Clinical and Experimental Allergy最新文献

{"title":"Increase of IL-17 Expression on Th2 Cells in Asthma by Cytokine-Induced Microenvironment.","authors":"Thais F C Fraga-Silva, Núbia S Martins, Ualter G Cipriano, Ana F Gembre, Mèdéton M M Boko, Andrea C A V Cetlin, Vânia L D Bonato","doi":"10.1111/cea.70105","DOIUrl":"https://doi.org/10.1111/cea.70105","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Impact on Dietary Intake and Quality of Life Post-Successful Oral Food Challenge to Peanut and Tree Nuts.","authors":"Jerry Shen, Dug Yeo Han, Kuang-Chih Hsiao","doi":"10.1111/cea.70104","DOIUrl":"https://doi.org/10.1111/cea.70104","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcomes and Provider Perceptions of Systemic Mastocytosis: Results From the PRISM Study","authors":"Massimo Triggiani,&nbsp;Jessica Hobart,&nbsp;Iván Alvarez-Twose,&nbsp;Cristina Bulai Livideanu,&nbsp;Franziska Ruëff,&nbsp;Stéphane Barete,&nbsp;Patrizia Bonadonna,&nbsp;Laurence Bouillet,&nbsp;Nauman M. Butt,&nbsp;Mark Drummond,&nbsp;Mar Guilarte,&nbsp;Karin Hartmann,&nbsp;Amélie Beaux,&nbsp;Celeste C. Finnerty,&nbsp;Nicole Hegmann,&nbsp;Patrizia Marcis,&nbsp;Eugenia Ribada,&nbsp;Waltraud Schinhofen,&nbsp;Gabriela Coletti,&nbsp;Andrew Dugdale,&nbsp;Cristian Perez,&nbsp;Dakota Powell,&nbsp;Teresa Green,&nbsp;Erin Sullivan,&nbsp;Deepti H. Radia,&nbsp;Ruben Mesa","doi":"10.1111/cea.70101","DOIUrl":"10.1111/cea.70101","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Systemic mastocytosis (SM) is a clonal mast cell disease primarily driven by the <i>KIT</i> D816V mutation and often characterised by unpredictable and debilitating symptoms. The Perceptions Realities and Insights on Systemic Mastocytosis (PRISM) survey queried patient and provider perceptions of SM in Europe.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PRISM (funded by Blueprint Medicines Corporation) was composed of two independent surveys: a 119-item patient survey on diagnosis, symptom burden, quality of life (QoL) and work impact; and a 103-item healthcare provider (HCP) survey on approaches to SM diagnosis and management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data were evaluated from 540 patient respondents from Italy (<i>n</i> = 136), France (<i>n</i> = 112), the UK (<i>n</i> = 101), Germany (<i>n</i> = 83), Spain (<i>n</i> = 64), Austria (<i>n</i> = 26) and Switzerland (<i>n</i> = 18). Patients reported a high symptom burden and reduced physical functioning and mental health due to SM, despite taking, on average, seven medications. A majority of patients reported that SM impacted their ability to work (58.9%). A total of 618 HCP responses were collected from Italy (<i>n</i> = 203), Germany (<i>n</i> = 123), the UK (<i>n</i> = 110), Austria (<i>n</i> = 63), France (<i>n</i> = 56), Switzerland (<i>n</i> = 44) and Spain (<i>n</i> = 19). Various HCP types reported treating patients with SM; the majority were haematologists/oncologists (<i>n</i> = 167) and general practitioners (<i>n</i> = 178). HCPs perceived that SM impacted their patients' QoL, with 54% reporting SM affected patients' lives ‘quite a bit’. The most frequently reported treatment goals were improving QoL and survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PRISM is the largest international and first European survey to evaluate the burden of SM from both patient and HCP perspectives. Patients and HCPs perceived a high symptom burden, reduced QoL and reduced ability to work due to SM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"784-794"},"PeriodicalIF":5.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Tralokinumab Concentrations in Serum and Tear Fluid of Atopic Dermatitis Patients and the Relationship With Treatment Response and Ocular Surface Disease.","authors":"Coco Dekkers, Erin H Smeijsters, Mohsin El Amrani, Constance den Hartog Jager, Kim C M van der Elst, Matthijs van Luin, Chantal van Luijk, Daphne S Bakker, Alwin D R Huitema, Marlies de Graaf, Femke van Wijk, Marjolein S de Bruin-Weller","doi":"10.1111/cea.70098","DOIUrl":"https://doi.org/10.1111/cea.70098","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Dose Oral Food Challenge in Food Protein-Induced Enterocolitis Syndrome and Severity of Reaction-Reply to Mackey et al.","authors":"Stefano Miceli Sopo, Matteo Di Toro Mammarella, Bruno Miceli Sopo, Tecla Fontana, Giulia Bersani","doi":"10.1111/cea.70102","DOIUrl":"https://doi.org/10.1111/cea.70102","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Badly Does India Need Biologics for Severe Asthma?","authors":"Subhabrata Moitra,&nbsp;Kalpesh T. Panchal,&nbsp;Saibal Moitra","doi":"10.1111/cea.70103","DOIUrl":"10.1111/cea.70103","url":null,"abstract":"&lt;p&gt;The treatment modalities for severe asthma have substantially changed in the past decades with the discovery of molecule-specific monoclonal antibodies (mAbs), commonly known as biologics. Unlike corticosteroids (CS) that create a blanket anti-inflammatory effect, these agents work on specific inflammatory pathways by targeting immunoglobulin E (IgE), interleukin (IL)-5, IL-4, IL-13, and a more recently discovered thymic stromal lymphopoietin (TSLP) pathway. While these personalised treatment options have transformed care for many selected patient populations in high-income countries, their applicability to the low-middle-income countries like India requires more discussions on clinical relevance. In a country like India, where basic asthma management is often inadequate, the rush toward biologics may represent a misplaced priority and thus warrants a more careful approach. This consideration is especially crucial when examining asthma management practices within India.&lt;/p&gt;&lt;p&gt;In India, where asthma affects over 35 million people, the case for biologics is tenuous, not due to a lack of clinical efficacy but due to fundamental gaps in the infrastructure of asthma diagnosis and care, poor adherence to standard therapies, widespread underdiagnosed comorbidities such as allergic rhinitis (AR), and a milieu of several environmental factors, including extremely high air pollution. In this commentary, we argue that biologics in asthma care in India have still miles to go, as a significant proportion of difficult-to-control asthma cases are mislabelled as ‘severe’ asthma cases and without resolving this core issue, biologics offer limited value in reducing the burden of asthma in India. There is no doubt that biologics are extremely useful for a small subset of patients with eosinophilic or allergic asthma, but in countries like India, where simple spirometry is not accessible in most parts of the country, let alone access to any specialised allergy testing or blood biomarkers, finding the right patient group for biologic therapies is seemingly unrealistic.&lt;/p&gt;&lt;p&gt;Let us focus on the primary question: how should we define severe asthma? Globally, severe asthma is defined as asthma that remains difficult to control despite optimal treatment with high-dose inhaled corticosteroids (ICS) and additional controller therapy, and optimal self-management in addition to the management of triggers and any comorbid conditions (Figure 1). However, this algorithm is rarely followed in India, and many patients with just difficult to control asthma are mislabelled as severe asthma without any guideline-based diagnostic approach in the first place. This overestimates the actual severe asthma cases where the disease is ‘truly’ severe despite full compliance with the treatment and management modalities.&lt;/p&gt;&lt;p&gt;The heuristic scenario of difficult-to-control asthma is primarily dependent on three fundamental pillars: adherence, comorbidities of AR and environmental triggers ","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":"518-520"},"PeriodicalIF":6.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Predictors of Longitudinal Respiratory Exacerbation Outcomes in Young Hospitalised Children.","authors":"Laura A Coleman, Siew-Kim Khoo, Kimberley Franks, Franciska Prastanti, Jonatan Leffler, Peter N Le Souëf, Yuliya V Karpievitch, David G Hancock, Ingrid A Laing","doi":"10.1111/cea.70099","DOIUrl":"https://doi.org/10.1111/cea.70099","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Allergy in China: A Comprehensive Population-Based Investigation","authors":"Yali Liu,&nbsp;Wenwen Xiong,&nbsp;Yibo Luo,&nbsp;Mingzhe Zhu,&nbsp;Ming Xia Lin,&nbsp;Shiwen Han,&nbsp;Huilian Che,&nbsp;Xiaohui Guo","doi":"10.1111/cea.70081","DOIUrl":"10.1111/cea.70081","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 8","pages":"716-718"},"PeriodicalIF":5.2,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Clinical Management of Eosinophilic Esophagitis in Australia: A National Survey.","authors":"A Clancy, A Swain, E Beck, V Soutter, R Loblay","doi":"10.1111/cea.70088","DOIUrl":"https://doi.org/10.1111/cea.70088","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Mental Health Symptoms in Patients With Atopic Dermatitis: A Systematic Review and Meta-Analysis.","authors":"Daniel G Rayner, David Gou, Jennifer Lin, Grace Xiong, Alessandra Giglia, Lola Irelewuyi, Jason Jianxin Zhao, Shreya Bera","doi":"10.1111/cea.70096","DOIUrl":"https://doi.org/10.1111/cea.70096","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}