Clinical and Experimental Allergy最新文献

{"title":"Role of MicroRNAs in Allergy and Basophil Activation Test for IgE-Mediated Drug Allergy","authors":"Mohamed H. Shamji, Robert J. Boyle","doi":"10.1111/cea.14616","DOIUrl":"10.1111/cea.14616","url":null,"abstract":"<p>In this month's editorial, the Editors of the journal have highlighted two fascinating studies that are included in this issue. The first article provides evidence that miR-107 is involved in the allergic response to house dust mites (HDM) in children with asthma [<span>1</span>]. Allergic asthma (AA) is a prevalent phenotype of asthma that presents atopic sensitisations in asthma patients exposed to allergens [<span>2, 3</span>]. Some, but not all, studies have suggested a possible increase in AA over time [<span>4</span>]. HDM are a significant trigger for AA in many regions, with HDM sensitisation potentially leading to severe, and in some instances, life-threatening asthma symptoms. In the study by Kim et al. [<span>1</span>], the relationship between microRNAs (miRNAs) and HDM sensitisation in children with asthma was investigated. The researchers examined serum samples from 1126 children in the Genetics of Asthma in Costa Rica Study (GACRS) and also replicated their findings in the Childhood Asthma Management Program (CAMP). Initially, the study revealed that 17 miRNAs were differentially expressed between HDM-sensitised and non-sensitised children in the GACRS group. Of the 17, miR-642a, let-7c-5p and miR-107 showed the strongest association with HDM sensitisation. Moreover, the CAMP cohort successfully replicated the elevated expression of miR-107 in HDM-sensitised children. Additional mediation analysis also presented significant effects of miR-107 on eosinophil count and total IgE after HDM sensitisation. These findings suggest new insights into the molecular mechanisms underlying HDM sensitisation in paediatric asthma and emphasise the potential of miRNAs, particularly, miR-107, which can be studied further for application as biomarkers or therapeutic targets for AA (Figure 1).</p><p>This issue's second editor's choice article reports on the optimisation of the basophil activation assay for identifying IgE-mediated drug allergies [<span>5</span>]. Diagnosing drug allergies is a complex and nuanced process that presents several challenges. Allergic reactions can manifest with a broad spectrum of clinical symptoms, ranging from mild rashes to life-threatening anaphylaxis, making it difficult to establish consistent diagnostic criteria. Reactions may occur immediately or be delayed, sometimes appearing days after exposure [<span>6</span>]. This variability complicates the temporal connection between drug intake and allergic symptoms. Additionally, patients may experience allergic reactions to drug molecules with similar structures, further complicating the identification of the exact trigger, especially in cases involving structurally similar drugs. Unlike testing for environmental allergens, there are limited standardised and clinically validated laboratory tests available for many drug allergies. The reliability and availability of tests like the Basophil Activation Test (BAT) can vary for different drugs [<span>7, 8</span>]. While o","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 1","pages":"11-13"},"PeriodicalIF":6.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Shican Zhou,&nbsp;Ju Lai,&nbsp;Na Che,&nbsp;Kai Fan,&nbsp;Chuanliang Zhao,&nbsp;Bojin Long,&nbsp;Chunyan Yao,&nbsp;Yu Zeng,&nbsp;Shaoqing Yu","doi":"10.1111/cea.14621","DOIUrl":"https://doi.org/10.1111/cea.14621","url":null,"abstract":"<p>The cover image is based on the article <i>Emerging Role of SAMSN1⁺Mast Cells: Insights From Mendelian Randomisation and Transcriptomic Analyses on Chronic Sinusitis and Obesity</i> by Shaoqing Yu et al.,\u0000https://doi.org/10.1111/cea.14529.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 1","pages":"i"},"PeriodicalIF":6.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis: Spotlight on Inflammation","authors":"Emilio Nuñez-Borque,&nbsp;Timothy E. Dribin,&nbsp;Pablo Rodriguez Del Rio,&nbsp;Carlos A. Camargo Jr,&nbsp;Vanesa Esteban,&nbsp;George du Toit,&nbsp;Rodrigo Jiménez-Saiz,&nbsp;Mattia Giovannini","doi":"10.1111/cea.14610","DOIUrl":"10.1111/cea.14610","url":null,"abstract":"&lt;p&gt;Anaphylaxis is a medical condition for which several definitions have been proposed (Table 1 is available in the repository information at https://osf.io/sc2ey/?view_only=f66e841be31b42418eecf639caa0b24d). Charles Richet and Paul Portier coined the term ‘anaphylaxis’ in 1902. If discovered earlier, it might have invigorated the ongoing scientific debate in the late 19th century between Rudolf Virchow and Iliá Méchnikov on the detrimental versus beneficial nature of inflammation [&lt;span&gt;1&lt;/span&gt;]. While inflammation typically serves as a response to tissue damage or infection, to restore homeostasis, anaphylaxis is a classic example of an immunopathological reaction in which an exaggerated and inappropriate response can lead, although rarely, to potentially fatal outcomes. Precisely, the role of inflammation has been underlined as central in several atopic diseases, but, surprisingly, not in anaphylaxis.&lt;/p&gt;&lt;p&gt;The most common triggers of anaphylaxis are foods, insect stings and medications, but the aetiology may be unknown in some cases (idiopathic). This reaction is a multisystem condition that may involve different findings from the skin/mucosal, respiratory, cardiovascular and/or gastrointestinal systems. However, patients may rarely present isolated respiratory or cardiovascular involvement, and skin/mucosal participation may be absent. In addition, anxiety about the possibility of a new episode of anaphylaxis significantly impairs the quality of life of patients and their relatives, restricting daily activities and increasing the state of constant alertness [&lt;span&gt;2&lt;/span&gt;]. The foundations of acute anaphylaxis management are removing the trigger, proper patient positioning, immediate administration of adrenaline and repeat adrenaline injections if severe clinical manifestations do not resolve. Moreover, this treatment can be supplemented with the use of second-line medications (e.g., β2-adrenergic agonists), as well as with the administration of supportive treatments (e.g., oxygen) [&lt;span&gt;2, 3&lt;/span&gt;]. Most patients treated with adrenaline experience prompt resolution of symptoms and signs. However, a minority of patients may require three or more doses of adrenaline (refractory anaphylaxis) or have recurrence after an asymptomatic period (biphasic anaphylaxis) [&lt;span&gt;4, 5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Different signalling pathways can mediate anaphylaxis (Figure 1). Among them, the classical one is mediated by immunoglobulin (Ig)E. In sensitised individuals, secreted IgE binds to its high-affinity receptor (FcεRI) on effector cells (mainly mast cells and basophils), which store preformed pro-inflammatory granules. Then, allergen binding by cell-bound IgE triggers effector cell activation, leading to the immediate release of potent pro-inflammatory mediators, such as histamine, tryptase, platelet-activating factor (PAF), prostaglandins, leukotrienes and TNF-α, which are responsible for the rapid clinical manifestations of anaphylaxis [&lt;span&gt;6&lt;/span&gt;]. Ho","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 1","pages":"8-10"},"PeriodicalIF":6.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14610","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalisation Trends of Severe Paediatric Asthma in Tokyo 2015-2019.","authors":"Kazu Ishikawa, Kiwako Yamamoto-Hanada, Tatsuki Fukuie, Akira Ishiguro, Yukihiro Ohya","doi":"10.1111/cea.14620","DOIUrl":"https://doi.org/10.1111/cea.14620","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Prize-Winning Abstracts From BSACI 2024 Meeting”","authors":"","doi":"10.1111/cea.14617","DOIUrl":"https://doi.org/10.1111/cea.14617","url":null,"abstract":"<p>\u0000 <span>Mohamed H. Shamji</span> and <span>Robert J. Boyle</span>, <span>Prize-Winning Abstracts From BSACI 2024 Meeting</span>. <i>Clinical &amp; Experimental Allergy</i>, <span>54</span> (<span>2024</span>): <span>953</span>–<span>955</span>. https://doi.org/10.1111/cea.14599\u0000 </p><p>Some text was missing from the article. The extra text is below, and should be added at the end of the article:</p><p>7. Allied Health Category Winner: Odette Rodda, University Hospital Dorset, UK</p><p><b>Assessing the need for an allergy service for Adolescents and Young Adults—a pilot study</b>.</p><p>Timely, appropriate diagnosis and treatment are imperative in food allergy. This service evaluation aimed to explore the need for a dedicated allergy clinic for adolescents and young adults (AYA).</p><p>AYA aged 12–20 years with food allergies and other allergic conditions were approached during routine clinic appointments over 6 months. Fifty questionnaires were collected. Most (86%) knew how to recognise an allergic reaction and most (81.6%) had an adrenaline auto-injectors. However, only 12.8% rated their allergies as potentially causing anaphylaxis. Most (62%) AYA used antihistamines as rescue medications (62%) and most (59%) did not carry their autoinjector. Only 18.4% of respondents would tell friends about their allergies. Most (62%) would like to attend clinic with other AYA and 81% would prefer clinics in the afternoon or evening. Thematic analysis identified three themes ‘I have to take responsibility’, ‘I need peer support’ and ‘what happens next’. This pilot study identified AYA understanding and behaviours about their allergies and transition to adult services.</p><p>We apologize for this error.</p><p>\u0000 \u0000 </p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 2","pages":"205"},"PeriodicalIF":6.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Allergy Prevalence in Two Population-Based UK Cohorts Born 12 Years Apart","authors":"William Fong,&nbsp;Kaci Pickett-Nairne,&nbsp;Manzi Venter,&nbsp;Veeresh Patil,&nbsp;Syed Hasan Arshad,&nbsp;Graham C. Roberts,&nbsp;Tara Dean,&nbsp;Ramesh J. Kurukulaaratchy,&nbsp;Carina Venter","doi":"10.1111/cea.14605","DOIUrl":"10.1111/cea.14605","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Adverse food reactions include food allergy (FA; immune-mediated) and food intolerances (non-immune-mediated). FA are classified into IgE- and non-IgE-mediated FA. There is limited information available about changes in FA prevalence over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two cohorts of children were evaluated, born on the Isle of Wight (IOW) 12 years apart, the IOW birth cohort (IOWBC; 1989–1990) and the FA and Intolerance Research birth cohort (FAIRBC; 2001–2002). We compared the prevalence of parental reported reactions to foods (adverse food reactions), allergic sensitisation to foods and FA between the IOWBC and FAIRBC, at ages 1, 2, 3–4 and 10 years. FA included both IgE- and non-IgE-mediated FA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Reported adverse reactions to food and sensitisation rates remained stable between the two cohorts. For example, FA at age 3–4 years was reported in 9.1% (95% CI: 7.5, 10.7) in IOWBC and 8.3% (95% CI: 6.5, 10.1) in FAIRBC (<i>p</i> = 0.57) and food sensitisation by skin prick test at age 3–4 years was found in 3.2% (95% CI: 2.1, 4.3) in IOWBC and 4.5% (95% CI: 2.9, 6.1) in FAIRBC (<i>p</i> = 0.20). Confirmed FA prevalence was lower in FAIRBC than IOWBC at ages 1, 2 and 3–4, but these differences were not significant after adjustment for multiple comparisons. For example, FA at age 3–4 years was confirmed in 5.0% (95% CI: 3.8, 6.2) in IOWBC and 3.0% (95% CI: 1.9, 4.2) in FAIRBC (<i>p</i> = 0.03, significance threshold after Bonferroni correction <i>p</i> &lt; 0.004). Confirmed cow's milk allergy rate was higher in IOWBC than FAIRBC at 3 years (&lt; 0.001) but not at other time points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our data show no evidence of changes in rates of adverse reactions to foods, food sensitisation or food allergy during the first 10 years of life between two cohorts born in England in 1989–1990 and 2001–2002.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 2","pages":"166-174"},"PeriodicalIF":6.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Relationship Between Serum Metabolites and Allergic Diseases: Mendelian Randomization Analysis.","authors":"Yanli Qiu, Bing Zhang, Haocong Chen, Jialin Zhang, Yu Zhang, Junfeng Zhang, Hongxia Lin, Yinzhong Lu","doi":"10.1111/cea.14615","DOIUrl":"https://doi.org/10.1111/cea.14615","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of Quick Response Coded Digital Allergy Patient Information Leaflets: Patient Perspectives and Key Digital Inclusion Considerations.","authors":"Oyindamola Stephanie Kayode, Cassim Akhoon, Annette Wagner, Olympia Tsilochristou, Stephen Till, Leonard Quok Chean Siew","doi":"10.1111/cea.14613","DOIUrl":"https://doi.org/10.1111/cea.14613","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KITY Study Protocol: A Randomised Controlled Trial for Eczema Prevention by Ingestion of Kestose in High-Risk Neonates.","authors":"Mayako Saito-Abe, Kenji Toyokuni, Hisako Ogasawara, Kyongsun Pak, Yusuke Inuzuka, Daisuke Harama, Nozomi Ando, Yutaka Koyano, Tohru Kobayashi, Yuka Hayashi, Hideaki Morita, Kenji Matsumoto, Tatsuki Fukuie, Yukihiro Ohya, Kiwako Yamamoto-Hanada","doi":"10.1111/cea.14612","DOIUrl":"https://doi.org/10.1111/cea.14612","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Co-Factors in Primary Hazelnut Allergy.","authors":"Morten J Christensen, Annemarie Schaeffer Senders, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz","doi":"10.1111/cea.14611","DOIUrl":"https://doi.org/10.1111/cea.14611","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}