Clinical and Experimental Allergy最新文献

{"title":"Evaluation of Skin Prick Tests Using Photoplethysmography Imaging.","authors":"Stefan Borik, Patrik Procka, Jan Seleng, Julia Kubascikova, Michal Labuda, Janka Komova","doi":"10.1111/cea.70049","DOIUrl":"https://doi.org/10.1111/cea.70049","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising Strategies for Patients With Prior Immediate Iodinated Contrast Media Reactions: Premedication or Changing Agents?","authors":"Aleena Banerji, Julia Moore, Jamie L. Waldron, Anna R. Wolfson, Rebecca R. Saff","doi":"10.1111/cea.70046","DOIUrl":"10.1111/cea.70046","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 6","pages":"455-457"},"PeriodicalIF":6.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma Associated Cytokines Regulate Gasdermin A and Gasdermin B Expression by Human Bronchial Epithelial Cells","authors":"Marina Miller, Allison LaFuze, Eric Leslie, Sofia Svyatskaya, Gil-Soon Choi, Joshua L. Kennedy, Michael Croft, David H. Broide","doi":"10.1111/cea.70042","DOIUrl":"10.1111/cea.70042","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":"586-588"},"PeriodicalIF":6.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclic Seasonal Variation of Pollen Specific IgE to Six Taxa Over 7 Years: A Population Study.","authors":"Angel Mazon, Dah Tay Jang, Sonia Uixera, Javier Suarez","doi":"10.1111/cea.70045","DOIUrl":"https://doi.org/10.1111/cea.70045","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Is Not Prediction—A Pervasive Issue in the Medical Literature","authors":"Kaitlin Stangroome, Michael R. Perkin","doi":"10.1111/cea.70040","DOIUrl":"10.1111/cea.70040","url":null,"abstract":"<p>To the Editor,</p><p>It has recently been observed by Varga et al. that the available scientific literature ‘demonstrates a common tendency to claim predictive value from studies aimed at determining associations’ [<span>1</span>]. While research studies often uncover numerous associations, associations themselves do not convey predictive value and ‘confusion between association and prediction harms clinicians, scientists, and ultimately, the patients’ [<span>1</span>]. Varga et al. systematically reviewed published papers in the field of diabetes epidemiology that made claims about prediction in their title and assessed whether they reported findings with proper relevant measures of prediction in their abstract [<span>1</span>]. The purpose of their research was to identify titles where certain biomarkers were evaluated for their predictive ability in relation to diabetes <i>as an outcome</i>, or where diabetes would predict <i>another outcome</i> (e.g., disease progression, response to treatment or the development of complications) [<span>1</span>]. They found that 61% of papers referring to prediction in their titles did not report metrics of predictive statistics in their abstracts [<span>1</span>]. In a simulation data exercise they demonstrated that biomarkers with large effect sizes and statistically significant <i>p</i> values can still offer poor discriminative utility [<span>1</span>]. We undertook a systematic review to see if similar results are seen in the field of allergy epidemiology, acknowledging that disease prediction is a much more established area of research for diabetes than it is for allergy. We used the same categorisation of statistical methodologies as Varga et al. [<span>1</span>] to identify measures of prediction and measures of association.</p><p>A PubMed search was conducted on the 25th of May 2023 to identify studies published between February 1981 and May 2023 that met the search criteria. The aim was to find studies which contained prediction in their titles alongside an allergy descriptor. The search retrieved 1003 titles, of which 173 were subsequently excluded, leaving 830 abstracts and titles. Abstracts were then divided according to content. The 830 abstracts were categorised by allergic condition and area of investigation.</p><p>Using the criteria specified in the Varga et al. paper, we identified those with prediction metrics and then those with association metrics. Those containing neither measures of prediction nor association were designated as undefined. Overall, only 39% of the studies (323/830) reported prediction metrics in their abstracts. The remaining 61% (507/830) were divided between 38% (317/830) which reported methods of association and 23% (190/830) that did not report a clear methodology (undefined). Only 17% of the studies reported sensitivity and specificity in their abstracts, with 142/830 reporting sensitivity and 139/830 reporting specificity.</p><p>The distribution of allergic con","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":"583-585"},"PeriodicalIF":6.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIFENSE Study Protocol: Early Intervention With Difamilast Ointment in Infantile Early-Onset Atopic Dermatitis for Prevention of Transcutaneous Sensitisation","authors":"Kiwako Yamamoto-Hanada, Kazuyoshi Okamoto, Nobuharu Kishimoto, Kunihiko Tsuchiya, Osamu Natsume, Yutaka Takemura, Masami Narita, Tohru Kobayashi, Yukihiro Ohya","doi":"10.1111/cea.70039","DOIUrl":"10.1111/cea.70039","url":null,"abstract":"<p>Atopic dermatitis (<span>AD</span>) is acknowledged as the first phase in the allergic march, with heightened IgE levels [<span>1</span>] linked to a greater likelihood of experiencing food allergy symptoms [<span>2</span>]. Importantly, the occurrence of early-onset <span>AD</span> during infancy has been found to significantly increase the odds ratio for the development of food allergies [<span>3</span>]. Additionally, suitable transdermal and oral interventions during infancy may impact the trajectory of the allergic march, which includes the prevention of food allergies. The ‘dual allergen exposure hypothesis’ has been suggested as a mechanistic framework for the development of allergies, and since randomised controlled trials (RCTs) have validated the effectiveness of both transdermal and oral treatments, this hypothesis has effectively evolved into an established theory.</p><p>Numerous RCTs have explored the potential of moisturisers in preventing food allergies as part of skincare strategies. Nevertheless, variations in study populations, types of moisturisers, frequencies of application and skin cleansing protocols have led to inconsistent results. Large-scale RCTs carried out in Northern Europe and the United Kingdom have not substantiated the preventative effects of moisturisers on food allergies. A Cochrane Review by Kelleher et al. [<span>4</span>] determined that skincare interventions, which include the use of moisturisers, do not aid in the prevention of food allergies in children.</p><p><span>AD</span> is distinguished by dysfunctional skin barrier, chronic inflammation and pruritus. Interventions that focus exclusively on the restoration of the skin barrier through moisturisers have been demonstrated to be insufficient in mitigating the onset of food allergies. In addition, a RCT performed demonstrated that the utilisation of a mild nonsteroidal topical agent (pimecrolimus) solely on affected eczema lesions did not inhibit the development of food allergies [<span>5</span>]. This outcome indicates that minimal anti-inflammatory treatments targeting only visibly affected eczema regions may fall short in reducing the risk of food allergies. Importantly, even skin that appears normal shows compromised barrier function and heightened inflammatory markers, reflecting the existence of subclinical inflammation at the molecular level [<span>6</span>]. As a result, successfully preventing percutaneous sensitisation demands a well-rounded strategy that integrates barrier improvement and anti-inflammatory interventions, reaching beyond visible lesions to cover nonlesional skin.</p><p>Infants who manifest eczema during the first 1–2 months of life exhibit the greatest likelihood of developing food allergies, particularly those exhibiting eczema before the introduction of solid foods, which exacerbates their risk further [<span>3</span>]. As a result, infants with early-onset <span>AD</span> are the demographic that most urgently needs prev","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":"580-582"},"PeriodicalIF":6.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK-air Study”","authors":"","doi":"10.1111/cea.70041","DOIUrl":"10.1111/cea.70041","url":null,"abstract":"<p>\u0000 <span>Sousa-Pinto, B.</span>, <span>Costa, E.M.</span>, <span>Vieira, R.J.</span>, <span>Klimek, L.</span>, <span>Czarlewski, W.</span>, <span>Pfaar, O.</span>, <span>Bedbrook, A.</span>, <span>Amaral, R.</span>, <span>Brussino, L.</span>, <span>Kvedariene, V.</span>, <span>Larenas-Linnemann, D.E.</span>, <span>Iinuma, T.</span>, <span>Pham-Thi, N.</span>, <span>Regateiro, F.S.</span>, <span>Taborda-Barata, L.</span>, <span>Ventura, M.T.</span>, <span>Ansotegui, I.J.</span>, <span>Bergmann, K.C.</span>, <span>Canonica, G.W.</span>, <span>Cardona, V.</span>, <span>Cecchi, L.</span>, <span>Cherrez-Ojeda, I.</span>, <span>Cingi, C.</span>, <span>Cruz, A.A.</span>, <span>Del Giacco, S.</span>, <span>Devillier, P.</span>, <span>Fokkens, W.J.</span>, <span>Gemicioglu, B.</span>, <span>Haahtela, T.</span>, <span>Ivancevich, J.C.</span>, <span>Kuna, P.</span>, <span>Kraxner, H.</span>, <span>Laune, D.</span>, <span>Louis, R.</span>, <span>Makris, M.</span>, <span>Morais-Almeida, M.</span>, <span>Mösges, R.</span>, <span>Niedoszytko, M.</span>, <span>Papadopoulos, N.G.</span>, <span>Patella, V.</span>, <span>Pereira, A.M.</span>, <span>Reitsma, S.</span>, <span>Robles-Velasco, K.</span>, <span>Rouadi, P.W.</span>, <span>Samolinski, B.</span>, <span>Sova, M.</span>, <span>Toppila-Salmi, S.K.</span>, <span>Sastre, J.</span>, <span>Valiulis, A.</span>, <span>Yorgancioglu, A.</span>, <span>Zidarn, M.</span>, <span>Zuberbier, T.</span>, <span>Fonseca, J.A.</span>, <span>Bousquet, J.</span> and (<span>2025</span>), <span>Adherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK-air Study</span>. <i>Clin Exp Allergy</i>, <span>55</span>: <span>226</span>–<span>238</span>. https://doi.org/10.1111/cea.70004\u0000 </p><p>1. Regarding the 3 affiliations of corresponding author Jean Bousquet</p><p>In our submission, affiliation #7 was listed last, after #29 and #30. However, in the publication, affiliation #7 appears first.</p><p>Correction: affiliation #29 must be listed first (29: Institute of Allergology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany) &gt;&gt; &gt; Jean Bousquet^29,30,7;</p><p>2. Please add this email address in the ‘Corresponding author’ section: <span>[email protected]</span></p><p>We apologize for this error.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Biomarkers predicting the controller dose of omalizumab in patients with chronic spontaneous urticaria”","authors":"","doi":"10.1111/cea.70038","DOIUrl":"10.1111/cea.70038","url":null,"abstract":"<p>\u0000 <span>Zubiaga-Fernandez, L</span>, <span>Testera-Montes, A</span>, <span>Rondon, C</span>, et al. <span>Biomarkers predicting the controller dose of omalizumab in patients with chronic spontaneous urticaria</span>. <i>Clin Exp Allergy.</i> <span>2024</span>; <span>54</span>: <span>402</span>–<span>411</span>. https://doi.org/10.1111/cea.14462\u0000 </p><p>L. Zubiaga-Fernandez^1,2 | A. Testera-Montes^2,3 | C. Rondon^2,3 | N. Perez-Sanchez^2,3 |</p><p>F. Gomez-Perez^2,3 | J. M. Vega-Chicote² | J. Bartra^3,4 | M. Ferrer^3,5 |</p><p>This article will serve as a basis for first author's (Laura Zubiaga Fernandez) thesis. Thus, the affiliation to the UMA should be included.</p><p>We apologize for this error.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 7","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Food-Focused Approach Is Needed to Progress Food Allergy and Hypersensitivity Diagnosis and Management in Adults","authors":"Kate Grimshaw,&nbsp;Sally-Ann Denton,&nbsp;Hannah Hunter,&nbsp;Liane Reeves,&nbsp;Isabel Skypala,&nbsp;Marianne Williams","doi":"10.1111/cea.70036","DOIUrl":"10.1111/cea.70036","url":null,"abstract":"<p>Food-focused approach in the management of adverse reactions to food in adults aids diagnosis and ongoing treatment plans. This is a holistic approach to care, addressing wider issues including nutritional deficiencies, food intake, diet diversity and availability whilst reducing fear and anxiety and time and cost associated with management.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 6","pages":"450-454"},"PeriodicalIF":6.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-Gal Sensitization Dynamics in Individuals After Tick Bites With or Without Erythema Migrans","authors":"Tamara van Gorkom,&nbsp;Michiel Heron,&nbsp;Agnetha Hofhuis,&nbsp;Carlijn Jongerius,&nbsp;Fiona R. M. van der Klis,&nbsp;Hanneke N. G. Oude Elberink,&nbsp;Hein Sprong,&nbsp;Steven F. T. Thijsen,&nbsp;Kristin Kremer","doi":"10.1111/cea.70011","DOIUrl":"10.1111/cea.70011","url":null,"abstract":"<p>α-Gal syndrome (AGS) is an emerging tick-borne disease characterised by the development of specific immunoglobulin E (sIgE) antibodies against galactose-α-1,3-galactose (α-gal), a carbohydrate found in most mammalian species, but not in humans. AGS occurs in individuals with a history of tick bites. Currently, no data exist on α-gal sIgE seroprevalence in the Dutch population, including those with tick bites or erythema migrans (EM). Therefore, this study aimed to determine the rate of α-gal sIgE seroprevalence in the Dutch population, to assess α-gal sIgE seroconversion after tick bites, and to determine the relationship between EM and α-gal sIgE in serum. α-Gal sensitisation rates were assessed in individuals with tick bites (TB), EM, and the general population. Blood samples were collected from TB- and EM-cases at baseline and again after 3 months. Single blood samples from controls were selected from a Dutch population survey. In total, 156 TB-cases, 160 EM-cases, and 316 population controls were included. α-Gal sensitisation rates were 1.9% for population controls and 10.3% and 19.1% for TB- and EM-cases at baseline, respectively (cut-off α-gal sIgE:  ≥ 0.10 kU_A/L). Rates increased to 17.9% for TB-cases, comparable to the 16.9% for EM-cases 3 months after EM-development. Distinct α-gal sensitisation rates were observed between TB- and EM-cases over a 3-month period. TB-cases showed a rising rate, while EM-cases had elevated rates at both time points. This difference is likely due to timing of the tick bite, with TB-cases having a recent bite and EM-cases developing EM days to weeks post-bite. Both groups had higher sensitisation rates than population controls, corroborating the link between tick bites and α-gal sensitisation.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"350-353"},"PeriodicalIF":6.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}