Clinical and Experimental Allergy最新文献

{"title":"Th2-Polarised CD4⁺ T Cells Enhance Staphylococcus aureus Growth in a 3D Skin Model.","authors":"Ina Suhrkamp, Melina Fonfara, Magdalena Magdalena, Jan N Hartmann, Elke Rodriguez, Jürgen Harder, Hila Emmert, Stephan Weidinger","doi":"10.1111/cea.70019","DOIUrl":"https://doi.org/10.1111/cea.70019","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic Oesophagitis in Adults: National Centre Retrospective Study in an Irish Cohort","authors":"Olga Fagan, Ciaran Judge, Ciara Ryan, Niall Conlon, Claire L. Donohoe, Joanne C. Masterson, Susan Mc Kiernan","doi":"10.1111/cea.70016","DOIUrl":"10.1111/cea.70016","url":null,"abstract":"<p>Incidence and prevalence of eosinophilic oesophagitis (EoE) may be increasing. Patients with fibrostenotic disease often present with dysphagia, food bolus obstruction and the inflammatory-predominant phenotype with vomiting and reflux [<span>1</span>]. Delayed diagnosis and treatment correlate with fibrosis [<span>2</span>]. Improved physician awareness could enable more timely diagnosis, reduce disease progression, and thus associated complications, treatment refractory disease and poorer quality of life. An Irish 2011 study indicated EoE was rare, noting an increasing referral pattern [<span>3</span>].</p><p>A retrospective study of St James's Hospital (SJH) pathology records (January 2016–December 2020) for patients with recorded eosinophilia on oesophageal biopsy was conducted. Those meeting the EoE [<span>4</span>] criteria were included. The incidence, characteristics and management of EoE patients were reviewed, when no specialty clinic existed and patients were managed by multiple disciplines. This clinical audit study was SJH Research and Innovation (7989) approved; ethics review was not required.</p><p>EoE endoscopic phenotypes representing severity of inflammation versus remodelling included (i) inflammatory (oedema, furrows and exudate), (ii) fibrostenotic (rings and strictures) and (iii) mixed (i+ii combined) [<span>1</span>]. Remission was reviewed separately across clinical, endoscopic and histologic criteria. ‘Clinical-remission’ refers to complete resolution of symptoms, whereas ‘clinical-response’ was any improvement. A single operator reviewed endoscopic photographs and calculated EREFS. ‘Endoscopic-remission’ was an EREFS of 0 and ‘endoscopic-response’ as any improvement. ‘Histological-remission’ was < 15-eosinophils/hpf and ‘histological-response’ as any improvement in eosinophils/hpf. Other histological features of EoE were not routinely reported.</p><p>New EoE patients were identified each year, divided by the Dublin City region adult population (aged ≥ 15 years) at the time of study, yielding annual incidence rate (cases/100,000-population). Cumulative prevalence was calculated similarly. Annual incidence of adult EoE diagnosis at SJH remained stable, ranging between 1.1 (2015) and 2.6 (2020); prevalence increased steadily, to a cumulative 12.2 by 2020.</p><p>A total of 133-patients with biopsy eosinophilia were identified; of these, 78 met the EoE diagnostic criteria (including ≥ 15eos/hpf) [<span>4</span>]. Symptoms included: dysphagia (55%), reflux (8%), impacted food bolus (7%), food sticking (5%), chest pain (1%) and no indication (20%) was documented on index OGDs, with no significant difference among phenotypes.</p><p>Mean age at OGD/biopsy was 33-years (SD14); males predominated (<i>n</i> = 61 [78%]). Mean outpatient follow-up was 46-months. Duration of pre-diagnosis symptoms was longer in phenotypes with fibrosis (mixed = 6-years; fibrostenotic = 7-years) versus inflammation (3.4-years; <i>p</i> = 0.0316).<","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"354-356"},"PeriodicalIF":6.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK-air Study","authors":"Bernardo Sousa-Pinto,&nbsp;Elísio M. Costa,&nbsp;Rafael José Vieira,&nbsp;Ludger Klimek,&nbsp;Wienczyslawa Czarlewski,&nbsp;Oliver Pfaar,&nbsp;Anna Bedbrook,&nbsp;Rita Amaral,&nbsp;Luisa Brussino,&nbsp;Violeta Kvedariene,&nbsp;Desiree E. Larenas-Linnemann,&nbsp;Tomohisa Iinuma,&nbsp;Nhân Pham-Thi,&nbsp;Frederico S. Regateiro,&nbsp;Luis Taborda-Barata,&nbsp;Maria Teresa Ventura,&nbsp;Ignacio J. Ansotegui,&nbsp;Karl C. Bergmann,&nbsp;G. Walter Canonica,&nbsp;Victoria Cardona,&nbsp;Lorenzo Cecchi,&nbsp;Ivan Cherrez-Ojeda,&nbsp;Cemal Cingi,&nbsp;Alvaro A. Cruz,&nbsp;Stefano Del Giacco,&nbsp;Philippe Devillier,&nbsp;Wytske J. Fokkens,&nbsp;Bilun Gemicioglu,&nbsp;Tari Haahtela,&nbsp;Juan Carlos Ivancevich,&nbsp;Piotr Kuna,&nbsp;Helga Kraxner,&nbsp;Daniel Laune,&nbsp;Renaud Louis,&nbsp;Michael Makris,&nbsp;Mario Morais-Almeida,&nbsp;Ralph Mösges,&nbsp;Marek Niedoszytko,&nbsp;Nikolaos G. Papadopoulos,&nbsp;Vincenzo Patella,&nbsp;Ana Margarida Pereira,&nbsp;Sietze Reitsma,&nbsp;Karla Robles-Velasco,&nbsp;Philip W. Rouadi,&nbsp;Boleslaw Samolinski,&nbsp;Milan Sova,&nbsp;Sanna K. Toppila-Salmi,&nbsp;Joaquin Sastre,&nbsp;Arunas Valiulis,&nbsp;Arzu Yorgancioglu,&nbsp;Mihaela Zidarn,&nbsp;Torsten Zuberbier,&nbsp;Joao A. Fonseca,&nbsp;Jean Bousquet,&nbsp;the MASK-air think tank","doi":"10.1111/cea.70004","DOIUrl":"10.1111/cea.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Adherence to rhinitis treatment has been insufficiently assessed. We aimed to use data from the MASK-air mHealth app to assess adherence to oral antihistamines (OAH), intra-nasal corticosteroids (INCS) or azelastine-fluticasone in patients with allergic rhinitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included regular European MASK-air users with self-reported allergic rhinitis and reporting at least 1 day of OAH, INCS or azelastine-fluticasone. We assessed weeks during which patients answered the MASK-air questionnaire on all days. We restricted our analyses to data provided between January and June, to encompass the pollen seasons across the different assessed countries. We analysed symptoms using visual analogue scales (VASs) and the combined symptom-medication score (CSMS), performing stratified analyses by weekly adherence levels. Medication adherence was computed as the proportion of days in which patients reported rhinitis medication use. Sensitivity analyses were performed considering all weeks with at most 1 day of missing data and all months with at most 4 days of missing data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We assessed 8212 complete weeks (1361 users). Adherence (use of medication &gt; 80% days) to specific drug classes ranged from 31.7% weeks for azelastine-fluticasone to 38.5% weeks for OAH. Similar adherence to rhinitis medication was found in users with or without self-reported asthma, except for INCS (better adherence in asthma patients). VAS and CSMS levels increased from no adherence to full adherence, except for INCS. A higher proportion of days with uncontrolled symptoms was observed in weeks with higher adherence. In full adherence weeks, 41.2% days reported rhinitis co-medication. The sensitivity analyses displayed similar results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A high adherence was found in patients reporting regular use of MASK-air. Different adherence patterns were found for INCS compared to OAH or azelastine-fluticasone that are likely to impact guidelines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"226-238"},"PeriodicalIF":6.3,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kiwi Allergy in Singaporean Children","authors":"Sansy Mathews,&nbsp;Si Hui Goh,&nbsp;Wenyin Loh,&nbsp;Kok Wee Chong","doi":"10.1111/cea.70015","DOIUrl":"10.1111/cea.70015","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"334-336"},"PeriodicalIF":6.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Depth Proteomic Profiles Prior to Symptom Development in Food Protein-Induced Enterocolitis","authors":"Yuzaburo Inoue,&nbsp;Hironori Sato,&nbsp;Masaki Ishikawa,&nbsp;Yusuke Kawashima,&nbsp;Hiroki Kawamura,&nbsp;Mayumi Enseki,&nbsp;Yuka Osaki,&nbsp;Sachiko Kaburagi,&nbsp;Masayuki Akashi,&nbsp;Arisa Ito,&nbsp;Eri Hayata,&nbsp;Takeshi Yamamoto,&nbsp;Taiji Nakano,&nbsp;Soichiro Toda,&nbsp;Yuki Okada,&nbsp;Hiroaki Ito,&nbsp;Daisuke Shigeta,&nbsp;Yuki Tsumura,&nbsp;Mariko Shimizu,&nbsp;Minako Tomiita,&nbsp;Yoshiyuki Yamada","doi":"10.1111/cea.70007","DOIUrl":"10.1111/cea.70007","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"270-272"},"PeriodicalIF":6.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Trajectories and Body Composition in Preschoolers With Allergic Conditions: Findings From the Japan Environment and Children's Study Pilot Cohort.","authors":"Daisuke Harama, Miori Sato, Limin Yang, Yumiko Miyaji, Nathan Mise, Reiko Suga, Mayumi Tsuji, Masayuki Ochiai, Masako Oda, Maki Fukami, Shoji F Nakayama, Makiko Sekiyama, Yukihiro Ohya, Kiwako Yamamoto-Hanada","doi":"10.1111/cea.14625","DOIUrl":"https://doi.org/10.1111/cea.14625","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NLRP1 Is a Prominent Inflammasome Sensor Found in Bronchial Epithelial Cells in Asthma and Can Be Activated by Rhinovirus A16","authors":"Anet Laanesoo,&nbsp;Mariel Mäe,&nbsp;Anu Remm,&nbsp;Sebastian L. Johnston,&nbsp;Alan Altraja,&nbsp;Grazyna Bochenek,&nbsp;Bogdan Jakiela,&nbsp;Ana Rebane","doi":"10.1111/cea.70010","DOIUrl":"10.1111/cea.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Asthma exacerbations are frequently triggered by human rhinoviruses (RVs). Among other pro-inflammatory responses, RV infection of airway epithelium promotes the activation of the inflammasome pathway, the role of which in asthma exacerbations and disease progression is still poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Bronchial brushing or biopsy specimens were collected from asthma patients and control subjects. Functional experiments were performed in cultured human bronchial epithelial cells (HBECs) using RV-A16, poly(I:C), and siRNA transfection. Gene expression was analysed by RNA-sequencing, RT-qPCR, immunofluorescence, western blot or ELISA. Caspase-1 activity was evaluated using FAM-FLICA assay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expression of NLRP1 was found to be the highest compared to other inflammasome sensors tested in brushed bronchial epithelium samples from asthma patients and control individuals, as well as in cultured primary HBECs. Additionally, we observed increased expression of CASP1 mRNA in bronchial epithelial cells from patients with neutrophilic asthma compared to those with paucigranulocytic and eosinophilic phenotypes. Changes in the expression of inflammasome pathway genes caused by RV-A16 infection were similar in HBEC cultures from asthma patients and controls, except for IL-1β, which showed increased response, and PYCARD, which exhibited decreased change in cells derived from asthma patients. Silencing of NLRP1 expression with siRNAs impeded RV-A16-induced activation of the inflammasome but had no effect on poly(I:C)-induced secretion of IL-1β and IL-18.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NLRP1 is highly expressed inflammasome sensor in both healthy and asthmatic bronchial epithelium and can be activated by RV-A16. RV-induced changes in the expression of inflammasome pathway genes suggest that there may be differences in HBECs derived from asthma patients, which may depend on the prevailing immunological phenotype of the disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"239-246"},"PeriodicalIF":6.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Mite Allergen Recognition in an Area of Low Environmental Exposure","authors":"D. Betancor,&nbsp;E. S. Castromil-Benito,&nbsp;J. Bernaola,&nbsp;J. Parrón-Ballesteros,&nbsp;C. Pastor-Vargas,&nbsp;J. Cuesta-Herranz","doi":"10.1111/cea.70006","DOIUrl":"10.1111/cea.70006","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"267-269"},"PeriodicalIF":6.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Economic Evaluation of Direct Oral Penicillin Challenge for De-Labelling Low Risk Patients With a Penicillin Allergy Label.","authors":"R Bestwick, R Bhogal, K Kildonaviciute, B Y Ng, B Jackson, C Moriarty, C Thomas, L Savic, S A Misbah, M T Krishna, R Mujica-Mota","doi":"10.1111/cea.14633","DOIUrl":"https://doi.org/10.1111/cea.14633","url":null,"abstract":"<p><strong>Background: </strong>Removing inaccurate penicillin allergy labels (PALs) can reduce unnecessary exposure to 'watch' and 'reserve' groups of antibiotics and thereby reduce antimicrobial resistance. The most efficient model for a non-allergy-specialist-led penicillin allergy de-labelling (PADL) service has not been established.</p><p><strong>Objective: </strong>To determine the costs to the UK National Health Service of a direct oral penicillin challenge (DPC) for low-risk patients with a PAL in three hospitals in England, each with a different non-allergy-specialist delivery model: pharmacist-led, nurse-led, and mixed multidisciplinary.</p><p><strong>Methods: </strong>Cost analysis of the DPC pathway, including resources related to staff time and antibiotics. The effect of de-labelling on healthcare utilisation over 5 years was modelled using data from the published literature.</p><p><strong>Results: </strong>In total, 2257 patients from the Acute Medical or Infectious Disease Unit (AMU/IDU), Pre-surgical, and Haematology-Oncology departments were screened. Subsequently, 126 underwent DPC, and 122 were de-labelled. Twenty-two of these were de-labelled in time to affect their antibiotic regimen; 6 from AMU/IDU and 16 Pre-surgery. The DPC represented 22%-23% of the pathway cost in the pharmacist-led and mixed models, and 15% in the nurse-led model. Across departments and models, the cost per de-labelled patient varied between £577 (95% Credible Interval: 370, 633) for haematology-oncology patients to £2329 (947, 19,504) for AMU/IDU patients, both under the nurse-led model. After 5 years, recouping costs was unlikely for AMU/IDU patients under any model or for all patients combined under the mixed model.</p><p><strong>Conclusions: </strong>The penicillin allergy de-labelling pathway cost was  ≥ 4-fold that of the DPC alone. Costs were up to 3 times higher in an acute compared to an elective setting. No short-term cost savings were identified from proactive or opportunistic penicillin allergy de-labelling in this study.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Prolonged Provocation Testing in Penicillin Allergy Evaluation","authors":"Andrea Jing Shi Ang,&nbsp;Haur Yueh Lee,&nbsp;Chaw Su Naing,&nbsp;Chiara Jiamin Chong,&nbsp;Chujie Li,&nbsp;Kavitha Garuna Murthee,&nbsp;Ibrahim Muhammad Hanif,&nbsp;Vivian Tan,&nbsp;Zi Teng Chai,&nbsp;Karen Jui Lin Choo","doi":"10.1111/cea.70008","DOIUrl":"10.1111/cea.70008","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"273-275"},"PeriodicalIF":6.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}