Clinical and Experimental Allergy最新文献

{"title":"Allergen-Sensitised Whole Blood Samples for Quality Control and Benchmarking of Basophil Activation Tests.","authors":"Léonard Bezinge, Federica Richina, Adrian Leathers, Liesel Schrake, Maximilien Lartigue, Michele Romano, Cédric Giegelmann, Christian-Benedikt Gerhold, Michael A Gerspach","doi":"10.1111/cea.70451","DOIUrl":"https://doi.org/10.1111/cea.70451","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Time Course of Symptom Improvement With Remibrutinib in Chronic Spontaneous Urticaria: Pooled Post Hoc Analyses of the REMIX-1/2 Phase 3 Studies.","authors":"Gordon Sussman, Nadine Chapman-Rothe, Tao Ding, Atsushi Fukunaga, Ana Maria Giménez-Arnau, Michihiro Hide, Mark Lebwohl, Paula G P Machado, El-Djouher Martzloff, Giselle Mosnaim, Christine-Elke Ortmann, Petra Staubach, Hui Tang, Ansgar Weyergraf, Bin Yang, John Reed","doi":"10.1111/cea.70450","DOIUrl":"https://doi.org/10.1111/cea.70450","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Siglec Expression Patterns in Food Allergy Reveal Altered Intensity but Not Frequency.","authors":"J S H Schaapherder, A M Ehlers, E F Knol, A C Knulst, G J P H Boons, K C M Verhoeckx","doi":"10.1111/cea.70458","DOIUrl":"https://doi.org/10.1111/cea.70458","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yeast Surface Display for Efficient Generation of Nanobody-Based Human IgG Targeting the 11S Globulin From Hazelnut, Cor a 9.","authors":"Bjarke Krogstrup Jensen, Rikke Mølbak Eskildsen, Anne-Sofie Ravn Ballegaard, Görkem Odabaş, Josephine Baunvig Aagaard, Michaela Miehe, Edzard Spillner","doi":"10.1111/cea.70454","DOIUrl":"https://doi.org/10.1111/cea.70454","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Resolvin D2 Is Elevated and Lipoxin A₄ Is Reduced in Atopic Dermatitis: A Candidate Lipid Mediator Imbalance.","authors":"Maho Tagui, Keisuke Shimizu, Koremasa Hayama, Yoshimi Miki, Shota Toyoshima, Mana Ito, Hideki Fujita, Yoshitaka Taketomi, Makoto Murakami, Yoshimichi Okayama","doi":"10.1111/cea.70455","DOIUrl":"https://doi.org/10.1111/cea.70455","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Penicillin Allergy Clinical Decision Rule Performs Differently in Immediate and Delayed Hypersensitivity.","authors":"Paul Bellmann, Maximilian Lammer, Alina Stock, Norbert Reider","doi":"10.1111/cea.70452","DOIUrl":"https://doi.org/10.1111/cea.70452","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROTEGO Study Protocol: A Cluster Randomised Crossover Trial of Vernix Caseosa Retention for Primary Prevention of Atopic Dermatitis.","authors":"Arturo Borzutzky, Carolina Cabalín, Juan Pablo Fraga, Jorge Fabres, Alberto Toso, Marcelo Farías, María Laura Cossio, María José Escalante, Paula Fajuri, Maite Rojas-Mckenzie, Magdalena Sande, Rosario Willatt, Carolina Barrientos, Robert J Boyle","doi":"10.1111/cea.70449","DOIUrl":"https://doi.org/10.1111/cea.70449","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and Timing of Specialized Formula Prescriptions for Children Under 2 Years.","authors":"Nikita Punjabi, Karen Li, Mark Cunningham, Kimberley Foley, Frank Moriarty, Sonia Saxena, Jennifer K Quint, Dougal Hargreaves, Robert J Boyle","doi":"10.1111/cea.70447","DOIUrl":"https://doi.org/10.1111/cea.70447","url":null,"abstract":"<p><strong>Background: </strong>Infants with non-specific symptoms are sometimes labelled as cow's milk allergic and managed with specialized formula. These products differ from standard infant formula in protein and carbohydrate source, typically containing lower quality protein and free/added sugars such as glucose polymers or sucrose. We evaluated the frequency, timing, duration and estimated volume of specialized formula prescribed to young children.</p><p><strong>Methods: </strong>We undertook a retrospective population-based cohort study of children up to age 2 years born between 2009 and 2021 who were registered with a contributing UK general practice, predominantly in England. Community prescribing and demographic data were obtained from the Clinical Practice Research Datalink (CPRD) Aurum, a de-identified primary care database representing approximately 24% of the population. National prescribing data for England were used to estimate community prescribing rates for 2022-2025.</p><p><strong>Results: </strong>Of 4,203,276 children born between 2009-2021 in the database, 1,944,323 (46.3%) were registered by age 3 months with complete data to age 2 years and were included. Of these, 111,478 (5.7%) were prescribed specialized formula, rising from 1.7% of children born in 2009 to 7.9% in 2021 and an estimated 9.7% in 2025. Prescriptions were most commonly initiated at age 0-2 months. Multiple prescriptions were documented for 85,370 (76.6%) of these children. Children with multiple amino-acid formula prescriptions consumed an estimated mean total of 242 L; those with multiple extensively hydrolysed formula prescriptions 203 L; and those with multiple soya formula prescriptions 137 L. Among these children, the median interval between first and last prescription was 257 days for amino-acid formula, 213 days for extensively hydrolysed formula and 152 days for soya formula.</p><p><strong>Conclusions: </strong>Community prescribing of specialized formula in England increased approximately five-fold over the study period, potentially triggering significant free sugars exposure during infancy.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tryptase Locus Variation Contributes to Normal-Range Basal Serum Tryptase Variability and Is Associated With Anaphylaxis.","authors":"Manca Svetina, Jonathan J Lyons, Peter Kopač, Julij Šelb, Mitja Košnik, Matija Rijavec, Peter Korošec","doi":"10.1111/cea.70448","DOIUrl":"https://doi.org/10.1111/cea.70448","url":null,"abstract":"<p><strong>Background: </strong>Increased basal serum tryptase level (BST) is associated with anaphylaxis. In the absence of clonal mast cell disease and hereditary α-tryptasemia (HαT), the contribution of the tryptase locus variation to BST and anaphylaxis remains undefined.</p><p><strong>Objective: </strong>To determine the impact of tryptase locus variation on BST and anaphylaxis.</p><p><strong>Methods: </strong>Individuals with systemic Hymenoptera venom allergic reactions, large local reactions and asymptomatic sensitization underwent a novel ddPCR-based tryptase genotyping to quantify active tryptase alleles. Individuals positive for KIT p.D816V or HαT were excluded.</p><p><strong>Results: </strong>The cohort consisted of 295 individuals with systemic reactions, 140 with large local reactions, and 29 asymptomatically sensitized individuals. Active tryptase allele number, excluding the inactive βIIIFS allele, correlated with BST levels (r = 0.34, p < 0.0001); all BST values were within the normal range. Patients with systemic reactions had higher BST compared with those with large local reactions and asymptomatic sensitization (median, 4.5 ng/mL vs. 3.5 ng/mL; p < 0.0001). Individuals carrying four active β-tryptase alleles were less likely to experience anaphylaxis than those carrying two or three active β-tryptase alleles (26.7% vs. 42.3%; p = 0.024). A trend towards more severe reactions was observed in individuals carrying α-tryptase allele together with a higher number of active β-tryptase alleles.</p><p><strong>Conclusion: </strong>Variation at the tryptase locus explains differences in BST levels within the normal range. Four active β-tryptase alleles were associated with a lower frequency of anaphylaxis.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochrane Corner: Probiotics in Infants for Prevention of Allergic Disease.","authors":"Prav Hamal, Robert Boyle","doi":"10.1111/cea.70445","DOIUrl":"https://doi.org/10.1111/cea.70445","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}