中国基层医药最新文献

{"title":"Quantitative detection of myocardial edema in acute myocardial infarction based on T2 mapping","authors":"Jie Yu, D. Lin, Xiaohui Huang, Jiajun Xu, Lu Zhou","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.001","url":null,"abstract":"Objective \u0000To investigate the clinical significance of quantitative detection of myocardial edema in acute myocardial infarction based on T2 mapping. \u0000 \u0000 \u0000Methods \u0000From July 2018 to February 2019, a total of 20 patients (observation group) who underwent cardiac MRI after interventional therapy in the People's Hospital of Wenzhou were enrolled.Another 20 healthy volunteers were selected as the control group.The image data of the observation group were collected, and the image data were post-processed.The T2 value, edema area and microcirculation obstacle area of the infarcted myocardium and its contralateral normal myocardium were measured and recorded by the image information.The infarcted myocardium and the contralateral normal myocardium were recorded.The T2 values were compared and the cardiac MRI, cardiac function, serological markers and heart failure related products of the two groups were compared. \u0000 \u0000 \u0000Results \u0000The patients in the observation group underwent self-comparison between infarcted myocardium and normal myocardium.The T2 value of the distal infarcted myocardium was (90.14±.51)ms, which was greater than that of the normal myocardium [(60.71±5.15)ms], the difference was statistically significant(t=8.49, P<0.05). The number of myocardial microvascular obstruction (MVO) in the observation group was 17 cases, which in the control group was 0 cases, the difference was statistically significant (χ2=41.45, P<0.05). The left ventricular end-diastolic volume of the observation group[(88.5±16.2)mL] was higher than that of the control group[(72.4±15.1)mL], and the difference was statistically significant (t=12.51, P<0.05). The ejection fraction of the observation group was (54.1±11.2)%, which was lower than that of the control group [(71.2±7.9)%], and the difference was statistically significant (t=18.71, P<0.05). The T2 value of the observation group was (69.4±6.4)ms, which was higher than that of the control group[(55.2±11.4)ms](t=11.98, P<0.05). The degree of myocardial delayed imaging (LGE) in the observation group was 13%, which in the control group was 0%, the difference was statistically significant (Z=27.62, P<0.05). T2 mapping showed that myocardial infarction sensitivity and positive predictive value were higher, but its specificity was relatively low. \u0000 \u0000 \u0000Conclusion \u0000Quantitative T2 mapping has high clinical value in the evaluation of myocardial edema after acute myocardial infarction.T2 mapping can be used to analyze the extent of lesions in patients with acute myocardial infarction. \u0000 \u0000 \u0000Key words: \u0000Magnetic resonance imaging; Myocardial infarction; Myocardial ischemia; Edema; Creatine kinase; Stroke volume; Troponin; Cardiac imaging techniques","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"769-772"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46822823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation on the effect of craniotomy with large bone flaps on acute craniocerebral trauma and its influence on stress response of patients","authors":"J. Xiong","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.021","url":null,"abstract":"Objective \u0000To investigate the effect of large bone flap craniotomy on acute craniocerebral trauma and its influence on stress response. \u0000 \u0000 \u0000Methods \u0000From January 2015 to December 2018, 80 patients with acute craniocerebral trauma were randomly divided into control group (40 cases) and observation group (40 cases) by random number table method.The patients in the control group were treated with conventional craniotomy and decompression, while the patients in the observation group were treated with craniotomy with large bone flaps.The changes of intracranial pressure, Glasgow coma index (GCS score), stress response index, prognosis and complications after 6 months were compared between the two groups before treatment and 2 weeks after treatment. \u0000 \u0000 \u0000Results \u0000Two weeks after treatment, the intracranial pressure in the observation group [(8.48±2.10)mmHg] was lower than that in the control group [(11.86±1.74) mmHg], while the GCS score[(10.35±1.87)points] was higher than that in the control group [(7.69±1.15)points](t=19.434, 7.663, all P<0.05). Two weeks after treatment, the serum levels of ACTH [(35.19±5.46)mg/L] and cortisol [(17.41±4.56)mg/L] in the observation group were lower than those in the control group [(48.91±4.95)mg/L and (28.93±7.48)mg/L] (t=11.774, 8.317, all P<0.05). Six months after treatment, the prognosis of the observation group(60.00%) was better than that of the control group (32.50%) (χ2=6.084, P<0.05). The incidence of complications of the observation group (5.00%) was lower than that of the control group (22.50%) (χ2=5.165, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Craniotomy with large bone flaps has good effect in the treatment of patients with acute craniocerebral trauma, and can reduce stress response and with fewer complications, which is worthy of clinical reference. \u0000 \u0000 \u0000Key words: \u0000Craniotomy; Decompression, surgical; Craniocerebral trauma; Intracranial pressure; Glasgow coma index; Stress response","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"859-862"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47244078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the influence of special health education and emotional nursing on the cognition and satisfaction of patients with acute myocardial infarction","authors":"Liuxian Xu, Jia Yu, Xiaoying Huang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.027","url":null,"abstract":"目的 \u0000研究专科特色健康教育和情志护理对急性心肌梗死患者疾病认知程度以及满意度的影响。 \u0000 \u0000 \u0000方法 \u0000选取2017年10月至2019年3月杭州市西溪医院心血管内科收治的急性心肌梗死患者50例为研究对象，采用随机数字表法分两组，每组25例。对照组应用常规护理，给予合理的休息和膳食、心理调整和药物治疗，观察组在对照组的基础上实施专科特色健康教育结合情志护理。比较两组患者对疾病的知晓率、护理满意度。 \u0000 \u0000 \u0000结果 \u0000观察组急性心肌梗死患者的疾病知晓率为92.00%，高于对照组的68.00%(χ2＝4.500，P＝0.033)；观察组患者的护理满意度为96.00%，高于对照组的76.00%(χ2＝4.152，P＝0.041)。 \u0000 \u0000 \u0000结论 \u0000在急性心肌梗死患者护理过程中应用专科特色健康教育和情志护理，可以明显提高患者对疾病认知程度以及满意度，值得应用。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"882-884"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48847936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation on the effect of thymus neoadjuvant chemotherapy for non-small cell lung cancer","authors":"Linjian Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.026","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.026","url":null,"abstract":"目的 \u0000观察胸腺法新联合化疗治疗非小细胞肺癌的临床效果及其对患者免疫功能的影响。 \u0000 \u0000 \u0000方法 \u0000选取新野县人民医院2017年1月至2019年1月收治的非小细胞肺癌患者58例，采用随机数字表法分成两组，每组29例。对照组采用紫杉醇、卡铂方案化疗，观察组采用紫杉醇、卡铂方案化疗联合胸腺法新治疗。观察两组临床疗效及免疫功能(CD4＋、CD8＋、CD4＋/CD8＋)的变化。 \u0000 \u0000 \u0000结果 \u0000观察组总有效率为93.1%(27/29)，高于对照组的65.5%(19/29)，差异有统计学意义(χ2＝5.874，P<0.05)。治疗后，观察组CD4＋、CD8＋、CD4＋/CD8＋分别为(52.3±1.6)%、(20.5±1.0)%、(2.6±0.5)，均高于对照组的(44.6±1.7)%、(17.6±1.1)%、(2.3±0.4)，差异均有统计学意义(t＝17.813、10.506、4.515，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000胸腺法新联合紫杉醇、卡铂方案化疗可显著提高非小细胞肺癌患者的治疗效果，改善患者的免疫功能。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"879-881"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49293311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on mycoplasma pneumoniae infection and high-density lipoprotein metabolism","authors":"Luke Kong, Tingting Liu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.030","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.030","url":null,"abstract":"Mycoplasma pneumoniae is a Gram-negative bacterium without cell wall, which mainly invades the respiratory tract and also can cause multi-system damage.Studies have shown that high-density lipoprotein can bind and neutralize lipopolysaccharide in the cell wall of Gram-negative bacteria and phosphoric acid in the cell wall of Gram-positive bacteria, inhibiting inflammation and protecting the body during pathogen infection.Because mycoplasma pneumoniae lacks cell walls, there were almost no studies about high density lipoprotein metabolism changes during mycoplasma pneumoniae infection.This paper will review the research progress of mycoplasma pneumoniae infection and high-density lipoprotein metabolism. \u0000 \u0000Key words: \u0000Mycoplasma pneumoniae; Bacteria; Infection; Cell wall; Teichoic acids; Lipoproteins, HDL; Lipopolysaccharides; Review","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"892-896"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41545666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of deep hydrolyzed protein formula used in feeding premature infants","authors":"Lei Shi, Minglei Han","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.014","url":null,"abstract":"Objective \u0000To investigate the effect of feeding preterm infants with extensively hydrolyzed formula and standard preterm formula on their growth, feeding tolerance and allergic diseases. \u0000 \u0000 \u0000Methods \u0000From October 2018 to April 2019, 84 premature infants admitted to NICU of the Third People's Hospital of Bengbu Affiliated to Bengbu Medical College were selected and randomly divided into observation group and control group, with 42 cases in each group.In the observation group, the preterm infants were fed with extensively hydrolyzed formula.When each feeding amount reached 20 ml, they were fed with concentrated extensively hydrolyzed formula that calorie was equivalent to standard preterm formula.In the control group, the preterm infants were fed with standard preterm formula.The head circumference, length and weight, the time of birth weight recovery, feeding intolerance, the incidence of neonatal necrotizing enterocolitis(NEC), the time to reach full enteral feeding, the length of hospitalization were compared between the two groups.The patients were followed up for 3 months in corrected age, the incidence rates of allergic diseases and extrauterine growth retardation (EUGR) were compared between the two groups. \u0000 \u0000 \u0000Results \u0000Compared with the control group, the observation group had shortened total parenteral nutrition time [(9.32±3.02)d vs.(11.25±3.70)d, t=2.333, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Extensively hydrolyzed formula can shorten the time to total parenteral nutrition, reduce the incidence of feeding intolerance and the incidence of allergic diseases in corrected age of 3 months. \u0000 \u0000 \u0000Key words: \u0000Infant, premature; Enteral nutrition; Enterocolitis, necrotizing; Fetal growth retardation; Extensively hydrolyzed formula; Neonatal necrotizing enterocolitis","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"828-831"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43229986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of edarafone combined with butyphenphthalein soft capsule in the treatment of patients with early acute cerebral infarction and its influence on neuron-specific enolase, S-100β protein and SOD levels","authors":"Hong'e Wang, Lei Dong","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.023","url":null,"abstract":"目的 \u0000探讨依达拉奉联合丁苯酞软胶囊治疗早期急性脑梗死(ACI)的疗效，分析该方法对血清神经元特异性烯醇化酶(NSE)、S-100β蛋白和超氧化物歧化酶(SOD)水平的影响。 \u0000 \u0000 \u0000方法 \u0000选择2017年2月至2018年12月临猗县人民医院神经内科诊疗的急性脑梗死患者96例，按照入院单双号随机标记法分为观察组和对照组各48例，对照组单独使用依达拉奉进行治疗，观察组患者在对照组的基础上联合丁苯酞软胶囊进行治疗；观察并分析治疗前后的NSE、S-100β、SOD水平变化以及美国国立卫生研究院卒中量表(NI-HSS)的评分变化。 \u0000 \u0000 \u0000结果 \u0000治疗前两组NSE、S-100β及SOD水平差异无统计学意义(P>0.05)；治疗后观察组血清NSE(6.29±1.72)μg/L、S-100β(3.73±1.56)μg/L，均低于治疗前，且均低于对照组(t＝3.769、3.317，均P<0.001)；治疗后观察组SOD(42.38±7.32)μg/L，明显高于对照组(t＝3.533，P<0.05)；观察组总有效治疗率为97.92%，高于对照组的75.00%(χ2＝10.766，P<0.001)。 \u0000 \u0000 \u0000结论 \u0000使用依达拉奉联合丁苯酞软胶囊进行对ACI进行治疗，可有效提高ACI的临床治疗效果，进一步保证早期急性脑梗死患者的术后恢复，值得在相关疾病诊治中推广。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"868-871"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47371080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and clinical significance of microRNA-126, microRNA-155, Klotho protein and TGF-β1 protein in peripheral blood of patients with essential hypertension","authors":"Junchong Chen","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.007","url":null,"abstract":"Objective \u0000To investigate the expression of microRNA-126, microRNA-155, Klotho protein and transforming growth factor-β1 (TGF-β1) in peripheral blood of patients with essential hypertension. \u0000 \u0000 \u0000Methods \u0000From December 2015 to December 2018, 80 patients with essential hypertension admitted to Lishui Central Hospital were selected in the study, and 80 healthy people from Lishui Central Hospital from December 2015 to December 2018 were selected as the control group.The expressions of microRNA-126 and microRNA-155 were detected by RT-PCR, and the expressions of Klotho and TGF-β1 were detected by ELISA.The changes of systolic and diastolic blood pressure, the expressions of microRNA-126 and microRNA-155 in peripheral blood, Klotho protein and TGF-β1 protein were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The expression of microRNA-126 (0.23±0.07) and microRNA-155 (0.84±0.14) in peripheral blood of the hypertension group was lower than that of the control group [(1.16±0.24) and (1.37±0.21)] (t=33.273, 18.782, all P<0.05). The serum levels of Klotho protein in the hypertension group[(123.42±9.47)ng/L] was lower than that in the control group [(143.56±14.68)ng/L], while the serum level of TGF-β1 protein the hypertension group[(561.32±58.39)ng/L] was higher than that in the control group [(408.97±25.13)ng/L] (t=10.312, 21.436, allP<0.05). \u0000 \u0000 \u0000Conclusion \u0000The expression of microRNA-126 and microRNA-155 in peripheral blood of patients with essential hypertension is down-regulated, and the expression of Klotho protein and TGF-β1 protein is up-regulated, which has certain guiding significance for clinical diagnosis and treatment. \u0000 \u0000 \u0000Key words: \u0000Hypertension; MicroRNA-126; MicroRNA-155; Klotho protein; Transforming growth factor β1","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"795-798"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43237976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study on the safety of dexmedetomidine withdrawal in patients undergoing mechanical ventilation after cardiopulmonary bypass in ICU","authors":"Junqiao He","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.013","url":null,"abstract":"Objective \u0000To compare the safety of dexmedetomidine and midazolam in weaning mechanical ventilation patients after cardiopulmonary bypass (CPB) in ICU. \u0000 \u0000 \u0000Methods \u0000From August 2016 to December 2018, 51 patients admitted to the People's Hospital of Jinhua for mechanical ventilation after ICU CPB cardiac surgery were randomly divided into dexmedetomidine group and midazolam group according to the numerical table method.During mechanical ventilation, dexmedetomidine was used to sedate the study group(26 cases), and midazolam was used in the control group (25 cases). The total time of mechanical ventilation, CPOT score, ICDSC score, incidence of sinus bradycardia during mechanical ventilation were counted, and the anterograde amnesia was observed after extubation.The safety and related factors of drug withdrawal in patients undergoing mechanical ventilation after CPB surgery of two different sedations were compared and evaluated. \u0000 \u0000 \u0000Results \u0000Statistical analysis showed that the CPOT score of the dexmedetomidine group was (1.04±0.45)points, which was significantly lower than that of the midazolam group[(2.24±0.83)points], the difference was statistically significant between the two groups(t=-6.40, P 0.05). The total time of mechanical ventilation was (29.71±17.96)h in the dexmedetomidine group and (26.13±20.02)h in the midazolam group, there was no statistically significant difference between the two groups(t=0.67, P>0.05). During mechanical ventilation sedation, the dexmedetomidine group had more bradycardia, the difference was statistically significant(χ2=11.96, P<0.01). There was no anterograde amnesia in the dexmedetomidine group, but all of the patients in the midazolam group had anterograde amnesia. \u0000 \u0000 \u0000Conclusion \u0000Compared with the midazolam group, the CPOT score was lower in the dexmedetomidine sedation group with the same SAS score of 4(superficial sedation), which in line with the principles of \" deep analgesia, shallow sedation\". Although bradycardia occurs during the use of drugs, it can recover spontaneously after withdrawal and is safe to use. \u0000 \u0000 \u0000Key words: \u0000Extracorporeal circulation; Cardiac surgical procedures; Respiration, artificial; Bradycardia; Dexmedetomidine; Midazolam","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"824-827"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43078780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significane of two-dimensional speckle tracking technique in the evaluation of diagnosis and prognosis of heart failure with left ventricular ejection fraction preservation","authors":"Jianxiang Yang, Jingbin Yan, Jian-hua Zheng","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.011","url":null,"abstract":"Objective \u0000To observe the clinical effect of two-dimensional speckle tracking technique in diagnosis and prognosis evaluation of heart failure with left ventricular ejection fraction preservation. \u0000 \u0000 \u0000Methods \u0000A total of 64 heart failure patients with reduced left ventricular ejection fraction (HFNEF) and 64 healthy volunteers in the Integrated Traditional Chinese and Western Medicine Hospital of Wenzhou were selected from July 2016 to July 2018.Conventional echocardiography and two-dimensional speckle tracking were performed in all subjects.The hemodynamic parameters and strain parameters of two-dimensional speckle tracking were recorded.The differences of conventional echocardiographic parameters and two-dimensional speckle tracking strain parameters in different subjects were analyzed. \u0000 \u0000 \u0000Results \u0000The E/A (0.79±0.24) and E/E' value (18.93±3.41) in HFNEF patients had statistically significant differences compared with healthy subjects [(1.28±0.35) and (6.84±1.37)] (t=9.507, 23.294; P=0.000, 0.000). There were no statistically significant differences in HR, LAD, LVD, LVSD, LVPWD, LVEF and LVFS between HFNEF patients [(71.37±5.93)times/min, (35.32±4.37)mm, (47.13±5.01)mm, (9.24±1.76)mm, (9.35±1.82)mm, (63.98±5.37)%, (35.49±4.46)%] and healthy subjects [(70.14±5.28)times/min, (37.64±4.69)mm, (49.26±5.54)mm, (9.39±1.82)mm, (9.48±1.90)mm, (66.35±5.41)%, (34.02±4.17)%] (t=0.384-1.628; P=0.102-0.564). In HFNEF patients, the anterior septum, anterior wall, posterior wall, inferior wall and posterior wall of apical segment of left ventricle, the inferior wall and posterior wall of papillary muscle and the posterior wall, inferior wall and posterior wall of basal segment, SRs and ROT of left ventricle were significantly lower than those of healthy subjects, while GLS (-13.52±4.18) and GCS (-10.43±3.85) of left ventricle in HFNEF patients were significantly higher than those of healthy subjects [(-19.89±4.61) and (-15.67±4.24)] (t=8.947~14.063; P=0.000-0.000<0.05). After treatment, the clinical symptoms of HFNEF patients improved significantly in the whole apical segment of left ventricle, inferior and posterior wall of papillary muscle segment, posterior lateral wall, inferior wall, posterior wall SRs and left ventricular GLS, GCS and ROT (t=7.258-13.193; P=0.000-0.000<0.05). Two-dimensional strain GLS and GC values in HFNEF patients were negatively correlated with E/A values and positively correlated with E/E' value (r=-0.817, -0.763; P=0.004, 0.012<0.05), while two-dimensional strain ROT results were positively correlated with E/A values and negatively correlated with E/E' values (r=-0.805, -0.759; P=0.006, 0.014<0.05). \u0000 \u0000 \u0000Conclusion \u0000Left ventricular systolic function damage has occurred in HFNEF patients.Two-dimensional speckle tracking technique is highly sensitive to the changes of myocardial systolic function for HFNEF patients.It has high clinical value in the diagnosis and prognosis evaluation of HFNEF.Relevant clinical workers should pay a","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"813-818"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45365267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}