Clinical and Experimental Allergy最新文献

{"title":"Efficacy and Safety of Subcutaneous vs. Sublingual Immunotherapy in Allergic Rhinitis: A Systematic Review and Meta-Analysis.","authors":"Shambo Samrat Samajdar, Saibal Moitra, Sougata Sarkar, Santanu K Tripathi","doi":"10.1111/cea.14574","DOIUrl":"https://doi.org/10.1111/cea.14574","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time Trends, Regional Variation and Associations of Low-Allergy Formula Prescribing in England","authors":"Karen H. T. Li,&nbsp;Olivia Wing,&nbsp;Hilary I. Allen,&nbsp;Timothy D. H. Smith,&nbsp;Frank Moriarty,&nbsp;Robert J. Boyle","doi":"10.1111/cea.14570","DOIUrl":"10.1111/cea.14570","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cow's milk allergy (CMA) overdiagnosis appears to be increasing and is associated with excessive low-allergy formula prescription. We evaluated recent trends and regional variation in low-allergy formula prescribing for CMA in England, and assessed potential risk factors for higher prescribing rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data on national and regional prescribing of low-allergy formulas were extracted from England's electronic prescription database using R. Region-level factors were evaluated for potential associations with regional low-allergy formula prescription rates using multivariate linear regression. Analysis of national prescribing trends covered 2007–2023, analysis of regional variation and region-level factors examined 2017–2019, prior to a re-organisation of the regional healthcare structure in England.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Low-allergy formula prescribing increased from 6.1 to 23.3 L per birth nationally, between 2007 and 2023. Regional prescribing rate varied from 0.8 to 47.6 L per birth in 2017–2019. We found significant associations between regional low-allergy formula prescribing rate and regional prescribing rates for milk feed thickeners Gaviscon Infant and Carobel Instant (<i>β</i> = 0.10, <i>p</i> &lt; 0.01), and for other anti-reflux medications used in young children (<i>β</i> = 0.89 <i>p</i> &lt; 0.01). Inconsistent associations were seen with prescribing junior adrenaline auto-injectors and oral antibiotics. A model including these four variables accounted for 37% of regional variation in low-allergy formula prescribing rate. Region-level socio-economic deprivation, CMA guideline recommendations and paediatric allergy service provision were not associated with low-allergy formula prescribing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Low-allergy formula prescribing in England is increasing, varies significantly by region and is consistently associated with prescribing rates for milk feed thickeners and other anti-reflux medication for young children. Community prescribing behaviours may be important determinants of CMA overdiagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 11","pages":"909-918"},"PeriodicalIF":6.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab Improves Clinical Symptoms and Biomarkers in Comorbid Seasonal Timothy Grass Pollen Allergic Rhinitis in Patients With CRSwNP.","authors":"Caroline Beutner, Stephan Traidl, Martin Wagenmann, Moritz Maximilian Hollstein, Dirk Beutner, Michael Peter Schön, Timo Buhl","doi":"10.1111/cea.14572","DOIUrl":"https://doi.org/10.1111/cea.14572","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Prognostic Clinical Risk Score for Subsequent Atopic Dermatitis Risk.","authors":"Tamar Landau, Keren Gamrasni, Alex Levin, Yotam Barlev, Oliver Sanders, Shira Benor, Michael Brandwein","doi":"10.1111/cea.14567","DOIUrl":"https://doi.org/10.1111/cea.14567","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Patients Into Programmes to Address the Allergy Knowledge Practice Gap","authors":"John O. Warner,&nbsp;Sophie Jacoba Irma Maria Spitters","doi":"10.1111/cea.14563","DOIUrl":"10.1111/cea.14563","url":null,"abstract":"<p>There is a wide gap between the first publication of new treatments with efficacy and their successful application in clinical practice. In many respects, the management of allergic diseases is a good exemplar of the knowledge/practice gap. It was assumed that systematic reviews and publication of guidelines would ensure timely delivery of effective care, but this has not proved to be the case. While there are many reasons to explain shortcomings in healthcare delivery, the lack of patient and carer involvement in the planning of research, evidence review, guideline development and guideline implementation is most compelling. To achieve adherence to evidence-based guidelines consistently across all levels of the health service requires the implementation of integrated care with clear pathways through which patients can navigate. Quality improvement methodology could be employed to plan and implement integrated care pathways (ICPs). There is evidence that ICPs achieve improved outcomes for acute hospital-based interventions, but less work has focussed on long-term conditions where more diverse agencies are involved. At all stages, stakeholder representation from the full range of healthcare professionals, patients, their families, social services, education, local government and employers must be involved. In this article we review the step-wise and iterative process by which knowledge is implemented into practice to improve patient experience and outcomes We argue how this process can benefit from the involvement of patients and their carers as equal partners, and we discuss how different initiatives have involved patients with allergic diseases. There currently is a gap in evidence that links patient involvement to improved outcomes. We recommend the use of the Core Outcome Sets (COS) and Patient Reported Experience Measures (PREMS) which have been developed for allergic diseases to monitor the effects of implementation research and the impact of patient and carer involvement on outcomes.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 10","pages":"723-733"},"PeriodicalIF":6.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Considerations of Plant-Based Diets for People With Food Allergy","authors":"Jennifer L. P. Protudjer,&nbsp;Franziska Roth-Walter,&nbsp;Rosan Meyer","doi":"10.1111/cea.14557","DOIUrl":"10.1111/cea.14557","url":null,"abstract":"<p>Plant-based diets (PBD) have been reported throughout history, but are increasingly common in current times, likely in part due to considerable emphasis on climate change and human health and wellness. Many dietary organisations around the world endorse well-planned, nutritionally adequate PBD, which exclude some or all forms of animal-based foods. However, special attention must be given to patients who follow PBD and also have food allergy (FA), as avoidance may increase the risk of developing nutritional deficiencies, including poor growth in children, weight loss in adults and vitamin and mineral deficiencies. Given the increasing prevalence of both PBD and food allergen avoidance diets, healthcare providers are likely to counsel patients with FA who also follow a PBD. In this review, an overview of PBD in patients with FA is provided, including recent trends, macro- and micronutrient needs, and growth for children and weight gain considerations for adults. With regard to a PBD, special attention should be given to ensure adequate fat and protein intake and improving the bioavailability of several minerals such as iron, zinc, iodine, calcium and magnesium, and vitamins such as A, B2, B12 and D. Although the collective data on growth amongst children following a PBD are varied in outcome and may be influenced in part by the type of PBD, growth must be regularly monitored and in adults weight gain assessed as part of any clinical assessment in those people with FA.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 11","pages":"895-908"},"PeriodicalIF":6.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents' Perspectives on Prevention and Risk Prediction of Food Allergies in Children: A Qualitative Study","authors":"Katharina Gerhardinger,&nbsp;Susanne Brandstetter,&nbsp;Madlen Hörold,&nbsp;Magdalena Rohr,&nbsp;Mara König,&nbsp;Christian Apfelbacher","doi":"10.1111/cea.14569","DOIUrl":"10.1111/cea.14569","url":null,"abstract":"&lt;p&gt;About 6%–8% of children in Western countries develop food allergy (FA) [&lt;span&gt;1&lt;/span&gt;], leading to severe, sometimes life-threatening symptoms. Therefore, predicting the risk of and preventing childhood FA is a significant public health concern. The last decades have seen a paradigm shift in allergy prevention [&lt;span&gt;2&lt;/span&gt;]. As a result, parents are faced with a wide range of sometimes conflicting information and may encounter additional challenges in finding accurate information, especially online [&lt;span&gt;3&lt;/span&gt;]. There is limited qualitative research on childhood FA prevention, as previous studies have focused on the challenges of managing FA [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;As part of the NAMIBIO app consortium [&lt;span&gt;5&lt;/span&gt;], our qualitative study aimed to systematically describe parental information needs and their information seeking behaviour regarding childhood FA risk prediction and prevention. Additionally, we sought to understand parents´ attitudes towards a health app for early risk prediction and prevention of FA in children [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In 2022, KG, MH, MR and CD conducted 30 semi-structured interviews (each 30–60 min), with parents of children up to 3 years of age in Germany. There was no personal relationship between interviewer and interviewees. Interviewees were parents of children diagnosed with FA (&lt;i&gt;n&lt;/i&gt; = 18), at risk of FA (&lt;i&gt;n&lt;/i&gt; = 13), or without known risk factors (&lt;i&gt;n&lt;/i&gt; = 3) [&lt;span&gt;7&lt;/span&gt;]. Using computer-assisted qualitative content analysis [&lt;span&gt;8&lt;/span&gt;], we identified five main (deductive) categories and 15 inductive subcategories [&lt;span&gt;7&lt;/span&gt;]. Transparency and intersubjectivity were ensured through communicative validation in weekly interpretation work sessions. Through reflection and discussion (prior to conducting our study), we were aware of our assumptions about recruitment, participants, target audience and the value of the planned app and were able to integrate these into the reflective interpretive work.&lt;/p&gt;&lt;p&gt;Data analysis (Figure 1) revealed varying parental information needs and degrees of healthcare utilisation regarding FA risk prediction and prevention. Parents' information-seeking behaviour was influenced by different reasons. For one, intuition (‘gut feeling’) strongly motivated parents to address FA issues and seek appropriate healthcare or preventive measures (&lt;i&gt;‘[…] it may sound stupid, but intuitively I googled milk protein allergy at the time […]&lt;/i&gt;', P27, female, early 30s). For another, pre-existing risk awareness (&lt;i&gt;‘Because I have many allergies […]’&lt;/i&gt;, P14, female, late 30s) and occurring symptoms in the child (&lt;i&gt;‘I saw a rash […] and googled it […]’&lt;/i&gt;, P06, female, early 40s) influenced the parents' behaviour. Limited competence in finding valuable information was found to be a barrier to prevention and risk prediction of childhood FA (&lt;i&gt;‘[…] the Internet is big and wide’&lt;/i&gt;, P15, female, mid 30s). Parents' information needs ranged from no interest (&lt;i&gt;","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 11","pages":"943-945"},"PeriodicalIF":6.3,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial Interleukin-1 Receptor-Like-1 Activation Is Contingent on Interleukin-33 Isoforms and Asthma-Related Receptor Variation","authors":"Michael A. Portelli,&nbsp;Maria E. Ketelaar,&nbsp;Stewart Bates,&nbsp;Eszter Csomor,&nbsp;Dominick Shaw,&nbsp;Jonas Emsley,&nbsp;Christopher Brightling,&nbsp;Ian Hall,&nbsp;Karen Affleck,&nbsp;Matthew Edwards,&nbsp;Martijn C. Nawijn,&nbsp;Gerard H. Koppelman,&nbsp;Antoon J. Van Oosterhout,&nbsp;Ian Sayers","doi":"10.1111/cea.14562","DOIUrl":"10.1111/cea.14562","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The interleukin-33/interleukin-1 receptor-like-1 (IL-33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with <i>IL1RL1</i> nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these variants' effect on IL1RL1 signalling induced by different IL33 isoforms thought to be elevated in the asthmatic airway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>In a project funded by GSK plc, which has developed an IL-33 receptor inhibitor for asthma treatment, human embryonic kidney 293 (HEK293) cells expressing secreted embryonic alkaline phosphatase (SEAP) driven by a nuclear factor kappa-beta (NF-κB) promoter, were transiently transfected with <i>IL1RL1</i>, containing one of four extracellular and Toll/interleukin 1 receptor (TIR) domain haplotypes. Cells were stimulated with seven different splice and proteolytic-generated IL-33 isoforms (0.001–50 ng/mL) for 24 h. Supernatant SEAP activity and interleukin-8 (IL-8) levels were determined. Primary human bronchial epithelial cells (HBECs) representing different genotype carriers were stimulated with IL-33_112–270 (50 ng/mL) and induced IL-8 mRNA expression measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>HEK293 cells carrying both asthma extracellular and TIR domain <i>IL1RL1</i> risk haplotypes presented maximal IL33-driven signalling, with minimal signalling after IL-33 activation in other protective haplotypes. All IL-33 isoforms activated IL1RL1 but with differing magnitudes. Proteolytically cleaved IL33_95–270 and IL33_106–270 had the greatest effect and the IL33_113–270, and Exon 3,4 deletion isoform exhibited the lowest. The effect of extracellular and TIR domain genetic variants on receptor signalling was replicated in primary HBECs. Maximal IL1RL1 signalling was observed in cells carrying both extracellular and TIR signalling domain risk haplotypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, our study suggests asthma patients carrying the extracellular and TIR domain risk haplotype and have a lung microenvironment that promotes elevated levels of cleaved IL33, particularly where IL33_95–270 and IL33_106–270 may be more amenable to IL33/IL1RL1 targeting.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 12","pages":"984-995"},"PeriodicalIF":6.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Modelling Links Maternal Hypertensive Disorders to Early Childhood Allergic Disease Burden","authors":"Duan Ni,&nbsp;Ralph Nanan","doi":"10.1111/cea.14566","DOIUrl":"10.1111/cea.14566","url":null,"abstract":"&lt;p&gt;As common pregnancy-related pathologies, maternal hypertensive disorders (MHD) are widespread globally, exhibiting a spectrum of severity and varying prevalence from pregnancy-induced hypertension to preeclampsia and eclampsia. MHD have been implicated in maternal and foetal immune alterations and are linked to increased allergic diseases in offsprings in several studies, albeit with overall inconclusive results [&lt;span&gt;1, 2&lt;/span&gt;]. Here, we harnessed comprehensive global data and systematically assessed the links between MHD and common allergic diseases, atopic dermatitis (AD) and asthma, in offsprings.&lt;/p&gt;&lt;p&gt;Disease data was obtained from Global Burden of Disease 2019 (GBD2019) database, covering close to 200 countries globally (Figure 1A). Per GBD definition, MHD includes &lt;i&gt;gestational hypertension (onset after 20-week gestation), pre-eclampsia, severe preeclampsia, and eclampsia, but excludes chronic hypertension (onset prior to pregnancy or prior to 20-week gestation) unless superimposed preeclampsia or eclampsia develop&lt;/i&gt;. AD refers to &lt;i&gt;relapsing inflammation of the dermal layer of the skin with disruption of the epidermal barrier (dermatitis) associated with elevated serum IgE and some degree of immune dysregulation, which can be localised or widespread&lt;/i&gt;. Asthma is defined as &lt;i&gt;a chronic lung disease characterised by reversible airway obstruction due to spasms and secretions in the bronchi usually resulting from an allergic reaction or hypersensitivity and causing difficulty in breathing&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;We focused on the early age group of 1–4-year-old, the peak incidence ages for AD and the first early manifestation of asthma [&lt;span&gt;3&lt;/span&gt;]. Ratios of 1–4-year-old AD or asthma cases versus number of pregnancies 2-year prior for each country were calculated. These ratios were used as proxies of percentages of pregnancies with offsprings developing AD (AD%) or asthma (asthma%) at the 2-year-old timepoint. These results were then compared with percentages of MHD-affected pregnancies (MHD%) at 2-year prior timepoint (Figure 1B). They were modelled as close proxies of the links between MHD and offspring allergic diseases. Additionally, socioeconomic status, reflected by GDP, was accounted as a potential confounder [&lt;span&gt;3, 4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Figure 1C illustrates the predicted response curves of AD% as a function of MHD%. The most recent available timepoint with complete data coverage, 2018, is shown as representative. Generally, across GDP quantiles (red, 25%; green, 50%; blue, 75%), MHD% were associated with elevated AD%. Likewise, MHD% were associated with increased asthma% (Figure 1D). Interestingly, aforementioned associations seemed to dissipate with age. For example, AD% for 10–14-year-old and 15–19-year-old exhibited less striking correlations with MHD% 12- and 17-year prior, respectively.&lt;/p&gt;&lt;p&gt;Collectively, we for the first time demonstrated positive associations between MHD% and offspring AD% and asthma% for 1–4-year-old on ","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 12","pages":"1024-1026"},"PeriodicalIF":6.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naturally Occurring Food Chemical Components and Extraintestinal and Gastrointestinal Symptoms in Adults: A Systematic Review","authors":"Zoe Cooke,&nbsp;Kathryn Lynam,&nbsp;Caroline Tuck,&nbsp;Gina Louise Trakman","doi":"10.1111/cea.14561","DOIUrl":"10.1111/cea.14561","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review aims to synthesise existing literature to examine the relationship between natural food chemical components and reported symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>A systematic literature review was completed. Databases CINAHL (Ebscohost), Medline (Ovid), Scopus, Informit Health and Google Scholar were searched to identify relevant articles. The population included human studies of adults (≥17 years) and excluded those with IgE-mediate food allergies. Studies examining food chemical components or ‘food chemical elimination diets’ and symptoms were included. Data was synthesised based on clinical conditions and specific food chemical components examined. The risk of bias was assessed using the Academy of Nutrition and Dietetics ‘Quality Criteria Checklist: Primary Research’.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 1659 articles retrieved, 21 met inclusion criteria. This included eight randomised controlled trials, four non-randomised controlled trials, four cohort studies with placebo-controlled challenge, one prospective cohort study, three cross sectional cohort studies, one case–controlled study. Available studies support the role of a low-histamine diet for symptoms in chronic urticaria and low-salicylate diet for reducing sino-nasal symptoms in aspirin exacerbated respiratory disease and chronic rhinosinusitis and/or asthma. While further evidence is needed to verify the role of glutamate in respiratory, pain, asthma and gastrointestinal symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Food chemical elimination diets may improve condition-specific symptoms across the adult cohorts outlined within this review, with the strongest evidence to support the role of a low-histamine diet for management of symptoms in chronic urticaria and a low-salicylate diet in aspirin exacerbated respiratory disease and/or asthma. Further well-designed trials are needed to elucidate the effect of specific natural food chemical components on symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Systematic review number: CRD42022322511.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"54 11","pages":"855-880"},"PeriodicalIF":6.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}