Clinical and Experimental Allergy最新文献

{"title":"Chronic Spontaneous Urticaria Endotypes: Exploratory Proteomic Analysis in the Benralizumab ARROYO Study.","authors":"Eva Rodríguez-Suárez, Mathias Cardner, Daniel Muthas, Chris Chamberlain, Adam Platt, Sabine Altrichter, Lisa A Beck, Jonathan A Bernstein, Ana Maria Giménez-Arnau, Martin Metz, Christopher McCrae","doi":"10.1111/cea.70434","DOIUrl":"https://doi.org/10.1111/cea.70434","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Patterns of Chronic Rhinosinusitis in A Large Tertiary Referral Centre.","authors":"Wenqiao Zhou, Xingchen Liu, Junying Hu, Yu Chen, Jifeng Liu, Jintao Du, Guo Liu, Bing Zhong, Feng Liu","doi":"10.1111/cea.70446","DOIUrl":"https://doi.org/10.1111/cea.70446","url":null,"abstract":"<p><p>CRS burden increased despite improving air quality, with greater allergic and type 2 inflammatory characteristics. Asthma is strongly associated with CRSwNP, while SO₂ was independently associated with eosinophilic inflammation.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble FGL2 Is Elevated and Associated With Type 2 Inflammation in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.","authors":"Xinyu Zhang, Li Fu, Nadiya Abulikemu, Yang Liu","doi":"10.1111/cea.70376","DOIUrl":"10.1111/cea.70376","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1270-1272"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Society for Allergy and Immunology Abstracts From the 2026 Annual Conference.","authors":"","doi":"10.1111/cea.70420","DOIUrl":"10.1111/cea.70420","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1279-1365"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Diagnostic Patterns and Symptom Progression in Aspirin-Exacerbated Respiratory Disease","authors":"Orli Weiser,&nbsp;Guy Melamed,&nbsp;Ronit Confino-Cohen,&nbsp;Yossi Rosman","doi":"10.1111/cea.70369","DOIUrl":"10.1111/cea.70369","url":null,"abstract":"&lt;p&gt;Aspirin-Exacerbated Respiratory Disease (AERD) is a chronic condition that impairs quality of life and may pose life-threatening risks [&lt;span&gt;1&lt;/span&gt;]. Patients typically suffer from severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Accurate and timely diagnosis is essential to ensure patient safety through education and safe medication use, and to enable the initiation of disease-tailored therapies for uncontrolled asthma and recurrent nasal polyps. Yet, diagnosis delay remains a defining feature of AERD [&lt;span&gt;1, 2&lt;/span&gt;]. The treatment of AERD is well-established, safe, and effective. Consequently, the main challenge highlighted in the literature is the difficulty in diagnosing this disease [&lt;span&gt;1-3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Despite its clinical importance, the timing of symptom onset and the progression of AERD remain poorly characterized [&lt;span&gt;4&lt;/span&gt;]. Clarifying these temporal dynamics is necessary, particularly given recent evidence that AERD follows a significantly more severe clinical course than aspirin-tolerant asthma [&lt;span&gt;5&lt;/span&gt;]. Understanding the progression and pace of disease development is crucial for facilitating earlier recognition and enabling timely, tailored treatment [&lt;span&gt;1&lt;/span&gt;], especially since early biologic intervention, prior to irreversible epithelial damage, holds the potential to fundamentally alter the disease course [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Advances in digital health data offer new opportunities to improve the identification of AERD patients through the coexistence of three diagnostic codes: asthma, nasal polyps, and NSAID sensitivity [&lt;span&gt;3-5, 7, 8&lt;/span&gt;]. Hence, the objective of this study is to investigate the diagnostic sequence and temporal intervals between AERD-related conditions through analysis of EMR data.&lt;/p&gt;&lt;p&gt;Our cohort included 181 MHS patients diagnosed with asthma, nasal polyps, and NSAID sensitivity between 2002 and 2022, of whom 101 were females (56%) and 80 were males (44%). Diagnoses were identified based on ICD codes for asthma (493) and nasal polyps (471). Most patients had repeated spirometry testing (median 4 tests per patient), with similar patterns observed across all sequence groups (&lt;i&gt;p&lt;/i&gt; = 0.889). This pattern suggests consistent diagnostic practices and ongoing clinical follow-up across the cohort. NSAID hypersensitivity was based on clinician-documented patient history, typically requiring at least two episodes. The study was approved by MHS Institutional Review Board.&lt;/p&gt;&lt;p&gt;Patients were classified into six groups based on the chronological order of symptom diagnosis. Diagnostic intervals, biomarkers, and healthcare utilization were analysed across groups (see Table 1). Consistent with previous studies, AERD was more prevalent in women [&lt;span&gt;3-5, 7, 9&lt;/span&gt;], and symptom onset typically occurs after age 40. In half of the cohort, asthma was the initial symptom, while 26% presented first with nasal polyps and the remainder (24%) with NSAID sensitivit","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 10","pages":"1256-1260"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Does the Immune System Choose? Rethinking Food Allergy Through the Lens of Immune Pathway Selection in a Changing World","authors":"Sowmya Arudi Nagarajan,&nbsp;Neeraj Gupta","doi":"10.1111/cea.70350","DOIUrl":"10.1111/cea.70350","url":null,"abstract":"&lt;p&gt;Food allergy research has advanced considerably over the past few decades, with important gains in allergen characterization, improved understanding of immunoglobulin E (IgE)–mediated mechanisms, and refinement of diagnostic approaches. Despite this progress, a fundamental question remains unresolved: why does the immune system respond so differently to the same food antigen across individuals?&lt;/p&gt;&lt;p&gt;A single dietary protein—whether casein, ovomucoid or gliadin—can provoke rapid systemic reactions in one individual, delayed gastrointestinal inflammation in another, and complete immunological tolerance in a third. Such variability suggests that the nature of the response is not dictated solely by the antigen itself, but by how the immune system interprets it within a given biological and environmental context. This observation challenges the traditional allergen-centric model of food allergy and calls for a broader framework that recognizes the dynamic interplay between host immunity, environmental exposures and developmental timing [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Traditionally, food allergy has been divided into IgE-mediated and non-IgE-mediated categories based on immunological mechanisms and timing of clinical symptoms. Immediate reactions are attributed to mast cell and basophil activation via allergen-specific IgE, whereas delayed manifestations are largely driven by cellular immune pathways, particularly T-cell–mediated inflammation. While this framework remains clinically useful, it risks oversimplifying what is likely a far more fluid and interconnected spectrum of immune responses. Increasing evidence supports the view that IgE and non-IgE responses represent different points along a continuum of immune regulation rather than entirely distinct disease entities [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Emerging evidence highlights the importance of early-life immune conditioning in shaping these outcomes. Factors such as epithelial barrier integrity, microbial colonization, timing and route of antigen exposure, and the surrounding cytokine environment appear to play decisive roles in determining whether a given antigen induces tolerance, IgE sensitization or non-IgE-mediated disease [&lt;span&gt;3, 4&lt;/span&gt;]. In this light, the immune response reflects not merely exposure, but contextual interpretation. The developing immune system integrates signals from epithelial surfaces, commensal microbes and environmental stimuli to establish patterns of immune reactivity that may persist throughout life.&lt;/p&gt;&lt;p&gt;The dual allergen exposure hypothesis has been instrumental in advancing this perspective. It proposes that exposure to food antigens through a compromised skin barrier favours allergic sensitization, whereas early oral exposure promotes tolerance [&lt;span&gt;5&lt;/span&gt;]. This concept has helped explain the observed association between atopic dermatitis and food allergy and has been supported by interventional studies demonstrating reduced rates of peanut and egg allergy follow","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 10","pages":"1159-1161"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging, Genetic Susceptibility and Risk of Chronic Inflammatory Upper Airway Diseases: Finding From A Prospective Cohort Study","authors":"Ao Huang,&nbsp;Wen-Xuan Xiang,&nbsp;Jing-Yi Ma,&nbsp;Zhuo Xu,&nbsp;Yan Nie,&nbsp;Ziwei Zhu,&nbsp;Jia Song,&nbsp;Yi-Ke Deng,&nbsp;Yin Yao,&nbsp;Heng Wang,&nbsp;Chaolong Wang,&nbsp;Zheng Liu","doi":"10.1111/cea.70371","DOIUrl":"10.1111/cea.70371","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 10","pages":"1261-1263"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Dependent Role of Cough Hypersensitivity in Transition to Refractory Chronic Cough.","authors":"Sung-Yoon Kang, Ha-Kyeong Won, Mi-Yeong Kim, Ji-Hyang Lee, Jin An, Ji-Yoon Oh, Jiung Jeong, Young-Chan Kim, So-Young Park, Hwa Young Lee, Eun-Jung Jo, Kyung-Min Ahn, Min-Hye Kim, So Ri Kim, Sae-Hoon Kim, Sang-Heon Kim, Yoon-Seok Chang, Byung-Jae Lee, Surinder S Birring, Woo-Jung Song","doi":"10.1111/cea.70373","DOIUrl":"10.1111/cea.70373","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1264-1266"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Piwi-Interacting RNAs Associate With Childhood Asthma ICS Response With Vitamin D Effect Modification","authors":"Jiang Li,&nbsp;Xiaoning Hong,&nbsp;Mengshi Chi,&nbsp;Alvin T. Kho,&nbsp;Zhongxu Zhu,&nbsp;Hui Zhang,&nbsp;Tao Liu,&nbsp;Michael J. McGeachie,&nbsp;Juan C. Celedón,&nbsp;Scott T. Weiss,&nbsp;Kelan G. Tantisira,&nbsp;Jiang Li","doi":"10.1111/cea.70314","DOIUrl":"10.1111/cea.70314","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Piwi-interacting RNAs (piRNAs) have been linked to type 2-high asthma phenotypes. Although vitamin D modulates inhaled corticosteroid (ICS) response via microRNAs, its potential role through piRNAs remains unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Baseline plasma piRNA expression was profiled by small RNA sequencing in 492 participants from the Childhood Asthma Management Program (CAMP), with 187 children randomised to the ICS arm. Serum vitamin D levels were classified as insufficient (≤ 30 ng/mL) or sufficient (&gt; 30 ng/mL). Linear regression was used to assess associations between piRNA expression and changes in prebronchodilator percent predicted forced expiratory volume in 1 s (FEV₁%) over 4 years, including interaction analyses with vitamin D status. Replication was performed in 375 ICS-treated participants from the Genetics of Asthma in Costa Rica Study (GACRS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fourteen piRNAs were significantly associated with FEV₁% changes among vitamin D–insufficient children, six showing significant interactions with vitamin D status (<i>p</i> &lt; 0.05). Four piRNAs were replicated in GACRS, with piR-36241 also confirmed in interaction analyses. Predicted targets of piR-36241 were enriched in immune- and respiratory-related pathways. piR-36241 demonstrated strong predictive performance for ICS response in vitamin D–insufficient children (AUROC = 0.84) and was detected in bronchial epithelial cells, where it was differentially expressed in asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Circulating piRNAs are associated with ICS response in childhood asthma, with vitamin D acting as an effect modifier, which may serve as non-invasive biomarkers for ICS responsiveness, particularly in vitamin D–insufficient patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov Identifier: NCT00000575 and NCT00021840</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 10","pages":"1215-1223"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant Formula Marketing: Lessons From Recent Litigation","authors":"Robert J. Boyle,&nbsp;Gerard Hastings","doi":"10.1111/cea.70433","DOIUrl":"10.1111/cea.70433","url":null,"abstract":"&lt;p&gt;In 2024, 2025 and 2026 several legal judgements were made in the United States against the infant formula industry, which are relevant to the allergy community. These cases give us potential insights into infant formula marketing both within and outside the field of allergy. The judgements are relevant for the allergy community to understand since, against World Health Organization recommendations, the formula industry still sponsors many allergy healthcare professional associations and conferences.&lt;/p&gt;&lt;p&gt;The most directly relevant case is a New York class action which was settled out of court last year by Gerber, previously owned by Nestlé. Plaintiffs alleged the company had ‘engaged in a pattern of false, deceptive, and unfair business practices through advertising and marketing representations’. The allegations were denied by Gerber. The alleged misrepresentations included statements that Gerber's partially hydrolysed whey formula was the ‘first and only formula that reduces the risk that infants will develop allergies’ [&lt;span&gt;1&lt;/span&gt;]. The narrative that partially hydrolysed formula reduces risk of allergies or eczema has been a prominent feature at allergy conferences and in allergy publications since the 1980s. However, independent assessments have cast doubt on the claim that consumption of hydrolysed cow's milk protein in infant formula has an impact on allergy or eczema development [&lt;span&gt;2&lt;/span&gt;]. The ‘hydrolysed formula narrative’ has been supported by fraudulent or retracted science and incomplete reporting of clinical trial findings. Importantly, the narrative that hydrolysed formula can prevent allergy was disseminated through formula industry funded healthcare professional education. So one lesson we might take from the hydrolysed formula story is that formula industry funded healthcare professional education has the potential to overemphasise unreliable scientific findings.&lt;/p&gt;&lt;p&gt;Further learning about formula marketing can be gleaned from the court case against Abbott Laboratories [&lt;span&gt;3&lt;/span&gt;]. The case concerned the inflammatory condition necrotising enterocolitis (NEC), which mainly affects infants born preterm or with a low birth weight. In 2024, a Missouri jury ordered Abbott Laboratories to pay $495 million in compensatory and punitive damages for allegedly not providing adequate warning about links between its preterm formula range and NEC [&lt;span&gt;3&lt;/span&gt;]. In August, Abbott issued a press release announcing agreements to resolve this lawsuit as well as NEC claims asserted on behalf of approximately 2000 additional infants for an aggregate amount of approximately $670 million [&lt;span&gt;4&lt;/span&gt;]. Abbott stated these agreements are a compromise of disputed claims and not in any way an admission of liability. Industry documents cited in the 2024 Abbott case can be viewed at the University of California San Francisco Industry Documents Library. While preterm formulas represent a small market segment with relatively low v","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 10","pages":"1156-1158"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}