Chronobiology International最新文献

{"title":"Evening minds online: The role of chronotype in digital addiction among patients with bipolar disorder.","authors":"Beyza Erdogan Akturk, Ayse Erdogan Kaya, Eda Aslan","doi":"10.1080/07420528.2025.2546009","DOIUrl":"10.1080/07420528.2025.2546009","url":null,"abstract":"<p><p>Chronotype has been increasingly linked to problematic digital technology use. However, its role among individuals diagnosed with bipolar disorder (BD) is not well studied. This study aimed to examine the association between chronotype and internet, social media, and smartphone addiction in BD patients. The study included 75 BD patients and 50 matched healthy controls (HC). Chronotype was measured using the Morningness - Eveningness Questionnaire (MEQ). Digital addiction was evaluated via the Internet Addiction Test (IAT), Bergen Social Media Addiction Scale (BSMAS), and Nomophobia Questionnaire (NMPQ).The BD group showed significantly higher nomophobia levels compared to the HC group (<i>p</i> = 0.036). Within the BD group, individuals with an evening chronotype had higher IAT and NMPQ scores than their non-evening counterparts (<i>p</i> = 0.008 and <i>p</i> = 0.020), although the difference in DIU was not significant (<i>p</i> = 0.302). In the MEQ scores were negatively correlated with IAT in the BD group (<i>r</i> = -0.255, <i>p</i> = 0.027), and with all addiction-related measures in the HC group. Covariance analysis indicated that the associations between eveningness and both IAT and NMPQ scores remained significant after controlling for DIU (<i>p</i> = 0.01 and <i>p</i> = 0.04) in BD group. Evening chronotype is associated with higher levels of internet addiction and nomophobia, particularly among individuals with BD. Chronotype should be considered a relevant factor in understanding digital addiction patterns in BD patients.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1360-1368"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of social jetlag and chronotype in the relationship between menstrual symptoms and mental health among university students.","authors":"Halime Esra Meram, Ebru Bekmezci, Deniz Kocoglu-Tanyer","doi":"10.1080/07420528.2025.2544845","DOIUrl":"10.1080/07420528.2025.2544845","url":null,"abstract":"<p><p>The mediator factors of the relationship between menstrual symptom severity and mental health are still not well understood. Previous studies have suggested that evening chronotype and social jetlag are associated with poorer physical and mental health. This study aimed to examine the mediating roles of chronotype and social jetlag in understanding the relationship between menstrual symptom severity and mental health. The study was designed according to a predictive correlational model, and a total of 1,064 university students were included. To this end, one-way analysis of variance, path analysis, mediation analysis, and multiple regression analyses were performed. Menstrual symptom severity was significantly lower among morning-type individuals compared to intermediate and evening types. The total effect of the relationship between menstrual symptom severity and mental health level is 0.230. The indirect effects are 0.019 through the chronotype and 0.012 through the social jetlag. Our findings suggest that a morning chronotype may be associated with less severe menstrual symptoms. These results indicate the importance of investigating the effects of reducing chronotype, social jetlag, and menstrual symptom severity to improve the mental health of university students.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1341-1349"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between chrononutrition, sleep behaviours, and glycaemic outcomes in individuals with prediabetes: Findings from the Chrono-DM^TM study.","authors":"Guey Yong Chong, Satvinder Kaur, Ruzita Abd Talib, See Ling Loy, Hui Yin Tan, Rosmiza Binti Abdullah, Hanisah Binti Mahmud, Woan Yie Siah, Lay Kim Tan, Chee Cheong Kee, Hui Chin Koo","doi":"10.1080/07420528.2025.2543298","DOIUrl":"10.1080/07420528.2025.2543298","url":null,"abstract":"<p><p>Little is known about the associations between chrononutrition and sleep behaviours with glycaemic responses. Hence, this study aimed to examine the associations between chrononutrition, sleep behaviours and glycaemic outcomes among adults with prediabetes. This was a cross-sectional study within a prospective longitudinal study in Malaysia. Data on chrononutrition, sleep behaviours and sleep quality were collected using the Malay translated Chrononutrition Profile Questionnaire, Munich Chronotype Questionnaire and Pittsburgh Sleep Quality Index Questionnaire respectively. Anthropometric measurements, body composition assessments and glycaemic measurements were obtained for all participants. Regression models were conducted to explore the associations between chrononutrition, sleep behaviours and glycaemic outcomes. A total of 142 participants with mean age of 54 ± 17 years were recruited. Consuming the first meal after 10.00 am was associated with lower odds of elevated glycaemic outcome (HbA1c ≥ 5.7%) (OR: 0.300, 95% CI: 0.107, 0.841), while having the last meal after 8.00 pm was associated with higher odds of HbA1c ≥ 5.7% (OR: 2.650, 95% CI: 1.125, 6.241). Furthermore, fasting blood glucose was positively associated with extended sleep time (β: 0.101; 95% CI: 0.001, 0.201), while higher 2-h postprandial glucose level was significantly associated with poorer sleep quality (β: 0.093; 95% CI: 0.001, 0.186). These findings demonstrate a positive association between chrononutrition, characterized by delayed meal times, and elevated HbA1c levels in individuals with prediabetes. Furthermore, extended sleep time and poor sleep quality are associated with adverse glycaemic outcomes. These results imply that postponing meal and sleep times may exacerbate glycaemic control. Therefore, further longitudinal and interventional studies are warranted to validate these findings and support the dietary guidelines. Clinicaltrial.gov trial registration: NCT05163964.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1328-1340"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shift work, gut dysbiosis, and circadian misalignment: The combined impact of nighttime light exposure, nutrients, and microbiota rhythmicity.","authors":"Yvan Touitou, Gabriel Perlemuter, Catherine Touitou","doi":"10.1080/07420528.2025.2540039","DOIUrl":"10.1080/07420528.2025.2540039","url":null,"abstract":"<p><p>Disruption of circadian rhythms, particularly in shift workers, has been increasingly associated with a wide range of adverse health outcomes, including metabolic, immune, cardiovascular, and neurobehavioral impairments. This review explores the intricate bidirectional interactions between the circadian clock and the gut microbiota, highlighting how nighttime exposure to artificial light and irregular nutritional timing affect microbial composition, rhythmicity, and microbial-derived metabolite production. We summarize current evidence linking circadian misalignment to gut dysbiosis, inflammation, and metabolic dysfunction, and discuss emerging strategies such as chrononutrition, light modulation, and targeted microbial interventions (e.g. targeted probiotics). Understanding this complex network of light exposure, food intake, circadian regulation, and microbial dynamics could pave the way for personalized preventive and therapeutic strategies in populations vulnerable to circadian disruption, such as night shift workers. These strategies have the potential to mitigate health risks and improve overall well-being in affected individuals.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1275-1290"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrononutrition and sleep patterns in individuals with diabetes mellitus: Assessing misalignments and social jetlag.","authors":"Micaela Rabelo Quadra, Fernanda Olivera Meller, Antônio Augusto Schäfer, Taísa Dimer Hendler, Emilio Luiz Streck","doi":"10.1080/07420528.2025.2552855","DOIUrl":"10.1080/07420528.2025.2552855","url":null,"abstract":"<p><p>The aim was to characterize the chrononutrition and sleep patterns of individuals with Diabetes mellitus (DM) and to assess misalignments and social jetlag. This cross-sectional study included individuals aged 18 years or older, diagnosed with DM. The Chrononutrition Profile Questionnaire was used to assess sleep and chrononutrition preferences and patterns on weekdays, weekends, and weekly. Weekly and weekday misalignments were calculated and presented using histograms. Differences between weekday and weekend patterns (social jetlag) were analysed using paired t-test for symmetrical variables, and the Wilcoxon test for asymmetric variables. In total, 365 individuals were studied. No significant weekly and weekday misalignments in sleep and chrononutrition were found. However, social jetlag was observed. Wake time, first eating event, eating midpoint, and sleep midpoint occurred earlier on weekdays. Lunch latency and eating window were shorter on weekends, and sleep duration was shorter on weekdays. Participants also went to sleep later on the weekends and had a longer morning latency (interval between wake-up and first eating event) on weekdays. In conclusion, interesting social jetlag was identified. These findings are relevant for understanding how sleep and chrononutrition patterns may influence the development or worsening of DM-related complications.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1427-1436"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional differences in the physique of Japanese children: Investigating the influence of seasonal variations in effective day length.","authors":"Masana Yokoya, Yukito Higuchi","doi":"10.1080/07420528.2025.2540049","DOIUrl":"10.1080/07420528.2025.2540049","url":null,"abstract":"<p><p>In the physique of Japanese children may arise from photoperiodic responses. This study aimed to investigate whether the geographical distribution of height and weight in Japanese pre-adolescent children (aged 13 years) can be explained by seasonal variations in effective day length (defined as the duration of daylight with an illuminance of 5000 lX or more). Using the average height and weight of 13-year-old boys and girls in 1993, 2007, and 2020 by prefecture as response variables, and the variation in monthly averages of effective day length over the past 13 years by prefecture as explanatory variables, we conducted a Partial Least Squares (PLS) regression analysis. The regional differences in height and weight were associated with two components of effective day length that exhibited seasonal fluctuations. The scores and loading vectors of these components suggested that, in both summer and winter, short days led to height gain and inhibited weight gain through activation of thyroid hormone-like activity, whereas long days inhibited height gain, promoted weight gain, and induced suppression of thyroid hormone-like activity. The results suggested that the short days of winter particularly contribute to height growth, while the long days of summer are more likely to contribute to weight gain.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1315-1327"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep patterns, circadian rhythms, and hair loss in young adults.","authors":"Qian Wu, Menghuan Li, Yuyun Xiong, Yumei Li, Yun-Wen Zheng, Liping Liu","doi":"10.1080/07420528.2025.2547938","DOIUrl":"10.1080/07420528.2025.2547938","url":null,"abstract":"<p><p>The increasing prevalence of delayed bedtimes and androgenetic alopecia (AGA) among younger individuals raises the question of whether late bedtimes could be a potential risk factor for AGA. This study aimed to investigate the relationship between sleep patterns and AGA in young individuals and explore whether circadian rhythms contribute to the underlying mechanisms. A cross-sectional survey among college students assessed AGA prevalence and chronotype. Circadian rhythms were evaluated through heart rate monitoring using wearable devices, and the expression of key clock genes in hair follicle samples. The results showed that evening chronotype was an independent risk factor for AGA. Severe AGA cases exhibited a significant delay in the acrophase of heart rate compared to non/mild cases, a trend also observed in participants with evening chronotypes. Molecular analysis revealed that severe AGA cases had lower expression of the clock gene <i>PER3</i> and a delayed acrophase shift relative to non/mild AGA. These findings suggest that altered circadian rhythms - manifested by shifts in heart rate patterns and clock gene expression - may help explain the increased risk of AGA observed in individuals with an evening chronotype. While preliminary, the results highlight the possible involvement of circadian mechanisms in the pathophysiology of AGA.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1395-1405"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, rest-activity rhythms, and the Charlson Comorbidity Index in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and Sueño.","authors":"Alexis C Garduno, Sanjay R Patel, Linda C Gallo, Loki Natarajan, Humberto Parada, Linda K McEvoy, Benjamin Smarr, Andrea Z LaCroix","doi":"10.1080/07420528.2025.2547026","DOIUrl":"10.1080/07420528.2025.2547026","url":null,"abstract":"<p><p>This study aimed to investigate the role of sleep and circadian health on disparities in overall disease burden among individuals of Hispanic/Latino heritage with differing nativity backgrounds. This study evaluated associations between self-reported sleep (from HCHS/SOL baseline, 2008-2011) and actigraphy-derived sleep/circadian measures (from Sueño, 2010-2013) with multimorbidity at follow-up (2011-2017). Zero-inflated Poisson regression modeled associations between categorical sleep metrics (e.g. standard cut-off values or tertiles) with a modified Charlson Comorbidity Index (CCI) after accounting for the complex sampling design. This study explored effect modification of sleep-CCI associations to understand potential health disparities by age group, gender, and nativity (non-US-born <10 yrs. 10-20 yrs. +20 yrs. and US-born). Actigraphy-assessed short (short-sleep, IRR:1.48 (95%CI:0.99-2.20)) and long sleep duration (long-sleep, IRR:1.52 (95%CI:0.95-2.43)), and sleep regularity index (T3vs.T1, IRR: 1.43 (95%CI:1.14-1.79)) were individually associated with higher overall multimorbidity 5-6 years later; similar associations were seen utilizing self-reported insomnia symptoms (WHI insomnia score ≥ 9 vs. < 9, IRR:1.23 (95%CI:1.13-1.34)) and excessive daytime sleepiness (ESS score ≥ 11 vs. < 11, IRR:1.10 (0.99-1.21). Tests for the interaction showed differences by nativity (two-sided, <i>p</i> < 0.05). Lower sleep satisfaction, daytime alertness, extreme sleep durations, and fragmented RARs were associated with greater chronic disease burden.<b>STATEMENT OF SIGNIFICANCE</b>Lower sleep satisfaction, extreme sleep durations, and decreased sleep regularity were associated with greater chronic disease burden. Our study expands on previous work in HCHS/SOL and Sueño by investigating a composite measure of disease burden in association with sleep, whereas prior studies in this cohort focused on individual associations between sleep and these chronic diseases.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1369-1383"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>NPAS2</i> gene variants modulate the circadian preference-depression link in Major Depressive Disorder: A mediation role of sleep and somatic symptoms.","authors":"Qinte Huang, Fan Wang, Meiti Wang, Dongbin Lyu, Yiming Chen, Zheyi Wei, Ni Zhou, Chuchen Xu, Wu Hong","doi":"10.1080/07420528.2025.2558107","DOIUrl":"https://doi.org/10.1080/07420528.2025.2558107","url":null,"abstract":"<p><p>Circadian dysregulation is implicated in Major Depressive Disorder (MDD). This study investigated the mediating roles of sleep disturbances and somatic symptoms in the circadian preference-depression relationship and explored moderating effects of <i>NPAS2</i> variants in 257 MDD patients. The Hamilton Rating Scale for Depression (HAMD-17,17-item clinician-rated measure of depression severity), Morningness-Eveningness Questionnaire (MEQ, circadian preference scale), Pittsburgh Sleep Quality Index (PSQI, sleep quality measure), and Depression and Somatic Symptoms Scale (DSSS, somatic symptom inventory) were obtained in all subjects. Genotypes of single nucleotide polymorphisms (SNPs) of <i>NPAS2</i> were determined by the PCR and MassArray SNP sequencing analysis. Spearman's correlation, bootstrap mediation, and moderated mediation analyses revealed that sleep disturbances and somatic symptoms sequentially mediated the circadian preference-depression link (preference→sleep: β = -0.075,<i>p</i> = 0.002; sleep→somatic: β = 0.711,<i>p</i> < 0.001; somatic→depression: β = 0.216,<i>p</i> < 0.001). <i>NPAS2</i> variants moderated these effects: rs3768984 strengthened eveningness-sleep associations (β = 2.944,<i>p</i> < 0.05), while rs3811561 showed similar amplification (β = 3.942,<i>p</i> < 0.05). Rs3768984 additionally moderated the mediation pathway (β = -0.054,95%CI[-0.09,-0.02]). These findings elucidate mechanistic pathways connecting circadian rhythms and MDD, highlighting <i>NPAS2</i> as a genetic moderator, which may inform targeted interventions. Future studies could explore circadian genetic influences on personalized depression interventions.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived stress as a mediator between chronotype and eating disorder symptoms among college students: Cross-sectional and prospective analyses.","authors":"Liping Zhang, Bingna Xu, Yong Yang, Dongfang Wang","doi":"10.1080/07420528.2025.2566722","DOIUrl":"https://doi.org/10.1080/07420528.2025.2566722","url":null,"abstract":"<p><p>The present study aimed to examine whether and how perceived stress mediates the association between chronotype and eating disorder symptoms (ED symptoms), using both cross-sectional and three-wave longitudinal data. A total of 7,892 college students completed three online surveys over one year: 17-29 October 2023 (Time 1, T1),15-24 April 2024 (Time 2, T2), and 16-29 October 2024 (Time 3, T3). Participants completed the reduced version of the Morningness-Eveningness Questionnaire, the 10-item Perceived Stress Scale, the short form of the Eating Disorder Examination Questionnaire, the three items in the Youth Self-Rating Insomnia Scale, and a self-developed demographic questionnaire. Cross-sectional analyses showed that T1 perceived stress partially mediated the relationship between T1 chronotype and T1 ED symptoms, after controlling for demographics and T1 insomnia symptoms. Prospective analyses indicated that T1 chronotype predicted T3 ED symptoms through T2 perceived stress, after controlling for demographics, T1 insomnia symptoms, T1 perceived stress, and T1 ED symptoms. This study highlights perceived stress as a mediator linking chronotype to ED symptoms, suggesting that early identification of evening chronotype and stress-reduction interventions may help prevent ED symptoms in college students.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}