{"title":"Multi-pulse chronotherapeutic approaches for circadian rhythm disease management.","authors":"Sanika Kole, Rutuja Vinchurkar, Rutuja Desai, Prajakta Wagh, Ambar Marne, Harshavardhan Karnik, Ashwini Gawade, Ashwin Kuchekar","doi":"10.1080/07420528.2025.2546008","DOIUrl":null,"url":null,"abstract":"<p><p>This review explores the field of multipulse drug delivery systems, emphasizing their potential to transform drug administration and improve therapeutic outcomes. Multipulse systems provide controlled and sustained medication release by emulating the body's natural rhythms and utilizing advanced technologies such as stimuli-responsive systems, artificial intelligence, and nanotechnology. The review examines the classification, mechanisms, and benefits of multipulse systems, highlighting their significance in chronic disease management and personalized medicine. Integrating artificial intelligence with personalized medicine enables the development of customized drug delivery systems that improve efficacy, reduce side effects, and enhance patient compliance. As we advance toward the era of precision medicine, the combination of technological and pharmaceutical innovations shows great promise for optimizing patient care and treatment outcomes.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1291-1314"},"PeriodicalIF":1.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronobiology International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07420528.2025.2546008","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This review explores the field of multipulse drug delivery systems, emphasizing their potential to transform drug administration and improve therapeutic outcomes. Multipulse systems provide controlled and sustained medication release by emulating the body's natural rhythms and utilizing advanced technologies such as stimuli-responsive systems, artificial intelligence, and nanotechnology. The review examines the classification, mechanisms, and benefits of multipulse systems, highlighting their significance in chronic disease management and personalized medicine. Integrating artificial intelligence with personalized medicine enables the development of customized drug delivery systems that improve efficacy, reduce side effects, and enhance patient compliance. As we advance toward the era of precision medicine, the combination of technological and pharmaceutical innovations shows great promise for optimizing patient care and treatment outcomes.
期刊介绍：
Chronobiology International is the journal of biological and medical rhythm research. It is a transdisciplinary journal focusing on biological rhythm phenomena of all life forms. The journal publishes groundbreaking articles plus authoritative review papers, short communications of work in progress, case studies, and letters to the editor, for example, on genetic and molecular mechanisms of insect, animal and human biological timekeeping, including melatonin and pineal gland rhythms. It also publishes applied topics, for example, shiftwork, chronotypes, and associated personality traits; chronobiology and chronotherapy of sleep, cardiovascular, pulmonary, psychiatric, and other medical conditions. Articles in the journal pertain to basic and applied chronobiology, and to methods, statistics, and instrumentation for biological rhythm study.
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