Clinical and Experimental Allergy最新文献

{"title":"Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma","authors":"Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth","doi":"10.1111/cea.14634","DOIUrl":"10.1111/cea.14634","url":null,"abstract":"<p>Airway hyperresponsiveness is a key tenet of persistent asthma, along with the type 2 inflammatory phenotype in most patients, while bronchodilator reversibility (BDR) may be absent in patients with a preserved FEV<sub>1</sub>. Biologics act on downstream type 2 cytokine pathways inhibiting signalling of interleukins (IL) 4, 5 and 13 [<span>1</span>]. A retrospective study in severe asthma patients receiving anti-IL-5 or anti-IL-5Rα showed no difference in clinical outcomes when stratified by baseline BDR. Dupilumab is a monoclonal antibody which targets the alpha subunit of IL4 receptor which in turn inhibits IL4 and IL13 signalling, resulting in reduced exacerbations, improved symptom control and better lung function [<span>2</span>]. We wanted to evaluate the putative relationship between baseline BDR to salbutamol and the lung function response to dupilumab, expressed as either force expiratory volume in 1 s (FEV<sub>1</sub>) or forced mid-expiratory flow (FEF<sub>25-75</sub>).</p><p>Here we assessed patients with uncontrolled severe asthma (EudraCT 2021-005593-25) who had BDR measured at their initial screening visit. Then after a 4 week run-in period patients also had lung function measured after receiving 12 weeks of dupilumab 300 mg given every 2 weeks. We assessed the spirometry response to either salbutamol or dupilumab calculated as % predicted changes from baseline, as well as relative % change from baseline (post–pre/pre), and absolute change (FEV<sub>1</sub> in L and FEF<sub>25-75</sub> as L/s). To ensure an equal comparison, the pre-salbutamol baseline at screening prior to run-in was used for both assessments.</p><p>Spirometry (Micromedical, Chatham, UK) measurements were performed in triplicate according to the ERS guidelines [<span>3</span>]. 400 μg of salbutamol via a pressurised metered dose inhaler with an Aerochamber spacer device (Trudell Medical, London, Canada) was administered to all patients and after 20 min, the spirometry was repeated to assess BDR. Following the manufacturer's instructions and ERS guidelines, FeNO was obtained using NIOX Vero (NIOX, Oxford, UK) [<span>4</span>]. SPSS version 29 was used for statistical analysis. Paired students <i>t</i>-tests were applied with an alpha error of 5% and Pearsons test was used to evaluate correlations. Nominal <i>p</i> values are quoted as either <i>p</i> < 0.05, < 0.01 or < 0.001 (two tailed).</p><p>The cohort consisted of 24 patients, 14 females, mean (SEM) age 52.3 (2.96); BMI 30.0 (1.23). The mean % predicted pre-bronchodilator pulmonary function values and type 2 inflammation markers were: FEV<sub>1</sub> 88.1% (3.5); FEF<sub>25-75</sub> 47.5% (3.0); FVC 105.8% (4.0) ACQ 3.0 (0.2); FeNO 68.0 ppb (8.9); eosinophils 510/μL (48), total IgE 204.7 kU/l (42.8).</p><p>There were significant improvements in FEV<sub>1</sub> and FEF<sub>25-75</sub> in response to salbutamol. However, the response to dupilumab was significant for FEV<sub>1</sub> but not FEF<sub>25","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"253-255"},"PeriodicalIF":6.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Lipid Production Profile of Patients With Food Allergy","authors":"Sakura Masuko, Shinichiro Inagaki, Taiki Hamabata, Takeru Ishii, Nanae Nagata, Kiwako Yamamoto-Hanada, Tatsuki Fukuie, Masami Narita, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata","doi":"10.1111/cea.14636","DOIUrl":"10.1111/cea.14636","url":null,"abstract":"<p>Upon immediate allergic inflammation, activated mast cells produce abundant bioactive lipid mediator prostaglandin (PG) D<sub>2</sub>. PGD<sub>2</sub> is metabolised and excreted in urine as tetranor-PGDM. We have previously reported urinary tetranor-PGDM as a sensitive biomarker for food allergy (FA) reactions in children [<span>1</span>]. However, the production profile of other lipid mediators in the urine of FA patients remains unknown. Bioactive lipids are produced by enzyme-dependent or independent metabolism of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), linoleic acid (LA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and dihomo-gamma-linolenic acid (DGLA). There are three types of oxidative enzymes for PUFAs: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP). The produced lipid mediators regulate inflammation and are extracted mainly in urine, thus their production profile can reflect the inflammatory status of our bodies. In this study, we comprehensively analysed the production profile of lipid mediators in the urine of subjects who received oral food challenge (OFC).</p><p>We collected the same urine samples from subjects as previously reported [<span>1</span>]. Children suspected of having FA who underwent OFC to milk, egg, peanut or sesame were recruited between December 2014 and August 2015, and urine samples were collected before (pre) and 4 h after OFC (post). Of a total of 42 children, 31 were assessed as having positive results (OFC-positive; FA). This study received ethical approval from the Committee, University of Tokyo School of Medicine (2017,10586). All participants provided informed consent.</p><p>Initially, we confirmed that OFC and/or its positivity did not influence urinary pH, or specific gravity, while they did influence the lipid content (Figure 1A). There was no difference in urinary lipid content in children who ingested offending food, suggesting that lipid content may reflect the inflammatory reaction in the body. Next, we analysed the levels of 196 types of lipid metabolites in urine using LC–MS/MS and detected 19 lipid metabolites. These methods are available in the following repository (https://zenodo.org/records/14207617).</p><p>Figure 1B shows the AA metabolites levels in subjects' urine. As reported previously, the urinary levels of tetranor-PGDM were increased in OFC-positive-post urine, and its levels were higher than those of OFC-negative-post urine [<span>1</span>]. The levels of other PGD<sub>2</sub> metabolites, 13,14-dihydro-15-keto-tetranor-PGD<sub>2</sub> and tetranor-PGJM (precursor and non-enzymatic metabolite of tetranor-PGDM, respectively), were also higher in the OFC-positive-post urine. It is well known that mast cells express H-PGDS and produce PGD<sub>2</sub> [<span>2</span>]. During the progression of FA, mast cells infiltrate into the relatively large area of intestinal mucosa and release PGD<sub>2</sub>. This phenomenon presumably re","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"256-259"},"PeriodicalIF":6.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Anxiety to Work Productivity and Activity Impairment: The Mediating Role of Fatigue in Hereditary Angioedema.","authors":"Hugo W F Mak, Jane C Y Wong, Valerie Chiang, Dorothy L Y Lam, Philip H Li","doi":"10.1111/cea.14632","DOIUrl":"https://doi.org/10.1111/cea.14632","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penicillin Allergy Management in India and Sri Lanka: Current Challenges.","authors":"Saibal Moitra, Guwani Liyanage, Sarah Tonkin-Crine, Neil Powell, Yogini Jani, Dhanushka Dasanayake, Nadisha Badanasinghe, Mohammad Ziaul Haque, Wasana Kudagammana, Raj Kumar, Padukudru Anand Mahesh, Bernard Yu-Hor Thong, Juan Meng, Devasahayam Jesudas Christopher, Mamidipudi Thirumala Krishna","doi":"10.1111/cea.14624","DOIUrl":"https://doi.org/10.1111/cea.14624","url":null,"abstract":"<p><p>Data regarding Penicillin allergy labels (PALs) from India and Sri Lanka are sparse. Emerging data suggests that the proportion of patients declaring an unverified PAL in secondary care in India and Sri Lanka (1%-4%) is lesser than that reported in High Income Countries (15%-20%). However, even this relatively small percentage translates into a large absolute number, as this part of the world accounts for approximately 25% of the global population. There is a huge unmet need for allergy specialists in India and Sri Lanka. Penicillin allergy management is further compromised by unavailability of skin test reagents, lack of formal training in drug allergy, pre-emptive, non-standardised and unregulated skin testing by untrained operators and a weak health service framework. This has an adverse impact on antimicrobial stewardship, particularly in the management of rheumatic fever, rheumatic heart disease, bacterial endocarditis, syphilis and other sexually transmitted infections. This narrative review highlights the burden of PALs in India and Sri Lanka, as well as gaps in the published literature. It describes current challenges and a pragmatic, cautious and staged bespoke mitigation approach to improve and standardise antimicrobial stewardship in accordance with the World Health Organisation AWaRe guidance.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Birth Order on Paediatric Allergic Diseases: A National Birth Cohort in Japan.","authors":"Mitsuro Kobayashi, Masanori Ikeda, Naomi Matsumoto, Mitsuru Tsuge, Masato Yashiro, Takashi Yorifuji, Hirokazu Tsukahara","doi":"10.1111/cea.14626","DOIUrl":"https://doi.org/10.1111/cea.14626","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Allergomic Study Reveals Two Novel Venom Allergens, Phospholipase A1 and Antigen 5, From the Social Wasp Apoica pallens","authors":"Amilcar Perez-Riverol,&nbsp;Gabriel Hideki Izuka Moraes,&nbsp;José Roberto Aparecido dos Santos-Pinto,&nbsp;Luis Gustavo Romani Fernandes,&nbsp;Alexis Musacchio Lasa,&nbsp;Brita Dorn,&nbsp;Maria Beatrice Biló,&nbsp;Ricardo de Lima Zollner,&nbsp;Thilo Jakob,&nbsp;Mario Sergio Palma","doi":"10.1111/cea.14630","DOIUrl":"10.1111/cea.14630","url":null,"abstract":"","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"250-252"},"PeriodicalIF":6.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach","authors":"Umesh Singh,&nbsp;Jonathan A. Bernstein","doi":"10.1111/cea.14628","DOIUrl":"10.1111/cea.14628","url":null,"abstract":"&lt;p&gt;Previous ATP inhalation studies and clinical trials have demonstrated an anti-tussive effect of P2X3 antagonists, supporting the mechanism of purinergic P2X3 receptor activation leading to unexplained chronic cough (UCC). However, the role of TRP receptors in UCC is currently unclear. In this study, an interaction between P2X3 receptors on airway bronchial epithelial cells (BECs) and TRPA1 channels on upper airway nerves was explored in vitro as a potential mechanism for UCC (Figure 1A) [&lt;span&gt;1-3&lt;/span&gt;]. It was hypothesised that irritants activating TRP channels can result in ATP release from airway nerves resulting in P2X3 receptor activation on adjacent airway epithelial cells [&lt;span&gt;3-6&lt;/span&gt;]. To investigate the role of TRPA1 channel activation of P2X3 receptors, an indirect in vitro cell model was developed to demonstrate whether activation of TRPA1 channels expressed on neuronal cells result in ATP release that subsequently activates P2X3 receptors on adjacent BECs.&lt;/p&gt;&lt;p&gt;Dorsal root ganglion cells (DRGN, ND8/34 cell line, Sigma), known to express TRPA1 were used as a surrogate for airway neuronal cells [&lt;span&gt;7&lt;/span&gt;]. Functional assays were performed on DRGNs to quantify TRPA1 activation using the TRPA1 specific agonist (JT010) by observing a change in fluorescence measured by [Ca&lt;sup&gt;2+&lt;/sup&gt;]i of 10% or greater from baseline under confocal microscopy. The DRGNs cultured on poly-Lysine coated plates and loaded with FLUO4, were preincubated in the presence or absence of the TRPA1 antagonist HC-030031 (EMD Milipore) and then treated with a TRPA1-specific agonist (JT010 100 nM, Tocris) (&lt;i&gt;n&lt;/i&gt; = 3 experiments). Culture media from the DRGNs cell wells were collected after stimulation and assayed for ATP. ATP release in response to JT010-induced TRPA1 activation and its suppression by the TRPA1-antagonist, HC-030031, were quantified from the cell supernatant on a luminometer using the ATP Bioluminescence Assay Kit HS II (Roche). Additional information about study methods are available in the following repository (DOI 10.5281/zenodo.14244289).&lt;/p&gt;&lt;p&gt;Human bronchoepithelial cells (BEAS2B, ATCC), were used as a surrogate for airway epithelium. The effect of P2X3-receptor antagonist, MAF-454, in preventing activation of P2X3 receptors were determined by treating cultured BEAS2B cells with ATP disodium 4 μM (Sigma) stabilised with KOH in the presence and absence of MAF-454 preincubation. Differential gene expression (DEGs) in these samples versus untreated controls were determined using TaqMan rat inflammation array (Thermo Fisher). Pathway analysis, and upstream regulator analysis of the DEGs in the ATP-treated samples, compared to the MAF-454 preincubated ATP-treated samples were performed using the Ingenuity Pathway Analysis platform (Qiagen). As this was an in vitro study and did not require patient serum or patient data, no IRB was required.&lt;/p&gt;&lt;p&gt;Descriptive statistics and t-tests were performed to analyse differences in the average","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"247-249"},"PeriodicalIF":6.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “T cells and eosinophils in bronchial smooth muscle cell death in asthma”","authors":"","doi":"10.1111/cea.14627","DOIUrl":"10.1111/cea.14627","url":null,"abstract":"<p>\u0000 <span>K. Solarewicz-Madejek</span>, <span>T. M. Basinski</span>, <span>R. Crameri</span>, <span>M. Akdis</span>, <span>A. Akkaya</span>, <span>K. Blaser</span>, <span>K. F. Rabe</span>, <span>C. A. Akdis</span> &amp; <span>M. Jutel</span>, “ <span>T cells and eosinophils in bronchial smooth muscle cell death in asthma</span>”, <i>Clinical &amp; Experimental Allergy</i> <span>39</span>, no. <span>6</span> (<span>2009</span>): <span>845</span>–<span>855</span>, https://doi.org/10.1111/j.1365-2222.2009.03244.x\u0000 </p><p>The authors apologize for all the inconveniences and confirm that all the experimental results and corresponding conclusions remain unaffected.</p><p>The corrected Figure 4 and Figure 5 are shown as follows.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 3","pages":"281-283"},"PeriodicalIF":6.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Self-Reported Dietary Intake and Atopic Dermatitis Risk in Young Adults From Singapore and Malaysia.","authors":"Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew","doi":"10.1111/cea.14629","DOIUrl":"https://doi.org/10.1111/cea.14629","url":null,"abstract":"<p><p>This cross-sequential study found that frequent intake of high-fat and high-protein foods was associated with higher odds of atopic dermatitis (AD). However, occasional intake across all three macronutrients significantly lowered AD odds, suggesting that moderation-not strict avoidance-may benefit AD management in allergic populations.</p>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Allergy and Mental Health in Children and Adolescents—The Role of Shared Familial Environment","authors":"Hanna Karim,&nbsp;Cecilia Lundholm,&nbsp;Tong Gong,&nbsp;Bronwyn Brew,&nbsp;Michael Silverman,&nbsp;Catarina Almqvist","doi":"10.1111/cea.14619","DOIUrl":"10.1111/cea.14619","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Evidence suggests a link between food allergy and poor mental health, however, this may be explained by shared genetic and environmental factors. We aimed to investigate the association between food allergy of different severity and mental health in children, and the role of familial factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This population-based, longitudinal cohort study is based on the Child and Adolescent Twin Study in Sweden with questionnaire data reported by parents and/or children. Food allergy ‘ever’ and doctor's diagnosis were reported at age 9–12 years, and ≥ 1 recent dispensation of adrenaline was used as a marker for current severe food allergy. Outcomes were identified using validated questionnaires for anxiety; Screen for Child Anxiety Related Disorders (SCARED); Strength and Difficulties Questionnaire (SDQ) and depression; Short Mood and Feelings Questionnaire (SMFQ), Center for Epidemiological Studies Depression Scale (CES-D) and Diagnostic and Statistical manual of Mental Disorders (DSM-IV-MDE) and reported at 9–12, 15 and 18 years of age. Multivariate linear and logistic modelling was applied to the whole cohort and a co-twin control approach to remove confounding by familial factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 3039 (8.9%) children had a parent-reported food allergy. Among these, 1292 (43.5%) had non-severe food allergy without diagnosis, 1490 (49%) had non-severe food allergy with diagnosis and 257 (8.5%) had severe food allergy. Compared to children with no food allergy, non-severe food allergy with diagnosis by 9–12 years was associated with parent-reported anxiety/depression; SCARED (adjOR 2.10, 95% CI 1.48–2.98), SMFQ (adjOR 1.92, 95% CI 1.19–3.10) at 9–12 years and SDQ (adj<i>β</i> 0.2, 95% CI 0.0–0.4) at 15 years. All other associations were null including for those with severe food allergy. All positive estimates in the full cohort were attenuated using co-twin controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Evidence associating paediatric food allergy severity and poor mental health was weak, and positive associations observed were likely due to familial confounding.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10207,"journal":{"name":"Clinical and Experimental Allergy","volume":"55 2","pages":"175-186"},"PeriodicalIF":6.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cea.14619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}