Clinical observation of deep hydrolyzed protein formula used in feeding premature infants

中国基层医药 Pub Date : 2020-04-01 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.07.014

Lei Shi, Minglei Han

{"title":"Clinical observation of deep hydrolyzed protein formula used in feeding premature infants","authors":"Lei Shi, Minglei Han","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.014","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the effect of feeding preterm infants with extensively hydrolyzed formula and standard preterm formula on their growth, feeding tolerance and allergic diseases. \n \n \nMethods \nFrom October 2018 to April 2019, 84 premature infants admitted to NICU of the Third People's Hospital of Bengbu Affiliated to Bengbu Medical College were selected and randomly divided into observation group and control group, with 42 cases in each group.In the observation group, the preterm infants were fed with extensively hydrolyzed formula.When each feeding amount reached 20 ml, they were fed with concentrated extensively hydrolyzed formula that calorie was equivalent to standard preterm formula.In the control group, the preterm infants were fed with standard preterm formula.The head circumference, length and weight, the time of birth weight recovery, feeding intolerance, the incidence of neonatal necrotizing enterocolitis(NEC), the time to reach full enteral feeding, the length of hospitalization were compared between the two groups.The patients were followed up for 3 months in corrected age, the incidence rates of allergic diseases and extrauterine growth retardation (EUGR) were compared between the two groups. \n \n \nResults \nCompared with the control group, the observation group had shortened total parenteral nutrition time [(9.32±3.02)d vs.(11.25±3.70)d, t=2.333, P 0.05). \n \n \nConclusion \nExtensively hydrolyzed formula can shorten the time to total parenteral nutrition, reduce the incidence of feeding intolerance and the incidence of allergic diseases in corrected age of 3 months. \n \n \nKey words: \nInfant, premature; Enteral nutrition; Enterocolitis, necrotizing; Fetal growth retardation; Extensively hydrolyzed formula; Neonatal necrotizing enterocolitis","PeriodicalId":10226,"journal":{"name":"中国基层医药","volume":"27 1","pages":"828-831"},"PeriodicalIF":0.0000,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国基层医药","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To investigate the effect of feeding preterm infants with extensively hydrolyzed formula and standard preterm formula on their growth, feeding tolerance and allergic diseases. Methods From October 2018 to April 2019, 84 premature infants admitted to NICU of the Third People's Hospital of Bengbu Affiliated to Bengbu Medical College were selected and randomly divided into observation group and control group, with 42 cases in each group.In the observation group, the preterm infants were fed with extensively hydrolyzed formula.When each feeding amount reached 20 ml, they were fed with concentrated extensively hydrolyzed formula that calorie was equivalent to standard preterm formula.In the control group, the preterm infants were fed with standard preterm formula.The head circumference, length and weight, the time of birth weight recovery, feeding intolerance, the incidence of neonatal necrotizing enterocolitis(NEC), the time to reach full enteral feeding, the length of hospitalization were compared between the two groups.The patients were followed up for 3 months in corrected age, the incidence rates of allergic diseases and extrauterine growth retardation (EUGR) were compared between the two groups. Results Compared with the control group, the observation group had shortened total parenteral nutrition time [(9.32±3.02)d vs.(11.25±3.70)d, t=2.333, P 0.05). Conclusion Extensively hydrolyzed formula can shorten the time to total parenteral nutrition, reduce the incidence of feeding intolerance and the incidence of allergic diseases in corrected age of 3 months. Key words: Infant, premature; Enteral nutrition; Enterocolitis, necrotizing; Fetal growth retardation; Extensively hydrolyzed formula; Neonatal necrotizing enterocolitis

查看原文本刊更多论文

深度水解蛋白配方奶粉用于早产儿喂养的临床观察

目的探讨广泛水解配方奶粉与标准配方奶粉喂养对早产儿生长发育、喂养耐受性及过敏性疾病的影响。方法选择2018年10月~ 2019年4月在蚌埠医学院附属蚌埠第三人民医院新生儿重症监护病房住院的早产儿84例，随机分为观察组和对照组，每组42例。观察组早产儿用广泛水解配方奶粉喂养。当每次投喂量达到20 ml时，喂食浓缩广泛水解配方奶粉，其热量与标准早产儿配方奶粉相当。对照组用标准早产儿配方奶粉喂养。比较两组患儿的头围、体长、体重、出生体重恢复时间、喂养不耐受、新生儿坏死性小肠结肠炎(NEC)发生率、达到完全肠内喂养时间、住院时间。在矫正年龄后随访3个月，比较两组患者变应性疾病和子宫外生长迟缓(EUGR)的发生率。结果观察组患儿总肠外营养时间较对照组缩短[(9.32±3.02)d比(11.25±3.70)d, t=2.333, P < 0.05]。结论广泛水解配方可缩短3月龄患儿接受全肠外营养的时间，降低喂养不耐受和过敏性疾病的发生率。关键词:婴儿;早产儿;肠内营养;坏死性小肠结肠炎;胎儿生长迟缓;广泛水解配方;新生儿坏死性小肠结肠炎

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.