Chronobiology International最新文献

{"title":"Sleep characteristics in association with risk of sporadic anovulation among eumenorrheic women.","authors":"Joshua R Freeman, Brian W Whitcomb, Elizabeth R Bertone-Johnson, Louise M O'Brien, Galit L Dunietz, Alexandra C Purdue-Smithe, Keewan Kim, Robert M Silver, Enrique F Schisterman, Sunni L Mumford","doi":"10.1080/07420528.2025.2481165","DOIUrl":"https://doi.org/10.1080/07420528.2025.2481165","url":null,"abstract":"<p><p>Few studies have evaluated sleep characteristics, including social jetlag, with ovulatory dysfunction, which may be an indicator of subfertility and poor metabolic health. Our objective was to evaluate whether sleep characteristics, including sleep duration, chronotype, social jetlag, sleep latency, nocturnal awakenings, and shift work, were associated with risk of anovulation among eumenorrheic women. Participants had a history of pregnancy loss and regular menstrual cycles, but no history of infertility. Typical sleep characteristics were self-reported at baseline. Participants were followed up to the cycle of conception or up to six menstrual cycles. Fertility monitor data and reproductive hormone concentrations were used to assess anovulation. We used generalized estimating equations with log-Poisson distributions to estimate relative risks (RR). The study is registered at clinicaltrials.gov (NCT00467363). Sleep duration, social jetlag, sleep latency, and nocturnal awakenings were not associated with anovulation. Later chronotype was associated with greater anovulation risk (3^rd vs. 2^nd tertile RR: 1.33, 95% CI: 1.05-1.68; per 1-hour increase RR: 1.05 95% CI 1.00-1.11). The RR for rotating work was 1.14 (95% CI: 0.90-1.46) and for night shift work was 1.22 (95% CI: 0.98-1.52). These results suggest that later chronotype and potentially shift work may be related to menstrual cycle dysfunction.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian antidepressant treatments in depression: A systematic review and meta-analysis.","authors":"Chuying Li, Pengpeng Cao, Yuhao Li, Shuo Zhang, Ye Zhang, Zheng Xu, Bei An, Ruixin Yong","doi":"10.1080/07420528.2025.2478127","DOIUrl":"https://doi.org/10.1080/07420528.2025.2478127","url":null,"abstract":"<p><p>The purpose of the present study was to explore whether maximum efficacy treatments would be dependent on the time of day at which antidepressants were taken. Databases were searched for randomized experiments or randomized controlled trials involving interventions of any antidepressants taken at a particular time of the day. Out of 10 348 screened articles, 10 studies were included in the meta-analyses. The optimal time of maximum efficacies in 5 out of 15 drugs in the 10 studies was at zeitgeber time (ZT) 2, including fluoxetine, sertraline, citalopram, doxepin, and agomelatine. The best therapeutic effects of mirtazapine, trazodone, and agomelatine were at ZT10, while maximum efficacies of venlafaxine and fluvoxamine were at ZT6 and ZT13, respectively. The optimal time of melatonin administration was the period of treatment dependence. We found antidepressants with different mechanisms might have same or different optimal administration times. These findings may guide evidence-based antidepressant treatment choices with optimal dosing time. More prospective randomized trials or randomized experiments are demanded to establish recommendations for optimal circadian timing of depression based on zeitgeber time. It would be of interest to further evaluate this time-selection as a potential viable novel therapeutic in future research.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between chrononutrition profile, social jet lag and obesity: A cross-sectional study of Chinese college students.","authors":"Yue Gong, Ji-Xin Zhang, Sheng-Nan Li, Le-Le Li, Xiao-Jie Dong, Ling-Jie Liu, Ze-Hui Fan, Yan Li, Yi-De Yang","doi":"10.1080/07420528.2025.2464664","DOIUrl":"10.1080/07420528.2025.2464664","url":null,"abstract":"<p><p>This study aimed to investigate the associations between chrononutrition profile, social jet lag (SJL) with obesity-related indicators (body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHTR), and percentage of body fat (PBF)). This cross-sectional study was conducted among college students in a university in Hunan Province, China, from 14 September 2023 to 8 June 2024. This study employed the Chrononutrition Profile - Questionnaire (CP-Q) along with physical examinations. SJL was defined as time difference of midpoint of sleep between the workdays and freedays. Sleep-corrected SJL (SJL_sc) is the absolute difference between the sleep onset on free days and workdays. Average evening latency is the time between the last meal of the day and bedtime. Eating jet lag is the difference in the midpoint of the eating window between workdays and freedays. Logistic regression was utilized to assess the associations between chrononutrition profile, SJL, and obesity-related indicators among college students. A total of 805 participants were recruited, of which 695 have complete data after excluding those who did not meet the inclusion criteria. After adjusting for potential covariates, average evening latency <4 h was related with lower risk of high BMI, WC, and PBF [<i>OR</i> (95% CI) = 0.435 (0.285-0.663), 0.508 (0.305-0.848), 0.564 (0.402-0.792), respectively]. Average eating window >12 h was associated with a lower risk of high BMI, WC, and PBF [<i>OR</i> (95% CI) = 0.511 (0.327-0.800), 0.485 (0.277-0.851), 0.651 (0.456-0.930), respectively]. Last eating occasion jet lag >1 h was a higher risk of high PBF [<i>OR</i> (95% CI) = 1.554 (1.018-2.371)]. SJL_sc > 1 h was associated with high PBF [<i>OR</i> (95% CI) = 1.527 (1.073-2.174)]. Circadian rhythm disruptions, including SJL and eating jet lag, are prevalent among college students. Long eating window, short evening latency, is associated with low risk of obesity, while short sleep duration, last eating occasion jet lag and larger SJL_sc were associated with higher risk of obesity among youths.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"328-339"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light levels in a modern intensive care unit: Impact of time of year, window directionality, and outdoor light levels.","authors":"Nikhil Chilakapati, Liz Timple, Sophia Pizzi, Janelle M Fine, Hirsh Makhija, Lauryn K Bruce, Robert L Owens, Douglas Alden, Atul Malhotra, Jennifer L Martin, Biren B Kamdar","doi":"10.1080/07420528.2025.2469885","DOIUrl":"10.1080/07420528.2025.2469885","url":null,"abstract":"<p><p>The intensive care unit (ICU) environment is designed for the care of acutely ill patients, with lighting conditions reflecting the needs of the busy clinical setting. Earlier ICU studies suggested that daytime and nighttime light levels were misaligned with those required for circadian rhythm entrainment, which can impact patient sleep-wake cycles and recovery from critical illness. In this investigation in San Diego, California, a coastal US city with over 260 days of sunshine annually, we performed a detailed evaluation of light levels in a contemporary academic medical-surgical ICU constructed in 2016, which features modern lighting and floor-to-ceiling windows in each of the 24 rooms. Using light meters mounted on poles and located directly behind the head of each patient's bed, our analysis of nearly 90,000 hours of data revealed daytime ICU light levels consistently lower than 150 lx, similar to studies in older ICUs and many magnitudes lower than outdoor levels at identical times. Hence, despite the modern design, we found that little to no light from the ~100 ft² windows reached the patient. While daytime light levels were low across all ICU rooms, those with windows facing South and Northwest featured higher light levels than those facing Southeast and Northeast, suggesting a contribution of window direction to ICU light levels.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"351-359"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Night work and sleep debt are associated with infections among Norwegian nurses.","authors":"Daniel Hartveit Hosøy, Philip Brevig Ørner, Ståle Pallesen, Ingvild West Saxvig, Bjørn Bjorvatn, Siri Waage","doi":"10.1080/07420528.2025.2455147","DOIUrl":"10.1080/07420528.2025.2455147","url":null,"abstract":"<p><p>This study investigates possible associations between sleep duration, sleep debt and shift work characteristics, and self-reported infections among 1335 Norwegian nurses (90.4% females, mean age 41.9 y). Participants reported their sleep duration, sleep need and shift work, and frequency of infections (common cold, pneumonia/bronchitis, sinusitis, gastrointestinal infection, urinary tract infection) experienced in the last 3 months. Chi-square tests and logistic regression (adjusted for sex, age, children at home, marital status) were used for data analyses. Sleep debt (1-120 min and >2 h, respectively) was dose-dependently associated with increased risk of common cold (adjusted odds ratio (aOR) 1.33, 95% CI 1.00-1.78; aOR 2.32, 95% CI 1.30-4.13), pneumonia/bronchitis (aOR 2.29, 95% CI 1.07-4.90; aOR 3.88, 95% CI 1.44-10.47), sinusitis (aOR 2.08, 95% CI 1.22-3.54; aOR 2.58, 95% CI 1.19-5.59), and gastrointestinal infection (aOR 1.45, 95% CI 1.00-2.11; aOR 2.45, 95% CI 1.39-4.31), compared to no sleep debt. Night work (yes/no) (aOR 1.28, 95% CI 1.00-1.64) and number of night shifts (1-20 compared to 0 nights) (aOR 1.49, 95% CI 1.08-2.06) were associated with increased risk of common cold. Sleep duration and quick returns were not associated with any of the infections. In conclusion, shift- and night work were associated with increased risk of common cold. Sleep debt was dose-dependently associated with an increased risk of several infections.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"309-318"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra- and interspecific temporal mating patterns in <i>Anastrepha fraterculus</i> and <i>Anastrepha obliqua</i> fruit flies.","authors":"Samira Chahad-Ehlers, Jéssica Tagliatela, João Marcos de Oliveira, Lucas Packer Arthur, Reinaldo Alves de Brito","doi":"10.1080/07420528.2025.2471868","DOIUrl":"10.1080/07420528.2025.2471868","url":null,"abstract":"<p><p>Daily rhythms, such as mating times, play a key role in shaping insect behavior and are pivotal in prezygotic reproductive isolation and speciation. To investigate whether mating behavior follows a daily rhythm under natural light-dark cycles and controlled temperature conditions, we examined the mating times of two related agricultural pest species, <i>Anastrepha fraterculus</i> and <i>Anastrepha obliqua</i>. Our observations revealed distinct patterns in their daily copulatory activities. <i>A. fraterculus</i> shows a unimodal pattern, peaking in the morning, while <i>A. obliqua</i> displays a bimodal pattern, with mating occurring in both the morning and late afternoon, all statistically validated. In <i>A. obliqua</i>, the morning peak is more pronounced before the winter solstice, reversing afterward. These results highlight the adaptability of these fruit flies' biological clocks, allowing them to adjust mating timing according to seasonal environmental changes. Our findings also reveal how each species gauges environmental light-dark durations, even if annual variation is less pronounced in tropical regions, with twilight serving as a daily marker. The observed plasticity, including phase shifts in both species and amplitude changes in <i>A. obliqua</i>, emphasizes their synchronization with environmental cycles, which may explain the absence of specific pre-mating behaviors and the initiation of mating in low-light conditions, as seen in <i>A. fraterculus</i>. This study underscores the importance of biological rhythm plasticity in understanding fruit fly mating behavior, with implications for population management and ecological dynamics, and reinforces the need for 24-h observations to capture these rhythms fully.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"360-377"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of the expression of circadian-clock genes with the severity of obstructive sleep apnea in patients.","authors":"Hsiu-Mei Wang, Kun-Ruey Shieh, En-Ting Chang","doi":"10.1080/07420528.2025.2480120","DOIUrl":"10.1080/07420528.2025.2480120","url":null,"abstract":"<p><p>This study investigates the connection of Obstructive Sleep Apnea (OSA) with the expression and daily oscillation patterns of core circadian clock genes and related genes. OSA, a sleep disorder characterized by repetitive airway occlusion leading to nocturnal arousals, sleep fragmentation, and intermittent hypoxemia (IH), shares sleep dysfunction as an overlapping phenotype with circadian clock genes. The research involved 40 subjects (30 OSA patients and 10 normal controls), categorized into four groups based on Polysomnography (PSG) results: normal, mild, moderate, and severe. Peripheral blood samples were collected twice from each participant in the evening before and the morning after PSG examination. Using real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR), the study measured the expression levels of target genes in leukocytes. Results revealed changes in diurnal expression patterns of several genes (<i>PER1, PER3, CRY1, BMAL1, CLOCK, HIF-1α, IL-1β, TNFα)</i> in OSA groups compared to normal controls. While <i>PER2, CRY2</i>, and <i>NPAS2</i> genes did not show diurnal patterns, their expression was significantly elevated in severe OSA. Notably, the expression levels of HIF-1α, IL-1β, and TNFα increased with OSA severity, consistent with the roles of IH and inflammation as clinical indicators in OSA. These findings not only demonstrate that circadian clock-related gene expression fluctuates with OSA but also provide potential molecular markers for early diagnosis and personalized treatment. By identifying biomarkers parallel to clinical indicators in OSA, this innovative study paves the way for future research and clinical applications in the field.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"428-439"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The length of night shift work is closely associated with cancer risk: A pan-cancer study of Mendelian randomization study.","authors":"Dili Song, Yong Li, Yuanyuan Li, Ying Zou, Yongguang Cai","doi":"10.1080/07420528.2025.2479098","DOIUrl":"10.1080/07420528.2025.2479098","url":null,"abstract":"<p><p>Night shift work (NSW) has been associated with cancer risk in animal studies, but epidemiological evidence remains insufficient and contradictory. This study sought to investigate the causal association between NSW and 13 common cancers using a two-sample Mendelian randomization (MR) study. Genetic variants associated with NSW were extracted from the UK Biobank and selected as instrumental variables (IVs). Genome-wide association study (GWAS) data for 13 cancers were obtained from relevant consortia and biobanks. Causality was estimated using inverse-variance weighted (IVW), MR-Egger, and weighted median (WM). Sensitivity analyses, including MR-Egger intercept tests, MR-PRESSO, leave-one-out analyses, and funnel plots, were conducted to detect pleiotropy and heterogeneity. A suggestive causal association was found between NSW duration and risks of cervical (IVW: <i>p</i> = 0.028) and gastric cancer (IVW: <i>p</i> = 0.011). No significant associations were observed for other cancers (<i>p</i> > 0.05). These findings suggest the need to reduce NSW duration and limit nocturnal light exposure to maintain circadian rhythms and mitigate cancer risks.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"418-427"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Caen Chronotype Questionnaire: Exploring the added value of amplitude and correlations with actigraphy.","authors":"Robert Hickman, Daniel Lai Jie, Sukhi Shergill, Sylvain Laborde, Teresa C D'Oliveira","doi":"10.1080/07420528.2025.2471887","DOIUrl":"10.1080/07420528.2025.2471887","url":null,"abstract":"<p><p>Chronotype self-report instruments are time and cost-efficient measures to profile diurnal or time-of-day preferences. The Caen Chronotype Questionnaire (CCQ) captures morningness and eveningness (CCQ-ME) and a circadian amplitude dimension for diurnal variation (distinctiveness; CCQ-DI). This study extends prior multilanguage validations for the English version of the CCQ. In total, 628 participants enrolled from a UK working population (mean age 30.34 ± 8.36 years, 61.3% female) including a subset of shift workers (<i>n</i> = 179; mean age 27.62 ± 5.95 years, 49.2% female). A subsample of participants also wore a consumer-grade actigraph device (Fitbit Charge 4) for seven days to compare chronotype estimates with objective sleep-wake parameters (<i>n</i> = 22; mean age 27.05 ± 3.99 years, 81.8% female, 90.9% worked standard daytime schedules, and 9.1% worked rotating shifts). All participants completed online chronotype measures, including the CCQ and Morningness-Eveningness Questionnaire (MEQ), depressive symptoms (Patient Health Questionnaire; PHQ-9), sleep quality (Pittsburgh Sleep Quality Index; PSQI), and other outcome measures. Results from the Confirmatory Factor Analysis (CFA) offer support for a two-factor structure of the CCQ in an English-speaking sample, highlighting how individual preferences for the timing of activities is associated with chronotype (morningness-eveningness; ME) and a second subjective amplitude dimension (DI). However, in contrast with the original CCQ structure, a more parsimonious solution and best overall fit involved the reduction of the original 16-item questionnaire (8 items per factor) to 4 ME items and 5 DI items. Convergent validity with the reduced CCQ scale (rME) and the MEQ was also established. The CCQ was sensitive in discriminating differences in actigraphic sleep-wake timings between morning-and evening-oriented individuals. Regression models demonstrated that amplitude (CCQ-DI) was a significant predictor explaining most of the variance in depressive symptoms (PHQ-9) compared to other variables. Overall, the English version of the CCQ was shown to be a robust tool in estimating chronotype in a sample of adults based in the UK.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"378-391"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar disorders in the rhythm of day and seasons: Link between bipolarity and seasonal affective disorder.","authors":"Mélissa Lesobre, Anthony Bonilla, Alexandra Foucher, Benjamin Calvet, Aurélie Lacroix, Éric Charles","doi":"10.1080/07420528.2025.2481163","DOIUrl":"10.1080/07420528.2025.2481163","url":null,"abstract":"<p><p>Seasonal Affective Disorder (SAD) is common among individuals with bipolar disorder, significantly impacting their quality of life and the course of their illness. This cross-sectional study aimed to determine the prevalence of SAD in a sample of 120 individuals with bipolar disorders using the Seasonal Pattern Assessment Questionnaire (SPAQ) and to identify predictive factors associated with SAD. Nearly half of bipolar subjects met the criteria for SAD, according to the SPAQ. Additionally, several factors linked to seasonality in individuals with bipolar disorders were identified, such as the presence of a cyclothymic temperament and heightened emotional reactivity, leading to greater functional impairment. SAD appears to be a marker of severity in bipolar disorder due to its association with worsened symptoms, increased functional difficulties, and additional treatment challenges. These findings underscore the importance of systematically assessing seasonal patterns in individuals with bipolar disorder to improve diagnosis and management strategies.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"440-450"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}