Clinical and Experimental Allergy最新文献

{"title":"Characterizing Allergen Profiles and Identifying Group 2 Allergens of Three Storage Mites: Acarus siro, Chortoglyphus arcuatus and Carpoglyphus lactis.","authors":"Xiaoyu Liu, Yu Xuan Lau, Jingyuan Bian, Ruyi Yuan, Kelvin Fu-Kiu Ao, Yi Feng, Runnan Ye, Weiyi He, Annie Wing-Tung Lee, Gilman Kit-Hang Siu, Franklin Wang-Ngai Chow, Fook Tim Chew, Ting Fan Leung, Baoqing Sun, Pavel B Klimov, Stephen Kwok-Wing Tsui, Jan Hubert, Qing Xiong","doi":"10.1111/cea.70438","DOIUrl":"https://doi.org/10.1111/cea.70438","url":null,"abstract":"<p><strong>Background: </strong>Storage mites are important contributors to allergic diseases, yet their allergens remain poorly characterized compared to those of house dust mites. Comprehensive molecular data on storage mite allergens are limited, hindering improved diagnosis and understanding of their allergenic potential.</p><p><strong>Methods: </strong>We assembled and annotated the genomes of three storage mite species, Acarus siro, Chortoglyphus arcuatus and Carpoglyphus lactis. Comprehensive allergen profiling was performed using integrated genomics, transcriptomics and proteomics approaches. Putative allergen genes were identified and classified into allergen groups. IgE-binding capacity of selected allergens was validated using ELISA assays. In addition, the immunostimulatory potential of newly identified allergens was assessed by measuring IL-6 production in a dendritic cell line.</p><p><strong>Results: </strong>We identified 75, 70 and 64 putative allergen genes in A. siro, C. arcuatus and C. lactis, corresponding to 33, 31 and 32 allergen groups, respectively. Extensive gene family expansions and multiple isoallergens were observed, particularly, among Group 2 allergens belonging to the NPC2 family. ELISA IgE-binding assays validated four Group 2 allergens in A. siro and one in each of C. arcuatus and C. lactis. Notably, these newly identified Group 2 allergens significantly induced the production of the pro-inflammatory cytokine IL-6 in a dendritic cell line.</p><p><strong>Conclusion: </strong>This study provides a comprehensive genomic and proteomic characterization of storage mite allergens and identifies previously unrecognized Group 2 allergens with IgE-binding and immunostimulatory capacity. These findings establish a foundational resource for improved diagnosis of storage mite allergy and support future investigations into the molecular mechanisms underlying mite allergenicity.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Circulating Mast Cell Progenitors in Healthy Adults: Associations With CD14⁺ Monocytes But Not With Clinical Characteristics.","authors":"Animamalar Mayavannan, Anna Sörman, Erika Mendez-Enriquez, Abigail Alvarado-Vazquez, Christer Janson, Andrei Malinovschi, Jenny Hallgren","doi":"10.1111/cea.70439","DOIUrl":"https://doi.org/10.1111/cea.70439","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Omalizumab: Emerging Biologic and Small Molecule Therapies in Chronic Spontaneous Urticaria.","authors":"Sahibpreet Kaur, Muthu Sendhil Kumaran, Saumya Singh, Davinder Parsad","doi":"10.1111/cea.70437","DOIUrl":"https://doi.org/10.1111/cea.70437","url":null,"abstract":"<p><p>Chronic spontaneous urticaria (CSU) remains inadequately controlled by H1-antihistamines and omalizumab in a substantial minority of patients at every age. Recognition that mast cell activation proceeds through IgE-independent as well as IgE-dependent routes has exposed several tractable targets-Bruton's tyrosine kinase, the IL-4/IL-13 axis, KIT, MRGPRX2 and the JAK-STAT pathway-hence the resulting expansion of the treatment armamentarium is the largest since omalizumab. The oral BTK inhibitor remibrutinib is now licensed for adults in the United States and European Union; Dupilumab, approved from 12 years of age in 2025, was extended to children aged 2-11 years in 2026 on basis of extrapolated efficacy supported by paediatric pharmacokinetic and safety data. Barzolvolimab has completed Phase 3 enrolment of 1939 adults, briquilimab, EVO756, EP262 and rilzabrutinib are advancing in adults and ligelizumab failed to demonstrate superiority over omalizumab. This review appraises these agents by mechanism, efficacy, safety and probable place in therapy and argues that the limiting factor is no longer the number of druggable targets but the distribution and quality of the evidence. Adults dominate the trial populations; adolescents are enrolled as underpowered subgroups; dedicated paediatric evidence is essentially confined to dupilumab; and older adults-in whom comorbidity, polypharmacy and the cardiovascular and malignancy signals of JAK inhibition matter most-are almost never analyzed separately. Head-to-head and sequencing trials, endotype-stratified patient selection, age-inclusive trial design and long-term safety data are the immediate priorities if mechanism-based treatment is to reach patients at every stage of life.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of Weighted Diagnostic Score for Allergic Bronchopulmonary Aspergillosis.","authors":"Ritesh Agarwal, Puneet Saxena, Valliappan Muthu, Inderpaul Singh Sehgal, Kuruswamy Thurai Prasad, Sahajal Dhooria, Mani Singh, Mandeep Garg, Ashutosh N Aggarwal, Shivaprakash M Rudramurthy, Arunaloke Chakrabarti","doi":"10.1111/cea.70432","DOIUrl":"https://doi.org/10.1111/cea.70432","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attack-Related Anxiety Relief Should Not Be Equated With Treatment of an Anxiety Disorder.","authors":"Ting-Yi Hung, Lien-Chung Wei","doi":"10.1111/cea.70435","DOIUrl":"https://doi.org/10.1111/cea.70435","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, Cultural Adaptation and Validation of the Italian Food Allergy Quality of Life Questionnaire-Parent Form (I-FAQLQ-PF).","authors":"Valeria Tallarico, Arianna Cafarotti, Lamia Dahdah, Licia Pensabene, Alessandro Fiocchi, Stefania Arasi","doi":"10.1111/cea.70431","DOIUrl":"https://doi.org/10.1111/cea.70431","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Specificity of sIgE to α-/β-Gliadin and Limited Reactivity to Non-Gluten Proteins in Wheat Allergy Dependent on Augmentation Factors (WALDA).","authors":"Valentina Faihs, Florian Schusta, Claudia Kugler, Tilo Biedermann, Monika Raulf, Margitta Worm, Knut Brockow, Ingrid Sander","doi":"10.1111/cea.70429","DOIUrl":"10.1111/cea.70429","url":null,"abstract":"<p><strong>Background: </strong>Wheat allergy dependent on augmentation factors (WALDA) represents the most common form of IgE-mediated wheat allergy in adults. Although ω5-gliadin is the major allergen in WALDA, sIgE reactivity to non-gluten wheat proteins remains poorly characterized.</p><p><strong>Methods: </strong>Serum samples from 54 adults with challenge-confirmed WALDA and 21 tolerant controls (including 5 with positive sIgE to ω5-gliadin) from two German centres were analysed for sIgE reactivity to 19 recombinant wheat proteins and the cross-reactive carbohydrate determinant (CCD) MUXF3.</p><p><strong>Results: </strong>sIgE to α-/β-gliadin (Tri a 21.0101) was highly specific for WALDA, present in 29/54 patients (53.7%) but absent in controls (100% specificity, p < 0.001). Receiver operating characteristic analysis revealed excellent discriminatory ability (area under the curve = 0.85) with an optimal cut-off of 0.22 kU/l. Reactivity to non-gluten wheat proteins was limited, with 24.1% of patients showing sIgE to thioredoxin, 11.3% to dehydrin, 9.3% to any α-amylase/trypsin inhibitor subunit, and minimal sIgE to non-specific lipid transfer proteins (Tri a 14), thiol reductase, triosephosphate isomerase, peroxiredoxin, serpin, glyceraldehyde-3-phosphate dehydrogenase, serine protease inhibitor-like allergen, and peroxidase. Non-gluten reactivity correlated strongly with MUXF3 CCD (ρ = 0.776), total IgE (ρ = 0.646), and wheat extract sIgE (ρ = 0.534; all p < 0.001). Grass pollen-sensitized individuals showed increased non-gluten protein reactivity (p < 0.001). Controls demonstrated higher MUXF3 CCD reactivity (38.1% vs. 11.6%, p < 0.05).</p><p><strong>Conclusion: </strong>The data suggest that WALDA is characterized by highly specific reactivity to gliadin proteins, with limited sensitization to non-gluten wheat components. sIgE to α-/β-gliadin represents a promising diagnostic biomarker with superior specificity compared with ω5-gliadin alone.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient Pollen Exposure During Pregnancy and Reduced Foetal Head Growth in the Queensland Family Cohort.","authors":"Nai-Yun Hsu, Shamshad Karatela, Andelija Milic, Louise Marquart-Wilson, Gunther Paul, Tom Cole-Hunter, Christopher Edwards, Erika Cavanagh, Sailesh Kumar, Kym M Rae, Janet M Davies, Vicki L Clifton","doi":"10.1111/cea.70428","DOIUrl":"https://doi.org/10.1111/cea.70428","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Outcomes With Dupilumab Versus Omalizumab in Severe Asthma.","authors":"Po-Cheng Shih, Chun-Ting Lin, James Cheng Chung Wei","doi":"10.1111/cea.70413","DOIUrl":"https://doi.org/10.1111/cea.70413","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Non-Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential.","authors":"Ashlyn Poole, Ingrid Laing, Ryan Mead-Hunter, Peter Le Souef, Guicheng Zhang","doi":"10.1111/cea.70427","DOIUrl":"https://doi.org/10.1111/cea.70427","url":null,"abstract":"<p><p>Asthma affects millions worldwide. Long non-coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma and respiratory illnesses. LncRNA serve important regulatory roles in numerous pathways, especially gene expression. Nuclear paraspeckle assembly transcript 1 (NEAT1) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) are two of the most well-studied lncRNA. This review highlights the current evidence of mechanisms involving lncRNA, particularly NEAT1 and MALAT1, in asthma pathophysiology and viral-induced exacerbations, and as novel targets for therapies targeting asthma, asthma-related symptoms and airway remodelling.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}