Clinical and Experimental Allergy最新文献

{"title":"Introduction of Quick Response Coded Digital Allergy Patient Information Leaflets: Patient Perspectives and Key Digital Inclusion Considerations.","authors":"Oyindamola Stephanie Kayode, Cassim Akhoon, Annette Wagner, Olympia Tsilochristou, Stephen Till, Leonard Quok Chean Siew","doi":"10.1111/cea.14613","DOIUrl":"https://doi.org/10.1111/cea.14613","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KITY Study Protocol: A Randomised Controlled Trial for Eczema Prevention by Ingestion of Kestose in High-Risk Neonates.","authors":"Mayako Saito-Abe, Kenji Toyokuni, Hisako Ogasawara, Kyongsun Pak, Yusuke Inuzuka, Daisuke Harama, Nozomi Ando, Yutaka Koyano, Tohru Kobayashi, Yuka Hayashi, Hideaki Morita, Kenji Matsumoto, Tatsuki Fukuie, Yukihiro Ohya, Kiwako Yamamoto-Hanada","doi":"10.1111/cea.14612","DOIUrl":"https://doi.org/10.1111/cea.14612","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Co-Factors in Primary Hazelnut Allergy.","authors":"Morten J Christensen, Annemarie Schaeffer Senders, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz","doi":"10.1111/cea.14611","DOIUrl":"https://doi.org/10.1111/cea.14611","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and Characterisation of Wasp Venom-Specific T Cells Using the ARTE Method in Allergic Patients.","authors":"Magdalena Kraft, Samira Saleh, Guido Heine, Alexander Scheffold, Petra Bacher, Margitta Worm","doi":"10.1111/cea.14606","DOIUrl":"https://doi.org/10.1111/cea.14606","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Integrity in the Field of Atopic Dermatitis Treatment","authors":"Robert J. Boyle, Mohamed H. Shamji","doi":"10.1111/cea.14601","DOIUrl":"10.1111/cea.14601","url":null,"abstract":"<p>In this month's issue of <i>Clinical and Experimental Allergy</i>, we highlight the prize-winners from the recent highly successful BSACI conference and present a Cochrane systematic review of topical anti-inflammatory treatments for eczema (atopic dermatitis). Prize-winner abstracts reflected the breadth and depth of research presented at the BSACI conference, which continues to grow and will move to a new, larger venue next year. Please mark 16–18 October at the International Convention Centre in Newport, Wales in your diary! The Cochrane review findings are striking. Not so much for the findings on effectiveness and safety of topical eczema treatments, but for the lack of independence and transparency in the included clinical trials. Eczema is a common, burdensome condition—probably the most burdensome skin condition affecting humans—and topical anti-inflammatory treatments have been used for generations to manage eczema symptoms. In this first comprehensive Cochrane review of the topic, authors identified almost 400 randomised controlled trials in over 50,000 people with eczema. One might hope that such a significant human effort would have yielded some reliable information to guide clinician, carers and people with eczema in making treatment decisions. However, the standout finding in this review was the lack of transparency in the field (Figure 1). Risk of bias was judged to be high in 89% of trials, with the most common issue being concern about selective reporting. While older clinical trials would not be expected to register their plans on a public clinical trial registry or to make their protocol publicly available—it is of some concern that even the modern trials commonly lacked appropriate trial registration. Trial findings were also rarely reported completely, meaning that for many trials and outcomes, it was not possible to include data in meta-analysis. A common issue here was trialists not stating the number of participants evaluated for an outcome.</p><p>This Cochrane review is a good example of the ways in which scientific progress, clinical practice and the health of relevant populations are held back when clinical trials are not conducted and reported in a transparent manner. It is relevant that only a tiny minority of these trials were funded independently—where stated, the funder was almost always the manufacturer of one of the topical treatments being tested. It is well-established that clinical trials funded in this way tend to report findings as more favourable, and in commercial trials, there are also obvious incentives for non-transparent reporting, unless this is legally mandated. While it is for the lawyers and regulators to legislate and oversee compliance with transparent reporting of clinical trials, journals also have a place in promoting better clinical trial practice. This is why <i>Clinical & Experimental Allergy</i> places great emphasis on transparency in reporting, especially for potentially influenti","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 12","pages":"950-952"},"PeriodicalIF":6.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Lichen Li,&nbsp;Dean J. Naisbitt,&nbsp;Yonghu Sun,&nbsp;Furen Zhang","doi":"10.1111/cea.14609","DOIUrl":"https://doi.org/10.1111/cea.14609","url":null,"abstract":"<p>The cover image is based on the article <i>Pathomechanism of Adverse Reactions to Biological Treatment of Inflammatory Skin Conditions</i> by Lichen Li et al., https://doi.org/10.1111/cea.14583.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 12","pages":"i"},"PeriodicalIF":6.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142859864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prize-Winning Abstracts From BSACI 2024 Meeting","authors":"Mohamed H. Shamji,&nbsp;Robert J. Boyle","doi":"10.1111/cea.14599","DOIUrl":"https://doi.org/10.1111/cea.14599","url":null,"abstract":"&lt;p&gt;The annual British Society of Allergy and Clinical Immunology (BSACI) conference was held in Harrogate, York, UK, from 2 to 5 October 2024. This year, the Barry Kay Award, which recognises Professor Kay's national and international research contributions to the field of allergy and asthma which inspired so many young Allergists and Respiratory scientists, was awarded for the best abstracts in the Adult Clinical, Paediatric Clinical, Medical Student, Equality, Inclusivity and Diversity and Education categories. Here, we have asked the award recipients to summarise their research findings.&lt;/p&gt;&lt;p&gt;Immunotherapy is a widely accepted treatment for allergic conditions, designed to alter the progression of the disease by promoting immune tolerance [&lt;span&gt;1&lt;/span&gt;]. I presented a case of a person affected by severe allergic rhinitis, eczema, asthma and multiple food allergies. Investigations revealed Der p 23 sensitisation, indicating house dust mite allergy. Rhinitis symptoms failed to respond to multiple interventions, including biologics. However, addition of dust mite immunotherapy to biologic treatment resulted in significant symptom improvement. Der p 23, a minor HDM allergen, is not always present in high concentrations in commercially available immunotherapy extracts. Studies show that many HDM extracts from different manufacturers mainly contain Der p 1 and Der p 2, lacking Der p 23. However, other studies using mass spectrometry have shown a broader range of allergen representation, including Der p 23, in products from Allergy Therapeutics and ALK-Abelló A/S. The case underscores the importance of clinicians having a thorough understanding of the allergen content in immunotherapy products, as well as conducting specific allergen component assessments before initiating treatment. This ensures that immunotherapy is tailored to the patient's individual sensitization profile, enhancing its effectiveness.&lt;/p&gt;&lt;p&gt;Educating parents on the recognition and management of allergic reactions is a central part of all paediatric allergy services [&lt;span&gt;2, 3&lt;/span&gt;]. However, individual, in-person education has implications on resource management and consistency in delivery. Our institution utilises a two-part hybrid model comprising condensed in-person training followed by an online group webinar. We aimed to explore the parent experience of this model to inform our understanding of their information and education needs. The personal experiences of seven parents who completed the hybrid webinar education model were explored using one-on-one, semi-structured interviews, with an Interpretive Descriptive approach. These accounts were synthesised into three interpretive themes which described their perceived educational needs. Parents experienced significant &lt;i&gt;barriers to learning&lt;/i&gt; during their clinic visit including cognitive overload, distractions and feeling overwhelmed. &lt;i&gt;Multiple learning events&lt;/i&gt; facilitated addressing knowledge gaps and improved c","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 12","pages":"953-955"},"PeriodicalIF":6.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142860557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Allergy in Children in China.","authors":"Agnes Sze-Yin Leung, Shao Jie, Yanjun Gu, Gary Wing-Kin Wong","doi":"10.1111/cea.14596","DOIUrl":"https://doi.org/10.1111/cea.14596","url":null,"abstract":"<p><p>The prevalence of food allergies in China seems to be increasing, but there are limited studies describing the pattern of food allergies across the country. This review highlights regional variations observed across China, with data indicating a higher prevalence in the more economically developed eastern and southern coastal regions compared to inland areas. Egg and milk are the most common allergies among children under 3 years old; for children above 3 years old, specific food allergens also show regional differences, with shellfish allergies being more common in southern and eastern coastal areas, while wheat and fruit allergies are more prevalent in northern regions. Emerging peanut and tree nut allergies have also been observed in China's megacities, although the prevalence remains relatively low compared to Western countries. These geographic and environmental influences highlight the complexity of the food allergy landscape in China and the need for a more nuanced understanding of the underlying drivers. Despite the growing burden of food allergies, significant gaps exist in effectively managing these conditions in China. Lack of standardised diagnostic tools, limited access to oral food challenges and a shortage of trained allergists pose major challenges. Another critical gap is the limited availability and affordability of epinephrine autoinjectors, essential for managing life-threatening anaphylactic reactions. Addressing these systemic deficiencies in China's food allergy management infrastructure will require concerted efforts from policymakers, healthcare systems and pharmaceutical companies. Investing in the development of standardised diagnostics, expanding the allergy speciality workforce and ensuring equitable access to emergency care and treatment options are crucial steps towards improving health outcomes for the millions of individuals affected by food allergies in China.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Year of Oral Immunotherapy Impacts the Gut Microbiota and Plasma Metabolome of Peanut-Allergic Young Children.","authors":"Isabella Badolati, Ymke de Jong, Carina Uhl, Josefin Ullberg, Marleen Joustra, Ulrika Lorentzon Fagerberg, Caroline Nilsson, Anna Asarnoj, Eva Sverremark-Ekström","doi":"10.1111/cea.14607","DOIUrl":"https://doi.org/10.1111/cea.14607","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Abnormal Body Weight and Allergic Rhinitis-A Systematic Review and Meta-Analysis.","authors":"Brian Sheng Yep Yeo, Elaine Jiaxin Guan, Kaiwen Ng, Yun Sun Lim, Ryan Tsui Hon Goh, Xuandao Liu, Chu Qin Phua, Kaijun Tay, Lu Hui Png, Shuhui Xu, Neville Wei Yang Teo, Tze Choong Charn","doi":"10.1111/cea.14604","DOIUrl":"https://doi.org/10.1111/cea.14604","url":null,"abstract":"<p><strong>Objective: </strong>Allergic rhinitis (AR) is a prevalent inflammatory condition of the nasal mucosa, with significant burden worldwide. While studies have demonstrated a relationship between body mass index (BMI) and other atopic diseases, its association with AR is uncertain. This study aims to clarify the association between non-normal BMI and AR.</p><p><strong>Design: </strong>According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, independent authors screened studies for eligibility, extracted data and assessed bias of included studies using the Newcastle-Ottawa scale and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. A random-effects meta-analysis was used to pool maximally covariate-adjusted estimates. Additional subgroup and bias analyses were performed.</p><p><strong>Data sources: </strong>PubMed, Embase, Cochrane Library, SCOPUS and CINAHL were searched from inception to 14 January, 2024.</p><p><strong>Eligibility criteria: </strong>Observational studies investigating the association between non-normal BMI and AR in both children and adults.</p><p><strong>Results: </strong>We included 32 articles comprising 2,008,835 participants. The risk of bias was low (N = 20) or moderate (N = 12) and GRADE certainty of evidence was very low to low. Pooled cross-sectional analyses indicated that obese children (OR = 0.99, 95% CI = 0.96-1.03, I² = 0%), obese adults (OR = 1.11, 95% CI = 0.92-1.33, I² = 73%), overweight children (OR = 1.02, 95% CI = 0.98-1.06, I² = 35%), and overweight adults (OR = 1.13, 95% CI = 0.90-1.40, I² = 0%) showed similar odds of AR compared to controls. Additionally, longitudinal analyses did not identify any evidence for an association between overweight (OR = 1.03, 95% CI = 0.85-1.24, I² = 29%) or underweight (OR = 1.09, 95% CI = 0.77-1.54, I² = 72%) children and AR risk. These results remained largely robust across various subgroups and sensitivity assessments.</p><p><strong>Conclusion: </strong>Abnormal BMI may not be associated with AR. This study adds to the expanding literature on the association between non-normal BMI and atopic diseases. Further prospective studies are needed to explore the longitudinal relationship between BMI and AR and the effect of weight loss interventions on AR, given the limits of existing literature.</p><p><strong>Trial registration: </strong>PROSPERO CRD42024503589.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}