Clinical and Experimental Allergy最新文献

{"title":"Allergen-Specific Immunotherapy: The Need for Content Transparency.","authors":"Melvin Lee Qiyu, Tom Dawson","doi":"10.1111/cea.70065","DOIUrl":"https://doi.org/10.1111/cea.70065","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Sex Disparities in Elderly Atopic Dermatitis Prevalence Among US Oldest-Old Adults: A Longitudinal Study.","authors":"Minmin Wang, Xueshan Cao, Mengge Zhou, Yuanqi Mi, Peixin Yu, Yang Guo","doi":"10.1111/cea.70060","DOIUrl":"https://doi.org/10.1111/cea.70060","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Cluster Analysis in Chinese Patients With Recurrent Angioedema.","authors":"Ruoyu Ji, Yuxiang Zhi","doi":"10.1111/cea.70063","DOIUrl":"https://doi.org/10.1111/cea.70063","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus fumigatus Serum IgG Cut-Off for the Diagnosis of Aspergillus-Associated Lung Disease: A Historic Cohort Analysis.","authors":"Alicia Enríquez-Matas, Beatriz Moya, Tatiana Navarro Cascales, Carmen Romero Ferreiro, Ana Alastruey-Izquierdo, Ismael Garcia-Moguel, Lys Herraez Herrera, J F Crespo, Consuelo Fernández Rodríguez","doi":"10.1111/cea.70057","DOIUrl":"https://doi.org/10.1111/cea.70057","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Food Allergen-Specific Antibodies, Beyond IgG4, Are Elevated in Eosinophilic Esophagitis.","authors":"Manal Bel Imam, Sayuri Iwasaki, Sophieke Lems, Lacin Cevhertas, Patrick Westermann, Lotte Bach Larsen, Nina Aagaard Poulsen, Mübeccel Akdis, Philipp Schreiner, Andrea Kreienbühl, Alex Straumann, Alain M Schoepfer, Luc Biedermann, Willem van de Veen","doi":"10.1111/cea.70055","DOIUrl":"https://doi.org/10.1111/cea.70055","url":null,"abstract":"<p><strong>Introduction: </strong>Eosinophilic esophagitis (EoE) is a chronic inflammatory condition with an incompletely understood immuno-pathogenesis involving a T2 response. EoE is triggered by food allergens although, unlike IgE-mediated allergies, it exhibits high IgG4 levels in oesophageal biopsies and in circulation. We investigated whether other antibody isotypes specific for food allergens are elevated in EoE and vary with disease activity.</p><p><strong>Methods: </strong>Plasma samples from patients with active EoE (n = 51), inactive EoE (n = 82) and non-EoE controls (n = 14) were analysed for food-specific IgG and IgA subclasses against casein, whey, wheat, egg and individual cow's milk allergens by ELISA. α-lactalbumin (Bos d 4)- and β-lactoglobulin (Bos d 5)-specific B cells were measured by flow cytometry in a subset of patients.</p><p><strong>Results: </strong>Food allergen-specific antibodies in the plasma varied across EoE subgroups and non-EoE controls. Elevated IgG4 in EoE patients confirmed a strong antibody response to food allergens, including casein, wheat and egg. α_S1-casein (Bos d 9)-specific IgG, IgG2, IgG4, IgA1 and IgA2 differed between EoE and non-EoE controls and between active and inactive EoE. β-casein (Bos d 11, A1 variant) measurements showed higher levels of specific IgG2 and IgG4 in both EoE groups, whereas whey-derived allergens showed opposing responses: Bos d 4 responses favoured IgG4, and Bos d 5 responses were elevated across multiple IgG and IgA subclasses in EoE. Allergen-specific B cells could not be isolated from the circulation.</p><p><strong>Conclusion: </strong>Our findings reveal distinct antibody profiles in EoE plasma, with elevated IgG and IgA subclasses beyond IgG4, highlighting a complex immune response to food allergens. Differential antibody responses support their clinical relevance in dietary management strategies, while the absence of allergen-specific B cells in circulation likely restricts antibody production to the inflamed oesophagus. Future research should explore whether these antibody profiles can guide personalised treatment and novel therapeutic targets in EoE.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Novel In-House Gliadin Skin Test Reagent for Diagnosing Wheat-Dependent Exercise-Induced Anaphylaxis (WDEIA).","authors":"Surapon Piboonpocanun, Thanachit Krikeerati, Lalita Lumkul, Valerie Chiang, Andy Ka Chun Kan, Phichayut Phinyo, Chamard Wongsa, Torpong Thongngarm, Philip Hei Li, Mongkhon Sompornrattanaphan","doi":"10.1111/cea.70053","DOIUrl":"https://doi.org/10.1111/cea.70053","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Lianne Soller,&nbsp;Edmond S. Chan,&nbsp;Scott B. Cameron,&nbsp;Elissa M. Abrams,&nbsp;Sandeep Kapur,&nbsp;Stuart N. Carr,&nbsp;Timothy K. Vander Leek","doi":"10.1111/cea.70052","DOIUrl":"https://doi.org/10.1111/cea.70052","url":null,"abstract":"<p>The cover image is based on the article <i>Oral Immunotherapy Should Play a Key Role in Preschool Food Allergy Management</i> by Lianne Soller et al., https://doi.org/10.1111/cea.70013.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"i"},"PeriodicalIF":6.3,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basophil Activation and Histamine Release Tests in Relation to Omalizumab Response in Peanut-Allergic Children.","authors":"Christian Nielsen, Per Stahl Skov, Carsten Bindslev-Jensen, Charlotte G Mortz","doi":"10.1111/cea.70058","DOIUrl":"https://doi.org/10.1111/cea.70058","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted Metabolomic Analysis of Exhaled Breath Condensate Identifies Disease-Specific Signatures in Adults With Asthma.","authors":"Hongfei Zhao, Yujuan Yang, Yan Hao, Wenbin Zhang, Limei Cui, Jianwei Wang, Ying Chen, Ting Zuo, Hang Yu, Yu Zhang, Xicheng Song","doi":"10.1111/cea.70059","DOIUrl":"https://doi.org/10.1111/cea.70059","url":null,"abstract":"<p><strong>Purpose: </strong>An objective test for the auxiliary diagnosis of asthma is still lacking. The aim of this study was to discriminate asthma signatures via an untargeted metabolomic analysis of exhaled breath condensate.</p><p><strong>Materials and methods: </strong>This study enrolled 19 patients diagnosed with asthma and 23 healthy volunteers. Samples of exhaled breath condensate (EBC) were collected from both groups. Untargeted metabolomic analyses of EBC were used to identify disease-specific signatures for asthma.</p><p><strong>Result: </strong>There were 30 identifiable differentially expressed metabolites and 7 disordered metabolic pathways between the EBCs of asthmatic patients and healthy control subjects. The main differential pathways included biosynthesis of unsaturated fatty acids, HIF-1 signalling pathway, Glutathione metabolism, Ascorbate and aldarate metabolism, and fatty acid biosynthesis. The integrated machine learning method was used to construct an asthma EBC metabolomic signature model from four differential metabolites; 3,4'-dimethoxy-2'-hydroxychalcone, C17-sphinganine, (z)-6-octadecenoic acid, and 2-butylaniline. The model showed a high level of discrimination efficiency (area under curve (AUC) = 0.98), with robust validation through logistic regression (LR), random forest (RF), and support vector machine (SVM) (LR AUC = 0.98, RF AUC = 0.94, SVM AUC = 1.00). The discriminative ability of the EBC metabolomic signature model in both the training set (AUC = 1.0) and testing data (AUC = 0.817) was superior to that of FeNO (AUC = 0.515 and 0.567, respectively) and FEV1/FVC % predicted (AUC = 0.767 and 0.765, respectively). Among the four biomarkers, (z)-6-octadecenoic acid was significantly correlated with serum IgE.</p><p><strong>Conclusion: </strong>The EBC metabolomic signature model demonstrated good feasibility for assisting in the diagnosis of asthma in adults.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Drug-Induced Severe Cutaneous Adverse Reactions Associated With 33 Classes of Antibiotics (1968-2024): An Analysis of International Pharmacovigilance Reports.","authors":"Jaehyun Kong, Jeongseon Oh, Jaeyu Park, Hyesu Jo, Tae Hyeon Kim, Jae E Lee, Jaehyeong Cho, Sooji Lee, Hayeon Lee, Michael Miligkos, Jiyoung Hwang, Dong Keon Yon, Nikolaos G Papadopoulos","doi":"10.1111/cea.70056","DOIUrl":"https://doi.org/10.1111/cea.70056","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}