Clinical and Experimental Allergy最新文献

{"title":"Roadmap of Anaphylaxis Registries Across the World.","authors":"Guillaume Pouessel, François Dubos, Stéphanie Lejeune, Diane Pelletier de Chambure, Paul-Michel Mertes, Charles Tacquard, Sébastien Lefevre, Pascal Demoly, Luciana Kase Tanno","doi":"10.1111/cea.70074","DOIUrl":"https://doi.org/10.1111/cea.70074","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Year Longitudinal Evaluation of Timing Effects on Subcutaneous Immunotherapy Efficacy and Safety in Allergic Rhinitis.","authors":"Hang Li, Xiaomei Yang, Yihui Wen, Dehua Chen, Xiumin Chen, Minghao Pan, Changhui Chen, Huimin Chen, Xingyu Lin, Wen Lyu, Wenbin Lei, Weiping Wen, Rui Xu","doi":"10.1111/cea.70075","DOIUrl":"https://doi.org/10.1111/cea.70075","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway Basal Stem Cell Population Is Enlarged in Bronchial Thermoplasty Treated Airways in Severe Asthma Patients.","authors":"Tessa E Gillett, Sofi M Vassileva, Els Weersink, Jouke Annema, René Lutter, Martijn C Nawijn, Maarten van den Berge, Peter I Bonta, Abilash Ravi","doi":"10.1111/cea.70071","DOIUrl":"https://doi.org/10.1111/cea.70071","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug-Specific Activation Responses In Vitro.","authors":"Paola Leonor Quan, Laia Ollé, Marina Sabaté-Bresco, Elizabeth Guruceaga, José Julio Laguna, Inmaculada Doña, Rosa Muñoz-Cano, José Luis Perez-Gracia, Margarita Martín, Gabriel Gastaminza","doi":"10.1111/cea.70068","DOIUrl":"https://doi.org/10.1111/cea.70068","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial Ties of Paediatric Allergy and Immunology Professional Associations With the Formula Milk Industry: A Global Cross-Sectional Study.","authors":"Katarzyna Henke-Ciążyńska, Daniel Pankowski, Daniel Munblit, Alice Fabbri, Quinn Grundy, Lisa Bero, Bartosz Helfer","doi":"10.1111/cea.70064","DOIUrl":"https://doi.org/10.1111/cea.70064","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ara h 2_105-124-Specific TH2A Cells Drive Peanut Allergy in DRB1*15:01 Individuals: A Detailed Epitope Analysis.","authors":"Rebecca A Gomez, Jue Hou, Vivian H Gersuk, I-Ting Chow, Mary L Farrington, David Robinson, William W Kwok","doi":"10.1111/cea.70072","DOIUrl":"https://doi.org/10.1111/cea.70072","url":null,"abstract":"<p><strong>Background: </strong>The IgE-mediated CD4 T-cell response to peanut (Arachis hypogaea) is heterogeneous, yet TH2 cells remain central drivers of pathology. This study aimed to dissect this complexity at the epitope level by focusing on the HLA-DRB1*15:01-DRB5*01:01 haplotype. Specifically, we examined how distinct epitope-specific T-cell subsets shape the immunological landscape of peanut allergy in peanut-allergic (PA) versus non-peanut-allergic (NPA) individuals.</p><p><strong>Methods: </strong>Using in vitro and ex vivo MHC-II tetramer approaches, the phenotype, frequency, function, and transcriptome of CD4 T-cell responses to novel Ara h epitopes were assessed. Bulk RNA sequencing further characterised these T cells, allowing identification of subsets associated with TH2 polarisation in PA individuals.</p><p><strong>Results: </strong>Eleven HLA-DRB1*15:01 and DRB5*01:01-restricted epitopes were identified in Ara h 1, 2, 3, 6, 7, and 8 using tetramer-guided epitope mapping on cell lines, followed by ex vivo validation in peripheral blood. T-cell phenotype was epitope-dependent, with a distinct TH2A population specific to the epitope Ara h 2_105-124 (Ara h 2 p14) detected only in PA donors. These TH2A cells were phenotypically and transcriptionally distinct, marked by high CRTH2/CD161, low CD27, IL-5 production, and gene enrichment in cytokine signalling and lipid metabolism. Other epitope-specific T-cell subsets displayed more heterogeneous gene profiles related to immune activation, differentiation, and antigen presentation, underscoring the complexity of peanut-specific responses even within a single HLA haplotype.</p><p><strong>Conclusion: </strong>These findings reveal that the strong TH2 bias in DRB1*15:01-DRB5*01:01 PA individuals arises from a distinct subset of Ara h 2 p14-specific TH2A cells characterised by a specialised metabolic and cytokine signalling program. At the same time, the functional diversity observed in non-Ara h 2 p14 subsets highlights the potential for leveraging these populations in tolerance-promoting therapies. Understanding the epitope-level heterogeneity of peanut-specific T-cells provides insight into the epitope-specific mechanisms driving peanut allergy and has potential implications for therapeutic interventions.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Childhood Atopic Dermatitis Incidence and Risk Factors Over Time: Results From Two German Birth Cohorts","authors":"Zhuoxin Peng,&nbsp;Linda P. Siziba,&nbsp;Hermann Brenner,&nbsp;Deborah Wernecke,&nbsp;Dietrich Rothenbacher,&nbsp;Jon Genuneit","doi":"10.1111/cea.70066","DOIUrl":"10.1111/cea.70066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atopic dermatitis (AD) is a common allergic skin disease. We aimed to assess the secular changes in the cumulative incidence of childhood AD and its risk factors over a decade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from two methodologically similar cohort studies in Ulm, Germany, the Ulm Birth Cohort Study (UBCS, recruited in 2000/2001) and the Ulm SPATZ Health Study (recruited in 2012/2013). The cumulative incidences of AD as reported by their family physicians and parents up to the age of 4 years were compared by log-rank test across the two cohorts, using propensity score–based weighting to control confounders. We fitted multivariable Cox regression models to estimate hazard ratios and 95% confidence intervals (CIs) for the factors associated with the occurrence of physician- and parent-reported AD and compared the results between the two cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 4-year cumulative incidence (95% confidence interval) of physician-reported AD (27.4% (24.4%–30.5%) in UBCS [2000/2001] vs. 26.4% (22.8%–30.2%) in SPATZ [2012/2013], <i>p</i> = 0.728) and parent-reported AD (14.5% (12.2%–17.0%) in UBCS [2000/2001] vs. 16.7% (14.0%–19.7%) in SPATZ [2012/2013], <i>p</i> = 0.211) remained stable between the two cohorts after propensity score–based weighting. We observed the changes in the association between AD and certain risk factors (e.g., family history of AD and infantile antibiotic use) over the decade, but the results need to be interpreted with caution due to the limited sample size, relatively high attrition rate and demographic differences between the two cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Over the decade, childhood AD incidence remained stable. Further studies are needed to verify whether there is a growing importance of environmental and microbiota-related factors for AD development over time.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 6","pages":"469-480"},"PeriodicalIF":6.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Oral Cyclosporine in Antihistamine Refractory Chronic Urticaria Among Children and Adolescents: A Retrospective Study.","authors":"Davinder Parsad, P Janaani, Anuradha Bishnoi, Hitaishi Mehta, Rahul Mahajan, Seema Negi, Muthu Sendhil Kumaran","doi":"10.1111/cea.70069","DOIUrl":"https://doi.org/10.1111/cea.70069","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Effects of Dupilumab, Effects of Peanut OIT on the Gut Microbiome and Allergy Training in the United Kingdom","authors":"Mohamed H. Shamji,&nbsp;Robert J. Boyle","doi":"10.1111/cea.70062","DOIUrl":"10.1111/cea.70062","url":null,"abstract":"&lt;p&gt;In this month's editorial, the Editors of the journal have selected three fascinating articles that are included in this issue. The first article investigates dupilumab-associated ocular surface disease (DAOSD) in paediatric patients with atopic dermatitis (AD) [&lt;span&gt;1&lt;/span&gt;]. Currently, moderate-to-severe AD is treated with biologics like dupilumab, which targets IL-4 and IL-13 pathways. Despite the well-known efficacy of dupilumab, it has been associated with ocular side effects, yet long-term real-world safety data have remained limited.&lt;/p&gt;&lt;p&gt;Therefore, the prospective study by Van der Rijst et al. explores the incidence and risk factors of DAOSD in paediatric AD patients with dupilumab treatment. Children participating in the BioDay Registry were assessed for ocular symptoms every 4–12 weeks in 104 patients aged 3–17 years. DAOSD was initially handled by applying lubricating eye drops, antihistamine eye drops or tacrolimus ointment—where persistent symptoms were additionally treated with ocular anti-inflammatory therapy.&lt;/p&gt;&lt;p&gt;The study revealed that 34.6% of AD patients developed DAOSD, with 30.6% of these cases requiring anti-inflammatory treatment. It was notable that baseline serum IgE levels ≥ 3000 kU/L were independently associated with DAOSD development. Examples of the most common ocular symptoms were pruritus (75%), redness (72.2%) and tearing (58.3%). All patients necessitating anti-inflammatory therapy had shown tarsal conjunctivitis on ophthalmological examination. In addition, 3.8% of patients with DAOSD had chosen dupilumab discontinuation.&lt;/p&gt;&lt;p&gt;These findings suggest new directions into the real-world management of DAOSD in paediatric AD patients. The high incidence of DAOSD highlights the importance of monitoring ocular symptoms during dupilumab treatment, especially in paediatric patients where the symptoms can be challenging to manage. This study also suggests the potential role of serum IgE levels in predicting DAOSD and emphasises the need for collaborative care and study between dermatologists and ophthalmologists to manage these side effects wisely (Figure 1).&lt;/p&gt;&lt;p&gt;The second editor's choice article studies the impact of 1 year of peanut oral immunotherapy (OIT) on the gut microbiota and plasma metabolome in peanut-allergic young children [&lt;span&gt;2&lt;/span&gt;]. Peanut allergy is one of the most common food allergies in children, which rarely triggers life-threatening anaphylaxis [&lt;span&gt;3&lt;/span&gt;]. While the allergic condition is persistent, only about 21% of children outgrow their allergy to adulthood [&lt;span&gt;4&lt;/span&gt;]. Peanut OIT has been recognised as a promising solution to desensitise allergic individuals, allowing tolerance of higher doses of peanut protein and potentially reducing dietary restrictions and improving quality of life [&lt;span&gt;5&lt;/span&gt;]. However, its broader effects on the microbiome and metabolic profiles have been understudied.&lt;/p&gt;&lt;p&gt;The study by Badolati et al. observes how peanut OIT modulates micro","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 5","pages":"364-366"},"PeriodicalIF":6.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Patients With Beta-Lactams Positive Provocation Tests by Biomarkers of IgG-Related Neutrophil Activation.","authors":"Adrienne Astrid Gallizzi, Rosa-Maria Guéant-Rodriguez, Cosmin Boteanu, Jean-Marc Alberto, Cécile Lakomy, Huguette Louis, Celine Chery, Pauline Renard, Véronique Regnault, Ramia Safar, Almut Heinken, Antonino Romano, Jose-Julio Laguna, Jean-Louis Guéant","doi":"10.1111/cea.70061","DOIUrl":"https://doi.org/10.1111/cea.70061","url":null,"abstract":"<p><strong>Background: </strong>Beta-lactams (BLs) are the predominant cause of immediate allergic reactions to drugs. Immediate hypersensitivity reactions (IHR) with positive provocation tests and negative skin and in vitro tests have undetermined mechanisms. We evaluated whether biomarkers of IgG-dependent neutrophil activation could help to assess this subgroup of BL IHRs.</p><p><strong>Methods: </strong>We evaluated biomarkers of neutrophil activation and neutrophil extracellular traps (NETs) in the serum of 26 BL IHR patients presenting with a positive provocation test, negative skin and serum specific IgE, and positive specific sIgG, and 8 perioperative BL IHR cases with positive skin tests and negative sIgE compared to 19 non-allergic matched controls.</p><p><strong>Results: </strong>We observed increased levels of DNase activity, neutrophil elastase (NE), myeloperoxidase (MPO)-DNA, IL8 and decreased IL4 and IL13 in patients, compared to matched controls, in the first 15 min of IHRs. DNAse activity, NE and MPO-DNA were maintained at high levels 2 h later (T0 + 2), while cell-free DNA and CXCR2 decreased significantly. IgG-related activation of neutrophils was suggested by significant correlations between NE, IL8 and CXCR2 axis and a single cluster associating BL sIgG antibodies and NE at T0 + 2, in principal factor analysis of all biomarkers.</p><p><strong>Conclusion: </strong>Biomarkers of neutrophil activation and NETs were increased in BL IHRs with negative skin tests, positive sIgG and negative serum sIgE, and positive provocation test. We propose DNAse activity and NE as biomarkers for the biological assessment of BL IHRs and provocation tests and to consider IgG-related neutrophil activation as one of the mechanisms involved in BL IHRs with undetermined cause.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}