Clinical observation of deep hydrolyzed protein formula used in feeding premature infants

Objective To investigate the effect of feeding preterm infants with extensively hydrolyzed formula and standard preterm formula on their growth, feeding tolerance and allergic diseases. Methods From October 2018 to April 2019, 84 premature infants admitted to NICU of the Third People's Hospital of Bengbu Affiliated to Bengbu Medical College were selected and randomly divided into observation group and control group, with 42 cases in each group.In the observation group, the preterm infants were fed with extensively hydrolyzed formula.When each feeding amount reached 20 ml, they were fed with concentrated extensively hydrolyzed formula that calorie was equivalent to standard preterm formula.In the control group, the preterm infants were fed with standard preterm formula.The head circumference, length and weight, the time of birth weight recovery, feeding intolerance, the incidence of neonatal necrotizing enterocolitis(NEC), the time to reach full enteral feeding, the length of hospitalization were compared between the two groups.The patients were followed up for 3 months in corrected age, the incidence rates of allergic diseases and extrauterine growth retardation (EUGR) were compared between the two groups. Results Compared with the control group, the observation group had shortened total parenteral nutrition time [(9.32±3.02)d vs.(11.25±3.70)d, t=2.333, P 0.05). Conclusion Extensively hydrolyzed formula can shorten the time to total parenteral nutrition, reduce the incidence of feeding intolerance and the incidence of allergic diseases in corrected age of 3 months. Key words: Infant, premature; Enteral nutrition; Enterocolitis, necrotizing; Fetal growth retardation; Extensively hydrolyzed formula; Neonatal necrotizing enterocolitis