Clinical and Experimental Allergy最新文献

{"title":"Global Incidence and Prevalence of Chronic Rhinosinusitis: A Systematic Review.","authors":"Hye Kyu Min, Sooji Lee, Soeun Kim, Yejun Son, Jaeyu Park, Hyeon Jin Kim, Jinseok Lee, Hayeon Lee, Lee Smith, Masoud Rahmati, Jiseung Kang, Nikolaos G Papadopoulos, Seong H Cho, Jong Woo Hahn, Dong Keon Yon","doi":"10.1111/cea.14592","DOIUrl":"10.1111/cea.14592","url":null,"abstract":"<p><strong>Objective: </strong>Data on the global prevalence of chronic rhinosinusitis (CRS) is significantly varied and limited across countries and over time. Therefore, we aimed to conduct a comprehensive investigation into the global, regional, and national burden of CRS from the years 1980 to 2021, as well as identify those factors that influence levels of such burden.</p><p><strong>Design: </strong>We conducted a systematic review and meta-analysis of general population-based observational studies focusing on CRS. We calculated pooled estimates of CRS prevalence and incidence with 95% confidence intervals (CIs). Subgroup analyses were conducted stratifying by sex, age cohorts, geographic regions, smoking status, obesity, and comorbid conditions.</p><p><strong>Data sources: </strong>PubMed/MEDLINE, EMBASE, CINAHL, Google Scholar, and Cochrane databases.</p><p><strong>Eligibility criteria for selection: </strong>We included general population-based observational studies on CRS published from database inception through October 20, 2023.</p><p><strong>Results: </strong>A total of 28 eligible studies, encompassing more than 237 million participants and 11,342,923 patients with CRS from 20 countries across four continents, were included in the analysis. Global pooled prevalence of CRS and CRS with nasal polyps (CRSwNP) was found to be 8.71% (95% CI, 6.69-11.33; number of studies, 20) and 0.65% (95% CI, 0.56-0.75; number of studies, 4), respectively. The prevalence of CRS was greater in Europe compared with North America, South America, and Asia; adults compared with children; smokers compared with never-smoker; those with obesity compared with normal weight; and those with comorbidities such as asthma, diabetes mellitus, eczema, and nasal septal deviation. Pooled prevalence of CRS increased from 1980 to 2020 (1980-2000: 4.72%; 95% CI, 2.12-10.49; 2014-2020: 19.40%; 95% CI, 12.12-31.07). Similar patterns were observed in CRS incidence.</p><p><strong>Conclusions: </strong>Our study provides valuable insights into CRS prevalence and incidence across diverse demographic and clinical factors, highlighting its increasing global burden. The reported prevalence of CRS varies internationally, and may be increasing over time. To enhance data quality and comparability, standardization of reporting methodologies is imperative.</p><p><strong>Systematic review registration: </strong>PROSPERO (registration no. CRD42024527805).</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-107 and Its Association With House Dust Mite Sensitisation: Implications for Asthma.","authors":"Byung-Keun Kim, Min-Suk Yang, Upasna Srivastava, Shraddha Piparia, Rinku Sharma, Anshul Tiwari, Alvin Kho, Richard Wong, Juan C Celedón, Scott T Weiss, Michael McGeachie, Kelan Tantisira","doi":"10.1111/cea.14590","DOIUrl":"https://doi.org/10.1111/cea.14590","url":null,"abstract":"<p><strong>Introduction: </strong>MicroRNAs (miRNAs) have been linked to allergic diseases but their effects on sensitisation to allergens in individuals with asthma are unknown. We aimed to identify miRNAs associated with house dust mite (HDM) sensitisation in childhood asthma.</p><p><strong>Methods: </strong>Serum samples from 1126 children with asthma who participated in the Genetics of Asthma in Costa Rica Study (GACRS) were profiled for 304 miRNAs. We first divided according to HDM sensitisation and then tested whether miRNAs were differentially expressed (DE) between the two groups. Gene enrichment analysis for target genes of the DE miRNAs was then performed to identify potential causal pathways. Replication analysis was performed in the Childhood Asthma Management Program (CAMP), in which expression data of 258 miRNAs in 491 children were available. A mediation analysis was conducted to discern relationships between miRNA and phenotype differences according to HDM sensitisation in GACRS cohort.</p><p><strong>Results: </strong>There were 906 (80.5%) and 220 (19.5%) subjects in the GACRS HDM+ and HDM- groups. Compared with HDM- participants, those in the HDM+ group were more likely to be severe in variables including pulmonary function, oral corticosteroid use and blood tests. A total of 17 miRNAs were DE (p < 0.05) between the two groups, with miR-642a-3p, let-7c-5p and miR-107 most significantly associated with HDM sensitisation. In CAMP, there were 39 DE miRNAs, and increased expression of miR-107 in HDM+ children was replicated in this cohort. In both GACRS and CAMP, the cadherin-binding pathway was enriched in an analysis of target genes for DE miRNA. In a mediation analysis, miR-107 showed significant indirect effects on eosinophil count and total IgE that were mediated by HDM sensitisation.</p><p><strong>Conclusion: </strong>In children with asthma, miR-107 is associated with HDM sensitisation. Furthermore, miR-107 was indirectly associated with total IgE and eosinophil count through HDM sensitisation.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 Immune-Dominant Endotype Is Not Associated With Increased Responsiveness to Dupilumab Treatment in Adult Atopic Dermatitis Patients.","authors":"Coco Dekkers, Hidde Smits, Dora Stölzl, Lotte Spekhorst, Edward Knol, Femke van Wijk, Inken Harder, Thomas Werfel, Jochen Schmitt, Andreas Kleinheinz, Susanne Abraham, Judith Thijs, Stephan Weidinger, Marjolein de Bruin-Weller, Daphne Bakker, Julia Drylewicz","doi":"10.1111/cea.14585","DOIUrl":"https://doi.org/10.1111/cea.14585","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Validation of the Traditional Chinese Chronic Urticaria Quality of Life Questionnaire.","authors":"Hugo W F Mak, Elaine Lee, Jane C Y Wong, Philip H Li","doi":"10.1111/cea.14586","DOIUrl":"https://doi.org/10.1111/cea.14586","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil-Derived Neurotoxin Determinants and Reference Values in a Swedish Middle-Aged General Population.","authors":"Suneela Zaigham, Nils Oskar Jõgi, Robert Movérare, Anders Sjölander, Niclas Rydell, Magnus Molin, Christer Janson, Andrei Malinovschi","doi":"10.1111/cea.14579","DOIUrl":"https://doi.org/10.1111/cea.14579","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathomechanism of Adverse Reactions to Biological Treatment of Inflammatory Skin Conditions","authors":"Lichen Li,&nbsp;Dean J. Naisbitt,&nbsp;Yonghu Sun,&nbsp;Furen Zhang","doi":"10.1111/cea.14583","DOIUrl":"10.1111/cea.14583","url":null,"abstract":"<div>\u0000 \u0000 <p>Biological agents are widely used across medicine, including for immune-mediated skin conditions such as psoriasis and atopic dermatitis. When used to treat a relevant pathological process, they demonstrate impressive efficacy and credible safety, helping to achieve remission and improved function and quality of life. However, with their expanded use, awareness and understanding of adverse reactions to biologicals have also increased. Herein, we discuss the pathomechanism of adverse reactions to biological agents used to treat skin conditions and apply these to Pichler's classification system. This classification differentiates five distinct types, namely overstimulation (type α), hypersensitivity or immunogenicity (β), immunodeviation (γ), cross-reactivity (δ) and nonimmunologic adverse reactions (ε). This classification covers most types of adverse reactions associated with use of biological agents and could be used to better understand the reaction pathogenesis and manage the clinical features of biological adverse effects.</p>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 12","pages":"973-983"},"PeriodicalIF":6.3,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Nasal Secretion Sampling for Assessing Inflammatory Phenotype of Adult Allergic Rhinitis Patients.","authors":"Liyue Li, Ziyi Long, Qianxue Hu, Pei Gao, Yue Zhou, Shan Chen, Tao Zhou, Liuqing Zhou, Qing Cheng, Hongjun Xiao, Jianjun Chen","doi":"10.1111/cea.14580","DOIUrl":"https://doi.org/10.1111/cea.14580","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole Blood Transcriptomics Identifies Differences in Innate Immune Pathway Expression in Infants at Risk for Peanut Allergy.","authors":"Abigail Lang, Samantha Gadd, Lauren Gunderman, Elizabeth Lippner, Ashley Devonshire, Matthew J Schipma, Sergejs Berdnikovs, Rajesh Kumar","doi":"10.1111/cea.14587","DOIUrl":"https://doi.org/10.1111/cea.14587","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition Industry Sponsorship of Healthcare Professional Associations","authors":"Robert J. Boyle,&nbsp;Victoria L. Sibson,&nbsp;Christoffer van Tulleken","doi":"10.1111/cea.14581","DOIUrl":"https://doi.org/10.1111/cea.14581","url":null,"abstract":"&lt;p&gt;Last month, the World Health Organisation (WHO) published new resources to support Healthcare Professional Associations (HCPA) wishing to avoid conflicts of interest in relation to nutrition companies marketing foods for infants and young children. The new WHO resources include a model policy, suggestions for alternative funding sources and case studies of good practice [&lt;span&gt;1&lt;/span&gt;]. The case studies include the Indian Academy of Paediatrics and examples from Africa, which are especially important given the harms associated with formula marketing in these regions [&lt;span&gt;2&lt;/span&gt;]. The new resources underscore a long-standing WHO recommendation, made more explicit since 2016—that HCPA (and health workers) should not accept funding from companies that market foods for infants and young children, for either the general running of the HCPA or for supporting HCPA educational or scientific meetings such as an annual congress [&lt;span&gt;3&lt;/span&gt;]. The scope of ‘foods’ that relevant companies might market is quite broad, including formula, ‘growing up’ drinks, specialised low-allergy formula, non-liquid foods and even bottles and teats sold for formula feeding. The scope of ‘infants and young children’ is from birth through to age 36 months, the period of time covered by the International Code of Marketing of Breastmilk Substitutes.&lt;/p&gt;&lt;p&gt;This WHO recommendation has met with significant resistance from HCPAs, including some allergy HCPAs [&lt;span&gt;4&lt;/span&gt;]. Two key reasons cited for continuing to accept nutrition industry funding are access to scientific information about nutrition products, and difficulty funding educational and scientific activities without nutrition industry support [&lt;span&gt;5&lt;/span&gt;]. Access to scientific information about nutrition products does not require a financial relationship, since companies already provide product information in the public domain and on request, without any exchange of funding. Finding alternative resources for educational and scientific activities is more challenging. So these new WHO resources aim to support HCPAs to address this challenge.&lt;/p&gt;&lt;p&gt;This month, the British Society for Allergy and Clinical Immunology (BSACI) hosted its first annual conference without sponsorship from any company that markets foods for infants and young children. It is 5 years since the society's announcement that it will no longer accept funding from commercial formula milk companies for its conference and educational activities. Culture change takes time, and reducing income sources is not something which organisations find easy. This is recognised by the WHO, hence the inclusion of case studies to help HCPAs understand that they are not alone in finding this difficult, and a journey is often required to transition away from nutrition industry funding. There are a number of other allergy societies which take a similar approach to BSACI of avoiding formula industry sponsorship. However, these are dwarfed by the major allergy HC","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 10","pages":"720-722"},"PeriodicalIF":6.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14581","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochrane Corner: Pharmacological Treatment of Gastro-Oesophageal Reflux in Children","authors":"Aahil Damani,&nbsp;Nabeela Bhaloo","doi":"10.1111/cea.14577","DOIUrl":"10.1111/cea.14577","url":null,"abstract":"&lt;p&gt;Reflux is commonly cited as the cause of common issues in babies, such as vomiting and crying. Though it is often self-limiting, in many cases, anti-reflux medications and feed thickeners are prescribed to infants and young children. Their use is controversial, and it is not clear whether they are effective. Data shown are trends in community prescribing for total quantity of thickener (Gaviscon infant and Instant Carobel) sachets/live births in England in the previous year (Figure 1); total items of infant anti-reflux medications prescribed/live birth in England in the previous year (Figure 2) [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;This Cochrane Corner aims to assess the evidence for pharmacological agents in treating GORD in infants and children.&lt;/p&gt;&lt;p&gt;GOR is common [&lt;span&gt;2&lt;/span&gt;], and GORD incidence in children is estimated at 0.84 per 1000 person years [&lt;span&gt;3&lt;/span&gt;]. Several pharmacological treatments are available to treat reflux, including PPIs and H2 receptor antagonists, and they are being prescribed more frequently in recent years [&lt;span&gt;4&lt;/span&gt;]. This Cochrane review aimed to establish which were beneficial in children split into subgroups of infants and older children. In addition to the cost of prescribing these medications, it is important to consider the potential side effects, which include infection risk, electrolyte abnormalities and fractures [&lt;span&gt;5&lt;/span&gt;]. Similarly, whilst prokinetics such as domperidone, cisapride and erythromycin are effective in managing reflux, they have been associated with the very rare but serious risks of drug-induced long-QT syndrome, Torsades de Pointes and sudden cardiac death, due to a combination of non-modifiable (age, family history of arrhythmias, genetic conditions and co-morbidities) and modifiable risk factors (electrolyte imbalances, concurrent use of other medications). Thus, use of these prokinetics is cautioned against, though cardiac complications of domperidone have not been noted in children [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;This Cochrane Review analysed 36 randomised control trials involving 2251 infants and children, out of which 22 trials were excluded due to insufficient data for extraction. The sample sizes of the studies included were small (range = 10–268), and due to methodological differences between the studies, a meta-analysis could not be performed. The trials often used subjective questionnaires, and blinding the trials was a challenge. Although blinding is less of an issue for trials using objective data such as 24-h pH impedance studies and endoscopic findings, the subjective outcome assessments used in these trials are vulnerable to detection bias in the absence of blinding. Such questionnaires do have the benefit of aiding clinicians with decision-making as they are patient-centred.&lt;/p&gt;&lt;p&gt;Though one trial [&lt;span&gt;7&lt;/span&gt;] performed endoscopic studies at baseline, they did not repeat them after the intervention; therefore, no comparisons could be made. In another case, pH indices w","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 12","pages":"956-959"},"PeriodicalIF":6.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14577","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}