Clinical and Experimental Allergy最新文献

{"title":"Untargeted Metabolomic Analysis of Exhaled Breath Condensate Identifies Disease-Specific Signatures in Adults With Asthma.","authors":"Hongfei Zhao, Yujuan Yang, Yan Hao, Wenbin Zhang, Limei Cui, Jianwei Wang, Ying Chen, Ting Zuo, Hang Yu, Yu Zhang, Xicheng Song","doi":"10.1111/cea.70059","DOIUrl":"https://doi.org/10.1111/cea.70059","url":null,"abstract":"<p><strong>Purpose: </strong>An objective test for the auxiliary diagnosis of asthma is still lacking. The aim of this study was to discriminate asthma signatures via an untargeted metabolomic analysis of exhaled breath condensate.</p><p><strong>Materials and methods: </strong>This study enrolled 19 patients diagnosed with asthma and 23 healthy volunteers. Samples of exhaled breath condensate (EBC) were collected from both groups. Untargeted metabolomic analyses of EBC were used to identify disease-specific signatures for asthma.</p><p><strong>Result: </strong>There were 30 identifiable differentially expressed metabolites and 7 disordered metabolic pathways between the EBCs of asthmatic patients and healthy control subjects. The main differential pathways included biosynthesis of unsaturated fatty acids, HIF-1 signalling pathway, Glutathione metabolism, Ascorbate and aldarate metabolism, and fatty acid biosynthesis. The integrated machine learning method was used to construct an asthma EBC metabolomic signature model from four differential metabolites; 3,4'-dimethoxy-2'-hydroxychalcone, C17-sphinganine, (z)-6-octadecenoic acid, and 2-butylaniline. The model showed a high level of discrimination efficiency (area under curve (AUC) = 0.98), with robust validation through logistic regression (LR), random forest (RF), and support vector machine (SVM) (LR AUC = 0.98, RF AUC = 0.94, SVM AUC = 1.00). The discriminative ability of the EBC metabolomic signature model in both the training set (AUC = 1.0) and testing data (AUC = 0.817) was superior to that of FeNO (AUC = 0.515 and 0.567, respectively) and FEV1/FVC % predicted (AUC = 0.767 and 0.765, respectively). Among the four biomarkers, (z)-6-octadecenoic acid was significantly correlated with serum IgE.</p><p><strong>Conclusion: </strong>The EBC metabolomic signature model demonstrated good feasibility for assisting in the diagnosis of asthma in adults.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Drug-Induced Severe Cutaneous Adverse Reactions Associated With 33 Classes of Antibiotics (1968-2024): An Analysis of International Pharmacovigilance Reports.","authors":"Jaehyun Kong, Jeongseon Oh, Jaeyu Park, Hyesu Jo, Tae Hyeon Kim, Jae E Lee, Jaehyeong Cho, Sooji Lee, Hayeon Lee, Michael Miligkos, Jiyoung Hwang, Dong Keon Yon, Nikolaos G Papadopoulos","doi":"10.1111/cea.70056","DOIUrl":"https://doi.org/10.1111/cea.70056","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Changes in Serum Cytokine Patterns in Patients With Atopic Dermatitis.","authors":"Xingyu Chen, Yu Zhang, Mingyang Wu, Yang Luo, Yingxia Gao, Wei Li, Xiaochun Liu, Xu Yao","doi":"10.1111/cea.70054","DOIUrl":"https://doi.org/10.1111/cea.70054","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Asthmatic Patients, Sexual Dimorphism correlates With Androgen Receptor Expression in ILC2s at Single Cell-Resolution.","authors":"Nina Anesi, Mathilde Calmels, Laurent Guilleminault, Flora Abbas, Claire Cenac, Thomas Villeneuve, Guillaume de Bonnecaze, Sophie Laffont, Jean-Charles Guéry","doi":"10.1111/cea.70047","DOIUrl":"https://doi.org/10.1111/cea.70047","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histamine H3 and H4 Receptor Antagonists Differentially Inhibit Mast Cell Activation via FcεRI and MRGPRX2 Pathways.","authors":"Yuxin Zhang, Jiahua Guo, Dan Ye, Xi Zhao, Hongmei Zhou, Mengyao Yang, Songmei Geng, Weihui Zeng, Zhao Wang","doi":"10.1111/cea.70048","DOIUrl":"https://doi.org/10.1111/cea.70048","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of IFN-γ-Producing MAIT Cell Correlates to Beneficial Allergen Immunotherapy in Allergic Rhinitis Patients","authors":"Ying Jiang,&nbsp;Xin Wang,&nbsp;Qing Jiang,&nbsp;Hao Chen,&nbsp;Lin Yang,&nbsp;Wei Wang,&nbsp;Junmei Weng,&nbsp;Mi Wu,&nbsp;Ting Zhou,&nbsp;Yin Yao,&nbsp;Shuyan Guo,&nbsp;Jin Xiong,&nbsp;Xiang Lu,&nbsp;Rongfei Zhu,&nbsp;Xiufang Weng","doi":"10.1111/cea.70051","DOIUrl":"10.1111/cea.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mucosal-associated invariant T cells (MAIT) are emerging as important regulators at mucosal surfaces. While these cells have been linked to a Th1-biased immune response and support for B cells, their roles in allergic diseases characterised by type 2 inflammation remain elusive. The study seeks to characterise MAIT cells in house dust mite (HDM)-induced allergic rhinitis (AR) and subsequent allergen immunotherapy (AIT), aiming to elucidate their clinical significance in AR and potential to enhance AIT effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>MAIT cells were assessed in patients with AR and individuals undergoing AIT. The ratio and cytokine-producing capacity of these cells were analysed to explore their correlations with AR progression and their responsiveness to HDM extracts and MAIT cell-specific agonists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In AR patients, there was an increase in the ratios of circulating MAIT cells and tonsil follicular T helper-like MAIT cells, alongside a decrease in the IFN-γ-producing MAIT cells. AIT restored their IFN-γ producing capacity, which was further boosted by T cell receptor (TCR) activation using MAIT cell-specific agonist-loaded artificial antigen-presenting cells (aAPCs). Synergistic effects of aAPCs and HDM enhance MAIT cell activation and IFN-γ production while reducing HDM-induced IgE levels in PBMC cocultures. Moreover, higher ratios of MAIT cells and IFN-γ-producing MAIT cells correlated with decreased IgE and increased IgG4 and improved clinical outcomes during AIT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings underscore the compromised IFN-γ-producing MAIT cells in AR and their restoration following AIT and TCR stimulation, highlighting the cell's therapeutic potential and predictive value for clinical outcomes in AR and AIT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 5","pages":"403-412"},"PeriodicalIF":6.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inequalities in Access to Specialist Allergy Services in the United Kingdom: A Report From the BSACI Registry for Immunotherapy (BRIT)","authors":"Mich Erlewyn-Lajeunesse,&nbsp;Luciano Perfetti Villa,&nbsp;Shifa Shaikh,&nbsp;Maria Smith,&nbsp;Vasiliki Balodima,&nbsp;Sarah Baker,&nbsp;Tom Dawson,&nbsp;Pamela Ewan,&nbsp;Sujoy Khan,&nbsp;Deborah Marriage,&nbsp;Louise Michaelis,&nbsp;Leyla Pur Ozygit,&nbsp;Anna Thursby-Pelham,&nbsp;Amena Warner,&nbsp;Olga Maslovskaya,&nbsp;the BRIT Practitioners Group","doi":"10.1111/cea.70034","DOIUrl":"10.1111/cea.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There is an unmet need for specialist allergy treatment in the United Kingdom. Allergen immunotherapy and treatment with omalizumab for chronic spontaneous urticaria (CSU) are key markers for these services. The British Society for Allergy and Clinical Immunology (BSACI) Registry for Immunotherapy (BRIT) is a national project to record the real-world effectiveness, safety and access to treatment for aero-allergen, venom and peanut immunotherapy as well as omalizumab for CSU.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We described participant demographics, the index of multiple deprivation (IMD) and access to treatment from the registry launch. Data for 1835 participants were available for analysis from 63 centres enrolled between 1st October 2018 and 24th August 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>96.5% (1771/1835) were living in England, with only 3.5% (64) being from the devolved nations. 14.4% (251/1748) were in the most affluent IMD decile compared to 4.5% (78/1748) in the most deprived IMD decile. White participants were 1.74 times more likely to be referred directly from primary care compared to people of Asian, black, mixed or other minority ethnic groups. Instead, these groups were referred more frequently from secondary or tertiary hospital services. The median distance travelled from home to the treatment centre was 15.2 miles, with evidence of clustering around specialist centres.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We have described disparities and unwarranted variation in the provision of treatment around the UK. The data suggest that there is limited access to immunotherapy in the devolved nations. Access is also reduced by socioeconomic deprivation. White participants were more likely to receive a direct referral from primary care than those from other ethnic groups whose referral pathways were more complex. Registry data are limited by participant enrolment and may have selection bias. Nevertheless, BRIT has highlighted inequity in access to specialist allergy services in the UK.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 6","pages":"458-468"},"PeriodicalIF":6.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Food Allergy—Public Perception and Reality","authors":"I. J. Skypala,&nbsp;C. E. N. Mills,&nbsp;A. Simpson","doi":"10.1111/cea.70044","DOIUrl":"10.1111/cea.70044","url":null,"abstract":"&lt;p&gt;Although the prevalence of IgE-mediated food allergy (IgE-FA) in adults varies, it is now considered to be equal to that seen in children and also increasingly affecting older adults [&lt;span&gt;1&lt;/span&gt;]. However, the foods involved are often at odds with the public perception of common food triggers, and the study on wheat allergy by Neyer and colleagues in this issue demonstrates this clearly. Extrapolation of their data showed that the prevalence of self-reported wheat sensitivity was 13.1% of the German population, but the confirmed prevalence of wheat allergy in adults was 0.25% [95% CI 0.08–0.9]. Although wheat is predominantly a carbohydrate, 10%–15% of the mass is made up of a complex collection of proteins, 28 of which have been identified as allergens (Figure 1). Wheat proteins are known to be associated with several diseases, including coeliac disease (Figure 2), which affects ~1% of the UK population, and bakers' asthma, which affects ~5% of bakers. Wheat allergy affects ~0.5% of children, often starting in infancy (and frequently associated with allergies to milk and egg) as a systemic IgE-mediated allergic reaction, and usually outgrown by adolescence (&gt; 80%) [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The study from Neyer and colleagues measured the prevalence of allergy to wheat in adults (and adolescents). Of note, only three subjects showed positive serology to whole wheat extract (and only one to wheat allergen components Tri a 19 and Tri a 14). The authors do not comment on whether these were adult-onset cases, or whether they were co-factor dependent. That is, ~1 in 50 of those with symptoms had confirmed food allergy to wheat. However, the design of the study, where sensitisation was only assessed in those with a history of reproducible symptoms on ingestion of wheat, risks missing cases. Wheat allergy can present with a variety of manifestations in adults and is not always obvious from the history as reactions can be infrequent and may only occur in the presence of cofactors. One study reported that 80% of patients with wheat anaphylaxis only reacted in conjunction with exercise [&lt;span&gt;3&lt;/span&gt;]. Other co-factors include non-steroidal anti-inflammatory drugs and alcohol. Adults presenting with moderate or severe reactions, where no discernible food trigger seems to be implicated due to perhaps having eaten more than 2 h before or after the symptoms, should always be investigated for co-factor involvement. Wheat dependent exercise-induced anaphylaxis is notoriously difficult to diagnose although sensitisation to ω-5 gliadin has been shown to be a good diagnostic marker. Symptoms may not be reproducible on challenge as a large dose of gluten protein is frequently required to elicit symptoms. This was reflected in the challenge protocol employed in this study, where gluten doses roughly equating to 20 slices of ordinary bread were given [&lt;span&gt;4&lt;/span&gt;]. The prevalence figures found in this study are similar to those observed by others usually ","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 4","pages":"291-293"},"PeriodicalIF":6.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterising Lipid Transfer Protein Allergy in UK Adults.","authors":"I J Skypala, B Olivieri, G Scadding","doi":"10.1111/cea.70050","DOIUrl":"https://doi.org/10.1111/cea.70050","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Expression of Type 1 and Type 17 Immune Pathways and Chemokines in Mild-to-Severe Asthma With Mid to High Neutrophilic Inflammation.","authors":"Elisa Arrigo, Vitina Carriero, Francesca Bertolini, Stefano Levra, Camilla Demasi, Antonino Di Stefano, Daniela Miglietta, Gino Villetti, Fabio Luigi Massimo Ricciardolo","doi":"10.1111/cea.70043","DOIUrl":"https://doi.org/10.1111/cea.70043","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}