Clinical and Experimental Allergy最新文献

{"title":"Efficacy and Safety of Oral Cyclosporine in Antihistamine Refractory Chronic Urticaria Among Children and Adolescents: A Retrospective Study","authors":"Davinder Parsad, P. Janaani, Anuradha Bishnoi, Hitaishi Mehta, Rahul Mahajan, Seema Negi, Muthu Sendhil Kumaran","doi":"10.1111/cea.70069","DOIUrl":"10.1111/cea.70069","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"877-879"},"PeriodicalIF":5.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Effects of Dupilumab, Effects of Peanut OIT on the Gut Microbiome and Allergy Training in the United Kingdom","authors":"Mohamed H. Shamji,&nbsp;Robert J. Boyle","doi":"10.1111/cea.70062","DOIUrl":"10.1111/cea.70062","url":null,"abstract":"<p>In this month's editorial, the Editors of the journal have selected three fascinating articles that are included in this issue. The first article investigates dupilumab-associated ocular surface disease (DAOSD) in paediatric patients with atopic dermatitis (AD) [<span>1</span>]. Currently, moderate-to-severe AD is treated with biologics like dupilumab, which targets IL-4 and IL-13 pathways. Despite the well-known efficacy of dupilumab, it has been associated with ocular side effects, yet long-term real-world safety data have remained limited.</p><p>Therefore, the prospective study by Van der Rijst et al. explores the incidence and risk factors of DAOSD in paediatric AD patients with dupilumab treatment. Children participating in the BioDay Registry were assessed for ocular symptoms every 4–12 weeks in 104 patients aged 3–17 years. DAOSD was initially handled by applying lubricating eye drops, antihistamine eye drops or tacrolimus ointment—where persistent symptoms were additionally treated with ocular anti-inflammatory therapy.</p><p>The study revealed that 34.6% of AD patients developed DAOSD, with 30.6% of these cases requiring anti-inflammatory treatment. It was notable that baseline serum IgE levels ≥ 3000 kU/L were independently associated with DAOSD development. Examples of the most common ocular symptoms were pruritus (75%), redness (72.2%) and tearing (58.3%). All patients necessitating anti-inflammatory therapy had shown tarsal conjunctivitis on ophthalmological examination. In addition, 3.8% of patients with DAOSD had chosen dupilumab discontinuation.</p><p>These findings suggest new directions into the real-world management of DAOSD in paediatric AD patients. The high incidence of DAOSD highlights the importance of monitoring ocular symptoms during dupilumab treatment, especially in paediatric patients where the symptoms can be challenging to manage. This study also suggests the potential role of serum IgE levels in predicting DAOSD and emphasises the need for collaborative care and study between dermatologists and ophthalmologists to manage these side effects wisely (Figure 1).</p><p>The second editor's choice article studies the impact of 1 year of peanut oral immunotherapy (OIT) on the gut microbiota and plasma metabolome in peanut-allergic young children [<span>2</span>]. Peanut allergy is one of the most common food allergies in children, which rarely triggers life-threatening anaphylaxis [<span>3</span>]. While the allergic condition is persistent, only about 21% of children outgrow their allergy to adulthood [<span>4</span>]. Peanut OIT has been recognised as a promising solution to desensitise allergic individuals, allowing tolerance of higher doses of peanut protein and potentially reducing dietary restrictions and improving quality of life [<span>5</span>]. However, its broader effects on the microbiome and metabolic profiles have been understudied.</p><p>The study by Badolati et al. observes how peanut OIT modulates micro","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 5","pages":"364-366"},"PeriodicalIF":6.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Patients With Beta-Lactams Positive Provocation Tests by Biomarkers of IgG-Related Neutrophil Activation.","authors":"Adrienne Astrid Gallizzi, Rosa-Maria Guéant-Rodriguez, Cosmin Boteanu, Jean-Marc Alberto, Cécile Lakomy, Huguette Louis, Celine Chery, Pauline Renard, Véronique Regnault, Ramia Safar, Almut Heinken, Antonino Romano, Jose-Julio Laguna, Jean-Louis Guéant","doi":"10.1111/cea.70061","DOIUrl":"https://doi.org/10.1111/cea.70061","url":null,"abstract":"<p><strong>Background: </strong>Beta-lactams (BLs) are the predominant cause of immediate allergic reactions to drugs. Immediate hypersensitivity reactions (IHR) with positive provocation tests and negative skin and in vitro tests have undetermined mechanisms. We evaluated whether biomarkers of IgG-dependent neutrophil activation could help to assess this subgroup of BL IHRs.</p><p><strong>Methods: </strong>We evaluated biomarkers of neutrophil activation and neutrophil extracellular traps (NETs) in the serum of 26 BL IHR patients presenting with a positive provocation test, negative skin and serum specific IgE, and positive specific sIgG, and 8 perioperative BL IHR cases with positive skin tests and negative sIgE compared to 19 non-allergic matched controls.</p><p><strong>Results: </strong>We observed increased levels of DNase activity, neutrophil elastase (NE), myeloperoxidase (MPO)-DNA, IL8 and decreased IL4 and IL13 in patients, compared to matched controls, in the first 15 min of IHRs. DNAse activity, NE and MPO-DNA were maintained at high levels 2 h later (T0 + 2), while cell-free DNA and CXCR2 decreased significantly. IgG-related activation of neutrophils was suggested by significant correlations between NE, IL8 and CXCR2 axis and a single cluster associating BL sIgG antibodies and NE at T0 + 2, in principal factor analysis of all biomarkers.</p><p><strong>Conclusion: </strong>Biomarkers of neutrophil activation and NETs were increased in BL IHRs with negative skin tests, positive sIgG and negative serum sIgE, and positive provocation test. We propose DNAse activity and NE as biomarkers for the biological assessment of BL IHRs and provocation tests and to consider IgG-related neutrophil activation as one of the mechanisms involved in BL IHRs with undetermined cause.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen-Specific Immunotherapy: The Need for Content Transparency","authors":"Melvin Lee Qiyu,&nbsp;Tom Dawson","doi":"10.1111/cea.70065","DOIUrl":"10.1111/cea.70065","url":null,"abstract":"&lt;p&gt;Allergen-specific immunotherapy (AIT) was first introduced by Noon in 1911 as a treatment for rhinitis using timothy grass pollen extract, showing significant symptom improvement [&lt;span&gt;1&lt;/span&gt;]. By exposing the immune system to controlled high doses of allergens, AIT fosters tolerance, reducing symptoms and potentially altering disease progression. Unlike natural allergen exposure, which is insufficient to induce tolerance, AIT delivers targeted immunomodulatory effects. AIT is widely used for allergic rhinitis, asthma, IgE-mediated food allergies, allergic conjunctivitis, atopic dermatitis and insect venom allergies. It is administered via subcutaneous immunotherapy (SCIT), which involves gradual dose escalation, or sublingual immunotherapy (SLIT), which starts at a fixed maintenance dose. Efficacy depends on both allergen quantity and immunogenicity. Some AIT products contain chemically modified allergoids to reduce IgE reactivity while preserving T-cell stimulation. However, these modifications complicate direct product comparisons. For example, Pollinex, the only licensed grass pollen SCIT in the United Kingdom, lacks full allergen characterisation, while the ALK SCIT product is well studied but remains unlicensed.&lt;/p&gt;&lt;p&gt;Despite international efforts, allergen quantification remains inconsistent. The CREATE and BSP90 initiatives have standardised a limited set of allergens, including Der p 1, Der f 1, Bet v 1 and Phl p 5, but exclude others, such as Der p 23, which may be clinically significant for specific patients. This lack of standardisation makes cross-product comparisons unreliable. This editorial reviews current evidence on aeroallergen content in AIT and highlights clinical implications through a case study.&lt;/p&gt;&lt;p&gt;Significant variability and limited transparency in allergen content across commercial immunotherapy products pose challenges to their standardisation, efficacy and safety. Allergen potency in AIT products is typically quantified by measuring the concentration of major allergens in micrograms, reflecting biological potency. Allergens are classified as major (binding IgE in &gt; 50% of patients) or minor allergens (binding &lt; 50% IgE), influencing their clinical relevance [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;European manufacturers commonly use in-house reference standards based on titrated skin prick testing, resulting in arbitrary potency units that complicate cross-product comparisons. Initiatives such as the EU CREATE project have established standardised protocols using mass units (micrograms) for key allergens like Der p 1, Der f 1, Der p 2, Der f 2, Bet v 1, Phl p 1, Phl p 5 and Ole e 1 [&lt;span&gt;3&lt;/span&gt;]. Despite these advances, inconsistencies persist due to varying manufacturing processes, allergen quantification methods and differing regulatory standards between Europe and the USA. These discrepancies hinder clinicians' ability to select appropriate AIT products, underscoring the need for greater standardisation, clearer la","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"752-754"},"PeriodicalIF":5.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Sex Disparities in Elderly Atopic Dermatitis Prevalence Among US Oldest-Old Adults: A Longitudinal Study","authors":"Minmin Wang,&nbsp;Xueshan Cao,&nbsp;Mengge Zhou,&nbsp;Yuanqi Mi,&nbsp;Peixin Yu,&nbsp;Yang Guo","doi":"10.1111/cea.70060","DOIUrl":"10.1111/cea.70060","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"870-872"},"PeriodicalIF":5.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Cluster Analysis in Chinese Patients With Recurrent Angioedema","authors":"Ruoyu Ji,&nbsp;Yuxiang Zhi","doi":"10.1111/cea.70063","DOIUrl":"10.1111/cea.70063","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 8","pages":"738-741"},"PeriodicalIF":5.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus fumigatus Serum IgG Cut-Off for the Diagnosis of Aspergillus-Associated Lung Disease: A Historic Cohort Analysis","authors":"Alicia Enríquez-Matas,&nbsp;Beatriz Moya,&nbsp;Tatiana Navarro Cascales,&nbsp;Carmen Romero Ferreiro,&nbsp;Ana Alastruey-Izquierdo,&nbsp;Ismael Garcia-Moguel,&nbsp;Lys Herraez Herrera,&nbsp;JF Crespo,&nbsp;Consuelo Fernández Rodríguez","doi":"10.1111/cea.70057","DOIUrl":"10.1111/cea.70057","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 9","pages":"867-869"},"PeriodicalIF":5.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Food Allergen-Specific Antibodies, Beyond IgG4, Are Elevated in Eosinophilic Esophagitis.","authors":"Manal Bel Imam, Sayuri Iwasaki, Sophieke Lems, Lacin Cevhertas, Patrick Westermann, Lotte Bach Larsen, Nina Aagaard Poulsen, Mübeccel Akdis, Philipp Schreiner, Andrea Kreienbühl, Alex Straumann, Alain M Schoepfer, Luc Biedermann, Willem van de Veen","doi":"10.1111/cea.70055","DOIUrl":"https://doi.org/10.1111/cea.70055","url":null,"abstract":"<p><strong>Introduction: </strong>Eosinophilic esophagitis (EoE) is a chronic inflammatory condition with an incompletely understood immuno-pathogenesis involving a T2 response. EoE is triggered by food allergens although, unlike IgE-mediated allergies, it exhibits high IgG4 levels in oesophageal biopsies and in circulation. We investigated whether other antibody isotypes specific for food allergens are elevated in EoE and vary with disease activity.</p><p><strong>Methods: </strong>Plasma samples from patients with active EoE (n = 51), inactive EoE (n = 82) and non-EoE controls (n = 14) were analysed for food-specific IgG and IgA subclasses against casein, whey, wheat, egg and individual cow's milk allergens by ELISA. α-lactalbumin (Bos d 4)- and β-lactoglobulin (Bos d 5)-specific B cells were measured by flow cytometry in a subset of patients.</p><p><strong>Results: </strong>Food allergen-specific antibodies in the plasma varied across EoE subgroups and non-EoE controls. Elevated IgG4 in EoE patients confirmed a strong antibody response to food allergens, including casein, wheat and egg. α_S1-casein (Bos d 9)-specific IgG, IgG2, IgG4, IgA1 and IgA2 differed between EoE and non-EoE controls and between active and inactive EoE. β-casein (Bos d 11, A1 variant) measurements showed higher levels of specific IgG2 and IgG4 in both EoE groups, whereas whey-derived allergens showed opposing responses: Bos d 4 responses favoured IgG4, and Bos d 5 responses were elevated across multiple IgG and IgA subclasses in EoE. Allergen-specific B cells could not be isolated from the circulation.</p><p><strong>Conclusion: </strong>Our findings reveal distinct antibody profiles in EoE plasma, with elevated IgG and IgA subclasses beyond IgG4, highlighting a complex immune response to food allergens. Differential antibody responses support their clinical relevance in dietary management strategies, while the absence of allergen-specific B cells in circulation likely restricts antibody production to the inflamed oesophagus. Future research should explore whether these antibody profiles can guide personalised treatment and novel therapeutic targets in EoE.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Novel In-House Gliadin Skin Test Reagent for Diagnosing Wheat-Dependent Exercise-Induced Anaphylaxis (WDEIA)","authors":"Surapon Piboonpocanun,&nbsp;Thanachit Krikeerati,&nbsp;Lalita Lumkul,&nbsp;Valerie Chiang,&nbsp;Andy Ka Chun Kan,&nbsp;Phichayut Phinyo,&nbsp;Chamard Wongsa,&nbsp;Torpong Thongngarm,&nbsp;Philip Hei Li,&nbsp;Mongkhon Sompornrattanaphan","doi":"10.1111/cea.70053","DOIUrl":"10.1111/cea.70053","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 8","pages":"734-737"},"PeriodicalIF":5.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Lianne Soller,&nbsp;Edmond S. Chan,&nbsp;Scott B. Cameron,&nbsp;Elissa M. Abrams,&nbsp;Sandeep Kapur,&nbsp;Stuart N. Carr,&nbsp;Timothy K. Vander Leek","doi":"10.1111/cea.70052","DOIUrl":"https://doi.org/10.1111/cea.70052","url":null,"abstract":"<p>The cover image is based on the article <i>Oral Immunotherapy Should Play a Key Role in Preschool Food Allergy Management</i> by Lianne Soller et al., https://doi.org/10.1111/cea.70013.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"i"},"PeriodicalIF":6.3,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}