Clinical and Experimental Allergy最新文献

{"title":"Diagnostic Usefulness of Detecting IgE Content and Profile Specific to 14 Epitopes Defined in Cow's Milk Allergen.","authors":"Kiyoaki Ito, Ikuo Okafuji, Mitsuhiro Kawano, Yusei Ohshima, Yoshihiro Watanabe","doi":"10.1111/cea.70091","DOIUrl":"https://doi.org/10.1111/cea.70091","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of IgE, IgA and IgG Levels in Preschool-Aged Children: Insights From the Subcohort Study of the Japan Environment and Children's Study.","authors":"Yumiko Miyaji, Limin Yang, Daisuke Harama, Mayako Saito-Abe, Miori Sato, Kei Sakamoto, Minaho Nishizato, Natsuhiko Kumasaka, Hidetoshi Mezawa, Yukihiro Ohya, Kiwako Yamamoto-Hanada","doi":"10.1111/cea.70085","DOIUrl":"https://doi.org/10.1111/cea.70085","url":null,"abstract":"<p><strong>Background: </strong>There is a significant lack of longitudinal research on specific immunoglobulin E (IgE), IgA, and IgG sensitisation levels among preschool-aged children, despite their critical role in elucidating the mechanisms underlying allergic disorders. The current study analysed the trajectories of IgE, IgA, IgG1, and IgG4 levels across general populations and their correlation with allergic diseases in children aged 2-4 years.</p><p><strong>Methods: </strong>This longitudinal study included 4872 children aged 2 years and 4437 children aged 4 years who participated in the Subcohort Study of the Japan Environment and Children's Study. Allergic diseases were evaluated utilising the diagnostic criteria established by the International Study of Asthma and Allergies in Childhood and the UK Working Party. The serum specific IgE (sIgE), IgG1, IgG4, and IgA levels of participants aged 2-4 years were quantified.</p><p><strong>Results: </strong>The prevalence of atopic dermatitis, hen's egg allergy, cow's milk allergy, and current wheezing decreased between ages 2 and 4 years. The prevalence of allergic rhinitis and conjunctivitis exhibited an upward trend. The serum IgE levels to hen's egg and cow's milk antigens in healthy children were similar to those in children with allergic diseases, and it decreased between ages 2 and 4 years. Der p1 sIgE levels decreased in healthy children, whereas they increased in allergic children. The high sIgE/total IgE and sIgE/specific IgG4 levels to Derf1 and Derp1 at age 2 years were associated with current wheezing at age 4 years.</p><p><strong>Conclusions: </strong>This study provided foundational benchmark values for IgE, IgG1, IgG4, and IgA levels against different allergens in a general population of children aged < 5 years. The levels of each allergen exhibited distinct characteristics in the general population.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Treatment of Type 2 High and Low Asthma Endotypes.","authors":"Timothy C Chin-See-Chong, Jasper H Kappen, Elizabeth Palmer, Janice A Layhadi, Mohamed H Shamji, Johanna P M van der Valk","doi":"10.1111/cea.70084","DOIUrl":"https://doi.org/10.1111/cea.70084","url":null,"abstract":"<p><p>Asthma is a complex, heterogeneous disease characterised by clinical phenotypes demonstrating distinct and overlapping immunological mechanisms, classified into type-2 high and type-2 low asthma endotypes. Both allergic and eosinophilic non-allergic asthma are driven through an underlying type-2 high-endotype, which can be targeted using therapeutic approaches such as allergen-specific immunotherapy (AIT) for allergic asthma and biologics. AIT demonstrates efficacy for the treatment of allergic asthma. Approved biologics for asthma management include using various interleukin antagonists and anti-immunoglobulin E, with Tezepelumab offering promising treatments for both type-2 high and type-2 low asthma patients. Novel therapeutic candidates, such as Itepekimab and depemokimab, have demonstrated promising results in a Phase 2 clinical trial in moderate-to-severe asthma patients.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, Diagnosis and Prevention of Allergic Rhinitis in High-Pollen Areas of Northern China.","authors":"T T Ma, C E Fan, X Tong, C Y An, H J Cai, L Y Ai, Y F Li, D Y Wang, X D Wang, G L Shang, Y D Hu, Y F Bai, Y L Chen, H T Wang, H Y Ning, L Zhang, J J Zhang, X Y Wang","doi":"10.1111/cea.70087","DOIUrl":"https://doi.org/10.1111/cea.70087","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Remission in Severe Asthma With Benralizumab: Latest Findings, Current Perspectives and Future Direction.","authors":"Renaud Louis, Marek Lommatzsch, David J Jackson, Andrew Menzies-Gow, Anat Shavit, David Cohen, Flavia C L Hoyte, Stephanie Korn","doi":"10.1111/cea.70083","DOIUrl":"https://doi.org/10.1111/cea.70083","url":null,"abstract":"<p><p>The introduction of biologics, such as benralizumab (an anti-IL-5 receptor α humanised monoclonal antibody), has made remission a feasible goal for patients with severe eosinophilic asthma (SEA). However, there are remaining research gaps and no clear consensus on the definition of remission. We consolidated post hoc remission data from clinical trials and real-world studies of benralizumab in patients with SEA to gather insights on: testing different definitions; predictors of remission; the effect of comorbidities on achieving remission; remission and background medication reduction; long-term remission patterns with benralizumab; and remission in a real-life setting. In the SIROCCO and CALIMA Phase 3 randomised studies, patients with remission had higher baseline median blood eosinophil counts, were more likely to have a FEV₁ of ≥ 65% predicted, had fewer exacerbations within 12 months and had lower mean ACQ-6 scores. Compared with the overall population, patients with a history of nasal polyps were also more likely to achieve remission with benralizumab. Analyses of the BORA and MELTEMI extension studies showed that in the longer term, once remission is achieved with benralizumab, patients are likely to remain in remission with continued treatment. In the open-label, single-arm ANDHI-In Practice and PONENTE studies, patients achieving remission had a shorter median time since asthma diagnosis, higher median age at asthma onset and lower median ACQ-6 scores. The SHAMAL study and the Phase 3b ANDHI-In Practice substudy demonstrate that remission is maintained with benralizumab even when patients reduce their background medication. Finally, the XALOC-1 real-world study highlights how patients with lower BMI are more likely to achieve remission with benralizumab. These findings demonstrate that achieving remission in patients with SEA is feasible with benralizumab and, in turn, inform future directions for research and treatment that includes a promising shift towards a new era of treat-to-target. This manuscript was supported by AstraZeneca, the manufacturer of benralizumab.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Food Challenges for Food Protein-Induced Enterocolitis Syndrome-A 10-Year Multicentre Audit.","authors":"L Mackey, M Norman, D Chan","doi":"10.1111/cea.70090","DOIUrl":"https://doi.org/10.1111/cea.70090","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Fatal and Near-Fatal Food Anaphylaxis: Analysis of the Allergy-Vigilance Network Database.","authors":"Guillaume Pouessel, Claire Egea, Amandine Divaret-Chauveau, Pascale Beaumont, Eléna Bradatan, Pascale Dumond, Rémy Diesnis, Sélina Tscheiller, Xavier Van der Brempt, Camille Braun, Dominique Sabouraud-Leclerc","doi":"10.1111/cea.70089","DOIUrl":"https://doi.org/10.1111/cea.70089","url":null,"abstract":"<p><strong>Background: </strong>Gaining a better understanding of the risk factors for severe anaphylaxis represents a crucial challenge for physicians. This survey aimed to analyse cases of severe food anaphylaxis and assess potential risk factors for severity.</p><p><strong>Methods: </strong>We retrospectively analysed food anaphylaxis cases recorded by the French-speaking Allergy-Vigilance Network (2002-2021) and compared the main characteristics of grade 3 (Ring classification) and grade 4 cases using univariate and multivariate statistical analyses.</p><p><strong>Results: </strong>Of the 2621 food anaphylaxis cases reported, 731 (27.9%) were considered severe (grade 3, n = 687 [94%] and grade 4, n = 44 [6%]; 19 deaths). Overall, 56.1% of cases were adults (mean age: 28.3 years) and 53.7% were male. The most frequent triggers were peanut (13.9%), wheat (9.4%), cashew (5.8%), shrimp (5.3%), and cow's milk (4.6%). More grade 4 anaphylaxis cases occurred in children than in adults (26 vs. 18; p = 0.01). In univariate analysis, individuals with grade 4 anaphylaxis were more likely to have a history of allergy to the culprit food (71.1% vs. 42.1%; p < 0.001), asthma diagnosis (59.5% vs. 30.4%; p < 0.001), and peanut as the culprit food (34.1% vs. 12.6%; p < 0.001). In multivariate analysis, factors predictive of grade 4 anaphylaxis were asthma diagnosis (OR [95% CI]: 3.41 [1.56-7.44]; p = 0.002) and peanut as the culprit trigger (OR [95% CI]: 3.46 [1.28-9.34]; p = 0.014).</p><p><strong>Conclusions: </strong>Our data highlight the risk factors for severe food anaphylaxis, notably a history of asthma and peanut as the culprit food. These individuals should benefit from personalised management strategies.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of First Oral Hen's Egg Challenge in Food Protein Induced Enterocolitis Syndrome.","authors":"Deniz Ilgun Gurel, Melike Ocak, Bulent Sekerel, Umit Murat Sahiner, Ozge Soyer","doi":"10.1111/cea.70086","DOIUrl":"https://doi.org/10.1111/cea.70086","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum.","authors":"Lisa P van der Rijst, Edward F Knol, Nicolaas P A Zuithoff, Constance F den Hartog Jager, Femke van Wijk, Marjolein S de Bruin-Weller, Marlies de Graaf","doi":"10.1111/cea.70082","DOIUrl":"https://doi.org/10.1111/cea.70082","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity.</p><p><strong>Methods: </strong>Twenty paediatric AD patients (< 18 years) starting dupilumab treatment were included. Serum samples and tape strips from lesional and non-lesional skin were collected at baseline, 4 and 16 weeks of treatment. Fifteen pre-specified proteins were measured at each visit by Luminex multiplex immunoassay. Clinical severity outcome measures included the Eczema Area and Severity Index (EASI) and Numeric Rating Scale (NRS) itch. Statistical analyses included Wilcoxon signed-rank tests and Spearman correlations.</p><p><strong>Results: </strong>Along with clinical improvement, 16 weeks of dupilumab treatment resulted in a rapid and significant reduction in the disease-associated mediators PARC/CCL18 and TARC/CCL17 in both tape-stripped skin and serum. While the cytokine and chemokine profiles differed between the sampling methods, both effectively captured immunological changes associated with dupilumab treatment. Tape strips demonstrated significant reductions in innate pro-inflammatory cytokines (IL-8/CXCL8, IL-18), the T cell-recruiting chemokine CTACK/CCL27, the Type 1 immune mediator CXCL10, and tissue repair and remodelling proteins (periostin, MMP-1) in response to treatment, but were less sensitive in detecting T cell-derived cytokines (IL-4, IL-13). In both skin and serum, several proteins were significantly correlated with AD severity, as measured by EASI and NRS itch, with PARC/CCL18 emerging as the strongest correlated protein.</p><p><strong>Conclusion: </strong>Our findings provide insight into the distinct local and systemic proteomic changes in response to dupilumab treatment in paediatric AD patients. These findings underscore the complementary roles of tape strips and serum in profiling immune and epidermal barrier proteins, highlighting the utility of minimally invasive tape stripping for monitoring proteomic responses to targeted therapies in paediatric AD.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Study of Fractional Exhaled Nitric Oxide (FeNO) and Spirometric Indices in Trainee Bakers and Confectioners.","authors":"Gina-Maria Klaut, Ludwig Frei-Stuber, Stefan Karrasch, Susanne Kutzora, Jonas Huss, Doris Gerstner, Dennis Nowak, Caroline Quartucci","doi":"10.1111/cea.70076","DOIUrl":"https://doi.org/10.1111/cea.70076","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}