian outcomes in young female Wistar rats maintained on a pre-existing Western-diet background. Post-weaning rats (<i>n</i> = 24) were divided into a control group (standard chow diet) (C) and an western group (Western-style diet) (W) <i>ad libitum</i> for 8 weeks. The western group was further split into two subgroups: western <i>ad libitum</i> (WA) and western time-restricted (WR, 12-hour feeding window - light phase). Body weight, fat deposition, food intake, locomotor activity, glycemic and lipid profiles, hepatic lipid content, and circadian parameters were evaluated. At the end of the experimental period, Western-style diet exposure was associated with increased visceral adiposity and metabolic disturbances, consistent with a diet-induced obese phenotype. TRF during the light phase reduced visceral adiposity but paradoxically increased plasma glucose levels and relative liver weight, altered feeding patterns, disrupted glycemic rhythms, and reduced robustness of locomotor activity rhythms. Overall, these findings suggest that mistimed TRF may promote circadian misalignment and metabolic alterations under Western-diet conditions, highlighting a dissociation between metabolic and circadian responses.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1779-1795"},"PeriodicalIF":2.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}