Clinical and Experimental Allergy最新文献

{"title":"Unraveling the Natural History of Atopic Dermatitis: Prospective Disease Trajectories and Longitudinal IgE Sensitization from Birth to Adolescence","authors":"Kiwako Yamamoto-Hanada, Limin Yang, Seiko Hirai, Kenji Toyokuni, Tatsuki Fukuie, Yukihiro Ohya","doi":"10.1111/cea.70325","DOIUrl":"10.1111/cea.70325","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 9","pages":"1076-1079"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation and Agreement Between Parent-Report and Self-Report Food Allergy Quality of Life Questionnaires After Oral Immunotherapy","authors":"Sophie A. Rosser, Melanie Lloyd, Rachel L. Peters, Rushani Wijesuriya, Paxton Loke, Sarah E. Ashley, Adriana Chebar Lozinsky, Mimi L. K. Tang","doi":"10.1111/cea.70352","DOIUrl":"10.1111/cea.70352","url":null,"abstract":"<p>Food allergy has major impacts on health-related quality of life (HRQL). The Food Allergy Quality-of-Life Questionnaires (FAQLQs) capture patient experiences of food allergy across distinct parent proxy-report, and child (8–12 years) and teenager (13–17 years) self-report perspectives, and are the recommended instruments for evaluation of HRQL in oral immunotherapy (OIT) studies [<span>1</span>]. However, correlation and agreement between parent- and self-report FAQLQs have not been evaluated post-treatment, and it remains unclear whether they can be used interchangeably as participants age during follow-up.</p><p>We analysed FAQLQ total and subscale scores collected 12–24 months post treatment from a pooled sample of 86 parent–child and 14 parent-teenager dyads enrolled in three trials evaluating the effectiveness of an 18-month course of peanut, egg or milk OIT at inducing remission of food allergy.</p><p>Briefly, the PPOIT-003/PPOIT-003LT trial and follow-on study (ACTRN12616000322437; HREC 35246/RGS2543) assessed peanut OIT with and without probiotic compared with placebo (randomised 2:2:1) in 201 children aged 1–10 years at study entry across Melbourne, Adelaide and Perth in Australia [<span>2</span>]. PEAT (ACTRN12619000480189; HREC 2019.082/2019/00029) evaluated egg OIT with probiotic versus placebo (randomised 1:1) in 41 participants aged 5–23 years at study entry in Melbourne, Australia and Singapore [<span>3</span>]. PrEMO (ACTRN12619000306112; HREC 48567/RCHM-2019) was an open-label study of egg or milk OIT with probiotic in 40 children aged 5–17 years at study entry in Melbourne, Australia [<span>4</span>]. Written informed consent was obtained from parents/guardians of the participants in all trials. Trial alignment, FAQLQ score calculation and participant selection details are available in the repository.</p><p>Correlation between parent- and self-reported FAQLQ scores was assessed using Spearman's correlation coefficients (<i>r</i><sub><i>s</i></sub>). Overall degree of agreement between FAQLQ scores was assessed with Lin's Concordance Correlation Coefficients (CCC) and scatterplots comparing the linear relationship between parent- and self-reported scores to a line of perfect concordance (where theoretically, parent-reported = self-reported scores). Bland–Altman analysis was used to estimate the mean difference (MD) and 95% limits of agreement (LoA) between parent- and self-reported scores. We considered an LoA width < 0.5 units between parent- and self-reported scores as clinically acceptable for interchangeability, based on the established 0.5 unit minimum clinically important difference for the FAQLQ-PF [<span>5</span>] and for 7-point Likert scales measuring quality of life [<span>6</span>].</p><p>Moderate positive correlations were observed between parent- and child-reported FAQLQ total scores (<i>r</i><sub><i>s</i></sub> = 0.63, 95% CI: 0.47–0.76), as well as parent- and teenager-reported total scores (<i>r</i><sub><i>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 9","pages":"1110-1113"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Use of Topical Treatments for Atopic Eczema in Children and Young People: Systematic Review","authors":"Phuong Hua, Sarah Newman, Farhad Shokraneh, Alyson L. Huntley, Matthew J. Ridd","doi":"10.1111/cea.70346","DOIUrl":"10.1111/cea.70346","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 9","pages":"1087-1089"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotype Classification of Nonsteroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease According to Chronic Rhinosinusitis Comorbidity.","authors":"Soyoon Sim, Jieun Seo, Junhyuk Chang, Yoo Seob Shin, Rae Woong Park, Hae-Sim Park","doi":"10.1111/cea.70341","DOIUrl":"10.1111/cea.70341","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1128-1130"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Intranasal Corticosteroids and Antihistamines in Enhancing Paediatric Quality of Life in Allergic Rhinoconjunctivitis.","authors":"Ellen Tameeris, Suzie J van den Berg, Arthur M Bohnen, Patrick J E Bindels, Gijs Elshout","doi":"10.1111/cea.70360","DOIUrl":"10.1111/cea.70360","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1137-1139"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'A Real-World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma'.","authors":"Shasha Ying, Qianqian Li","doi":"10.1111/cea.70370","DOIUrl":"10.1111/cea.70370","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1140-1141"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There Is No Gold Standard in Allergy Diagnosis: Time for Methodologically Correct Terminology.","authors":"Danilo Villalta","doi":"10.1111/cea.70399","DOIUrl":"10.1111/cea.70399","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1149-1150"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults","authors":"Florent Fauchère,&nbsp;Aikaterina Alexiou,&nbsp;Veronika Höfer,&nbsp;Kirsten Beyer,&nbsp;Sabine Dölle-Bierke,&nbsp;Andreas Thiel,&nbsp;Margitta Worm,&nbsp;Julian Braun","doi":"10.1111/cea.70264","DOIUrl":"10.1111/cea.70264","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Peanut (PN) allergy is an IgE-mediated hypersensitivity with a deviated adaptive immune response dominated by IgE-producing B cells and type 2 T cells (Th2). The in vivo immune response upon antigen encounter, for example, after oral food challenge (OFC), has not been investigated over prolonged timeframes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Here, we investigated the kinetics of allergen-specific adaptive immune responses in PN-allergic and non-allergic adults before OFC (d0) and thereafter at d7, d14, d21, d28 by determining PN-specific CD40L⁺4-1BB⁺ conventional (Tconv) and FoxP3⁺ Helios⁺ CD40L⁻4-1BB⁺ regulatory T cells (Treg), Ara h 2-specific B cells and PN-specific sIgE and sIgG4 antibody levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In PN-allergic donors, PN sIgE levels increased until d28 after OFC, but to a variable extent. This variability was associated with a differential increase of Ara h 2⁺ B cells at d7, based on which we identified strong and weak responders (SR and WR). SR exhibited a more pronounced increase of PN sIgE, stronger in vivo activation of T and B cells (HLA-DR⁺, Ki-67⁺, CD21⁻), as well as prominent induction of the low-affinity IgE receptor CD23 in Ara h 2⁺ B cells. In contrast, WR exhibited strong activation of PN-specific Tregs at d7. At baseline, SR and WR differed regarding Ara h 2⁺ memory B cells and frequencies of Th2 and type 2-driving Helios-expressing PN-specific Tconv. Minor changes in Th1 cells were also observed in non-allergic donors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results indicate differential adaptive immune responses towards OFC in PN-allergic adults. In summary, SR displayed a more allergy-maintaining immune response, while WR displayed a rather suppressive immune response. Underlying responsible factors such as genetics, as well as clinical consequences, will require further investigation in larger cohorts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 9","pages":"1063-1075"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fixed Very-Low-Dose Oral Immunotherapy in Infants and Toddlers With Low-Threshold Egg, Milk or Wheat Allergy: A Prospective Cohort Study","authors":"Katsumasa Kitamura,&nbsp;Teruaki Matsui,&nbsp;Yoshihiro Takasato,&nbsp;Shiro Sugiura,&nbsp;Komei Ito","doi":"10.1111/cea.70336","DOIUrl":"10.1111/cea.70336","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 9","pages":"1107-1109"},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Parental Self-Efficacy in Managing Child Food-Induced Anaphylaxis (PSEMA) Questionnaire for Ethnic Chinese Families With Food-Allergic Children.","authors":"Christy Wing Man Leung, Nam Sze Cheng, Daphne Hoh Ching Ng, Yin Shan Wong, Michał Ordak, Ting Fan Leung","doi":"10.1111/cea.70426","DOIUrl":"https://doi.org/10.1111/cea.70426","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}