Chronobiology International最新文献

{"title":"Associations between morning heart rate variability and ambulatory blood pressure characteristics in young adults.","authors":"Ann Claire E Blalock, James E Brown, Joseph D Vondrasek, Brett L Cross, Gregory J Grosicki, Andrew A Flatt","doi":"10.1080/07420528.2025.2538578","DOIUrl":"https://doi.org/10.1080/07420528.2025.2538578","url":null,"abstract":"<p><p>We aimed to quantify associations between resting heart rate variability (HRV) and ambulatory blood pressure (BP) characteristics in young adults. Thirty-two apparently healthy young adults (50% male) were included in the study. Short-term HRV was obtained via electrocardiography in the laboratory following an overnight fast to determine the mean RR interval, standard deviation of normal RR intervals (SDNN), and root-mean square of successive differences (RMSSD). Participants left the laboratory wearing an ambulatory BP monitor for 24 h to determine awake, asleep, and overall systolic and diastolic BP, and asleep BP dipping ratios. In males, higher SDNN and RMSSD were associated with lower asleep systolic and diastolic BP, and greater systolic BP dipping, with SDNN also associated with diastolic BP dipping (<i>Ps</i> <0.05). In females, higher mean RR, RMSSD, and SDNN were associated with lower awake diastolic BP, and RMSSD with lower overall diastolic BP (<i>Ps</i> <0.05). Our findings indicate potential sex differences in how cardiac-autonomic function associates with BP regulation throughout the day. In males, HRV showed stronger associations with nocturnal BP characteristics, whereas in females, HRV associations were more pronounced with daytime BP.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are 24-hour variations in food intake and subjective food perceptions different between day and night shift workers?","authors":"Nowane Borges Alves Silva Morais, Catarina Mendes Silva, Milena Ferreira Ramos, Gabriela Pereira Teixeira, Cibele Aparecida Crispim","doi":"10.1080/07420528.2025.2534007","DOIUrl":"https://doi.org/10.1080/07420528.2025.2534007","url":null,"abstract":"<p><p>Shift workers have an increased likelihood of developing obesity and metabolic disorders, and the dietary intake during nighttime seems to increase the risk of these conditions. Nevertheless, it remains unclear if hunger, food preferences, and satiety differ between night workers and day workers. This study aimed to compare the daily patterns of dietary intake and subjective dietary perceptions among day and night workers. A total of 60 workers participated in this study (30-day workers and 30-night workers). Dietary intake was assessed using a daily food record for a full working day, along with a Numerical Rating Scale (ranging from 0 to 10) used to measure subjective feelings of food satisfaction (appetite, hunger, and satiety) after each meal. Night workers showed a stronger preference for vegetables during the evening snack (<i>p</i> < 0.001) and a greater appetite for meat, eggs, and savory foods during the morning snack (<i>p</i> < 0.001 and <i>p</i> = 0.007, respectively) compared to day workers. In conclusion, night workers demonstrated different food perceptions compared to day workers.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic literature review of the potential relationship between tumour response and the timing of radiation therapy.","authors":"Jagtar Singh, Siddhartha Baxi, Martin Ashdown","doi":"10.1080/07420528.2025.2538581","DOIUrl":"https://doi.org/10.1080/07420528.2025.2538581","url":null,"abstract":"<p><p>This systematic review aims to examine the previously published studies on the application of radiotherapy (RT) and determine the possible benefits of incorporating a circadian-based time-of-day RT concept to improve outcomes. A literature search was conducted to identify relevant studies published between 2008 and 2024 using PubMed, Science Direct and Google Scholar databases. This systematic review included studies that analysed outcomes of patients with cancer who underwent RT in relation to the time of the day for those treatments. Nineteen studies were included in the systematic review; fourteen were retrospective, and five were prospective randomized trials. This review revealed that 64.3% (9/14) studies measured overall survival (OS) and tumour control, 14.3% (2/14) studies measured clinical outcomes and treatment toxicity, and 21.4% (3/14) retrospective studies measured Chrono-RT-induced toxicity only; however, they do not have consistent results. In addition, 100% (5/5) prospective studies measured treatment toxicity effects only whether patients were treated in the morning or evening. Existing literature suggests that Chrono-RT may reduce adverse symptoms in highly proliferative tissues and improve clinical outcomes. However, further examination of the Chrono-RT concept, in well-designed prospective trials and retrospective studies, is warranted to validate this hypothesis and for consistent results.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morning lark or night owl? Understanding the role of sleep quality and chronotype on dietary quality and hedonic hunger in university students.","authors":"Gözde Dumlu Bilgin, Hasan Kaan Kavsara, Pınar Usta Ulutaş, Yaren Aray, İrem Derin Gündüz, Melike Koç, Çağla Kurt, Esra Küçükömeroğlu","doi":"10.1080/07420528.2025.2536519","DOIUrl":"https://doi.org/10.1080/07420528.2025.2536519","url":null,"abstract":"<p><p>The role of sleep quality and chronotype on diet quality and hedonic hunger has not been fully clarified. This cross-sectional study aimed to examine these associations and included a total of 2124 participants (1459 women and 665 men; mean age 21.3 ± 2.5 years). Data were collected using validated instruments: the Morningness-Eveningness Questionnaire (MEQ) to assess chronotype, the Pittsburgh Sleep Quality Index (PSQI) for sleep quality, the Power of Food Scale (PFS) and Turkish Palatable Eating Motives Scale (T-PEMS) to evaluate hedonic hunger, and a 24-hour dietary recall to determine diet quality via the Healthy Eating Index-2020 (HEI-2020). Anthropometric measurements were obtained by the researcher. Results indicated that men had significantly higher body mass index (BMI) (<i>p</i> < 0.001) and were more likely to exhibit an evening chronotype (<i>p</i> = 0.023), whereas women demonstrated higher MEQ and T-PEMS scores (<i>p</i> < 0.001). Poor sleep quality was prevalent in 80.6% of participants and was associated with increased T-PEMS (<i>p</i> < 0.001). Evening chronotypes exhibited significantly poorer sleep quality, higher T-PEMS scores, and lower HEI-2020 scores compared to morning types (<i>p</i> < 0.001). These findings may indicate that both sleep patterns and circadian preferences can play a significant role in shaping diet quality among university students.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional differences in the physique of Japanese children: Investigating the influence of seasonal variations in effective day length.","authors":"Masana Yokoya, Yukito Higuchi","doi":"10.1080/07420528.2025.2540049","DOIUrl":"https://doi.org/10.1080/07420528.2025.2540049","url":null,"abstract":"<p><p>In the physique of Japanese children may arise from photoperiodic responses. This study aimed to investigate whether the geographical distribution of height and weight in Japanese pre-adolescent children (aged 13 years) can be explained by seasonal variations in effective day length (defined as the duration of daylight with an illuminance of 5000 lX or more). Using the average height and weight of 13-year-old boys and girls in 1993, 2007, and 2020 by prefecture as response variables, and the variation in monthly averages of effective day length over the past 13 years by prefecture as explanatory variables, we conducted a Partial Least Squares (PLS) regression analysis. The regional differences in height and weight were associated with two components of effective day length that exhibited seasonal fluctuations. The scores and loading vectors of these components suggested that, in both summer and winter, short days led to height gain and inhibited weight gain through activation of thyroid hormone-like activity, whereas long days inhibited height gain, promoted weight gain, and induced suppression of thyroid hormone-like activity. The results suggested that the short days of winter particularly contribute to height growth, while the long days of summer are more likely to contribute to weight gain.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent dietary patterns and methyl-donor nutrient intakes in relation to blood leukocyte DNA methylation of circadian genes.","authors":"Jennifer T Lee, Jaclyn M Goodrich, Dana C Dolinoy, Karen E Peterson, Martha M Téllez-Rojo, Alejandra Cantoral, Libni A Torres-Olascoaga, Edward A Ruiz-Narváez, Erica C Jansen","doi":"10.1080/07420528.2025.2532796","DOIUrl":"https://doi.org/10.1080/07420528.2025.2532796","url":null,"abstract":"<p><p>Dietary composition may impact circadian rhythms, potentially through DNA methylation of circadian genes. However, research among adolescents remains limited. Cross-sectional association of three dietary patterns, derived from principal component analysis of energy-adjusted food groups, and five energy-adjusted methyl-donor nutrients (folate, methionine, riboflavin, and vitamins B6 and B12) on DNA methylation of 18 circadian-related genes in 526 adolescents was examined. DNA methylation levels at CpG sites were quantified from blood leukocytes using the Illumina Infinium Methylation EPIC BeadChip, with false discovery rate adjustments (<i>q ≤ 0.20</i>). Linear regression was used, adjusting for age, sex, maternal education, smoking status, batch effects, and cell-type proportions. Correlations between CpG sites and gene expression data (RNA-seq) of the corresponding genes were evaluated. Riboflavin was negatively associated with cg06337557 (<i>MTNR1B</i>) and cg02076826 (<i>RORA</i>). Vitamin B6 was positively associated with cg09615953 (<i>PER3</i>) and negatively with cg06337557 (<i>MTNR1B</i>). In males, the <i>Breakfast</i> pattern was negatively associated with cg13146553 (<i>RORA</i>), and riboflavin was positively associated with cg06487986 (<i>PER3</i>). No significant associations were found for the <i>Plant-based & lean proteins</i> pattern, folate, methionine, or vitamin B12. DNA methylation of the 18 clock genes were not correlated with gene expression data of the corresponding genes. Dietary patterns and methyl-donor nutrients may influence core clock and melatonin-related genes, with potential sex-specific relationships.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-16"},"PeriodicalIF":2.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of glucose supplementation on physiology and metabolism of a nocturnal migrant (<i>Emberiza bruniceps</i>) under laboratory conditions.","authors":"Anupama Yadav, Ranju Chetri, Anand S Dixit, Sangeeta Rani","doi":"10.1080/07420528.2025.2529348","DOIUrl":"https://doi.org/10.1080/07420528.2025.2529348","url":null,"abstract":"<p><p>Glucose is the simplest sugar and the ultimate source of energy for the cells. In the present study, we have tried to investigate the plausible role of glucose on seasonal physiology of redheaded bunting such as: hyperphagia, initiation and persistence of migratory restlessness, life history state-dependent plasma metabolite profile and fuel preference during migratory phenotype. Buntings are photosensitive species and exposure to short (8 L:16D) and long (13 L:11D) photoperiod leads to simulation of non-migratory and migratory life history states, respectively, in these birds. For experiment, birds were divided into three groups (<i>N</i> = 5 each), where, group I served as control, group II and III received 5% and 15% glucose (w/v), respectively, in drinking water. Our results clearly demonstrate the role of glucose in early initiation of <i>zugunruhe</i> (migratory restlessness) followed by its sustenance for longer duration of time. Food intake was inversely proportional to glucose concentration; however, water intake was substantially high for birds of 5% glucose group. Besides these, the circulating plasma concentration of glucose, triglycerides and cholesterol were significantly high because of external glucose supplementation. The study also provides the evidence of non-dependence of fat alone in fueling the migratory journey. Thus, the current study clearly illustrates the role of glucose in different life history states of migratory redheaded bunting.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morningness-eveningness scale for children: Difficulties in establishing reference score intervals by age and sex throughout adolescence.","authors":"Jeanny Joana Rodrigues Alves de Santana, Jefferson Souza Santos, Fernando Mazzilli Louzada, Sabine Pompeia","doi":"10.1080/07420528.2025.2532798","DOIUrl":"https://doi.org/10.1080/07420528.2025.2532798","url":null,"abstract":"<p><p>As adolescents become older, they tend to prefer sleeping and waking later due to biological maturation and social/environmental changes. Higher evening preferences relate to risks of developing physical and mental ill-health and/or academic underachievement. To identify individuals who are more vulnerable to these negative outcomes, prior studies have mostly established percentile cutoff scores in questionnaires of morningness-eveningness (M-E) preferences, a method that leads to biased estimates, and/or used linear statistical methods, which do not consider that M-E can fit other types of distribution. We reanalyzed cross-sectional data of 1815 10-18-year-old Brazilians who filled in the most popular circadian preference scale, the M-E Scale for Children (MESC). Age/sex MESC sum raw score differences were analyzed using correlations, general linear models and 44 different curve fittings based on fractional polynomials and exponential data transformation. We found a very slight correlation and general linear increase in eveningness with age, but none of the 44 tested curve fit patterns reliably explained score changes across ages, being highly variable at all ages. Hence, establishing MESC reference score intervals by age/sex is of little practical value. We discuss other factors combined with MESC scores that may help identify adolescents at risk of circadian-related problem.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>NR1D1 (REVERBalpha)</i> may be novel candidate gene for coronary artery disease in men: Differential effects of <i>NR1D1</i> polymorphisms by gender.","authors":"Rukiye Yesil, Cagatay Aydogan, Gulcin Ozkara, Bengu Tokat, Ahmet Yildiz, Abdullah Omer Ebeoglu, Mehmet Fatih Seyhan, Oguz Ozturk, Hulya Yilmaz-Aydogan","doi":"10.1080/07420528.2025.2532797","DOIUrl":"https://doi.org/10.1080/07420528.2025.2532797","url":null,"abstract":"<p><p>Circadian rhythms are strongly linked to cardiometabolic syndromes such as coronary artery disease (CAD). <i>NR1D1(REVERBalpha)</i> regulates lipid metabolism and circadian clock. This study investigated possible associations between the <i>NR1D1</i> rs2314339 C > T and rs72836608 C > A polymorphisms and metabolic parameters in 126 CAD patients and 125 controls. Allelic discrimination was performed by Real-Time PCR using TaqMan Genotyping Assays. The rs2314339-CC and rs72836608-AA genotypes were associated with an increased risk of CAD (<i>p</i> < 0.05), which varied according to cardiovascular risk factors. The rs72836608-A allele and rs2314339-CC genotypes were associated with an increased risk of CAD in healthy-weight, non-diabetic, normolipidemic, and male patients (<i>p</i> < 0.05). Additionally, the rs72836608-A allele was associated with an elevated risk of CAD in patients with hypertension (<i>p</i> = 0.016). Subgroup analysis by gender showed that the rs72836608-A allele (<i>p</i> = 0.018), the rs2314339-CC genotype (<i>p</i> = 0.008), hyperlipidemia (<i>p</i> = 0.001), hypertension (<i>p</i> = 0.001), and type 2 diabetes mellitus (T2DM) (<i>p</i> = 0.001) were associated with an increased risk of CAD in men. Nevertheless, the presence of hypertension (<i>p</i> = 0.008), hyperlipidemia (<i>p</i> = 0.025), and T2DM (<i>p</i> = 0.001) were significantly associated with CAD risk in the females. Multivariate regression analysis revealed that the rs72836608-A allele (<i>p</i> = 0.034), male gender (<i>p</i> = 0.01), hyperlipidemia (<i>p</i> = 0.008), hypertension (<i>p</i> = 0.001), and T2DM (<i>p</i> = 0.001) were associated with an increased risk for CAD in the overall cohort. The findings suggest that both polymorphisms may be associated with an increased risk of CAD, particularly in men, and may be influenced by factors including age and other cardiovascular risk factors.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of the Japanese version of the reduced morningness-eveningness questionnaire (rMEQ) score using dim light melatonin onset and sleep-wake behavior in young adults.","authors":"Taisuke Eto, Yuki Nishimura, Hiroki Ikeda, Taiki Kunieda, Minori Enomoto, Tomohide Kubo, Ana Adan, Shingo Kitamura","doi":"10.1080/07420528.2025.2532795","DOIUrl":"10.1080/07420528.2025.2532795","url":null,"abstract":"<p><p>The Reduced Morningness-Eveningness Questionnaire (rMEQ), a five-item version of the 19-item MEQ, is a practical tool for assessing circadian typology or \"morningness\" and \"eveningness\" preference. Although we previously validated the Japanese version of rMEQ with MEQ, external validation against an established standard was lacking. This study aimed to additionally validate the Japanese rMEQ in young adults by assessing the dim light melatonin onset (DLMO), a marker of circadian phase, and subjective/objective sleep-wake habits. Twenty healthy young adults (mean age: 23.0 ± 1.9 years) participated in this study and were assessed the circadian typology by rMEQ and MEQ. The sleep-wake habits were measured by sleep diary, actigraphy and the Pittsburgh Sleep Quality Index (PSQI). Salivary melatonin samples were collected to determine DLMO. Results showed significant correlations between rMEQ scores and DLMO, as well as sleep variables based on sleep diary, actigraphy and PSQI. Correlations between rMEQ scores and these variables were consistently stronger than those for MEQ. These findings highlight the validity of the Japanese rMEQ and that the rMEQ more accurately reflects circadian typology and internal circadian phases compared to MEQ, at least in Japanese young adults. The Japanese rMEQ could be a valuable tool for efficiently assessing circadian typologies in Japanese young adults.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}