Chronobiology International最新文献

Cognitive correlates of circadian rhythm and sleep-wake behaviour in chronic obstructive pulmonary disease patients. 慢性阻塞性肺病患者昼夜节律和睡眠-觉醒行为的认知相关性。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-10-04 DOI: 10.1080/07420528.2024.2410242

Babita Pande, Meenakshi Sinha, Ramanjan Sinha, Ajoy Kumar Behera, Arti Parganiha, Rachita Nanda, Lokesh Kumar Singh

{"title":"Cognitive correlates of circadian rhythm and sleep-wake behaviour in chronic obstructive pulmonary disease patients.","authors":"Babita Pande, Meenakshi Sinha, Ramanjan Sinha, Ajoy Kumar Behera, Arti Parganiha, Rachita Nanda, Lokesh Kumar Singh","doi":"10.1080/07420528.2024.2410242","DOIUrl":"https://doi.org/10.1080/07420528.2024.2410242","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) patients often experience reduced physical activity, sleep disturbances, and cognitive impairment. However, reports on measurement of rest-activity rhythm and sleep-wake behavior and their impact on cognitive functions in COPD patients are limited. This study aimed to objectively measure circadian rhythms (rest-activity and ambient illuminance) and sleep behaviors in clinically stable COPD patients and their relationship with cognitive functions. The study involved 65 male COPD patients and 50 age-matched controls, monitored over 3-7 days using actigraphy. Cognitive status was assessed using the Montreal Cognitive Assessment (MoCA) followed by short interbal time estimation via time production and reproduction with reaction time measurement using TimeProd software. Findings indicated significant disruptions in circadian rhythms in COPD patients, characterized by lower mesor, amplitude, and autocorrelation coefficients compared to controls. Patients also reported poorer sleep quality and higher sleep fragmentation, with 85.7% displaying cognitive impairment. Notably, longer time estimations, increased variability in task performance, and slower reaction times suggested cognitive deterioration. Positive correlations emerged between rhythm parameters (amplitude and circadian quotient) and cognitive performance metrics. This highlights the relevance of circadian and sleep disturbances in COPD, suggesting that addressing these rhythms could help mitigate cognitive decline, potentially through chronotherapeutic strategies.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronotype, sleep quality, impulsivity and aggression in patients with borderline personality disorder and healthy controls. 边缘型人格障碍患者和健康对照组的时间型、睡眠质量、冲动性和攻击性。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-10-01 DOI: 10.1080/07420528.2024.2410239

Yasin Taşdelen, Ali İnaltekin

{"title":"Chronotype, sleep quality, impulsivity and aggression in patients with borderline personality disorder and healthy controls.","authors":"Yasin Taşdelen, Ali İnaltekin","doi":"10.1080/07420528.2024.2410239","DOIUrl":"https://doi.org/10.1080/07420528.2024.2410239","url":null,"abstract":"Impulsivity, aggression, and suicide are the major clinical symptoms of borderline personality disorder (BPD). Although previous studies indicated poor sleep quality and its relationship with clinical symptoms in patients with BPD, chronotype, an important sleep parameter, was not investigated in these patients. This study aimed to analyze chronotype and its relationship with clinical symptoms in patients with BPD. Participants in this study consisted of 68 BPD patients and 65 healthy controls. Subjective sleep characteristics, impulsivity, aggression, suicide probability, and chronotype were assessed using the Pittsburgh Sleep Quality Index (PSQI), Barratt Impulsivity Scale, Buss-Perry Aggression Scale (BPAQ), Suicide Probability Scale, and Morningness - Eveningness Questionnaire, respectively. PSQI total and subscale scores subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, and daytime drowsiness were significantly higher in the BPD group (p < 0.001). There was a positive correlation between the PSQI total score and the BPAQ total score (r = 0.268, p = 0.027). The rate of evening type was significantly higher in the control group (p = 0.004). Suicide attempts and the subscale of suicide probability hopelessness, suicidal ideation, and negative self-evaluation scores were significantly higher in evening type BPD patients. (p = 0.017, p = 0.009, p = 0.001, p = 0.047). Sleep quality is associated with aggression, and the eveningness chronotype is associated with suicide. It may be useful to focus on sleep problems in treating BPD patients.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive impairment induced by circadian rhythm disorders involves hippocampal brain-derived neurotrophic factor reduction and amyloid-β deposition. 昼夜节律紊乱引起的认知障碍涉及海马脑源性神经营养因子减少和淀粉样蛋白-β沉积。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-09-23 DOI: 10.1080/07420528.2024.2406545

Yue-Jia Yan, Chang-Quan Huang

{"title":"Cognitive impairment induced by circadian rhythm disorders involves hippocampal brain-derived neurotrophic factor reduction and amyloid-β deposition.","authors":"Yue-Jia Yan, Chang-Quan Huang","doi":"10.1080/07420528.2024.2406545","DOIUrl":"https://doi.org/10.1080/07420528.2024.2406545","url":null,"abstract":"Circadian rhythm disruptions have been implicated in numerous health issues, including cognitive decline and the exacerbation of neurodegenerative diseases, like Alzheimer disease (AD). Brain-derived neurotrophic factor (BDNF), vital for neuronal plasticity and cognitive function, is regulated by the circadian clock and exerts protective effects against AD. Thus, we investigated the impact of circadian rhythm disorders (CRDs) on cognitive impairment and explored the underlying neurobiological mechanisms by assessing BDNF and amyloid-β (Aβ) levels. We divided male C57BL/6 mice into three groups (n = 30): a control group (normal 12/12 hour light-dark cycle) and two CRD model groups (3/3 and 22/22 hour cycles, respectively). After 12 weeks, we assessed cognitive functions using the Morris water maze. Following behavioral tests, hippocampal levels of BDNF and Aβ were quantified using enzyme-linked immunosorbent assays. CRDs significantly impaired learning and memory, as evidenced by longer times to reach and find the platform in the CRD groups (p < 0.01). Furthermore, BDNF levels were notably decreased and Aβ levels increased in the CRD groups compared with the control group (p < 0.01). Thus, CRDs elicit cognitive impairment by reducing BDNF levels and increasing Aβ deposition in the hippocampus.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian rhythm in hypertension: An updated bibliometrics analysis and knowledge mapping from 1990 to 2022 高血压的昼夜节律：1990年至2022年最新文献计量学分析和知识图谱

IF 2.8 4区医学

Chronobiology International Pub Date : 2024-09-16 DOI: 10.1080/07420528.2024.2403434

Heng Bai, Si-Yang Liu, Jie Tian, Yu Li

引用次数: 0

Investigating the interplay of chronotypes, neuropsychiatric dimensions, demographic and clinical characteristics and disability in migraine patients: A cross-sectional assessment. 调查偏头痛患者的时型、神经精神层面、人口学和临床特征与残疾之间的相互作用：横断面评估

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-09-16 DOI: 10.1080/07420528.2024.2399126

Yasemin Ekmekyapar Fırat, Barış Yılbaş, Emine Kılıçparlar Cengiz, Süleyman Dönmezler

{"title":"Investigating the interplay of chronotypes, neuropsychiatric dimensions, demographic and clinical characteristics and disability in migraine patients: A cross-sectional assessment.","authors":"Yasemin Ekmekyapar Fırat, Barış Yılbaş, Emine Kılıçparlar Cengiz, Süleyman Dönmezler","doi":"10.1080/07420528.2024.2399126","DOIUrl":"https://doi.org/10.1080/07420528.2024.2399126","url":null,"abstract":"The study investigated associations between chronotypes (Morning [M], Neither [N], Evening [E]), sociodemographic characteristics, body mass index (BMI), smoking habits, years with migraines, sleep quality (PSQI), anxiety (HADS-A), depression (HADS-D), migraine disability (MIDAS), headache frequency, and pain intensity (VAS) in 80 individuals with migraine. Significant age differences emerged (p < 0.001), with M-types being the oldest. BMI also varied, with M-types presenting the highest median BMI (p = 0.005). While migraine duration and headache frequency showed no significant variance, sleep quality did, with E-types reporting the poorest sleep (p = 0.030). Anxiety and depression were significantly worse in E-types (HADS-A: p = 0.002; HADS-D: p = 0.010). Differences in MIDAS levels were notable (p = 0.038); however, differences in MIDAS scores were not significant (p = 0.115). Pain intensity varied, with E-types experiencing the most severe pain (p = 0.009). Post-hoc analysis showed higher MIDAS scores in E-types compared to N-types (χ2 = 6.56, p = 0.038, ε2 = 0.0831). The findings highlight the need for thorough patient evaluations and tailored care, considering the complex interplay of factors affecting migraine severity, particularly among different chronotypes.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between chronotype, social jetlag, sleep quality, and academic burnout among nursing students: A cross-sectional study. 护理专业学生的时间型、社会时差、睡眠质量与学业倦怠之间的关系：一项横断面研究

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-09-03 DOI: 10.1080/07420528.2024.2397396

Hamideh Hakimi, Zahra Hosseinkhani, Omid Taherkhani, Maryam Momeni

{"title":"Association between chronotype, social jetlag, sleep quality, and academic burnout among nursing students: A cross-sectional study.","authors":"Hamideh Hakimi, Zahra Hosseinkhani, Omid Taherkhani, Maryam Momeni","doi":"10.1080/07420528.2024.2397396","DOIUrl":"https://doi.org/10.1080/07420528.2024.2397396","url":null,"abstract":"Academic burnout in nursing students is a serious problem worldwide that results in emotional exhaustion, cynicism and low professional efficacy. The aim of the current study was to examine the association between sleep quality and circadian rhythm indicators and academic burnout among Iranian nursing students. This cross-sectional study was conducted on 325 undergraduate nursing students studying at Qazvin University of Medical Sciences between November and February 2023. Data collection was carried out using self-report questionnaires including demographic characteristics, The Pittsburgh Sleep Quality Index (PSQI), reduced-Morningness-Eveningness Questionnaire (r-MEQ), and the Maslach Burnout Inventory-Student Survey (MBI-SS). Social jetlag (SJL) was defined as the absolute value of the difference between the midpoint of sleep on free days (MSF) and the midpoint of sleep on workdays (MSW). Data were analyzed using univariate and multivariate linear regression models. About 31.4% of participants had evening chronotype and almost half of them suffered from poor sleep quality. About 47.7% of the participants had SJL ≥ 2 h. In the multivariate linear regression model, students with evening chronotype compared to morning chronotype experienced more academic burnout in emotional exhaustion, cynicism and professional efficacy. PSQI score was only correlated with emotional exhaustion and cynicism subscales. Increased SJL was a predictor on all three subscales of academic burnout. The findings suggested that evening chronotype, poor sleep quality, and high SJL were associated with increased likelihood of academic burnout in nursing students. Assessment of circadian preference and sleep quality is beneficial for timely identification and prevention of academic burnout in nursing students.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between morningness-eveningness and naturalness bias. 晨昏度与自然度偏差之间的关系。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-08-29 DOI: 10.1080/07420528.2024.2397390

Heng Li

{"title":"The relationship between morningness-eveningness and naturalness bias.","authors":"Heng Li","doi":"10.1080/07420528.2024.2397390","DOIUrl":"https://doi.org/10.1080/07420528.2024.2397390","url":null,"abstract":"The naturalness bias in which people perceive natural items to be safer, healthier, and better than synthetic alternatives has been found to be associated with numerous individual difference variables (e.g. connectedness to nature and religiosity). However, no research has examined the role of morningness-eveningness in influencing preferences for naturalness. Here, we propose that evening individuals may exhibit a weaker preference for naturalness compared to morning individuals due to their greater exposure to artificial lighting, technology, and stimuli. To systematically test our theoretical perspective, we conducted three complementary and high-powered studies. In an online survey (Study 1), student participants with a stronger evening orientation displayed a diminished preference for natural drugs compared to those with a morning orientation. Using a sample of community adults, Study 2 replicated the findings of Study 1 in a real-world, behavioral context. Study 3 examined the relationship between morningness-eveningness and preference for naturalness within the domain of beverages. The results revealed that individuals with an evening-orientation had decreased odds of selecting natural water without minerals. Taken together, the findings suggest that an individual's diurnal preference toward eveningness may have implications for their bias toward and perception of naturalness across various domains.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of shift work on sleep quality, diet quality, and obesity-related factors: A male population study. 轮班工作对睡眠质量、饮食质量和肥胖相关因素的影响：一项男性人口研究。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-08-29 DOI: 10.1080/07420528.2024.2397391

Busra Turan-Demirci, Kubra Isgin-Atici, Suleyman Nahit Sendur, Tomris Erbas, Zehra Buyuktuncer

{"title":"The effects of shift work on sleep quality, diet quality, and obesity-related factors: A male population study.","authors":"Busra Turan-Demirci, Kubra Isgin-Atici, Suleyman Nahit Sendur, Tomris Erbas, Zehra Buyuktuncer","doi":"10.1080/07420528.2024.2397391","DOIUrl":"https://doi.org/10.1080/07420528.2024.2397391","url":null,"abstract":"Recent studies suggest that shift working may trigger health issues through disrupted circadian rhythms and altered eating habits. This study aimed to examine the possible associations of shift work with sleep quality, diet quality and obesity-related parameters. This study was conducted with 150 males (75 shift and daytime workers) aged 24-50 years. Dietary intake was determined using the 24-hour recall method, and dietary quality was evaluated using the Healthy Eating Index-2010 (HEI-2010). Anthropometrical measurements and body composition were assessed. The Pittsburgh Sleep Quality Index was used to evaluate sleep quality. Fasting and postprandial glucose and insulin, and fasting lipid levels were analyzed. HOMA-IR was calculated, and blood pressure was measured. The total HEI-2010 score of shift workers (52.6 [45.4-58.8]) was lower than the daytime workers (55.9 [49.1-64.9]) (p = 0.016). Among individuals with good sleep quality, the total HEI-2010 score, seafood and plant proteins, fatty acids, and sodium scores were lower in shift workers compared to others (p < 0.05 for each). Non-obese shift workers had higher body weight, waist circumference, waist/hip ratio, VLDL-cholesterol, triglyceride, postprandial glucose, and insulin levels compared to daytime workers (p < 0.05 for each). This study demonstrates that shift working is associated with lower diet quality independent of sleep quality.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of social frailty is associated with stability of nonparametric characteristics of the rest-activity rhythm and improvement of the usual walking ability in the elderly. 社会脆弱性的改善与老年人休息-活动节奏非参数特征的稳定和通常行走能力的提高有关。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-08-20 DOI: 10.1080/07420528.2024.2393877

Yu Kume, Ayuto Kodama, Sayaka Arai, Makiko Nagaoka, Akiko Sato, Akira Saito, Hidetaka Ota, Hideaki Ando

{"title":"Improvement of social frailty is associated with stability of nonparametric characteristics of the rest-activity rhythm and improvement of the usual walking ability in the elderly.","authors":"Yu Kume, Ayuto Kodama, Sayaka Arai, Makiko Nagaoka, Akiko Sato, Akira Saito, Hidetaka Ota, Hideaki Ando","doi":"10.1080/07420528.2024.2393877","DOIUrl":"https://doi.org/10.1080/07420528.2024.2393877","url":null,"abstract":"Our study, conducted between April 2022 and January 2024, was aimed at clarifying components of the rest-activity rhythm (RAR) involved in improvement of social frailty state before or after a 3-month multi-component exercise intervention in the elderly. Participants were recruited from the general population in Akita prefecture, Japan. We administered a four-item social frailty screening questionnaire to classify the severity of social frailty in each participant before and after the 3-month intervention. The RAR parameters were measured on an Actiwatch Spectrum Plus device worn by the subjects for 7 continuous days. As the final sample, 65 participants classified into the improved/maintained group (n = 36) or the deteriorated group (n = 29) according to the change in the social frailty classification after the intervention were included in the analysis. The results of a binomial logistic regression analysis showed significantly higher values of interdaily stability (IS) and usual walking speed at the post-test after the intervention. Based on our findings, we propose that stability of the rest-activity rhythm related to synchronization with external stimuli (such as social effect and physical activity) might have clinical impact on improvement of social frailty state in elderly community-dwellers.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daylight exposure and mood in real life: Direct association and mediating role of sleep and routine regularity. 日光照射与现实生活中的情绪：睡眠和作息规律的直接关联和中介作用。

IF 2.2 4区医学

Chronobiology International Pub Date : 2024-08-01 Epub Date: 2024-07-26 DOI: 10.1080/07420528.2024.2381590

Fernanda S Bonatto, Luísa K Pilz, Rogério B Borges, Nicóli B Xavier, André C Tonon, Fernanda G do Amaral, Maria Paz L Hidalgo

{"title":"Daylight exposure and mood in real life: Direct association and mediating role of sleep and routine regularity.","authors":"Fernanda S Bonatto, Luísa K Pilz, Rogério B Borges, Nicóli B Xavier, André C Tonon, Fernanda G do Amaral, Maria Paz L Hidalgo","doi":"10.1080/07420528.2024.2381590","DOIUrl":"10.1080/07420528.2024.2381590","url":null,"abstract":"The light/dark cycle is the main external cue to synchronize the human biological clock. Modern lifestyles typically lead to less daylight exposure and blunted 24 h-amplitude. We evaluated the association of outdoor daylight exposure (frequency, duration, regularity and shift) with chronotype estimated by sleep phase, regularity of routines, sleep, well-being (WHO-5), and depressive symptoms (PHQ-9), in a sample of 1,095 participants (81.8% female; 87.9% aged 18-49) surveyed online between July and November 2020. We analyzed direct and indirect associations in daylight-mood relationship with chronotype-estimate, routine regularity, and sleep as mediators. Outdoor daylight exposure was associated with WHO-5/PHQ-9 scores in mediation models, with higher total effects when the exposure was every day (β = 4.13 ± 0.53/ β = -3.81 ± 0.67), for more than 4 hours (β = 3.77 ± 0.91/ β = -3.83 ± 1.31) and during the morning (β = 3.41 ± 0.53/ β = -3.74 ± 0.70) in reference to lack of exposure. Chronotype-estimate, routine regularity score, and sleep problems acted as mediators, while social jetlag and sleep duration did not play an important role in this association. This study advanced the understanding of the complex interplay between light exposure, mental health, and individual characteristics of sleep and other routine regularities, and showed the benefits of optimizing daylight exposure to improve mental health.","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0