Clinical and Experimental Allergy最新文献

{"title":"Oral Food Challenges for Food Protein-Induced Enterocolitis Syndrome-A 10-Year Multicentre Audit.","authors":"L Mackey, M Norman, D Chan","doi":"10.1111/cea.70090","DOIUrl":"https://doi.org/10.1111/cea.70090","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Fatal and Near-Fatal Food Anaphylaxis: Analysis of the Allergy-Vigilance Network Database","authors":"Guillaume Pouessel,&nbsp;Claire Egea,&nbsp;Amandine Divaret-Chauveau,&nbsp;Pascale Beaumont,&nbsp;Eléna Bradatan,&nbsp;Pascale Dumond,&nbsp;Rémy Diesnis,&nbsp;Sélina Tscheiller,&nbsp;Xavier Van der Brempt,&nbsp;Camille Braun,&nbsp;Dominique Sabouraud-Leclerc","doi":"10.1111/cea.70089","DOIUrl":"10.1111/cea.70089","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gaining a better understanding of the risk factors for severe anaphylaxis represents a crucial challenge for physicians. This survey aimed to analyse cases of severe food anaphylaxis and assess potential risk factors for severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analysed food anaphylaxis cases recorded by the French-speaking Allergy-Vigilance Network (2002–2021) and compared the main characteristics of grade 3 (Ring classification) and grade 4 cases using univariate and multivariate statistical analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 2621 food anaphylaxis cases reported, 731 (27.9%) were considered severe (grade 3, <i>n</i> = 687 [94%] and grade 4, <i>n</i> = 44 [6%]; 19 deaths). Overall, 56.1% of cases were adults (mean age: 28.3 years) and 53.7% were male. The most frequent triggers were peanut (13.9%), wheat (9.4%), cashew (5.8%), shrimp (5.3%), and cow's milk (4.6%). More grade 4 anaphylaxis cases occurred in children than in adults (26 vs. 18; <i>p</i> = 0.01). In univariate analysis, individuals with grade 4 anaphylaxis were more likely to have a history of allergy to the culprit food (71.1% vs. 42.1%; <i>p</i> &lt; 0.001), asthma diagnosis (59.5% vs. 30.4%; <i>p</i> &lt; 0.001), and peanut as the culprit food (34.1% vs. 12.6%; <i>p</i> &lt; 0.001). In multivariate analysis, factors predictive of grade 4 anaphylaxis were asthma diagnosis (OR [95% CI]: 3.41 [1.56–7.44]; <i>p</i> = 0.002) and peanut as the culprit trigger (OR [95% CI]: 3.46 [1.28–9.34]; <i>p</i> = 0.014).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data highlight the risk factors for severe food anaphylaxis, notably a history of asthma and peanut as the culprit food. These individuals should benefit from personalised management strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":"532-540"},"PeriodicalIF":6.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of First Oral Hen's Egg Challenge in Food Protein Induced Enterocolitis Syndrome.","authors":"Deniz Ilgun Gurel, Melike Ocak, Bulent Sekerel, Umit Murat Sahiner, Ozge Soyer","doi":"10.1111/cea.70086","DOIUrl":"https://doi.org/10.1111/cea.70086","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum","authors":"Lisa P. van der Rijst,&nbsp;Edward F. Knol,&nbsp;Nicolaas P. A. Zuithoff,&nbsp;Constance F. den Hartog Jager,&nbsp;Femke van Wijk,&nbsp;Marjolein S. de Bruin-Weller,&nbsp;Marlies de Graaf","doi":"10.1111/cea.70082","DOIUrl":"10.1111/cea.70082","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty paediatric AD patients (&lt; 18 years) starting dupilumab treatment were included. Serum samples and tape strips from lesional and non-lesional skin were collected at baseline, 4 and 16 weeks of treatment. Fifteen pre-specified proteins were measured at each visit by Luminex multiplex immunoassay. Clinical severity outcome measures included the Eczema Area and Severity Index (EASI) and Numeric Rating Scale (NRS) itch. Statistical analyses included Wilcoxon signed-rank tests and Spearman correlations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Along with clinical improvement, 16 weeks of dupilumab treatment resulted in a rapid and significant reduction in the disease-associated mediators PARC/CCL18 and TARC/CCL17 in both tape-stripped skin and serum. While the cytokine and chemokine profiles differed between the sampling methods, both effectively captured immunological changes associated with dupilumab treatment. Tape strips demonstrated significant reductions in innate pro-inflammatory cytokines (IL-8/CXCL8, IL-18), the T cell-recruiting chemokine CTACK/CCL27, the Type 1 immune mediator CXCL10, and tissue repair and remodelling proteins (periostin, MMP-1) in response to treatment, but were less sensitive in detecting T cell-derived cytokines (IL-4, IL-13). In both skin and serum, several proteins were significantly correlated with AD severity, as measured by EASI and NRS itch, with PARC/CCL18 emerging as the strongest correlated protein.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings provide insight into the distinct local and systemic proteomic changes in response to dupilumab treatment in paediatric AD patients. These findings underscore the complementary roles of tape strips and serum in profiling immune and epidermal barrier proteins, highlighting the utility of minimally invasive tape stripping for monitoring proteomic responses to targeted therapies in paediatric AD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":"552-563"},"PeriodicalIF":6.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Study of Fractional Exhaled Nitric Oxide (FeNO) and Spirometric Indices in Trainee Bakers and Confectioners.","authors":"Gina-Maria Klaut, Ludwig Frei-Stuber, Stefan Karrasch, Susanne Kutzora, Jonas Huss, Doris Gerstner, Dennis Nowak, Caroline Quartucci","doi":"10.1111/cea.70076","DOIUrl":"https://doi.org/10.1111/cea.70076","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walnut Allergy in Children: A Diagnostic Test Accuracy Study.","authors":"Mattia Giovannini, Camilla Fazi, Martina Tesi, Giulia Liccioli, Lucrezia Sarti, Simona Barni, Leonardo Tomei, Benedetta Pessina, Claudia Valleriani, Robert Boyle, Riccardo Pertile, Francesca Mori","doi":"10.1111/cea.70078","DOIUrl":"https://doi.org/10.1111/cea.70078","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis and Treatment of Atopic Dermatitis: Lessons From China","authors":"Xu Yao,&nbsp;Wei Li","doi":"10.1111/cea.14631","DOIUrl":"10.1111/cea.14631","url":null,"abstract":"<p>Atopic dermatitis (AD) is a complex and heterogeneous skin disease characterised by Th2-dominant inflammation with differential contribution of Th22-, Th17- or Th1-type cells and molecules, which results from interactions among genetic susceptibility, environmental factors, barrier function, skin microbiome and immune responses. AD has been attracting increasing attention from both the public and academic society in China during the past 10 years. More and more dermatologists are pursuing in research on AD, covering almost all aspects of AD which span from genetics, clinical features and endotypes, to pathogenesis and innovative treatment. Chinese patients with AD share the common features with the patients from western countries on the one hand and, on the other hand, present with unique clinical and molecular phenotypes, which helps to enrich the understanding on AD and indicates special consideration for therapy.</p><p>Ethnic heterogeneity of AD has long been an interesting topic in this field. It has been reported that Chinese patients with AD are characterised with blended AD–psoriasis phenotype and endotype [<span>1</span>]. Chronic lichenification is commonly seen in Chinese patients with AD, accompanied by epidermal hyperplasia and an increased infiltration of Th17-related molecules in the lesional skin [<span>1</span>]. Recently, the application of bulk RNA-sequencing technique has revealed distinct inflammation patterns in the skin lesions of Chinese patients with AD across different ages. There is a notable upregulation in Th2 and Th17 inflammation in children, a significant increase in Th2 and Th22 inflammation in adults, and a marked decline of Th2 and Th22 inflammation in the elderly. In elderly patients with AD, genes related to skin barrier function, natural killer cells, macrophages, senescence-associated secretory phenotype and fibroblasts within the skin lesions have also been found. These findings collectively underscored the heterogeneity of AD and emphasised the urgent need for detailed researches to inform future precise therapies [<span>2</span>].</p><p>Apart from the endotype, dermatologists in China frequently encounter patients with AD with ‘atypical’ manifestations, many of them present with mild, localised or special forms of skin lesions. Unlike the referral system in western countries, where patients with skin conditions typically visit dermatologist following a referral from a primary care physician, in China, patients usually consult dermatologists directly. This practice allows Chinese dermatologists to see patients with AD with all kinds of manifestations, posing a challenge on diagnosis of AD. Researchers in China have dedicated great efforts to developing diagnostic criteria for AD (Table 1) [<span>3</span>], which have greatly advanced the understanding and awareness of AD in China. Elderly AD, a relatively new subtype distinct from infantile, childhood and adult AD, has attracted increasing attention. Wan","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 8","pages":"603-606"},"PeriodicalIF":5.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14631","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction Between Lifestyle, Immunity and Gut Microbiota in Milk Allergy Children.","authors":"Kiwako Yamamoto-Hanada, Eiryo Kawakami, Miori Sato, Makoto Irahara, Kenji Toyokuni, Erika Hiraide-Kotaki, Naomi Harima-Mizusawa, Norihiro Kubota, Hideaki Morita, Kenji Matsumoto, Tatsuki Fukuie, Yukihiro Ohya","doi":"10.1111/cea.70080","DOIUrl":"https://doi.org/10.1111/cea.70080","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 on Patients With Bradykinin-Mediated Angioedema in the ITACA Cohort.","authors":"Riccardo Senter, Andrea Zanichelli, Agolini Stefano, Francesco Arcoleo, Donatella Bignardi, Paolo Borrelli, Chiara Cogliati, Caterina Colangelo, Tiziana De Pasquale, Stefano Del Giacco, Davide Firinu, Antonio Gidaro, Mariangela Lo Pizzo, Roberta Parente, Francesca Perego, Angelica Petraroli, Valentina Popescu Janu, Stefano Pucci, Paolina Quattrocchi, Irene Ridolfi, Oliviero Rossi, Federica Ruin, Giuseppe Spadaro, Paola Triggianese, Alessandra Zoli, Massimo Triggiani, Mauro Cancian","doi":"10.1111/cea.70079","DOIUrl":"https://doi.org/10.1111/cea.70079","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising Use and Need for Oral Food Challenges in Adolescents and Young Adults: Implications for Allergy Management.","authors":"Marei Omori, Kiwako Yamamoto-Hanada, Daisuke Harama, Sayaka Hamaguchi, Kouhei Hagino, Daichi Suzuki, Kotaro Umezawa, Fumi Ishikawa, Seiko Hirai, Kenji Toyokuni, Tatsuki Fukuie, Yukihiro Ohya","doi":"10.1111/cea.70073","DOIUrl":"https://doi.org/10.1111/cea.70073","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}