Clinical and Experimental Allergy最新文献

{"title":"Aspergillus fumigatus Serum IgG Cut-Off for the Diagnosis of Aspergillus-Associated Lung Disease: A Historic Cohort Analysis","authors":"Alicia Enríquez-Matas, Beatriz Moya, Tatiana Navarro Cascales, Carmen Romero Ferreiro, Ana Alastruey-Izquierdo, Ismael Garcia-Moguel, Lys Herraez Herrera, JF Crespo, Consuelo Fernández Rodríguez","doi":"10.1111/cea.70057","DOIUrl":"10.1111/cea.70057","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"867-869"},"PeriodicalIF":5.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Food Allergen-Specific Antibodies, Beyond IgG4, Are Elevated in Eosinophilic Esophagitis","authors":"Manal Bel Imam,&nbsp;Sayuri Iwasaki,&nbsp;Sophieke Lems,&nbsp;Lacin Cevhertas,&nbsp;Patrick Westermann,&nbsp;Lotte Bach Larsen,&nbsp;Nina Aagaard Poulsen,&nbsp;Mübeccel Akdis,&nbsp;Philipp Schreiner,&nbsp;Andrea Kreienbühl,&nbsp;Alex Straumann,&nbsp;Alain M. Schoepfer,&nbsp;Luc Biedermann,&nbsp;Willem van de Veen,&nbsp;Swiss EoE Cohort Study Group","doi":"10.1111/cea.70055","DOIUrl":"10.1111/cea.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Eosinophilic esophagitis (EoE) is a chronic inflammatory condition with an incompletely understood immuno-pathogenesis involving a T2 response. EoE is triggered by food allergens although, unlike IgE-mediated allergies, it exhibits high IgG4 levels in oesophageal biopsies and in circulation. We investigated whether other antibody isotypes specific for food allergens are elevated in EoE and vary with disease activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Plasma samples from patients with active EoE (<i>n</i> = 51), inactive EoE (<i>n</i> = 82) and non-EoE controls (<i>n</i> = 14) were analysed for food-specific IgG and IgA subclasses against casein, whey, wheat, egg and individual cow's milk allergens by ELISA. α-lactalbumin (Bos d 4)- and β-lactoglobulin (Bos d 5)-specific B cells were measured by flow cytometry in a subset of patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Food allergen-specific antibodies in the plasma varied across EoE subgroups and non-EoE controls. Elevated IgG4 in EoE patients confirmed a strong antibody response to food allergens, including casein, wheat and egg. α_S1-casein (Bos d 9)-specific IgG, IgG2, IgG4, IgA1 and IgA2 differed between EoE and non-EoE controls and between active and inactive EoE. β-casein (Bos d 11, A1 variant) measurements showed higher levels of specific IgG2 and IgG4 in both EoE groups, whereas whey-derived allergens showed opposing responses: Bos d 4 responses favoured IgG4, and Bos d 5 responses were elevated across multiple IgG and IgA subclasses in EoE. Allergen-specific B cells could not be isolated from the circulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings reveal distinct antibody profiles in EoE plasma, with elevated IgG and IgA subclasses beyond IgG4, highlighting a complex immune response to food allergens. Differential antibody responses support their clinical relevance in dietary management strategies, while the absence of allergen-specific B cells in circulation likely restricts antibody production to the inflamed oesophagus. Future research should explore whether these antibody profiles can guide personalised treatment and novel therapeutic targets in EoE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 10","pages":"916-927"},"PeriodicalIF":5.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Novel In-House Gliadin Skin Test Reagent for Diagnosing Wheat-Dependent Exercise-Induced Anaphylaxis (WDEIA)","authors":"Surapon Piboonpocanun,&nbsp;Thanachit Krikeerati,&nbsp;Lalita Lumkul,&nbsp;Valerie Chiang,&nbsp;Andy Ka Chun Kan,&nbsp;Phichayut Phinyo,&nbsp;Chamard Wongsa,&nbsp;Torpong Thongngarm,&nbsp;Philip Hei Li,&nbsp;Mongkhon Sompornrattanaphan","doi":"10.1111/cea.70053","DOIUrl":"10.1111/cea.70053","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 8","pages":"734-737"},"PeriodicalIF":5.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Lianne Soller,&nbsp;Edmond S. Chan,&nbsp;Scott B. Cameron,&nbsp;Elissa M. Abrams,&nbsp;Sandeep Kapur,&nbsp;Stuart N. Carr,&nbsp;Timothy K. Vander Leek","doi":"10.1111/cea.70052","DOIUrl":"https://doi.org/10.1111/cea.70052","url":null,"abstract":"<p>The cover image is based on the article <i>Oral Immunotherapy Should Play a Key Role in Preschool Food Allergy Management</i> by Lianne Soller et al., https://doi.org/10.1111/cea.70013.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"i"},"PeriodicalIF":6.3,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basophil Activation and Histamine Release Tests in Relation to Omalizumab Response in Peanut-Allergic Children","authors":"Christian Nielsen,&nbsp;Per Stahl Skov,&nbsp;Carsten Bindslev-Jensen,&nbsp;Charlotte G. Mortz","doi":"10.1111/cea.70058","DOIUrl":"10.1111/cea.70058","url":null,"abstract":"&lt;p&gt;The growing prevalence of food allergy (FA) worldwide [&lt;span&gt;1&lt;/span&gt;] poses an increasing challenge for public health and a significant burden on affected individuals and their families. Among children, food allergy remains the leading cause of anaphylaxis, with peanut allergy as the primary cause of severe food-related allergic reactions [&lt;span&gt;2&lt;/span&gt;]. Standard care includes allergen avoidance and access to self-injectable epinephrine for emergency situations. However, these measures are reactive rather than preventive, leaving a need for effective long-term therapeutic options.&lt;/p&gt;&lt;p&gt;Recent advancements in treatment options, such as oral immunotherapy (OIT) and biological agents, show promise in altering the natural course of FA. Among biologics, Omalizumab (Xolair), an anti-IgE humanised monoclonal antibody, offers potential as either monotherapy or in combination with OIT in severe FA cases [&lt;span&gt;3&lt;/span&gt;]. By binding to free circulating IgE, Omalizumab inhibits IgE-mediated responses, specifically preventing the binding of IgE to FcεRI receptors on effector cells like basophils and mast cells. This inhibition reduces cell degranulation and, consequently, the release of pro-inflammatory mediators, thereby targeting FA at a fundamental immunological level.&lt;/p&gt;&lt;p&gt;To explore the performance of BAT and BHRA results in predicting Omalizumab treatment and the correlation to clinical response, a single-centre, double-blind, placebo-controlled study was conducted at the Allergy Centre, Odense University Hospital, Denmark (TOFAC: Treatment with Omalizumab in food-allergic children; clinicaltrials.gov: ID NCTO4037176) [&lt;span&gt;4&lt;/span&gt;]. The study included peanut-allergic children aged 6–17 years with a cumulative threshold dose at or below 443 mg peanut protein determined by double-blind, placebo-controlled food challenges [DBPCFC]. Participants were randomised to receive Omalizumab or a placebo (3:1) and were re-evaluated after three and 6 months by DBPCFC to assess treatment efficacy. Patients' characteristics are given in reference [&lt;span&gt;4&lt;/span&gt;]. Our focus was to evaluate the performance of the Basophil Activation Test (BAT) and the Basophil Histamine Release Assay (BHRA) in predicting and correlating with clinical outcomes following Omalizumab therapy.&lt;/p&gt;&lt;p&gt;BAT and BHRA are two in vitro tests that measure basophil degranulation in response to allergens, with distinct methodologies and endpoints [&lt;span&gt;5&lt;/span&gt;]. BAT assesses basophil degranulation by measuring the cell surface expression of exposed granular membrane markers, specifically CD63, on activated basophils, while BHRA quantifies histamine release directly from activated basophils. Both tests have been instrumental in identifying patients responsive to Omalizumab in conditions such as asthma and chronic spontaneous urticaria, and are increasingly used to assess treatment efficacy [&lt;span&gt;6, 7&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In our study, BAT and BHRA were conducted as previously described [&lt;span&gt;","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"840-844"},"PeriodicalIF":5.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted Metabolomic Analysis of Exhaled Breath Condensate Identifies Disease-Specific Signatures in Adults With Asthma","authors":"Hongfei Zhao,&nbsp;Yujuan Yang,&nbsp;Yan Hao,&nbsp;Wenbin Zhang,&nbsp;Limei Cui,&nbsp;Jianwei Wang,&nbsp;Ying Chen,&nbsp;Ting Zuo,&nbsp;Hang Yu,&nbsp;Yu Zhang,&nbsp;Xicheng Song","doi":"10.1111/cea.70059","DOIUrl":"10.1111/cea.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>An objective test for the auxiliary diagnosis of asthma is still lacking. The aim of this study was to discriminate asthma signatures via an untargeted metabolomic analysis of exhaled breath condensate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This study enrolled 19 patients diagnosed with asthma and 23 healthy volunteers. Samples of exhaled breath condensate (EBC) were collected from both groups. Untargeted metabolomic analyses of EBC were used to identify disease-specific signatures for asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>There were 30 identifiable differentially expressed metabolites and 7 disordered metabolic pathways between the EBCs of asthmatic patients and healthy control subjects. The main differential pathways included biosynthesis of unsaturated fatty acids, HIF-1 signalling pathway, Glutathione metabolism, Ascorbate and aldarate metabolism, and fatty acid biosynthesis. The integrated machine learning method was used to construct an asthma EBC metabolomic signature model from four differential metabolites; 3,4′-dimethoxy-2′-hydroxychalcone, C17-sphinganine, (z)-6-octadecenoic acid, and 2-butylaniline. The model showed a high level of discrimination efficiency (area under curve (AUC) = 0.98), with robust validation through logistic regression (LR), random forest (RF), and support vector machine (SVM) (LR AUC = 0.98, RF AUC = 0.94, SVM AUC = 1.00). The discriminative ability of the EBC metabolomic signature model in both the training set (AUC = 1.0) and testing data (AUC = 0.817) was superior to that of FeNO (AUC = 0.515 and 0.567, respectively) and FEV1/FVC % predicted (AUC = 0.767 and 0.765, respectively). Among the four biomarkers, (z)-6-octadecenoic acid was significantly correlated with serum IgE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The EBC metabolomic signature model demonstrated good feasibility for assisting in the diagnosis of asthma in adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 10","pages":"928-938"},"PeriodicalIF":5.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Drug-Induced Severe Cutaneous Adverse Reactions Associated With 33 Classes of Antibiotics (1968–2024): An Analysis of International Pharmacovigilance Reports","authors":"Jaehyun Kong,&nbsp;Jeongseon Oh,&nbsp;Jaeyu Park,&nbsp;Hyesu Jo,&nbsp;Tae Hyeon Kim,&nbsp;Jae E. Lee,&nbsp;Jaehyeong Cho,&nbsp;Sooji Lee,&nbsp;Hayeon Lee,&nbsp;Michael Miligkos,&nbsp;Jiyoung Hwang,&nbsp;Dong Keon Yon,&nbsp;Nikolaos G. Papadopoulos","doi":"10.1111/cea.70056","DOIUrl":"10.1111/cea.70056","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"837-839"},"PeriodicalIF":5.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Changes in Serum Cytokine Patterns in Patients With Atopic Dermatitis","authors":"Xingyu Chen,&nbsp;Yu Zhang,&nbsp;Mingyang Wu,&nbsp;Yang Luo,&nbsp;Yingxia Gao,&nbsp;Wei Li,&nbsp;Xiaochun Liu,&nbsp;Xu Yao","doi":"10.1111/cea.70054","DOIUrl":"10.1111/cea.70054","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"864-866"},"PeriodicalIF":5.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Asthmatic Patients, Sexual Dimorphism correlates With Androgen Receptor Expression in ILC2s at Single Cell-Resolution","authors":"Nina Anesi,&nbsp;Mathilde Calmels,&nbsp;Laurent Guilleminault,&nbsp;Flora Abbas,&nbsp;Claire Cenac,&nbsp;Thomas Villeneuve,&nbsp;Guillaume de Bonnecaze,&nbsp;Sophie Laffont,&nbsp;Jean-Charles Guéry","doi":"10.1111/cea.70047","DOIUrl":"10.1111/cea.70047","url":null,"abstract":"&lt;p&gt;Asthma, a chronic inflammatory airway condition, is the most common respiratory disease. There is a sex bias in asthma with a predominance of females affected by this disease in adulthood [&lt;span&gt;1&lt;/span&gt;]. Type 2 innate lymphoid cells (ILC2s) have been identified as key players during allergic and/or asthmatic responses [&lt;span&gt;2&lt;/span&gt;] through their capacity to licence dendritic cells (DC) for optimal Th2 cell priming [&lt;span&gt;3&lt;/span&gt;]. The ILC2/IL33 axis was also reported to maintain airway hyperreactivity and remodelling in a chronic asthma model independently of T cells [&lt;span&gt;4&lt;/span&gt;]. Indeed, the non-redundant role of ILC2 in recruiting eosinophils in the airway in allergic asthma models has been established in mice selectively lacking ILC2 [&lt;span&gt;5&lt;/span&gt;]. ILC2 are found at higher numbers in female tissues, including the lung, compared to males, and express high levels of the &lt;i&gt;Nr3c4&lt;/i&gt; androgen receptor (AR) [&lt;span&gt;6, 7&lt;/span&gt;]. Androgen, via the AR receptor, acts directly within ILC2s to limit their expansion and cytokine production, thus protecting males and females from ILC2-dependent lung inflammation [&lt;span&gt;6, 7&lt;/span&gt;]. Interestingly, children and adults with complete androgen insensitivity syndrome due to inherited loss of AR activity exhibit an increased asthma risk [&lt;span&gt;8&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Studies investigating sex-bias in ILC2 in asthmatic subjects, as well as AR gene expression in human ILC2, are scarce. Here, we analysed the frequency of circulating ILC2s in adult male and female asthmatic patients without pre-selection criteria based on sex (Table S1). However, since the prevalence of asthma is higher in women compared to males, as reported by others [&lt;span&gt;1&lt;/span&gt;], fewer males were recruited during the course of the study. ILC2s were identified as CD45&lt;sup&gt;+&lt;/sup&gt;Lin&lt;sup&gt;−&lt;/sup&gt;CD7&lt;sup&gt;+&lt;/sup&gt;CD127&lt;sup&gt;hi&lt;/sup&gt;CD161&lt;sup&gt;+&lt;/sup&gt;CRTH2&lt;sup&gt;+&lt;/sup&gt; (Figure 1A; Figure S1) and their frequency was significantly higher in asthmatic females compared to males. The sex-bias was more pronounced in younger individuals than in patients above 40, suggesting a role for sexual hormones. Interestingly, the frequency of ILC2 was markedly higher in females with uncontrolled asthma when compared to males (Figure 1A). Since androgen-signalling has been reported to negatively control ILC2 numbers in mice, we next investigated whether human inflammatory ILC2 express &lt;i&gt;AR&lt;/i&gt; gene at single-cell resolution (Figure 1B). Because tissue ILC2s could be easily obtained from nasal polyp (NP), we isolated NP-ILC2 and expanded them in vitro (Figure S2A). Moreover, the presence of inflammatory CD45RO+ ILC2s in NP has been linked to severe asthma and steroid resistance [&lt;span&gt;9&lt;/span&gt;]. After 7 to 10 days of culture, we obtained homogeneous populations of lymphoid cells expressing the expected ILC2 markers, CD7, CD161 and GATA-3, and lacking T cell markers such as CD3 (Figure S2B) and CD4 (data not shown). After PMA/ionomycin activation, these ILC2s p","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"851-853"},"PeriodicalIF":5.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histamine H3 and H4 Receptor Antagonists Differentially Inhibit Mast Cell Activation via FcεRI and MRGPRX2 Pathways","authors":"Yuxin Zhang,&nbsp;Jiahua Guo,&nbsp;Dan Ye,&nbsp;Xi Zhao,&nbsp;Hongmei Zhou,&nbsp;Mengyao Yang,&nbsp;Songmei Geng,&nbsp;Weihui Zeng,&nbsp;Zhao Wang","doi":"10.1111/cea.70048","DOIUrl":"10.1111/cea.70048","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"854-856"},"PeriodicalIF":5.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}