Clinical and Experimental Allergy最新文献

{"title":"Determinants of Total and Inhaled Allergen-Specific Immunoglobulin E in the Middle-Aged and Elderly Population","authors":"M. Al Fatly, S. Leonard, P.L.A. van Daele, G. Helleman, E. Torabi-Azhandeh, L. Lahousse, S. Veenbergen, L. Chaker","doi":"10.1111/cea.70383","DOIUrl":"10.1111/cea.70383","url":null,"abstract":"<p>Immunoglobulin E (IgE) plays a key role in hypersensitivity reactions and immune responses against parasites and venom. While total IgE (tIgE) is generic, allergen-specific IgE (sIgE) can confirm allergen-specific sensitization [<span>1</span>]. Beyond IgE's conventionally established roles, there is increasing evidence linking tIgE and sIgE to chronic non-communicable diseases, potentially through chronic inflammatory mechanisms [<span>1</span>]. Nevertheless, determinants of tIgE and sIgE remain poorly understood, especially in the general middle-aged and elderly population, where the burden of chronic diseases is increasing.</p><p>Therefore, we utilized Rotterdam Study (RS) data to investigate age, sex, smoking, alcohol consumption, body mass index (BMI), season and corticosteroid use (topical, inhaled, oral) as potential determinants of tIgE and sIgE. A detailed description of the analyses, quality assurance, analytical considerations and results are available in an online repository (data availability statement).</p><p>The RS is a population-based cohort including middle-aged and elderly residents of Ommoord, Rotterdam, the Netherlands [<span>2</span>]. All participants provided written informed consent. We measured tIgE and sIgE between 2023–12 and 2024–11 in serum samples stored in −80°C using NOVEOS, a fully automated chemiluminescent immunoassay system [<span>3</span>]. The tIgE detection range was 5–5000 kU/L (kilounits/L). Serum sIgE was measured with a molecular inhalant allergen mix (SX01) in Standard Arbitrary Units (SAU). We investigated the determinants of tIgE and sIgE through multivariable linear regression analyses. We log-transformed the outcomes and evaluated nonlinearity of age using restricted cubic splines. Lastly, we used linear mixed models to investigate longitudinal changes in tIgE and sIgE, and dose–response effects of inhaled and oral corticosteroids. We quantified the associations in odds ratios with 95% confidence intervals (OR [95% CI]).</p><p>Cross-sectional analyses included 8679 participants (mean ± SD age 64.2 ± 9.8 years; 56.9% female), of which 478 had repeated measurements (median follow-up 5.56 years). We identified age, sex, smoking, BMI, season and topical and inhaled corticosteroid use as determinants of tIgE and/or sIgE. Figure 1 shows the cross-sectional and longitudinal relationships of age with tIgE and sIgE. Figures and effect estimates of other determinants are available in the online repository. First, age and tIgE showed a U-shaped relationship (<i>p</i>-nonlinearity < 0.001). Until approximately 70 years of age, older age was associated with lower tIgE, while after 70 years, older age was associated with higher tIgE values. For sIgE, the relationship with age was L-shaped (<i>p</i>-nonlinearity < 0.001), where older age was associated with lower sIgE levels and the association was most pronounced in younger ages. Both tIgE and sIgE decreased over time (<i>p</i> < 0.001). Mechanistic","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"56 10","pages":"1240-1242"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Diseases and Risk of Incident Autoimmune Diseases: Phenotype-Specific Patterns and Multimorbidity Effects in a Nationwide Cohort.","authors":"Kyung Min Kang, Jeung Min Lee, Seong Heon Kim, Seogsong Jeong, Hwamin Lee","doi":"10.1111/cea.70379","DOIUrl":"10.1111/cea.70379","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":"1273-1275"},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting National Allergy Priorities for Research in Australia: A Priority Setting Consumer Survey.","authors":"Rachel L Peters, Lauren Pikó, Janet Davies, Lisa Gamble, Jennifer J Koplin, Michaela Lucas, Sheryl van Nunen, Sally Voukelatos, Yichao Wang, Nyanhial Yang, Kirsten P Perrett","doi":"10.1111/cea.70440","DOIUrl":"10.1111/cea.70440","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sublingual House Dust Mite (HDM) Immunotherapy Comes to UK Children: Equity of Access and the Unanswered Question of Asthma.","authors":"Prasad Nagakumar, Adel H Mansur, Mamidipudi Thirumala Krishna","doi":"10.1111/cea.70443","DOIUrl":"https://doi.org/10.1111/cea.70443","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prespecified Margins Are Essential Before Claiming Non-Inferiority in Paediatric Egg-Ladder Follow-Up.","authors":"Ercan Yılmaz, Nezihe Koker Özer, Erdem Topal","doi":"10.1111/cea.70436","DOIUrl":"https://doi.org/10.1111/cea.70436","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Glucagon-Like Peptide-1 Receptor Agonists in Allergic Inflammation and Asthma: A Mechanistic Review.","authors":"Alberto Alvarez-Perea, Ana Entrala, Laura Palomino-Lozano, Elena Rodríguez-Mazariego, Gabriela Zambrano Ibarra","doi":"10.1111/cea.70442","DOIUrl":"https://doi.org/10.1111/cea.70442","url":null,"abstract":"<p><p>Asthma and allergic diseases represent a substantial global health burden, frequently compounded by the modern epidemics of obesity and metabolic syndrome to create a complex immunometabolic challenge. The emerging epithelial barrier hypothesis provides a mechanistic framework linking environmental exposures to systemic inflammation and metabolic dysfunction. Standard therapies often fail to address these underlying systemic drivers, particularly in difficult-to-treat phenotypes like obesity-related asthma. This review explores the dual-action potential of glucagon-like peptide-1 receptor agonists (GLP-1RA) as a novel therapeutic strategy. Beyond their established roles in glycemic control and weight loss, GLP-1RA exert direct, weight-independent immunomodulatory effects. Mechanistic evidence demonstrates that the GLP-1 receptor (GLP-1R) is expressed on key immune cells, including eosinophils, macrophages, and Group 2 innate lymphoid cells. Agonism of these receptors suppresses Type 2 (T2) inflammation by reducing cytokine production (IL-5, IL-13) and upstream alarmins (IL-33). Furthermore, GLP-1R signalling enhances regulatory T cell function and may restore epithelial barrier integrity in both the gut and airways. Clinical observations suggest that GLP-1RA initiation improves asthma control and reduces exacerbations, often independently of body mass index reduction. However, prospective trials utilizing specific T2 biomarkers are needed to confirm these direct cellular mechanisms in humans. Transitioning to an immunometabolic approach with GLP-1RA may offer a comprehensive solution for patients at the intersection of metabolic and allergic disease.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Prior Sponge and Lavage Sampling on Gene Expression of Nasal CMA1 and TSLP Collected With Brush.","authors":"Abigail Davis, Sophie Spicer, Lubnaa Hossenbaccus, Anne K Ellis","doi":"10.1111/cea.70441","DOIUrl":"https://doi.org/10.1111/cea.70441","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Resolution of Paediatric Cow's Milk Allergy Is Associated With Low Tfh Cell Frequencies and Elevated IL-17 and IL-22 Levels'.","authors":"Ercan Yılmaz, Nezihe Koker Özer, Erdem Topal","doi":"10.1111/cea.70444","DOIUrl":"https://doi.org/10.1111/cea.70444","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Allergen Profiles and Identifying Group 2 Allergens of Three Storage Mites: Acarus siro, Chortoglyphus arcuatus and Carpoglyphus lactis.","authors":"Xiaoyu Liu, Yu Xuan Lau, Jingyuan Bian, Ruyi Yuan, Kelvin Fu-Kiu Ao, Yi Feng, Runnan Ye, Weiyi He, Annie Wing-Tung Lee, Gilman Kit-Hang Siu, Franklin Wang-Ngai Chow, Fook Tim Chew, Ting Fan Leung, Baoqing Sun, Pavel B Klimov, Stephen Kwok-Wing Tsui, Jan Hubert, Qing Xiong","doi":"10.1111/cea.70438","DOIUrl":"https://doi.org/10.1111/cea.70438","url":null,"abstract":"<p><strong>Background: </strong>Storage mites are important contributors to allergic diseases, yet their allergens remain poorly characterized compared to those of house dust mites. Comprehensive molecular data on storage mite allergens are limited, hindering improved diagnosis and understanding of their allergenic potential.</p><p><strong>Methods: </strong>We assembled and annotated the genomes of three storage mite species, Acarus siro, Chortoglyphus arcuatus and Carpoglyphus lactis. Comprehensive allergen profiling was performed using integrated genomics, transcriptomics and proteomics approaches. Putative allergen genes were identified and classified into allergen groups. IgE-binding capacity of selected allergens was validated using ELISA assays. In addition, the immunostimulatory potential of newly identified allergens was assessed by measuring IL-6 production in a dendritic cell line.</p><p><strong>Results: </strong>We identified 75, 70 and 64 putative allergen genes in A. siro, C. arcuatus and C. lactis, corresponding to 33, 31 and 32 allergen groups, respectively. Extensive gene family expansions and multiple isoallergens were observed, particularly, among Group 2 allergens belonging to the NPC2 family. ELISA IgE-binding assays validated four Group 2 allergens in A. siro and one in each of C. arcuatus and C. lactis. Notably, these newly identified Group 2 allergens significantly induced the production of the pro-inflammatory cytokine IL-6 in a dendritic cell line.</p><p><strong>Conclusion: </strong>This study provides a comprehensive genomic and proteomic characterization of storage mite allergens and identifies previously unrecognized Group 2 allergens with IgE-binding and immunostimulatory capacity. These findings establish a foundational resource for improved diagnosis of storage mite allergy and support future investigations into the molecular mechanisms underlying mite allergenicity.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Circulating Mast Cell Progenitors in Healthy Adults: Associations With CD14⁺ Monocytes But Not With Clinical Characteristics.","authors":"Animamalar Mayavannan, Anna Sörman, Erika Mendez-Enriquez, Abigail Alvarado-Vazquez, Christer Janson, Andrei Malinovschi, Jenny Hallgren","doi":"10.1111/cea.70439","DOIUrl":"https://doi.org/10.1111/cea.70439","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}