中国基层医药最新文献

{"title":"Characteristics and treatment of methadone maintenance therapy in Pingdingshan city, Henan province","authors":"Xiaoling Duan, G. Ma","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.024","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.024","url":null,"abstract":"目的 \u0000了解平顶山市参加美沙酮维持治疗(MMT)人群的基本特征、治疗依从性以及脱失原因，为提高门诊治疗效率提供依据。 \u0000 \u0000 \u0000方法 \u0000统计平顶山市疾病预防控制中心药物维持治疗中心2017年12月以来首次入组的阿片类物质成瘾者信息，对其人口学特征、既往毒品使用情况和MMT治疗情况进行描述性分析，并用回归模型分析维持率的影响因素。 \u0000 \u0000 \u0000结果 \u0000首次入组MMT的鸦片或海洛因成瘾者共141例。男女比例为3.86∶1；年龄(43.96±8.05)岁；未婚、离异或丧偶82例，占58.16%；初中及以下文化程度94例，占66.67%；初次吸毒年龄为(25.06±6.34)岁；吸毒时间(9.07±6.48)年，最短5个月，最长27年；单纯使用阿片类者134例，占95.04%；曾有毒品注射行为者26例，占18.44%。治疗期间平均服药剂量为(69.54±25.07)mL。MMT维持率为40.43%(57/141)。MMT维持率在文化程度高、居住地离门诊近、交通方便、吸毒时间长、日均服药剂量大的患者中较高。 \u0000 \u0000 \u0000结论 \u0000平顶山市MMT患者以男性、非在婚状态者、初中及以下文化程度者为主，与其他地区一致。提高维持率需增设服务延伸点，应关注低文化、吸毒时间短、服药剂量小的人群。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"872-875"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48954453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and clinical significance of endostatin and angiostatin in pterygium","authors":"Jinrong Zhao, Weiwei Chen, Zhongping Jin, Zheng Zhang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.006","url":null,"abstract":"Objective \u0000To investigate the expression and clinical significance of endostatin (ES) and angiostatin (AS) in pterygium. \u0000 \u0000 \u0000Methods \u0000From January 2016 to December 2018, 60 cases (60 eyes) of pterygium tissue and 60 cases (60 eyes) of normal human conjunctival tissue were selected from the eye surgery of Traditional Chinese Medicine Hospital of Yiwu.HE staining was used to observe the morphological changes of pterygium and normal conjunctival tissue.Western blot was used to measure ES and AS protein levels in the tissues of pterygium group and control group. \u0000 \u0000 \u0000Results \u0000HE staining showed that in the normal bulbar conjunctival tissue, the stromal layer was connective tissue and the epithelial layer was columnar epithelium; in the pterygium, the basal layer had a large number of new blood vessels, fibroblasts, collagen fibers, and inflammatory cells infiltrated around the blood vessels; the epithelium showed different degrees of hyperplasia.The protein levels of ES and AS in pterygium tissues[(0.35±0.12), (0.62±0.17)] were higher than those in the control group [(0.13±0.08), (0.16±0.09)](t=11.816, 18.524, P=0.000, 0.000). The protein levels of ES and AS in the pterygium tissues of the recurrent group [(0.63±0.15), (0.87±0.21)] were higher than those in the initial group [(0.22±0.11), (0.45±0.16)](t=17.073, 12.323, P=0.000, 0.000). There was positive correlation between ES and AS in pterygium (r=0.571, P=0.000). \u0000 \u0000 \u0000Conclusion \u0000The levels of ES and AS in pterygium tissue are increased, and ES and AS may be involved in the occurrence and recurrence of pterygium. \u0000 \u0000 \u0000Key words: \u0000Pterygium; Inhibins; Angiostatins; Endothelial cells; Recurrence","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"791-794"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44135307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of implementation of VIP in obstetric ward on the quality of nursing management","authors":"L. Chen","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.028","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.028","url":null,"abstract":"目的 \u0000分析产科病房开展贵宾式(VIP)护理模式对产妇分娩的影响和临床应用价值。 \u0000 \u0000 \u0000方法 \u0000选取义乌中心医院2017年1月至2018年12月住院分娩的产妇250例，根据护理方法不同分为对照组125例和观察组125例。对照组采取常规产科护理，观察组采取VIP产科护理模式，分析两组患者护理效果。 \u0000 \u0000 \u0000结果 \u0000观察组第一产程时间(321.13±28.91)min，第二产程时间(23.25±8.66)min，第三产程时间(6.12±1.02)min，总产程时间(259.18±36.03)min，均短于对照组，差异均有统计学意义(t＝11.308、13.874、12.194、15.879，均P<0.05)。观察组产后出血量(171.43±19.06)mL，疼痛评分(1.78±1.01)分，住院时间(4.02±1.12)d，护理满意度评分(95.13±3.76)分，剖宫产率12.80%，与对照组比较差异均有统计学意义(t＝14.438、12.398、14.392、15.093、χ2＝4.013，均P<0.05)。观察组发生产褥期感染2例，宫颈裂伤1例，产后尿潴留4例，新生儿窒息0例；对照组发生产褥期感染11例，宫颈裂伤13例，产后尿潴留16例，新生儿窒息6例，两组差异均有统计学意义(χ2＝3.478、3.917、4.018、4.881，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000产科病房开展VIP护理模式可以缩短产程和住院时间，减少产后出血量和围生期并发症，降低剖宫产率。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"885-887"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45981544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and analysis of syphilis antibody in 80 478 cases of inpatients","authors":"Honghong Su, Chen Gong, Jinhu Wang, Cao Ji-jun, Yong Li, Yuemei Zhang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.002","url":null,"abstract":"Objective \u0000To understand the infection and distribution of syphilis in hospitalized patients, thus to provide reference for syphilis prevention and control. \u0000 \u0000 \u0000Methods \u0000TP-ELISA test was used to examine early syphilis antibody, and adopted the TPPA test to validation syphilis antibody, and TRUST was used to determine the titer of syphilis antibody in 80 478 hospitalized patients from January 2015 to November 2017, then the results were retrospectively analyzed. \u0000 \u0000 \u0000Results \u0000Among 80 478 inpatients, 1 326 cases were positive by TP-ELISA test(1 223 cases positive, 101 cases weak positive and 2 cases negative by TPPA confirmed). The positive rates of TP-ELISA in different years were 1.62%(445/27 394), 1.72%(490/28 412) and 1.58%(389/24 672), respectively, and the difference was not statistically significant(P>0.05). The positive rates of male and female patients were 2.02%(689/33 985) and 1.37%(635/46 479), and the difference was statistically significant(χ2=52.91, P=0.00). The positive rates of ≤18 years old, >18-59 years old, >59-79 years old and>79 years old were 0.32%(7/2 161), 1.44%(765/53 001), 2.31%(488/21 163) and 1.50%(62/4 153), respectively.The highest proportion of syphilis patients was in the group of >59-79 years old, and the differences were statistically significant compared with the other groups(χ2=37.08, 67.05, 10.80, all P<0.01). Among the TP-ELISA positive patients, 54.90%(728/1 326) had TRUST titer negative, 36.50%(484/1 326) had titer less than 1∶8, and the others had 8.44%(112/1 326). \u0000 \u0000 \u0000Conclusion \u0000The incidence of syphilis was higher in males than in females in 80 478 hospitalized patients.The highest positive rate was found in >59-79 years old group, and the number of elderly cases increased rapidly.Therefore, the effective interventions should be developed to control the transmission of syphilis according to the epidemiological features. \u0000 \u0000 \u0000Key words: \u0000Inpatients; Syphilis; Antibodies; Syphilis serodiagnosis; Enzyme-linked immunosorbent assay; Agglutination tests; False positive reactions; Laboratory techniques and procedures","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"773-775"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49430342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of 42 primary hyperthyroidism patients complicated with thyroid microcarcinoma","authors":"Yan Cheng, Lingcheng Wang, Yaqiong Li, D. Cheng","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.016","url":null,"abstract":"Objective \u0000To analyze the clinical data of primary hyperthyroidism patients complicated with thyroid microcarcinoma, and to guide clinical diagnosis and treatment. \u0000 \u0000 \u0000Methods \u0000From January 2013 to March 2019, the clinical data of 42 cases of hyperthyroidism with thyroid microcarcinoma(study group) and 410 cases of thyroid microcarcinoma without hyperthyroidism(control group) who underwent surgical treatment in the People's Hospital Affiliated to Hubei University of Medicine were retrospectively analyzed.The epidemiological characteristics, clinical diagnosis and treatment, clinical stage, B-ultrasound characteristics, thyroid function and antibody, pathological data and prognosis of the two groups were compared. \u0000 \u0000 \u0000Results \u0000In study group and control group, the proportion of microcalcification detected by B-ultrasonography was 61.9%(26/42) and 33.4%(137/410), respectively, the difference was statistically significant between the two groups(χ2=13.411, P<0.05). In study group and control group, 47.62%(20/42) and 69.02%(283/410) of multifocal nodules were detected by B-ultrasound, the difference was statistically significant between the two groups(χ2=7.899, P<0.05). The diagnostic rates of intraoperative frozen-section examination of the study group and the control group were 61.9%(26/42) and 66.1%(271/410), respectively, the difference was statistically significant between the two groups(χ2=4.460, P<0.05). The lymph node metastasis rates of the study group and the control group were 9.5%(4/42) and 26.8%(110/410), respectively, the difference was statistically significant between the two groups(χ2=6.049, P<0.05). The middle follow-up period was 37 months(1 month to 74 months). There was no recurrence of thyroid cancer in the study group, 2 cases with recurrence of hyperthyroidism after operation, and 3 cases with recurrence in the control group, with secondary surgical resection.There were no deaths in the two groups during follow-up. \u0000 \u0000 \u0000Conclusion \u0000Thyroid cancer should be paid attention to when hyperthyroidism combined with nodules, but the prognosis of hyperthyroidism with microcarcinoma is better.The operation method tends to be bilateral lobectomy, which can prevent the recurrence of hyperthyroidism.In order to reduce the chance of parathyroid gland and recurrent laryngeal nerve injury, there may be no need of preventive lymph node dissection in area VI. \u0000 \u0000 \u0000Key words: \u0000Hyperthyroidism; Thyroid neoplasms; Epidemiology; Ultrasonography; Pathology, clinical; Calcium compounds; Neoplasm staging; Lymphatic metastasis; Prognosis","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"836-840"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48617022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of efficacy and safety of new oral anticoagulants in the treatment of elderly patients with non-valvular atrial fibrillation","authors":"Zhidi Li","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.022","url":null,"abstract":"Objective \u0000To investigate the efficacy and safety of new oral anticoagulants in the treatment of elderly patients with non-valvular atrial fibrillation. \u0000 \u0000 \u0000Methods \u0000From March 2016 to September 2018, 176 elderly patients with non-valvular atrial fibrillation admitted to Lyucheng Cardiovascular Hospital of Zhejiang Province were selected and divided into warfarin group(56 cases), dabiga group(64 cases) and rivaroxaban group(56 cases) according to the treatment conditions.All three groups were treated for 6 months.The incidence of embolism and bleeding events, the changes of blood sugar and liver, kidney function before and after treatment in three groups were compared. \u0000 \u0000 \u0000Results \u0000The incidence rates of thromboembolism in the warfarin group, dabiga group and rivaroxaban group were 7.14%(4/56), 1.56%(1/64), 3.57%(2/56), respectively, there was no statistically significant difference among the three groups(U=2.457, P>0.05). The incidences of bleeding in the warfarin group, dabiga group and rivaroxaban group were 16.07%(9/56), 3.13%(2/64), 1.79%(1/56), respectively, there was statistically significant difference among the three groups(U=11.090, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Compared with warfarin, the new oral anticoagulant dapigatron ester and rivaroxaban have similar effects in preventing stroke and thromboembolism in elderly patients with non-valvular atrial fibrillation, while the risk of bleeding events during the administration of dapigatron ester and rivaroxaban is lower, suggesting that the new oral anticoagulant is effective in the treatment of stroke and thromboembolism in elderly patients with non-valvular atrial fibrillation.The therapy has high efficacy and safety, which is worthy of clinical promotion. \u0000 \u0000 \u0000Key words: \u0000Atrial fibrillation; Anticoagulants; Warfarin; Dabicarbonate; Rivaroxaban; Safety; Aged","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"863-867"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44418620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of PVA artery embolization through coaxial microcatheter in the treatment of massive hemoptysis","authors":"Bo Jia, Jian Li","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.025","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.025","url":null,"abstract":"目的 \u0000探讨同轴微导管技术聚乙烯醇(PVA)颗粒栓塞支气管动脉治疗大咯血的有效性、安全性。 \u0000 \u0000 \u0000方法 \u0000选取浙江普陀医院2015年8月至2019年10月收治的咯血患者42例为研究对象，对患者行支气管动脉及其它责任血管造影，并根据术中造影结果选用PVA颗粒行栓塞治疗，术后随访1～12个月，对栓塞治疗效果、安全性进行评价。 \u0000 \u0000 \u0000结果 \u000042例患者栓塞后24 h内咯血症状消失；5例患者在术后1～12个月行2～3次介入术后症状消失；1例患者行3次介入术后仍有间断性咯血。患者术中均未出现异位栓塞情况。 \u0000 \u0000 \u0000结论 \u0000同轴微导管技术PVA颗粒栓塞供血动脉能有效制止咯血，明显减少栓塞后血管再通，栓塞过程中及栓塞后无明显严重并发症。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"876-878"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42370897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of stent-assisted and non-stent-assisted coils in the treatment of ruptured wide-necked anterior communicating artery aneurysm in acute stage","authors":"Lin Shi, Yang Zhan, Xuetong Sun","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.018","url":null,"abstract":"Objective \u0000To compare the safety and efficacy of stent-assisted and non-stent-assisted coil embolization in the treatment of anterior communicating ruptured wide-necked aneurysms in acute phase. \u0000 \u0000 \u0000Methods \u0000The clinical data of 76 patients with anterior traffic rupture wide-necked aneurysm treated by interventional embolism from January 2014 to December 2018 were collected in the People's Hospital of Dezhou.According to whether or not stents were assisted during the operation, 76 cases were divided into stent group (41 cases) and non-stent group (35 cases). The stent group selected the Solitaire AB neurovascular remodoring device or the LVIS support for the corresponding size according to the diameter of the patients’ artery, and the non-stent group used a single catheter, a double catheter, or a balloon assist.The perioperative complications, mortality and clinical prognosis between the two groups were compared. \u0000 \u0000 \u0000Results \u0000There were no statistically significant differences in bleeding complications, symptomatic vasospasm, mortality and clinical prognosis between the two groups (all P>0.05). The incidence of ischemic complications in the stent group was 17.07%(7/41), which was significantly higher than that in the non-stent group[2.86%(1/35)](χ2=4.052, P<0.05). The overall complication rate of the stent group was 21.95%(9/41), which was significantly higher than 5.71%(2/35) of the non-stent group (χ2=4.021, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Both stent-assisted and non-stent-assisted coils can achieve good clinical results in the treatment of anterior communicating ruptured wide-necked aneurysms in acute phase.Stent-assisted embolism has a high incidence of ischemic complications and needs caution in clinical application. \u0000 \u0000 \u0000Key words: \u0000Intracranial aneurysm; Subarachnoid hemorrhage; Embolization, therapeutic; Tissue scaffolds; Postoperative complications; Prognosis","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"846-849"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46018440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of transcranial Doppler ultrasonography combined with carotid ultrasonography in the diagnosis of vertebral-basilar artery stenosis","authors":"Jie-Wei Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.005","url":null,"abstract":"Objective \u0000To investigate the clinical value of transcranial Doppler ultrasound(TCD) combined with carotid ultrasound in the diagnosis of vertebral-basilar artery stenosis. \u0000 \u0000 \u0000Methods \u0000From March 2016 to December 2018, 147 patients with suspected vertebrobasilar artery stenosis admitted to the People's Hospital of Zhuji were selected.TCD combined with carotid artery ultrasonography were used to diagnose vertebrobasilar artery stenosis, and X-ray computed tomography angiography (CTA) was performed.The diagnostic accuracy of TCD combined with carotid artery ultrasonography for vertebrobasilar artery stenosis was analyzed based on the results of CTA. \u0000 \u0000 \u0000Results \u0000The diagnostic value of TCD combined with carotid ultrasound for vertebrobasilar artery stenosis was analyzed by using CTA as diagnostic gold standard.The diagnostic sensitivity for left vertebral artery was 86.42%, specificity was 89.39%, positive predictive value was 90.91%, negative predictive value was 84.29%.The diagnostic sensitivity for right vertebral artery was 80.26%, specificity was 90.14%, positive predictive value was 89.71%, negative predictive value was 81.01%.The sensitivity, specificity, positive predictive value and negative predictive value for basilar artery were 81.69%, 93.42%, 92.06% and 84.52%.respectively.There were no statistically significant differences between TCD combined with carotid ultrasound and CTA in the diagnosis of left vertebral artery, right vertebral artery and basilar artery stenosis (Z=-0.360, -0.851, -0.828, all P>0.05). \u0000 \u0000 \u0000Conclusion \u0000TCD combined with carotid ultrasonography is an effective screening method for patients with vertebrobasilar artery stenosis, which is helpful to the detection of patients' condition and the guidance of clinical treatment, and is worthy of clinical application. \u0000 \u0000 \u0000Key words: \u0000Ultrasonography, doppler, transcranial; Ultrasonography, doppler, color; Basilar artery; Vertebral artery; Carotid arteries; X-ray computed tomography angiography; Intracranial atherosclerotic stenosis","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"786-790"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43955926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the correlation between plasma NT-proBNP, hs-CRP, cTnI, CA125 and cardiac function in patients with acute heart failure","authors":"Jinhua Chen, Yilin Zhang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.010","url":null,"abstract":"Objective \u0000To investigate the relationship between plasma N-terminal B-type natriuretic peptide precursor (NT-proBNP), hypersensitive C-reactive protein (hs-CRP), troponin Ⅰ (cTnⅠ) and carbohydrate antigen 125 (CA125) and cardiac function in patients with acute heart failure. \u0000 \u0000 \u0000Methods \u0000From May 2017 to May 2019, 97 patients with acute heart failure admitted to Hangzhou Dajiangdong Hospital were selected as the observation group.According to the cardiac function classification of New York Heart Association (NYHA), 29 patients were classified as grade Ⅱ group, 51 patients as grade Ⅲ group and 17 patients as grade Ⅳ group.Fifty healthy people were selected as control group.The changes of plasma NT-proBNP, hs-CRP, cTnⅠ and CA125 levels, left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were compared between the two groups.The changes of plasma NT-proBNP, hs-CRP, cTnⅠ and CA125 levels, as well as the changes of LVED and LVEF in the different heart function grading group were compared.The correlation between plasma NT-proBNP, hs-CRP, cTnⅠ, CA125 and LVEDD, LVEF was analyzed. \u0000 \u0000 \u0000Results \u0000The plasma NT-proBNP[(5 684.21±174.39)ng/L], hs-CRP[(16.54±3.27)mg/L], cTnⅠ[(0.43±0.13)g/L] and CA125[(83.24±15.46)U/mL] in the observation group were higher than those in the control group(t=216.813, 25.684, 19.432, 34.138, all P<0.05). The LVEDD in the observation group[(63.21±4.87)mm] was higher than that in the control group[(48.97±2.41)mm], and the LVEFin the observation group[(39.27±3.25)%] was lower than that in the control group[(62.87±4.36)%], the differences were statistically significant (t=19.461, 37.008, all P<0.05). The levels of NT-proBNP[(7 368.18±201.05)ng/L], hs-CRP[(24.19±4.18)mg/L], cTnⅠ[(0.63±0.14)μg/L] and CA125[(164.52±27.48)U/mL] in the grade Ⅳ group were higher than those in the grade Ⅱ group and grade Ⅲ group(grade Ⅲ group: t=31.109, 6.557, 5.321, 13.017; grade Ⅱ group: t=75.873, 16.582, 11.755, 23.178, all P<0.05). The plasma NT-proBNP[(5 751.42±180.34)ng/L], hs-CRP[(15.98±4.56)mg/L], cTnⅠ[(0.41±0.15)g/L] and CA125[(87.97±18.45)U/mL] in the grade Ⅲ group were higher than those in the grade Ⅱ group[(3 481.34±145.26)ng/L, (8.23±2.37)mg/L, (0.25±0.08)μg/L and (28.43±12.21)U/mL](t=57.893, 8.507, 5.320, 15.530, all P<0.05). The LVEDD[(67.95±5.15)mm] in the grade Ⅳ group was higher than that in the grade Ⅱ group and grade Ⅲ group(grade Ⅲ group: t=3.553, grade Ⅱ group: t=8.157, P<0.05), while the LVEF[(34.28±2.36)%] in the grade Ⅳ group was lower than that in the grade Ⅱ group and grade Ⅲ group(grade Ⅲ group: t=6.673, grade Ⅱ group: t=10.417, all P<0.05). The LVEDD[(62.78±5.21)mm] in the grade Ⅲ group was higher than that in the grade Ⅱ group[(57.87±3.25)mm](t=4.586, P<0.05), while the LVEF in the grade Ⅲ group[(39.98±3.24)%] was lower than that in the grade Ⅱ group[(45.98±4.25)%](t=7.097, P<0.05). LVEDD was positively correlated with NT-proBNP, hs-CRP, cTnⅠ and CA125, while LVEF was negatively correl","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"808-812"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43982926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}