Clinical and Experimental Allergy最新文献

{"title":"Penicillin Allergy Management in India and Sri Lanka: Current Challenges.","authors":"Saibal Moitra, Guwani Liyanage, Sarah Tonkin-Crine, Neil Powell, Yogini Jani, Dhanushka Dasanayake, Nadisha Badanasinghe, Mohammad Ziaul Haque, Wasana Kudagammana, Raj Kumar, Padukudru Anand Mahesh, Bernard Yu-Hor Thong, Juan Meng, Devasahayam Jesudas Christopher, Mamidipudi Thirumala Krishna","doi":"10.1111/cea.14624","DOIUrl":"https://doi.org/10.1111/cea.14624","url":null,"abstract":"<p><p>Data regarding Penicillin allergy labels (PALs) from India and Sri Lanka are sparse. Emerging data suggests that the proportion of patients declaring an unverified PAL in secondary care in India and Sri Lanka (1%-4%) is lesser than that reported in High Income Countries (15%-20%). However, even this relatively small percentage translates into a large absolute number, as this part of the world accounts for approximately 25% of the global population. There is a huge unmet need for allergy specialists in India and Sri Lanka. Penicillin allergy management is further compromised by unavailability of skin test reagents, lack of formal training in drug allergy, pre-emptive, non-standardised and unregulated skin testing by untrained operators and a weak health service framework. This has an adverse impact on antimicrobial stewardship, particularly in the management of rheumatic fever, rheumatic heart disease, bacterial endocarditis, syphilis and other sexually transmitted infections. This narrative review highlights the burden of PALs in India and Sri Lanka, as well as gaps in the published literature. It describes current challenges and a pragmatic, cautious and staged bespoke mitigation approach to improve and standardise antimicrobial stewardship in accordance with the World Health Organisation AWaRe guidance.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Birth Order on Paediatric Allergic Diseases: A National Birth Cohort in Japan.","authors":"Mitsuro Kobayashi, Masanori Ikeda, Naomi Matsumoto, Mitsuru Tsuge, Masato Yashiro, Takashi Yorifuji, Hirokazu Tsukahara","doi":"10.1111/cea.14626","DOIUrl":"https://doi.org/10.1111/cea.14626","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Allergomic Study Reveals Two Novel Venom Allergens, Phospholipase A1 and Antigen 5, From the Social Wasp Apoica pallens","authors":"Amilcar Perez-Riverol,&nbsp;Gabriel Hideki Izuka Moraes,&nbsp;José Roberto Aparecido dos Santos-Pinto,&nbsp;Luis Gustavo Romani Fernandes,&nbsp;Alexis Musacchio Lasa,&nbsp;Brita Dorn,&nbsp;Maria Beatrice Biló,&nbsp;Ricardo de Lima Zollner,&nbsp;Thilo Jakob,&nbsp;Mario Sergio Palma","doi":"10.1111/cea.14630","DOIUrl":"10.1111/cea.14630","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"250-252"},"PeriodicalIF":6.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach","authors":"Umesh Singh,&nbsp;Jonathan A. Bernstein","doi":"10.1111/cea.14628","DOIUrl":"10.1111/cea.14628","url":null,"abstract":"&lt;p&gt;Previous ATP inhalation studies and clinical trials have demonstrated an anti-tussive effect of P2X3 antagonists, supporting the mechanism of purinergic P2X3 receptor activation leading to unexplained chronic cough (UCC). However, the role of TRP receptors in UCC is currently unclear. In this study, an interaction between P2X3 receptors on airway bronchial epithelial cells (BECs) and TRPA1 channels on upper airway nerves was explored in vitro as a potential mechanism for UCC (Figure 1A) [&lt;span&gt;1-3&lt;/span&gt;]. It was hypothesised that irritants activating TRP channels can result in ATP release from airway nerves resulting in P2X3 receptor activation on adjacent airway epithelial cells [&lt;span&gt;3-6&lt;/span&gt;]. To investigate the role of TRPA1 channel activation of P2X3 receptors, an indirect in vitro cell model was developed to demonstrate whether activation of TRPA1 channels expressed on neuronal cells result in ATP release that subsequently activates P2X3 receptors on adjacent BECs.&lt;/p&gt;&lt;p&gt;Dorsal root ganglion cells (DRGN, ND8/34 cell line, Sigma), known to express TRPA1 were used as a surrogate for airway neuronal cells [&lt;span&gt;7&lt;/span&gt;]. Functional assays were performed on DRGNs to quantify TRPA1 activation using the TRPA1 specific agonist (JT010) by observing a change in fluorescence measured by [Ca&lt;sup&gt;2+&lt;/sup&gt;]i of 10% or greater from baseline under confocal microscopy. The DRGNs cultured on poly-Lysine coated plates and loaded with FLUO4, were preincubated in the presence or absence of the TRPA1 antagonist HC-030031 (EMD Milipore) and then treated with a TRPA1-specific agonist (JT010 100 nM, Tocris) (&lt;i&gt;n&lt;/i&gt; = 3 experiments). Culture media from the DRGNs cell wells were collected after stimulation and assayed for ATP. ATP release in response to JT010-induced TRPA1 activation and its suppression by the TRPA1-antagonist, HC-030031, were quantified from the cell supernatant on a luminometer using the ATP Bioluminescence Assay Kit HS II (Roche). Additional information about study methods are available in the following repository (DOI 10.5281/zenodo.14244289).&lt;/p&gt;&lt;p&gt;Human bronchoepithelial cells (BEAS2B, ATCC), were used as a surrogate for airway epithelium. The effect of P2X3-receptor antagonist, MAF-454, in preventing activation of P2X3 receptors were determined by treating cultured BEAS2B cells with ATP disodium 4 μM (Sigma) stabilised with KOH in the presence and absence of MAF-454 preincubation. Differential gene expression (DEGs) in these samples versus untreated controls were determined using TaqMan rat inflammation array (Thermo Fisher). Pathway analysis, and upstream regulator analysis of the DEGs in the ATP-treated samples, compared to the MAF-454 preincubated ATP-treated samples were performed using the Ingenuity Pathway Analysis platform (Qiagen). As this was an in vitro study and did not require patient serum or patient data, no IRB was required.&lt;/p&gt;&lt;p&gt;Descriptive statistics and t-tests were performed to analyse differences in the average","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"247-249"},"PeriodicalIF":6.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “T cells and eosinophils in bronchial smooth muscle cell death in asthma”","authors":"","doi":"10.1111/cea.14627","DOIUrl":"10.1111/cea.14627","url":null,"abstract":"<p>\u0000 <span>K. Solarewicz-Madejek</span>, <span>T. M. Basinski</span>, <span>R. Crameri</span>, <span>M. Akdis</span>, <span>A. Akkaya</span>, <span>K. Blaser</span>, <span>K. F. Rabe</span>, <span>C. A. Akdis</span> &amp; <span>M. Jutel</span>, “ <span>T cells and eosinophils in bronchial smooth muscle cell death in asthma</span>”, <i>Clinical &amp; Experimental Allergy</i> <span>39</span>, no. <span>6</span> (<span>2009</span>): <span>845</span>–<span>855</span>, https://doi.org/10.1111/j.1365-2222.2009.03244.x\u0000 </p><p>The authors apologize for all the inconveniences and confirm that all the experimental results and corresponding conclusions remain unaffected.</p><p>The corrected Figure 4 and Figure 5 are shown as follows.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"281-283"},"PeriodicalIF":6.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Self-Reported Dietary Intake and Atopic Dermatitis Risk in Young Adults From Singapore and Malaysia.","authors":"Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew","doi":"10.1111/cea.14629","DOIUrl":"https://doi.org/10.1111/cea.14629","url":null,"abstract":"<p><p>This cross-sequential study found that frequent intake of high-fat and high-protein foods was associated with higher odds of atopic dermatitis (AD). However, occasional intake across all three macronutrients significantly lowered AD odds, suggesting that moderation-not strict avoidance-may benefit AD management in allergic populations.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Allergy and Mental Health in Children and Adolescents—The Role of Shared Familial Environment","authors":"Hanna Karim,&nbsp;Cecilia Lundholm,&nbsp;Tong Gong,&nbsp;Bronwyn Brew,&nbsp;Michael Silverman,&nbsp;Catarina Almqvist","doi":"10.1111/cea.14619","DOIUrl":"10.1111/cea.14619","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Evidence suggests a link between food allergy and poor mental health, however, this may be explained by shared genetic and environmental factors. We aimed to investigate the association between food allergy of different severity and mental health in children, and the role of familial factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This population-based, longitudinal cohort study is based on the Child and Adolescent Twin Study in Sweden with questionnaire data reported by parents and/or children. Food allergy ‘ever’ and doctor's diagnosis were reported at age 9–12 years, and ≥ 1 recent dispensation of adrenaline was used as a marker for current severe food allergy. Outcomes were identified using validated questionnaires for anxiety; Screen for Child Anxiety Related Disorders (SCARED); Strength and Difficulties Questionnaire (SDQ) and depression; Short Mood and Feelings Questionnaire (SMFQ), Center for Epidemiological Studies Depression Scale (CES-D) and Diagnostic and Statistical manual of Mental Disorders (DSM-IV-MDE) and reported at 9–12, 15 and 18 years of age. Multivariate linear and logistic modelling was applied to the whole cohort and a co-twin control approach to remove confounding by familial factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 3039 (8.9%) children had a parent-reported food allergy. Among these, 1292 (43.5%) had non-severe food allergy without diagnosis, 1490 (49%) had non-severe food allergy with diagnosis and 257 (8.5%) had severe food allergy. Compared to children with no food allergy, non-severe food allergy with diagnosis by 9–12 years was associated with parent-reported anxiety/depression; SCARED (adjOR 2.10, 95% CI 1.48–2.98), SMFQ (adjOR 1.92, 95% CI 1.19–3.10) at 9–12 years and SDQ (adj<i>β</i> 0.2, 95% CI 0.0–0.4) at 15 years. All other associations were null including for those with severe food allergy. All positive estimates in the full cohort were attenuated using co-twin controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Evidence associating paediatric food allergy severity and poor mental health was weak, and positive associations observed were likely due to familial confounding.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 2","pages":"175-186"},"PeriodicalIF":6.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advocacy in Action: International Patient Group Improves Hereditary Angioedema Diagnosis and Care Across the Asia-Pacific.","authors":"Jane C Y Wong, Cheryl C W Tsui, Kristie C W Lao, Jovilia Abong, Adli Ali, Dharmagat Bhattarai, Michihiro Hide, Ankur Jindal, Anthony Jordan, Hye-Ryun Kang, Constance H Katelaris, Narissara Suratannon, Sze-Chin Tan, Yong-Hao Lim, Deborah Corcoran, Fiona Wardman, Henrik Balle Boysen, Anthony J Castaldo, Philip H Li","doi":"10.1111/cea.14623","DOIUrl":"https://doi.org/10.1111/cea.14623","url":null,"abstract":"<p><p>This study demonstrates that patient advocacy groups significantly enhance medication availability and improve diagnosis of hereditary angioedema (HAE), particularly in emerging economies within the Asia-Pacific region. This study supports integrating patient advocacy group involvement into management guidelines, emphasising their role in improving access to diagnostics and treatment for HAE.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Cost Questionnaires Aimed at Measuring the Household Financial Burden of Food Allergy","authors":"Zoe Harbottle,&nbsp;Michael A. Golding,&nbsp;Ayel Luis R. Batac,&nbsp;Andrew T. Fong,&nbsp;Mê-Linh Lê,&nbsp;Elissa M. Abrams,&nbsp;Edmond S. Chan,&nbsp;Moshe Ben-Shoshan,&nbsp;Peter S. Hsu,&nbsp;Jodi A. Shroba,&nbsp;Juho E. Kivistö,&nbsp;Matthew J. Greenhawt,&nbsp;Gregory Mason,&nbsp;Mika J. Mäkelä,&nbsp;Antonella Muraro,&nbsp;Staffan Ahlstedt,&nbsp;Jennifer L. P. Protudjer","doi":"10.1111/cea.14622","DOIUrl":"10.1111/cea.14622","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"357-360"},"PeriodicalIF":6.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Recognise Mastocytosis?","authors":"Clive Grattan,&nbsp;Sigurd Broesby-Olsen,&nbsp;Knut Brockow","doi":"10.1111/cea.14608","DOIUrl":"10.1111/cea.14608","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 1","pages":"14-18"},"PeriodicalIF":6.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}